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P42348

- PI3K2_SOYBN

UniProt

P42348 - PI3K2_SOYBN

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Protein

Phosphatidylinositol 3-kinase, nodule isoform

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Associated with membrane proliferation.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 2483.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase, nodule isoform (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Alternative name(s):
SPI3K-1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Phosphatidylinositol 3-kinase, nodule isoformPRO_0000088821Add
BLAST

Expressioni

Inductioni

Highly expressed in young root nodules in parallel with membrane proliferation but is repressed in mature nodules.

Gene expression databases

GenevestigatoriP42348.

Structurei

3D structure databases

ProteinModelPortaliP42348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 175162C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini272 – 447176PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini560 – 812253PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK00914.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54452. SSF54452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42348-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGNEFRFFL SCDISVPVTF RVERLEGNLP LPKSPDLENN APTDNRTTEL
60 70 80 90 100
FVECALYIDG APFGLPMRTR LESLGPSYCW NELITLTTKY RDLTAQSQLT
110 120 130 140 150
FTVWDLSHGE GLIGGATILL FNNKKQLKTG KQKLRLWAGK EADGTFPTST
160 170 180 190 200
PGKVPRHERG ELERLEKLVN KYERGQIQRV DWLDRLTFKT MERIKERESL
210 220 230 240 250
KNGSSHMYLV VDFCSFEHRV VFQESGANFL FPSPIASTND IVVVWDPEVG
260 270 280 290 300
KINPSEHKQL KLARSLTRGV IDRDLKPSSN ERKSIQRILK YPPTRTLSGD
310 320 330 340 350
ERQLLWKFRF SLMSEKRALT KFLRCVEWSD VQEAKQALEL MGKWEMIDVC
360 370 380 390 400
DALELLSPVF ESEEVRAYAV SVLERADDEE LQCYLLQLVQ ALRFERSAKS
410 420 430 440 450
RLSHFLIQCA LRNIELASFL RWYVAVELYD PAYAKRFYCT YEILEENMMK
460 470 480 490 500
IAAGVNGEED GFKQWQSLVR QTELTAQLCS ITREVSNVRG NTQKKIEKLR
510 520 530 540 550
QLLSGLLSEL TYFDEPIRSP LAPGVLITGI VPSESSIFKS ALHPLRLTFR
560 570 580 590 600
AANGGTCKII FKKGDDIRQD QLVVQMVSLM DRLLKLENLD LHLTPYKVLA
610 620 630 640 650
TGQDEGMLEF IPSRSLAQIL SENRSIISYL QKFHPDDHGP FGITATCLET
660 670 680 690 700
FIKSCAGYSV ITYILGIGDR HLDNLLLRND GGLFHVDFGF ILGRDPKPFP
710 720 730 740 750
PPMKLCKEMV EAMGGAESQY YTRFKSYCCE AYHILRKSSN LILNLFYLMA
760 770 780 790 800
GSNIPDIASD PEKGILKLQE KFRLDLDDEA SIHFFQDLIN ESVSALFPQM
810
VETIHRWAQY WR
Length:812
Mass (Da):93,002
Last modified:November 1, 1995 - v1
Checksum:i94C5A922AF198A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29770 mRNA. Translation: AAA64468.1.
PIRiT07745.
RefSeqiNP_001242315.1. NM_001255386.1.
UniGeneiGma.64312.

Genome annotation databases

GeneIDi100778348.
KEGGigmx:100778348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29770 mRNA. Translation: AAA64468.1 .
PIRi T07745.
RefSeqi NP_001242315.1. NM_001255386.1.
UniGenei Gma.64312.

3D structure databases

ProteinModelPortali P42348.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100778348.
KEGGi gmx:100778348.

Phylogenomic databases

KOi K00914.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 2483.

Gene expression databases

Genevestigatori P42348.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
SMARTi SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54452. SSF54452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation."
    Hong Z., Verma D.P.S.
    Proc. Natl. Acad. Sci. U.S.A. 91:9617-9621(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Prize.
    Tissue: Root nodule.

Entry informationi

Entry nameiPI3K2_SOYBN
AccessioniPrimary (citable) accession number: P42348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3