Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 3-kinase, root isoform

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Associated with membrane proliferation.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 2483.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase, root isoform (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Alternative name(s):
SPI3K-5
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Phosphatidylinositol 3-kinase, root isoformPRO_0000088820Add
BLAST

Expressioni

Inductioni

Repressed during nodule organogenesis and reinduced in mature nodules.

Gene expression databases

GenevestigatoriP42347.

Structurei

3D structure databases

ProteinModelPortaliP42347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 177164C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini274 – 449176PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini558 – 811254PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK00914.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54452. SSF54452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42347-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGNEFRFFL SCDISVPVTF RVERLEGNLP LPNPKSPDLE TNAPTENRTK
60 70 80 90 100
ELFVECALYI DGAPFGLPTR TRLESSGPSY CWNELITLTT KYRDLTAQSQ
110 120 130 140 150
LTFTVWDLSH GEGLIGGATI LLFNNKKQLK TGKQKLRLWA GKEADGTFPT
160 170 180 190 200
STPGKVPRHE RGELERLEKL VNKYERGQIQ RVDWLDRLTF KTMERIKERE
210 220 230 240 250
SLKNGSSHLY LVVDFCSFEH RVVFQESGAN FLFPSPIAST NDIVVVWDPE
260 270 280 290 300
VGKINPSEHK QLKLARSLTR GVIDRDLKPS SNERKSIQRI LKYPPTRTLS
310 320 330 340 350
GDERQLLWKF RFSLMSEKRA LTKFLRCVEW SDVQEAKQAL ELMGKWEMID
360 370 380 390 400
VCDALELLSP VFESEEVRAY AVSVLERADD EELQCYLLQL VQALRFERSD
410 420 430 440 450
KSRLSHFLVQ RALRNIELAS FLRWYVAVEL YDPAYAKRFY CTYEILEENM
460 470 480 490 500
MKIAAGVNGE EDGFKQWQSL VRQTELTAQL CSITREVRNV RGNTQKKIEK
510 520 530 540 550
LRQLLSGLLS ELTYFDEPIR SPLAPGVLIA GIVPSESSIF KSALHPLRLS
560 570 580 590 600
FRTANGGTCK IIFKKGDDLR QDQLVVQMVS LMDRLLKLEN LDLHLTPYKV
610 620 630 640 650
LATGQDEGML EFIPSRSLAQ ILSENRSIIS YLQKFHPDDH GPFGITATCL
660 670 680 690 700
ETFIKSCAGY SVITYILGIG DRHLDNLLLR NDGGLFHVDF GFILGRDPKP
710 720 730 740 750
FPPPMKLCKE MVEAMGGAES QYYTRFKSYC CEAYNILRKS SNLILNLFYL
760 770 780 790 800
MAGSNIPDIA SDPEKGILKL QEKFRLDLDD EASIHFFQDL INESVSALFP
810
QMVETIHRWA QYWR
Length:814
Mass (Da):93,282
Last modified:November 1, 1995 - v1
Checksum:i5B13A7DE16FFA0AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27265 mRNA. Translation: AAA83995.1.
PIRiT07761.
RefSeqiNP_001236955.1. NM_001250026.2.
UniGeneiGma.2544.

Genome annotation databases

GeneIDi547983.
KEGGigmx:547983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27265 mRNA. Translation: AAA83995.1.
PIRiT07761.
RefSeqiNP_001236955.1. NM_001250026.2.
UniGeneiGma.2544.

3D structure databases

ProteinModelPortaliP42347.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi547983.
KEGGigmx:547983.

Phylogenomic databases

KOiK00914.

Enzyme and pathway databases

BRENDAi2.7.1.137. 2483.

Gene expression databases

GenevestigatoriP42347.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54452. SSF54452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation."
    Hong Z., Verma D.P.S.
    Proc. Natl. Acad. Sci. U.S.A. 91:9617-9621(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Prize.
    Tissue: Root.

Entry informationi

Entry nameiPI3K1_SOYBN
AccessioniPrimary (citable) accession number: P42347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.