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Protein

Phosphatidylinositol 3-kinase, root isoform

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Associated with membrane proliferation.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 2483.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase, root isoform (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Alternative name(s):
SPI3K-5
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888201 – 814Phosphatidylinositol 3-kinase, root isoformAdd BLAST814

Expressioni

Inductioni

Repressed during nodule organogenesis and reinduced in mature nodules.

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA04G10090.1.

Structurei

3D structure databases

ProteinModelPortaliP42347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 177C2 PI3K-typePROSITE-ProRule annotationAdd BLAST164
Domaini274 – 449PIK helicalPROSITE-ProRule annotationAdd BLAST176
Domaini558 – 811PI3K/PI4KPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0906. Eukaryota.
COG5032. LUCA.
KOiK00914.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR035892. C2_domain_sf.
IPR011009. Kinase-like_dom_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000403. PI3/4_kinase_cat_dom.
IPR036940. PI3/4_kinase_cat_sf.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
PANTHERiPTHR10048. PTHR10048. 3 hits.
PfamiView protein in Pfam
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiView protein in SMART
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54452. SSF54452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.

Sequencei

Sequence statusi: Complete.

P42347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGNEFRFFL SCDISVPVTF RVERLEGNLP LPNPKSPDLE TNAPTENRTK
60 70 80 90 100
ELFVECALYI DGAPFGLPTR TRLESSGPSY CWNELITLTT KYRDLTAQSQ
110 120 130 140 150
LTFTVWDLSH GEGLIGGATI LLFNNKKQLK TGKQKLRLWA GKEADGTFPT
160 170 180 190 200
STPGKVPRHE RGELERLEKL VNKYERGQIQ RVDWLDRLTF KTMERIKERE
210 220 230 240 250
SLKNGSSHLY LVVDFCSFEH RVVFQESGAN FLFPSPIAST NDIVVVWDPE
260 270 280 290 300
VGKINPSEHK QLKLARSLTR GVIDRDLKPS SNERKSIQRI LKYPPTRTLS
310 320 330 340 350
GDERQLLWKF RFSLMSEKRA LTKFLRCVEW SDVQEAKQAL ELMGKWEMID
360 370 380 390 400
VCDALELLSP VFESEEVRAY AVSVLERADD EELQCYLLQL VQALRFERSD
410 420 430 440 450
KSRLSHFLVQ RALRNIELAS FLRWYVAVEL YDPAYAKRFY CTYEILEENM
460 470 480 490 500
MKIAAGVNGE EDGFKQWQSL VRQTELTAQL CSITREVRNV RGNTQKKIEK
510 520 530 540 550
LRQLLSGLLS ELTYFDEPIR SPLAPGVLIA GIVPSESSIF KSALHPLRLS
560 570 580 590 600
FRTANGGTCK IIFKKGDDLR QDQLVVQMVS LMDRLLKLEN LDLHLTPYKV
610 620 630 640 650
LATGQDEGML EFIPSRSLAQ ILSENRSIIS YLQKFHPDDH GPFGITATCL
660 670 680 690 700
ETFIKSCAGY SVITYILGIG DRHLDNLLLR NDGGLFHVDF GFILGRDPKP
710 720 730 740 750
FPPPMKLCKE MVEAMGGAES QYYTRFKSYC CEAYNILRKS SNLILNLFYL
760 770 780 790 800
MAGSNIPDIA SDPEKGILKL QEKFRLDLDD EASIHFFQDL INESVSALFP
810
QMVETIHRWA QYWR
Length:814
Mass (Da):93,282
Last modified:November 1, 1995 - v1
Checksum:i5B13A7DE16FFA0AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27265 mRNA. Translation: AAA83995.1.
PIRiT07761.
RefSeqiNP_001236955.1. NM_001250026.2.
UniGeneiGma.2544.

Genome annotation databases

GeneIDi547983.
KEGGigmx:547983.

Similar proteinsi

Entry informationi

Entry nameiPI3K1_SOYBN
AccessioniPrimary (citable) accession number: P42347
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families