P42383 (CH60_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60 kDa chaperonin

Alternative name(s):
GroEL protein
Heat shock protein 60
Protein Cpn60

Gene names

Name:	groL
Synonyms:	groEL, hsp60, hspB, mopA
Ordered Locus Names:	HP_0010

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity. HAMAP MF_00600
Subunit structure	Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00600.
Sequence similarities	Belongs to the chaperonin (HSP60) family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein refolding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	60 kDa chaperonin HAMAP MF_00600		PRO_0000063389
Natural variations
	Natural variant	76	1	V → D in strain: 85P.
	Natural variant	123	1	A → P in strain: 85P.
	Natural variant	293	1	I → V in strain: 85P.
	Natural variant	320 – 321	2	GR → K in strain: 85P.
Experimental info
	Sequence conflict	339	1	H → D in CAA52062. Ref.1
	Sequence conflict	527	1	A → T in CAA52062. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P42383 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 00E5DB7FAAC82282	FASTA	546	58,264
	10 20 30 40 50 60 MAKEIKFSDS ARNLLFEGVR QLHDAVKVTM GPRGRNVLIQ KSYGAPSITK DGVSVAKEIE 70 80 90 100 110 120 LSCPVANMGA QLVKEVASKT ADAAGDGTTT ATVLAYSIFK EGLRNITAGA NPIEVKRGMD 130 140 150 160 170 180 KAAEAIINEL KKASKKVGGK EEITQVATIS ANSDHNIGKL IADAMEKVGK DGVITVEEAK 190 200 210 220 230 240 GIEDELDVVE GMQFDRGYLS PYFVTNAEKM TAQLDNAYIL LTDKKISSMK DILPLLEKTM 250 260 270 280 290 300 KEGKPLLIIA EDIEGEALTT LVVNKLRGVL NIAAVKAPGF GDRRKEMLKD IAILTGGQVI 310 320 330 340 350 360 SEELGLSLEN AEVEFLGKAG RIVIDKDNTT IVDGKGHSHD VKDRVAQIKT QIASTTSDYD 370 380 390 400 410 420 KEKLQERLAK LSGGVAVIKV GAASEVEMKE KKDRVDDALS ATKAAVEEGI VIGGGAALIR 430 440 450 460 470 480 AAQKVHLNLH DDEKVGYEII MRAIKAPLAQ IAINAGYDGG VVVNEVEKHE GHFGFNASNG 490 500 510 520 530 540 KYVDMFKEGI IDPLKVERIA LQNAVSVSSL LLTTEATVHE IKEEKAAPAM PDMGGMGGMG GMGGMM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases." Macchia G., Massone A., Burroni D., Covacci A., Censini S., Rappuoli R. Mol. Microbiol. 9:645-652(1993) [PubMed: 8105364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
[2]	"Helicobacter pylori hspA-hspB heat-shock gene cluster: nucleotide sequence, expression, putative function and immunogenicity." Suerbaum S., Thiberge J.-M., Kansau I., Ferrero R.L., Labigne A. Mol. Microbiol. 14:959-974(1994) [PubMed: 7715457] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 85P.
[3]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73840 Genomic DNA. Translation: CAA52062.1. L23798 Genomic DNA. Translation: AAC41441.1. AE000511 Genomic DNA. Translation: AAD07080.1.
PIR	S36237. B64521.
RefSeq	NP_206812.1. NC_000915.1.
3D structure databases
ProteinModelPortal	P42383.
SMR	P42383. Positions 2-521.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3069N.
MINT	MINT-164875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899089.
GenomeReviews	Gene locus HP_0010 in contig AE000511_GR.
KEGG	hpy:HP0010.
NMPDR	fig|85962.1.peg.10.
PATRIC	20591213. VBIHelPyl33062_0008.
TIGR	HP_0010.
Phylogenomic databases
HOGENOM	HBG625289.
OMA	VGQLISQ.
ProtClustDB	PRK00013.
Family and domain databases
HAMAP	MF_00600. CH60. [Tree]
InterPro	IPR018370. Chaperonin_Cpn60_CS. IPR001844. Chaprnin_Cpn60. IPR002423. Cpn60/TCP-1. [Graphical view]
KO	K04077.
PANTHER	PTHR11353. Cpn60/TCP-1. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. [Graphical view]
PRINTS	PR00298. CHAPERONIN60.
SUPFAM	SSF48592. GroEL-ATPase. 1 hit.
TIGRFAMs	TIGR02348. GroEL. 1 hit.
PROSITE	PS00296. CHAPERONINS_CPN60. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CH60_HELPY

Accession

Primary (citable) accession number: P42383

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program