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P42392

- TRPD_BUCAP

UniProt

P42392 - TRPD_BUCAP

Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

    Catalytic activityi

    N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per monomer.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791Anthranilate 1; via carbonyl oxygenUniRule annotation
    Binding sitei79 – 791Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
    Binding sitei87 – 871PhosphoribosylpyrophosphateUniRule annotation
    Metal bindingi91 – 911Magnesium 1UniRule annotation
    Binding sitei110 – 1101Anthranilate 1UniRule annotation
    Binding sitei119 – 1191Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
    Binding sitei165 – 1651Anthranilate 2UniRule annotation
    Metal bindingi223 – 2231Magnesium 2UniRule annotation
    Metal bindingi224 – 2241Magnesium 1UniRule annotation
    Metal bindingi224 – 2241Magnesium 2UniRule annotation

    GO - Molecular functioni

    1. anthranilate phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-283-MONOMER.
    UniPathwayiUPA00035; UER00041.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
    Gene namesi
    Name:trpDUniRule annotation
    Ordered Locus Names:BUsg_269
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Anthranilate phosphoribosyltransferasePRO_0000154435Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg269.

    Structurei

    3D structure databases

    ProteinModelPortaliP42392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 832Phosphoribosylpyrophosphate bindingUniRule annotation
    Regioni89 – 924Phosphoribosylpyrophosphate bindingUniRule annotation
    Regioni107 – 1159Phosphoribosylpyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0547.
    KOiK00766.
    OMAiQPFPRPD.
    OrthoDBiEOG6D5G6B.

    Family and domain databases

    Gene3Di3.40.1030.10. 2 hits.
    HAMAPiMF_00211. TrpD.
    InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    [Graphical view]
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    TIGRFAMsiTIGR01245. trpD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P42392-1 [UniParc]FASTAAdd to Basket

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    MQNIFNKIYE SKSLNQEESY QLFKSIALGK INEIQLSSIL TAMQMHGESE    50
    KEILGAIYAF SERMKFFPRP NYIFSDIVGT GGDSKNTINV STSSAFVAAS 100
    CGFKIIKHCN KGVSSKSGSS DLLNKFKINL NTSLENSKKI LDKLNICFLF 150
    APKYHSVFKY ASKTRSILKI KTIFNLLGPF LNPSRPPLTL IGVYKKDLVN 200
    PMSRILKKLK YQRGIILHGD DTDEVTLHGT TYISELLNNK IYSYELEPED 250
    FGIKRHSKSI FVEYSPEENY HIIKKTMQGK GEKLHEELIA VNVALLLKIF 300
    GHENLKENTK IALKKIRSGD VYKHIMQVSN MLKED 335
    Length:335
    Mass (Da):38,090
    Last modified:November 1, 1995 - v1
    Checksum:iE33F51F2126013AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19055 Genomic DNA. Translation: CAA79498.1.
    AE013218 Genomic DNA. Translation: AAM67827.1.
    PIRiA49897.
    RefSeqiNP_660616.1. NC_004061.1.
    WP_011053794.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67827; AAM67827; BUsg_269.
    GeneIDi1005471.
    KEGGibas:BUsg269.
    PATRICi21247343. VBIBucAph100086_0281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19055 Genomic DNA. Translation: CAA79498.1 .
    AE013218 Genomic DNA. Translation: AAM67827.1 .
    PIRi A49897.
    RefSeqi NP_660616.1. NC_004061.1.
    WP_011053794.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali P42392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67827 ; AAM67827 ; BUsg_269 .
    GeneIDi 1005471.
    KEGGi bas:BUsg269.
    PATRICi 21247343. VBIBucAph100086_0281.

    Phylogenomic databases

    eggNOGi COG0547.
    KOi K00766.
    OMAi QPFPRPD.
    OrthoDBi EOG6D5G6B.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00041 .
    BioCyci BAPH198804:GHMG-283-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 2 hits.
    HAMAPi MF_00211. TrpD.
    InterProi IPR005940. Anthranilate_Pribosyl_Tfrase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    [Graphical view ]
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    TIGRFAMsi TIGR01245. trpD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequence of a putative trpDC(F)BA operon in Buchnera aphidicola (endosymbiont of the aphid Schizaphis graminum)."
      Munson M.A., Baumann P.
      J. Bacteriol. 175:6426-6432(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiTRPD_BUCAP
    AccessioniPrimary (citable) accession number: P42392
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3