P42356 (PI4KA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-kinase alpha
Short name=PI4-kinase alpha
Short name=PI4K-alpha
Short name=PtdIns-4-kinase alpha
EC=2.7.1.67

Gene names

Name:	PI4KA
Synonyms:	PIK4, PIK4CA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2044 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Enzyme regulation	This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine.
Tissue specificity	Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. Ref.1 Ref.2
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Contains 1 PI3K/PI4K domain. Contains 1 PIK helical domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phosphatidylinositol biosynthetic process Traceable author statement. Source: ProtInc phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: ProtInc
Cellular component	Golgi-associated vesicle Traceable author statement. Source: ProtInc
Molecular function	1-phosphatidylinositol 4-kinase activity Traceable author statement. Source: ProtInc ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P42356-1)

Also known as: PI4K230;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P42356-2)

Also known as: PI4K97;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1190: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2044	2044	Phosphatidylinositol 4-kinase alpha		PRO_0000088827
Regions
	Domain	1472 – 1660	189	PIK helical
	Domain	1788 – 2021	234	PI3K/PI4K
	Region	1661 – 1793	133	Pleckstrin homology (PH) domain conferring phosphoinositide binding specificity By similarity
Amino acid modifications
	Modified residue	172	1	Phosphoserine Ref.5 Ref.9
	Modified residue	197	1	Phosphothreonine Ref.9
	Modified residue	198	1	Phosphoserine Ref.5 Ref.6
	Modified residue	199	1	Phosphoserine Ref.6
	Modified residue	202	1	Phosphoserine Ref.6
	Modified residue	204	1	Phosphoserine Ref.6
	Modified residue	207	1	Phosphoserine Ref.5 Ref.6 Ref.10
	Modified residue	1096	1	Phosphotyrosine Ref.8
	Modified residue	1378	1	Phosphoserine Ref.10
	Modified residue	1770	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 1190	1190	Missing in isoform 2.		VSP_008805
	Natural variant	322	1	M → V. Corresponds to variant rs17819211 [ dbSNP | Ensembl ].		VAR_050531
	Natural variant	1793	1	V → L. Corresponds to variant rs2539908 [ dbSNP | Ensembl ].		VAR_059549
Experimental info
	Sequence conflict	380	1	N → S in AAD13352. Ref.2
	Sequence conflict	1889	1	S → I in AAH53654. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PI4K230) [UniParc]. Last modified December 16, 2008. Version 3. Checksum: 7516EE4AA1E66465	FASTA	2,044	231,319
	10 20 30 40 50 60 MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDCVVP YLLRLLKGLP KVYWVEESTA 70 80 90 100 110 120 RKGRGALPVA ESFSFCLVTL LSDVAYRDPS LRDEILEVLL QVLHVLLGMC QALEIQDKEY 130 140 150 160 170 180 LCKYAIPCLI GISRAFGRYS NMEESLLSKL FPKIPPHSLR VLEELEGVRR RSFNDFRSIL 190 200 210 220 230 240 PSNLLTVCQE GTLKRKTSSV SSISQVSPER GMPPPSSPGG SAFHYFEASC LPDGTALEPE 250 260 270 280 290 300 YYFSTISSSF SVSPLFNGVT YKEFNIPLEM LRELLNLVKK IVEEAVLKSL DAIVASVMEA 310 320 330 340 350 360 NPSADLYYTS FSDPLYLTMF KMLRDTLYYM KDLPTSFVKE IHDFVLEQFN TSQGELQKIL 370 380 390 400 410 420 HDADRIHNEL SPLKLRCQAN AACVDLMVWA VKDEQGAENL CIKLSEKLQS KTSSKVIIAH 430 440 450 460 470 480 LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVIPSPVL VKLYKYHSQY HTVAGNDIKI 490 