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P42391

- TRPB_BUCAP

UniProt

P42391 - TRPB_BUCAP

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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-281-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain (EC:4.2.1.20)
Gene namesi
Name:trpB
Ordered Locus Names:BUsg_267
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Tryptophan synthase beta chainPRO_0000098927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiP42391.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg267.

Structurei

3D structure databases

ProteinModelPortaliP42391.
SMRiP42391. Positions 2-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiCOG0133.
KOiK01696.
OMAiEFMTLLQ.
OrthoDBiEOG6GFGH7.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLLNPYFGK FGGMYVPQIL MPALYQLEKN FVDAKKDSNF QKSFFNYLKN
60 70 80 90 100
YAGRPTPLTL CNNLTNGTKT RIYLKREDLL HGGAHKTNQV LGQAMLAVKM
110 120 130 140 150
KKKEIIAETG AGQHGVAAAI ASALFNLKCK IYMGYKDIKR QSPNVFRMKL
160 170 180 190 200
MGAEVVSVES GSGTLKDACN EALRDWSRNY QKSHYMIGTA AGPHPYPTIV
210 220 230 240 250
KEFQKMIGEE AKKQILEQEN RLPDAIIACV GGGSNAIGIF SDFIDEDVNL
260 270 280 290 300
IGVEPAGQGI ETGKHGAPLN HGRTGIYFGM KSHLMQSQEG QIEKSWSISA
310 320 330 340 350
GLDFPSVGPE HSWLNSIHRA KYVSITDIEA LEAFQILSKK EGIIPALESS
360 370 380 390
HALAYALKLM YLDPKKEQVF IVNLSGRGDK DIFTVREILK KTEKKHESL
Length:399
Mass (Da):44,247
Last modified:November 1, 1995 - v1
Checksum:iDEBFD45D2C859C30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19055 Genomic DNA. Translation: CAA79500.1.
AE013218 Genomic DNA. Translation: AAM67825.1.
PIRiC49897.
RefSeqiNP_660614.1. NC_004061.1.
WP_011053792.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67825; AAM67825; BUsg_267.
GeneIDi1005469.
KEGGibas:BUsg267.
PATRICi21247339. VBIBucAph100086_0279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19055 Genomic DNA. Translation: CAA79500.1 .
AE013218 Genomic DNA. Translation: AAM67825.1 .
PIRi C49897.
RefSeqi NP_660614.1. NC_004061.1.
WP_011053792.1. NC_004061.1.

3D structure databases

ProteinModelPortali P42391.
SMRi P42391. Positions 2-390.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg267.

Proteomic databases

PRIDEi P42391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67825 ; AAM67825 ; BUsg_267 .
GeneIDi 1005469.
KEGGi bas:BUsg267.
PATRICi 21247339. VBIBucAph100086_0279.

Phylogenomic databases

eggNOGi COG0133.
KOi K01696.
OMAi EFMTLLQ.
OrthoDBi EOG6GFGH7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .
BioCyci BAPH198804:GHMG-281-MONOMER.

Family and domain databases

HAMAPi MF_00133. Trp_synth_beta.
InterProi IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00263. trpB. 1 hit.
PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and nucleotide sequence of a putative trpDC(F)BA operon in Buchnera aphidicola (endosymbiont of the aphid Schizaphis graminum)."
    Munson M.A., Baumann P.
    J. Bacteriol. 175:6426-6432(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiTRPB_BUCAP
AccessioniPrimary (citable) accession number: P42391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3