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Protein

Phosphatidylinositol 3-kinase, nodule isoform

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associated with membrane proliferation.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137 2483

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase, nodule isoform (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Alternative name(s):
SPI3K-1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888211 – 812Phosphatidylinositol 3-kinase, nodule isoformAdd BLAST812

Proteomic databases

PRIDEiP42348

Expressioni

Inductioni

Highly expressed in young root nodules in parallel with membrane proliferation but is repressed in mature nodules.

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA06G10090.1

Structurei

3D structure databases

ProteinModelPortaliP42348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 175C2 PI3K-typePROSITE-ProRule annotationAdd BLAST162
Domaini272 – 447PIK helicalPROSITE-ProRule annotationAdd BLAST176
Domaini560 – 812PI3K/PI4KPROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0906 Eukaryota
COG5032 LUCA
KOiK00914

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54452 SSF54452, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

P42348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGNEFRFFL SCDISVPVTF RVERLEGNLP LPKSPDLENN APTDNRTTEL
60 70 80 90 100
FVECALYIDG APFGLPMRTR LESLGPSYCW NELITLTTKY RDLTAQSQLT
110 120 130 140 150
FTVWDLSHGE GLIGGATILL FNNKKQLKTG KQKLRLWAGK EADGTFPTST
160 170 180 190 200
PGKVPRHERG ELERLEKLVN KYERGQIQRV DWLDRLTFKT MERIKERESL
210 220 230 240 250
KNGSSHMYLV VDFCSFEHRV VFQESGANFL FPSPIASTND IVVVWDPEVG
260 270 280 290 300
KINPSEHKQL KLARSLTRGV IDRDLKPSSN ERKSIQRILK YPPTRTLSGD
310 320 330 340 350
ERQLLWKFRF SLMSEKRALT KFLRCVEWSD VQEAKQALEL MGKWEMIDVC
360 370 380 390 400
DALELLSPVF ESEEVRAYAV SVLERADDEE LQCYLLQLVQ ALRFERSAKS
410 420 430 440 450
RLSHFLIQCA LRNIELASFL RWYVAVELYD PAYAKRFYCT YEILEENMMK
460 470 480 490 500
IAAGVNGEED GFKQWQSLVR QTELTAQLCS ITREVSNVRG NTQKKIEKLR
510 520 530 540 550
QLLSGLLSEL TYFDEPIRSP LAPGVLITGI VPSESSIFKS ALHPLRLTFR
560 570 580 590 600
AANGGTCKII FKKGDDIRQD QLVVQMVSLM DRLLKLENLD LHLTPYKVLA
610 620 630 640 650
TGQDEGMLEF IPSRSLAQIL SENRSIISYL QKFHPDDHGP FGITATCLET
660 670 680 690 700
FIKSCAGYSV ITYILGIGDR HLDNLLLRND GGLFHVDFGF ILGRDPKPFP
710 720 730 740 750
PPMKLCKEMV EAMGGAESQY YTRFKSYCCE AYHILRKSSN LILNLFYLMA
760 770 780 790 800
GSNIPDIASD PEKGILKLQE KFRLDLDDEA SIHFFQDLIN ESVSALFPQM
810
VETIHRWAQY WR
Length:812
Mass (Da):93,002
Last modified:November 1, 1995 - v1
Checksum:i94C5A922AF198A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29770 mRNA Translation: AAA64468.1
PIRiT07745
RefSeqiNP_001242315.1, NM_001255386.1
UniGeneiGma.64312

Genome annotation databases

GeneIDi100778348
KEGGigmx:100778348

Similar proteinsi

Entry informationi

Entry nameiPI3K2_SOYBN
AccessioniPrimary (citable) accession number: P42348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health