500 510 520 530 540 SVTNEHSEST LNVMSGKKSQ PSMYEQLRDI AIDNICRCLK AGLTVDPVIV EAFLASLSNR 550 560 570 580 590 600 LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID 610 620 630 640 650 660 QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA 670 680 690 700 710 720 NIQDEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT 730 740 750 760 770 780 RRLPPIKEAK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK 790 800 810 820 830 840 EPLRSVLQYN SAMKNDTVTP AELSELRSTI INLLDPPPEV SALINKLDFA MSTYLLSVYR 850 860 870 880 890 900 LEYMRVLRST DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFDAFL NMMADKAKTK 910 920 930 940 950 960 ENEEELERHA QFLLVNFNHI HKRIRRVADK YLSGLVDKFP HLLWSGTVLK TMLDILQTLS 970 980 990 1000 1010 1020 LSLSADIHKD QPYYDIPDAP YRITVPDTYE ARESIVKDFA ARCGMILQEA MKWAPTVTKS 1030 1040 1050 1060 1070 1080 HLQEYLNKHQ NWVSGLSQHT GLAMATESIL HFAGYNKQNT TLGATQLSER PACVKKDYSN 1090 1100 1110 1120 1130 1140 FMASLNLRNR YAGEVYGMIR FSGTTGQMSD LNKMMVQDLH SALDRSHPQH YTQAMFKLTA 1150 1160 1170 1180 1190 1200 MLISSKDCDP QLLHHLCWGP LRMFNEHGME TALACWEWLL AGKDGVEVPF MREMAGAWHM 1210 1220 1230 1240 1250 1260 TVEQKFGLFS AEIKEADPLA ASEASQPKPC PPEVTPHYIW IDFLVQRFEI AKYCSSDQVE 1270 1280 1290 1300 1310 1320 IFSSLLQRSM SLNIGGAKGS MNRHVAAIGP RFKLLTLGLS LLHADVVPNA TIRNVLREKI 1330 1340 1350 1360 1370 1380 YSTAFDYFSC PPKFPTQGEK RLREDISIMI KFWTAMFSDK KYLTASQLVP PDNQDTRSNL 1390 1400 1410 1420 1430 1440 DITVGSRQQA TQGWINTYPL SSGMSTISKK SGMSKKTNRG SQLHKYYMKR RTLLLSLLAT 1450 1460 1470 1480 1490 1500 EIERLITWYN PLSAPELELD QAGENSVANW RSKYISLSEK QWKDNVNLAW SISPYLAVQL 1510 1520 1530 1540 1550 1560 PARFKNTEAI GNEVTRLVRL DPGAVSDVPE AIKFLVTWHT IDADAPELSH VLCWAPTDPP 1570 1580 1590 1600 1610 1620 TGLSYFSSMY PPHPLTAQYG VKVLRSFPPD AILFYIPQIV QALRYDKMGY VREYILWAAS 1630 1640 1650 1660 1670 1680 KSQLLAHQFI WNMKTNIYLD EEGHQKDPDI GDLLDQLVEE ITGSLSGPAK DFYQREFDFF 1690 1700 1710 1720 1730 1740 NKITNVSAII KPYPKGDERK KACLSALSEV KVQPGCYLPS NPEAIVLDID YKSGTPMQSA 1750 1760 1770 1780 1790 1800 AKAPYLAKFK VKRCGVSELE KEGLRCRSDS EDECSTQEAD GQKISWQAAI FKVGDDCRQD 1810 1820 1830 1840 1850 1860 MLALQIIDLF KNIFQLVGLD LFVFPYRVVA TAPGCGVIEC IPDCTSRDQL GRQTDFGMYD 1870 1880 1890 1900 1910 1920 YFTRQYGDES TLAFQQARYN FIRSMAAYSL LLFLLQIKDR HNGNIMLDKK GHIIHIDFGF 1930 1940 1950 1960 1970 1980 MFESSPGGNL GWEPDIKLTD EMVMIMGGKM EATPFKWFME MCVRGYLAVR PYMDAVVSLV 1990 2000 2010 2020 2030 2040 TLMLDTGLPC FRGQTIKLLK HRFSPNMTER EAANFIMKVI QSCFLSNRSR TYDMIQYYQN DIPY
	Isoform 2 (PI4K97) [UniParc]. Checksum: F519168FA721644E	FASTA	854	96,984
	10 20 30 40 50 60 MREMAGAWHM TVEQKFGLFS AEIKEADPLA ASEASQPKPC PPEVTPHYIW IDFLVQRFEI 70 80 90 100 110 120 AKYCSSDQVE IFSSLLQRSM SLNIGGAKGS MNRHVAAIGP RFKLLTLGLS LLHADVVPNA 130 140 150 160 170 180 TIRNVLREKI YSTAFDYFSC PPKFPTQGEK RLREDISIMI KFWTAMFSDK KYLTASQLVP 190 200 210 220 230 240 PDNQDTRSNL DITVGSRQQA TQGWINTYPL SSGMSTISKK SGMSKKTNRG SQLHKYYMKR 250 260 270 280 290 300 RTLLLSLLAT EIERLITWYN PLSAPELELD QAGENSVANW RSKYISLSEK QWKDNVNLAW 310 320 330 340 350 360 SISPYLAVQL PARFKNTEAI GNEVTRLVRL DPGAVSDVPE AIKFLVTWHT IDADAPELSH 370 380 390 400 410 420 VLCWAPTDPP TGLSYFSSMY PPHPLTAQYG VKVLRSFPPD AILFYIPQIV QALRYDKMGY 430 440 450 460 470 480 VREYILWAAS KSQLLAHQFI WNMKTNIYLD EEGHQKDPDI GDLLDQLVEE ITGSLSGPAK 490 500 510 520 530 540 DFYQREFDFF NKITNVSAII KPYPKGDERK KACLSALSEV KVQPGCYLPS NPEAIVLDID 550 560 570 580 590 600 YKSGTPMQSA