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P42347 (PI3K1_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase, root isoform

Short name=PI3-kinase
Short name=PI3K
Short name=PtdIns-3-kinase
EC=2.7.1.137
Alternative name(s):
SPI3K-5
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Associated with membrane proliferation.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Induction

Repressed during nodule organogenesis and reinduced in mature nodules.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 814814Phosphatidylinositol 3-kinase, root isoform
PRO_0000088820

Regions

Domain14 – 177164C2 PI3K-type
Domain274 – 449176PIK helical
Domain558 – 811254PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
P42347 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5B13A7DE16FFA0AD

FASTA81493,282
        10         20         30         40         50         60 
MTGNEFRFFL SCDISVPVTF RVERLEGNLP LPNPKSPDLE TNAPTENRTK ELFVECALYI 

        70         80         90        100        110        120 
DGAPFGLPTR TRLESSGPSY CWNELITLTT KYRDLTAQSQ LTFTVWDLSH GEGLIGGATI 

       130        140        150        160        170        180 
LLFNNKKQLK TGKQKLRLWA GKEADGTFPT STPGKVPRHE RGELERLEKL VNKYERGQIQ 

       190        200        210        220        230        240 
RVDWLDRLTF KTMERIKERE SLKNGSSHLY LVVDFCSFEH RVVFQESGAN FLFPSPIAST 

       250        260        270        280        290        300 
NDIVVVWDPE VGKINPSEHK QLKLARSLTR GVIDRDLKPS SNERKSIQRI LKYPPTRTLS 

       310        320        330        340        350        360 
GDERQLLWKF RFSLMSEKRA LTKFLRCVEW SDVQEAKQAL ELMGKWEMID VCDALELLSP 

       370        380        390        400        410        420 
VFESEEVRAY AVSVLERADD EELQCYLLQL VQALRFERSD KSRLSHFLVQ RALRNIELAS 

       430        440        450        460        470        480 
FLRWYVAVEL YDPAYAKRFY CTYEILEENM MKIAAGVNGE EDGFKQWQSL VRQTELTAQL 

       490        500        510        520        530        540 
CSITREVRNV RGNTQKKIEK LRQLLSGLLS ELTYFDEPIR SPLAPGVLIA GIVPSESSIF 

       550        560        570        580        590        600 
KSALHPLRLS FRTANGGTCK IIFKKGDDLR QDQLVVQMVS LMDRLLKLEN LDLHLTPYKV 

       610        620        630        640        650        660 
LATGQDEGML EFIPSRSLAQ ILSENRSIIS YLQKFHPDDH GPFGITATCL ETFIKSCAGY 

       670        680        690        700        710        720 
SVITYILGIG DRHLDNLLLR NDGGLFHVDF GFILGRDPKP FPPPMKLCKE MVEAMGGAES 

       730        740        750        760        770        780 
QYYTRFKSYC CEAYNILRKS SNLILNLFYL MAGSNIPDIA SDPEKGILKL QEKFRLDLDD 

       790        800        810 
EASIHFFQDL INESVSALFP QMVETIHRWA QYWR 

« Hide

References

[1]"A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation."
Hong Z., Verma D.P.S.
Proc. Natl. Acad. Sci. U.S.A. 91:9617-9621(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Prize.
Tissue: Root.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27265 mRNA. Translation: AAA83995.1.
PIRT07761.
RefSeqNP_001236955.1. NM_001250026.2.
UniGeneGma.2544.

3D structure databases

ProteinModelPortalP42347.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID547983.
KEGGgmx:547983.

Phylogenomic databases

KOK00914.

Enzyme and pathway databases

BRENDA2.7.1.137. 2483.

Gene expression databases

GenevestigatorP42347.

Family and domain databases

Gene3D1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFPIRSF000587. PI3K_Vps34. 1 hit.
SMARTSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54452. SSF54452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePI3K1_SOYBN
AccessionPrimary (citable) accession number: P42347
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families