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P42338

- PK3CB_HUMAN

UniProt

P42338 - PK3CB_HUMAN

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Protein

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Gene

PIK3CB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.4 Publications

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

Pathwayi

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. phosphatidylinositol 3-kinase activity Source: UniProtKB
  5. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

GO - Biological processi

  1. activation of MAPK activity Source: ProtInc
  2. autophagy Source: UniProtKB-KW
  3. blood coagulation Source: Reactome
  4. cell migration Source: UniProtKB
  5. cellular calcium ion homeostasis Source: Ensembl
  6. chemotaxis Source: ProtInc
  7. embryonic cleavage Source: Ensembl
  8. epidermal growth factor receptor signaling pathway Source: Reactome
  9. Fc-epsilon receptor signaling pathway Source: Reactome
  10. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  11. fibroblast growth factor receptor signaling pathway Source: Reactome
  12. G-protein coupled receptor signaling pathway Source: UniProtKB
  13. homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
  14. innate immune response Source: Reactome
  15. insulin receptor signaling pathway Source: Reactome
  16. leukocyte migration Source: Reactome
  17. neurotrophin TRK receptor signaling pathway Source: Reactome
  18. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  19. phosphatidylinositol biosynthetic process Source: Reactome
  20. phosphatidylinositol-mediated signaling Source: Reactome
  21. phospholipid metabolic process Source: Reactome
  22. platelet activation Source: UniProtKB
  23. platelet aggregation Source: UniProtKB
  24. positive regulation of autophagy Source: UniProtKB
  25. regulation of cell-matrix adhesion Source: Ensembl
  26. regulation of clathrin-mediated endocytosis Source: UniProtKB
  27. signal transduction Source: ProtInc
  28. small molecule metabolic process Source: Reactome
  29. T cell receptor signaling pathway Source: Reactome
  30. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Autophagy, Cell adhesion, Endocytosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS00644-MONOMER.
ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_12464. PI3K/AKT activation.
REACT_12555. Downstream TCR signaling.
REACT_12621. Tie2 Signaling.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_147814. DAP12 signaling.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_1695. GPVI-mediated activation cascade.
REACT_17025. Downstream signal transduction.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_228166. VEGFA-VEGFR2 Pathway.
REACT_23787. Regulation of signaling by CBL.
REACT_23832. Nephrin interactions.
REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
REACT_75829. PIP3 activates AKT signaling.
REACT_976. PI3K Cascade.
SignaLinkiP42338.
UniPathwayiUPA00220.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC:2.7.1.153)
Short name:
PI3-kinase subunit beta
Short name:
PI3K-beta
Short name:
PI3Kbeta
Short name:
PtdIns-3-kinase subunit beta
Alternative name(s):
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
Short name:
PtdIns-3-kinase subunit p110-beta
Short name:
p110beta
Gene namesi
Name:PIK3CB
Synonyms:PIK3C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:8976. PIK3CB.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Interaction with PIK3R2 is required for nuclear localization and export.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: UniProtKB-KW
  3. phosphatidylinositol 3-kinase complex Source: RefGenome
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi342 – 3421K → N: Enhanced inhibition by PIK3R1 leading to reduced lipid kinase activity and reduced oncogenicity. Does not modify regulation by GPCRs. 1 Publication
Mutagenesisi805 – 8051K → R: Loss of lipid kinase activity. May not affect insulin signaling and cell proliferation. Partially affects oncogene-induced trasformation. 1 Publication

Organism-specific databases

PharmGKBiPA33309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10701070Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPRO_0000088787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1070 – 10701Phosphoserine; by autocatalysis1 Publication

Post-translational modificationi

Phosphorylation at Ser-1070 down-regulates lipid kinase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP42338.
PaxDbiP42338.
PeptideAtlasiP42338.
PRIDEiP42338.

PTM databases

PhosphoSiteiP42338.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Gene expression databases

BgeeiP42338.
CleanExiHS_PIK3CB.
ExpressionAtlasiP42338. baseline and differential.
GenevestigatoriP42338.

