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Protein

60 kDa chaperonin

Gene

groL

Organism
Ehrlichia chaffeensis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
55 kDa major antigen
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiEhrlichia chaffeensis
Taxonomic identifieri945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633621 – 55060 kDa chaperoninAdd BLAST550

Proteomic databases

PRIDEiP42382

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP42382
SMRiP42382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

P42382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVVVTGEQ LDKSIREVVR ILEDAVGCTA GPKGLTVAIG KSYGAPEVTK
60 70 80 90 100
DGYKVIKSIK PEDPLALAIA NIITQSASQC NDKVGDGTTT CSILTAKVIE
110 120 130 140 150
EVSKAKAAGA DIVCIKEGVL KAKEAVLEAL MSMKREVLSE EEIAQVATIS
160 170 180 190 200
ANGDKNIGSK IAQCVQEVGK DGVITVEESK GFKELDVEKT DGMQFDRGYL
210 220 230 240 250
SPYFVTNSEK MLVEFENPYI LLTEKKLNII QPILPILENV ARSGRPLLII
260 270 280 290 300
AEDVEGEALS TLVLNKLRGG LHVAAVKAPG FGDRRKDMLG DIAILTGAKH
310 320 330 340 350
VISDDLAIKM EDLTLAELGT AKNIRITKDT TTIIGSVDNS SANVQSRINQ
360 370 380 390 400
IKMQIEASTS DYDKEKLRER LAKLSGGVAV LKVGGSSEVE VKERKDRVED
410 420 430 440 450
ALHATRAAVE EGVVPGGGAA LLYTLSVLEN LKSKNDDEQL GINIVKRALQ
460 470 480 490 500
APIKRIIKNS GSENAPCVIA HLLKQNDKEL IFNVDTMNFA NAFTSGVIDP
510 520 530 540 550
LKVVRIAFDF AVSLAAVFMT LNAIVVDVPS KDDANAGAGG MGGMGGMGGF
Length:550
Mass (Da):58,544
Last modified:November 1, 1995 - v1
Checksum:i8B3391F8902630B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10917 Genomic DNA Translation: AAB49805.1
PIRiS61297

Similar proteinsi

Entry informationi

Entry nameiCH60_EHRCH
AccessioniPrimary (citable) accession number: P42382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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