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P42392

- TRPD_BUCAP

UniProt

P42392 - TRPD_BUCAP

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Protein

Anthranilate phosphoribosyltransferase

Gene
trpD, BUsg_269
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) By similarity.UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Anthranilate 1; via carbonyl oxygen By similarity
Binding sitei79 – 791Phosphoribosylpyrophosphate; via amide nitrogen By similarity
Binding sitei87 – 871Phosphoribosylpyrophosphate By similarity
Metal bindingi91 – 911Magnesium 1 By similarity
Binding sitei110 – 1101Anthranilate 1 By similarity
Binding sitei119 – 1191Phosphoribosylpyrophosphate; via amide nitrogen By similarity
Binding sitei165 – 1651Anthranilate 2 By similarity
Metal bindingi223 – 2231Magnesium 2 By similarity
Metal bindingi224 – 2241Magnesium 1 By similarity
Metal bindingi224 – 2241Magnesium 2 By similarity

GO - Molecular functioni

  1. anthranilate phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-283-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase (EC:2.4.2.18)
Gene namesi
Name:trpD
Ordered Locus Names:BUsg_269
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Anthranilate phosphoribosyltransferaseUniRule annotationPRO_0000154435Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg269.

Structurei

3D structure databases

ProteinModelPortaliP42392.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Phosphoribosylpyrophosphate binding By similarity
Regioni89 – 924Phosphoribosylpyrophosphate binding By similarity
Regioni107 – 1159Phosphoribosylpyrophosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0547.
KOiK00766.
OMAiQPFPRPD.
OrthoDBiEOG6D5G6B.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

P42392-1 [UniParc]FASTAAdd to Basket

« Hide

MQNIFNKIYE SKSLNQEESY QLFKSIALGK INEIQLSSIL TAMQMHGESE    50
KEILGAIYAF SERMKFFPRP NYIFSDIVGT GGDSKNTINV STSSAFVAAS 100
CGFKIIKHCN KGVSSKSGSS DLLNKFKINL NTSLENSKKI LDKLNICFLF 150
APKYHSVFKY ASKTRSILKI KTIFNLLGPF LNPSRPPLTL IGVYKKDLVN 200
PMSRILKKLK YQRGIILHGD DTDEVTLHGT TYISELLNNK IYSYELEPED 250
FGIKRHSKSI FVEYSPEENY HIIKKTMQGK GEKLHEELIA VNVALLLKIF 300
GHENLKENTK IALKKIRSGD VYKHIMQVSN MLKED 335
Length:335
Mass (Da):38,090
Last modified:November 1, 1995 - v1
Checksum:iE33F51F2126013AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19055 Genomic DNA. Translation: CAA79498.1.
AE013218 Genomic DNA. Translation: AAM67827.1.
PIRiA49897.
RefSeqiNP_660616.1. NC_004061.1.
WP_011053794.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67827; AAM67827; BUsg_269.
GeneIDi1005471.
KEGGibas:BUsg269.
PATRICi21247343. VBIBucAph100086_0281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19055 Genomic DNA. Translation: CAA79498.1 .
AE013218 Genomic DNA. Translation: AAM67827.1 .
PIRi A49897.
RefSeqi NP_660616.1. NC_004061.1.
WP_011053794.1. NC_004061.1.

3D structure databases

ProteinModelPortali P42392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67827 ; AAM67827 ; BUsg_269 .
GeneIDi 1005471.
KEGGi bas:BUsg269.
PATRICi 21247343. VBIBucAph100086_0281.

Phylogenomic databases

eggNOGi COG0547.
KOi K00766.
OMAi QPFPRPD.
OrthoDBi EOG6D5G6B.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00041 .
BioCyci BAPH198804:GHMG-283-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 2 hits.
HAMAPi MF_00211. TrpD.
InterProi IPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view ]
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsi TIGR01245. trpD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and nucleotide sequence of a putative trpDC(F)BA operon in Buchnera aphidicola (endosymbiont of the aphid Schizaphis graminum)."
    Munson M.A., Baumann P.
    J. Bacteriol. 175:6426-6432(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiTRPD_BUCAP
AccessioniPrimary (citable) accession number: P42392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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