Organism-specific databases

HPAiCAB031938.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HCKP086312EBI-2609540,EBI-346340
PIK3R2O004593EBI-2609540,EBI-346930

Protein-protein interaction databases

BioGridi111309. 20 interactions.
DIPiDIP-44775N.
IntActiP42338. 14 interactions.
MINTiMINT-1505441.
STRINGi9606.ENSP00000289153.

Structurei

3D structure databases

ProteinModelPortaliP42338.
SMRiP42338. Positions 123-1067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 11590PI3K-ABDPROSITE-ProRule annotationAdd
BLAST
Domaini194 – 28592PI3K-RBDPROSITE-ProRule annotationAdd
BLAST
Domaini327 – 496170C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini524 – 701178PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini800 – 1067268PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi410 – 4189Nuclear localization signal

Domaini

The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K-ABD domain.PROSITE-ProRule annotation
Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000252911.
HOVERGENiHBG052721.
InParanoidiP42338.
KOiK00922.
OMAiAMHTCLK.
OrthoDBiEOG70CR65.
PhylomeDBiP42338.
TreeFamiTF102031.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42338-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MCFSFIMPPA MADILDIWAV DSQIASDGSI PVDFLLPTGI YIQLEVPREA
60 70 80 90 100
TISYIKQMLW KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC
110 120 130 140 150
DVRPFLPVLK LVTRSCDPGE KLDSKIGVLI GKGLHEFDSL KDPEVNEFRR
160 170 180 190 200
KMRKFSEEKI LSLVGLSWMD WLKQTYPPEH EPSIPENLED KLYGGKLIVA
210 220 230 240 250
VHFENCQDVF SFQVSPNMNP IKVNELAIQK RLTIHGKEDE VSPYDYVLQV
260 270 280 290 300
SGRVEYVFGD HPLIQFQYIR NCVMNRALPH FILVECCKIK KMYEQEMIAI
310 320 330 340 350
EAAINRNSSN LPLPLPPKKT RIISHVWENN NPFQIVLVKG NKLNTEETVK
360 370 380 390 400
VHVRAGLFHG TELLCKTIVS SEVSGKNDHI WNEPLEFDIN ICDLPRMARL
410 420 430 440 450
CFAVYAVLDK VKTKKSTKTI NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG
460 470 480 490 500
QLRTGDIILH SWSSFPDELE EMLNPMGTVQ TNPYTENATA LHVKFPENKK
510 520 530 540 550
QPYYYPPFDK IIEKAAEIAS SDSANVSSRG GKKFLPVLKE ILDRDPLSQL
560 570 580 590 600
CENEMDLIWT LRQDCREIFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK
610 620 630 640 650
LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP
660 670 680 690 700
FLDCALSRFL LERALGNRRI GQFLFWHLRS EVHIPAVSVQ FGVILEAYCR
710 720 730 740 750
GSVGHMKVLS KQVEALNKLK TLNSLIKLNA VKLNRAKGKE AMHTCLKQSA
760 770 780 790 800
YREALSDLQS PLNPCVILSE LYVEKCKYMD SKMKPLWLVY NNKVFGEDSV
810 820 830 840 850
GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG CLATGDRSGL
860 870 880 890 900
IEVVSTSETI ADIQLNSSNV AAAAAFNKDA LLNWLKEYNS GDDLDRAIEE
910 920 930 940 950
FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG
960 970 980 990 1000
IKRERVPFIL TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF
1010 1020 1030 1040 1050
ITLFALMLTA GLPELTSVKD IQYLKDSLAL GKSEEEALKQ FKQKFDEALR
1060 1070
ESWTTKVNWM AHTVRKDYRS
Length:1,070
Mass (Da):122,762
Last modified:November 1, 1995 - v1
Checksum:i81135FE93452C00E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti672 – 6721Q → H.
Corresponds to variant rs2230462 [ dbSNP | Ensembl ].
VAR_050530

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67334 mRNA. Translation: AAB29081.1.
AJ297549
, AJ297550, AJ297551, AJ297552, AJ297553, AJ297554, AJ297555, AJ297556, AJ297557, AJ297558, AJ297559, AJ297560 Genomic DNA. Translation: CAC21449.1.
CH471052 Genomic DNA. Translation: EAW79053.1.
CH471052 Genomic DNA. Translation: EAW79055.1.
BC114432 mRNA. Translation: AAI14433.1.
CCDSiCCDS3104.1.
PIRiA54600.
RefSeqiNP_006210.1. NM_006219.2.
XP_005247587.1. XM_005247530.1.
XP_005247588.1. XM_005247531.1.
XP_006713722.1. XM_006713659.1.
UniGeneiHs.239818.

