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P42348

- PI3K2_SOYBN

UniProt

P42348 - PI3K2_SOYBN

Protein

Phosphatidylinositol 3-kinase, nodule isoform

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Associated with membrane proliferation.

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. endocytosis Source: EnsemblPlants/Gramene
    2. microgametogenesis Source: EnsemblPlants/Gramene
    3. phosphatidylinositol-mediated signaling Source: InterPro
    4. reactive oxygen species metabolic process Source: EnsemblPlants/Gramene
    5. response to salt stress Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.137. 2483.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase, nodule isoform (EC:2.7.1.137)
    Short name:
    PI3-kinase
    Short name:
    PI3K
    Short name:
    PtdIns-3-kinase
    Alternative name(s):
    SPI3K-1
    OrganismiGlycine max (Soybean) (Glycine hispida)
    Taxonomic identifieri3847 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
    ProteomesiUP000008827: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 812812Phosphatidylinositol 3-kinase, nodule isoformPRO_0000088821Add
    BLAST

    Expressioni

    Inductioni

    Highly expressed in young root nodules in parallel with membrane proliferation but is repressed in mature nodules.

    Gene expression databases

    GenevestigatoriP42348.

    Structurei

    3D structure databases

    ProteinModelPortaliP42348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 175162C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 447176PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini560 – 812253PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK00914.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54452. SSF54452. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGNEFRFFL SCDISVPVTF RVERLEGNLP LPKSPDLENN APTDNRTTEL    50
    FVECALYIDG APFGLPMRTR LESLGPSYCW NELITLTTKY RDLTAQSQLT 100
    FTVWDLSHGE GLIGGATILL FNNKKQLKTG KQKLRLWAGK EADGTFPTST 150
    PGKVPRHERG ELERLEKLVN KYERGQIQRV DWLDRLTFKT MERIKERESL 200
    KNGSSHMYLV VDFCSFEHRV VFQESGANFL FPSPIASTND IVVVWDPEVG 250
    KINPSEHKQL KLARSLTRGV IDRDLKPSSN ERKSIQRILK YPPTRTLSGD 300
    ERQLLWKFRF SLMSEKRALT KFLRCVEWSD VQEAKQALEL MGKWEMIDVC 350
    DALELLSPVF ESEEVRAYAV SVLERADDEE LQCYLLQLVQ ALRFERSAKS 400
    RLSHFLIQCA LRNIELASFL RWYVAVELYD PAYAKRFYCT YEILEENMMK 450
    IAAGVNGEED GFKQWQSLVR QTELTAQLCS ITREVSNVRG NTQKKIEKLR 500
    QLLSGLLSEL TYFDEPIRSP LAPGVLITGI VPSESSIFKS ALHPLRLTFR 550
    AANGGTCKII FKKGDDIRQD QLVVQMVSLM DRLLKLENLD LHLTPYKVLA 600
    TGQDEGMLEF IPSRSLAQIL SENRSIISYL QKFHPDDHGP FGITATCLET 650
    FIKSCAGYSV ITYILGIGDR HLDNLLLRND GGLFHVDFGF ILGRDPKPFP 700
    PPMKLCKEMV EAMGGAESQY YTRFKSYCCE AYHILRKSSN LILNLFYLMA 750
    GSNIPDIASD PEKGILKLQE KFRLDLDDEA SIHFFQDLIN ESVSALFPQM 800
    VETIHRWAQY WR 812
    Length:812
    Mass (Da):93,002
    Last modified:November 1, 1995 - v1
    Checksum:i94C5A922AF198A4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29770 mRNA. Translation: AAA64468.1.
    PIRiT07745.
    RefSeqiNP_001242315.1. NM_001255386.1.
    UniGeneiGma.64312.

    Genome annotation databases

    GeneIDi100778348.
    KEGGigmx:100778348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29770 mRNA. Translation: AAA64468.1 .
    PIRi T07745.
    RefSeqi NP_001242315.1. NM_001255386.1.
    UniGenei Gma.64312.

    3D structure databases

    ProteinModelPortali P42348.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100778348.
    KEGGi gmx:100778348.

    Phylogenomic databases

    KOi K00914.

    Enzyme and pathway databases

    BRENDAi 2.7.1.137. 2483.

    Gene expression databases

    Genevestigatori P42348.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54452. SSF54452. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation."
      Hong Z., Verma D.P.S.
      Proc. Natl. Acad. Sci. U.S.A. 91:9617-9621(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Prize.
      Tissue: Root nodule.

    Entry informationi

    Entry nameiPI3K2_SOYBN
    AccessioniPrimary (citable) accession number: P42348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3