Reviewed, UniProtKB/Swiss-Prot P42387 (TRPE_BUCAP)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	BUsg_PT1

Encoded on

Plasmid pBSc

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Anthranilate synthase component 1		PRO_0000154081

Sequences

	Sequence		Length	Mass (Da)
	P42387-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EDD52BF2E9DDD5C7	FASTA	515	58,687
	10 20 30 40 50 60 MSKNPYEIEI IQKTAPYHPD PTMIFNHLCA SRPGTLLLET AEVNKKRDLE SIMIIDSAMR 70 80 90 100 110 120 ISSEDNSVKL TPLSINGTDI LSTLKKTIPK KIEIYEKNNS TILVFPKIKK NIDEDKKLFS 130 140 150 160 170 180 LSVFDAFRLM IRIFENREKK SKAMFFGGLF SYDLISVFES LPKLKGNQKC SNFCFYLAET 190 200 210 220 230 240 LLVLDHQKKT CLIQNSLFSK NLKERKRIKK RSVEIERKLN EKLKLIPKTK IKDINLTSNM 250 260 270 280 290 300 NNFEYGTIIK KLQKLIQKGE IFQVVPSRKF YLPCPNPLSA YQKLKKSNPS PYMFFMQDQD 310 320 330 340 350 360 FTLFGASPES SLKYDEKTRK IELYPIAGTR PRGKTEDGNL DLDLDSRIEL EMRTNHKELA 370 380 390 400 410 420 EHLMLVDLAR NDLARICKPG SRYVSDLVRV DRYSHVMHLV SRVIGELREG LDALHAYASC 430 440 450 460 470 480 MNMGTLTGAP KVRAMQLIAE HEGEKRGSYG GAIGYFTDLG NLDTCITIRS AYVEKQVATI 490 500 510 QAGAGIVYNS IPENEVNESL NKAQAVINAI KNAHY

References

[1]	"Amplification of trpEG: adaptation of Buchnera aphidicola to an endosymbiotic association with aphids." Lai C.-Y., Baumann L., Baumann P. Proc. Natl. Acad. Sci. U.S.A. 91:3819-3823(1994) [PubMed: 8170994] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z21938 Genomic DNA. Translation: CAA79931.1. Z21938 Genomic DNA. Translation: CAA79933.1.
PIR	I40052.
3D structure databases
HSSP	HSSP built from PDB template 1I1Q based on UniProtKB P00898.
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus BUsg_PT1 in contig Z21938_GR. Gene locus trpE in contig Z21938_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P42387.
OMA	HKELAEH.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCAP

Accession

Primary (citable) accession number: P42387

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)