AKAPYLAKFK VKRCGVSELE KEGLRCRSDS EDECSTQEAD GQKISWQAAI 610 620 630 640 650 660 FKVGDDCRQD MLALQIIDLF KNIFQLVGLD LFVFPYRVVA TAPGCGVIEC IPDCTSRDQL 670 680 690 700 710 720 GRQTDFGMYD YFTRQYGDES TLAFQQARYN FIRSMAAYSL LLFLLQIKDR HNGNIMLDKK 730 740 750 760 770 780 GHIIHIDFGF MFESSPGGNL GWEPDIKLTD EMVMIMGGKM EATPFKWFME MCVRGYLAVR 790 800 810 820 830 840 PYMDAVVSLV TLMLDTGLPC FRGQTIKLLK HRFSPNMTER EAANFIMKVI QSCFLSNRSR 850 TYDMIQYYQN DIPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a human phosphatidylinositol 4-kinase." Wong K., Cantley L.C. J. Biol. Chem. 269:28878-28884(1994) [PubMed: 7961848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230." Gehrmann T., Guelkan H., Suer S., Herberg F.W., Balla A., Vereb G. Jr., Mayr G.W., Heilmeyer L.M.G. Jr. Biochim. Biophys. Acta 1437:341-356(1999) [PubMed: 10101268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1142-2044 (ISOFORM 1). Tissue: Uterus.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172; SER-198 AND SER-207, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-199; SER-202; SER-204 AND SER-207, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1770, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1096, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[9]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND THR-197, MASS SPECTROMETRY.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND SER-1378, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L36151 mRNA. Translation: AAA56839.1. AF012872 mRNA. Translation: AAD13352.1. AC007050 Genomic DNA. No translation available. AC007308 Genomic DNA. No translation available. BC018120 mRNA. Translation: AAH18120.2. BC053654 mRNA. Translation: AAH53654.1.
IPI	IPI00031424. IPI00070943.
PIR	A55404.
RefSeq	NP_002641.1. NM_002650.2.
UniGene	Hs.529438.
3D structure databases
ProteinModelPortal	P42356.
SMR	P42356. Positions 1501-2028.
ModBase	Search...
Protein-protein interaction databases
IntAct	P42356. 7 interactions.
MINT	MINT-1388461.
STRING	P42356.
PTM databases
PhosphoSite	P42356.
Polymorphism databases
DMDM	218512114.
Proteomic databases
PRIDE	P42356.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255882; ENSP00000255882; ENSG00000241973.
GeneID	5297.
KEGG	hsa:5297.
UCSC	uc002zsy.2. human. uc002zsz.2. human.
Organism-specific databases
CTD	5297.
GeneCards	GC22M021061.
H-InvDB	HIX0016262.
HGNC	HGNC:8983. PI4KA.
HPA	CAB009092.
MIM	600286. gene.
neXtProt	NX_P42356.
PharmGKB	PA162399305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15200.
HOVERGEN	HBG052742.
InParanoid	P42356.
OrthoDB	EOG4FJ87V.
PhylomeDB	P42356.
Enzyme and pathway databases
BioCyc	MetaCyc:ENSG00000133511-MONOMER.
Pathway_Interaction_DB	avb3_integrin_pathway. Integrins in angiogenesis.
Gene expression databases
ArrayExpress	P42356.
Bgee	P42356.
CleanEx	HS_PI4KA.
Genevestigator	P42356.
GermOnline	ENSG00000133511. Homo sapiens.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. G3DSA:1.25.40.70. PI3Ka. 1 hit.
KO	K00888.
PANTHER	PTHR10048. PI_Kinase. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
SMART	SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20474.
SOURCE	Search...

Entry information

Entry name

PI4KA_HUMAN

Accession

Primary (citable) accession number: P42356
Secondary accession number(s): Q7Z625, Q9UPG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.