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P42391

- TRPB_BUCAP

UniProt

P42391 - TRPB_BUCAP

Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-281-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase beta chain (EC:4.2.1.20)
    Gene namesi
    Name:trpB
    Ordered Locus Names:BUsg_267
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Tryptophan synthase beta chainPRO_0000098927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP42391.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg267.

    Structurei

    3D structure databases

    ProteinModelPortaliP42391.
    SMRiP42391. Positions 2-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpB family.Curated

    Phylogenomic databases

    eggNOGiCOG0133.
    KOiK01696.
    OMAiEFMTLLQ.
    OrthoDBiEOG6GFGH7.

    Family and domain databases

    HAMAPiMF_00133. Trp_synth_beta.
    InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view]
    PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00263. trpB. 1 hit.
    PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLLNPYFGK FGGMYVPQIL MPALYQLEKN FVDAKKDSNF QKSFFNYLKN    50
    YAGRPTPLTL CNNLTNGTKT RIYLKREDLL HGGAHKTNQV LGQAMLAVKM 100
    KKKEIIAETG AGQHGVAAAI ASALFNLKCK IYMGYKDIKR QSPNVFRMKL 150
    MGAEVVSVES GSGTLKDACN EALRDWSRNY QKSHYMIGTA AGPHPYPTIV 200
    KEFQKMIGEE AKKQILEQEN RLPDAIIACV GGGSNAIGIF SDFIDEDVNL 250
    IGVEPAGQGI ETGKHGAPLN HGRTGIYFGM KSHLMQSQEG QIEKSWSISA 300
    GLDFPSVGPE HSWLNSIHRA KYVSITDIEA LEAFQILSKK EGIIPALESS 350
    HALAYALKLM YLDPKKEQVF IVNLSGRGDK DIFTVREILK KTEKKHESL 399
    Length:399
    Mass (Da):44,247
    Last modified:November 1, 1995 - v1
    Checksum:iDEBFD45D2C859C30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19055 Genomic DNA. Translation: CAA79500.1.
    AE013218 Genomic DNA. Translation: AAM67825.1.
    PIRiC49897.
    RefSeqiNP_660614.1. NC_004061.1.
    WP_011053792.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67825; AAM67825; BUsg_267.
    GeneIDi1005469.
    KEGGibas:BUsg267.
    PATRICi21247339. VBIBucAph100086_0279.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19055 Genomic DNA. Translation: CAA79500.1 .
    AE013218 Genomic DNA. Translation: AAM67825.1 .
    PIRi C49897.
    RefSeqi NP_660614.1. NC_004061.1.
    WP_011053792.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali P42391.
    SMRi P42391. Positions 2-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg267.

    Proteomic databases

    PRIDEi P42391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67825 ; AAM67825 ; BUsg_267 .
    GeneIDi 1005469.
    KEGGi bas:BUsg267.
    PATRICi 21247339. VBIBucAph100086_0279.

    Phylogenomic databases

    eggNOGi COG0133.
    KOi K01696.
    OMAi EFMTLLQ.
    OrthoDBi EOG6GFGH7.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci BAPH198804:GHMG-281-MONOMER.

    Family and domain databases

    HAMAPi MF_00133. Trp_synth_beta.
    InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view ]
    PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00263. trpB. 1 hit.
    PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequence of a putative trpDC(F)BA operon in Buchnera aphidicola (endosymbiont of the aphid Schizaphis graminum)."
      Munson M.A., Baumann P.
      J. Bacteriol. 175:6426-6432(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiTRPB_BUCAP
    AccessioniPrimary (citable) accession number: P42391
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3