Genome annotation databases

EnsembliENST00000289153; ENSP00000289153; ENSG00000051382.
ENST00000477593; ENSP00000418143; ENSG00000051382.
GeneIDi5291.
KEGGihsa:5291.
UCSCiuc011bmq.3. human.

Polymorphism databases

DMDMi1171955.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67334 mRNA. Translation: AAB29081.1 .
AJ297549
, AJ297550 , AJ297551 , AJ297552 , AJ297553 , AJ297554 , AJ297555 , AJ297556 , AJ297557 , AJ297558 , AJ297559 , AJ297560 Genomic DNA. Translation: CAC21449.1 .
CH471052 Genomic DNA. Translation: EAW79053.1 .
CH471052 Genomic DNA. Translation: EAW79055.1 .
BC114432 mRNA. Translation: AAI14433.1 .
CCDSi CCDS3104.1.
PIRi A54600.
RefSeqi NP_006210.1. NM_006219.2.
XP_005247587.1. XM_005247530.1.
XP_005247588.1. XM_005247531.1.
XP_006713722.1. XM_006713659.1.
UniGenei Hs.239818.

3D structure databases

ProteinModelPortali P42338.
SMRi P42338. Positions 123-1067.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111309. 20 interactions.
DIPi DIP-44775N.
IntActi P42338. 14 interactions.
MINTi MINT-1505441.
STRINGi 9606.ENSP00000289153.

Chemistry

BindingDBi P42338.
ChEMBLi CHEMBL3145.
DrugBanki DB00201. Caffeine.
GuidetoPHARMACOLOGYi 2154.

PTM databases

PhosphoSitei P42338.

Polymorphism databases

DMDMi 1171955.

Proteomic databases

MaxQBi P42338.
PaxDbi P42338.
PeptideAtlasi P42338.
PRIDEi P42338.

Protocols and materials databases

DNASUi 5291.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000289153 ; ENSP00000289153 ; ENSG00000051382 .
ENST00000477593 ; ENSP00000418143 ; ENSG00000051382 .
GeneIDi 5291.
KEGGi hsa:5291.
UCSCi uc011bmq.3. human.

Organism-specific databases

CTDi 5291.
GeneCardsi GC03M138372.
HGNCi HGNC:8976. PIK3CB.
HPAi CAB031938.
MIMi 602925. gene.
neXtProti NX_P42338.
PharmGKBi PA33309.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5032.
GeneTreei ENSGT00760000119110.
HOGENOMi HOG000252911.
HOVERGENi HBG052721.
InParanoidi P42338.
KOi K00922.
OMAi AMHTCLK.
OrthoDBi EOG70CR65.
PhylomeDBi P42338.
TreeFami TF102031.

Enzyme and pathway databases

UniPathwayi UPA00220 .
BioCyci MetaCyc:HS00644-MONOMER.
Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_12464. PI3K/AKT activation.
REACT_12555. Downstream TCR signaling.
REACT_12621. Tie2 Signaling.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_147814. DAP12 signaling.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_1695. GPVI-mediated activation cascade.
REACT_17025. Downstream signal transduction.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_228166. VEGFA-VEGFR2 Pathway.
REACT_23787. Regulation of signaling by CBL.
REACT_23832. Nephrin interactions.
REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
REACT_75829. PIP3 activates AKT signaling.
REACT_976. PI3K Cascade.
SignaLinki P42338.

Miscellaneous databases

GeneWikii PIK3CB.
GenomeRNAii 5291.
NextBioi 20446.
PROi P42338.
SOURCEi Search...

Gene expression databases

Bgeei P42338.
CleanExi HS_PIK3CB.
ExpressionAtlasi P42338. baseline and differential.
Genevestigatori P42338.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85."
    Hu P., Mondino A., Skolnik E.Y., Schlessinger J.
    Mol. Cell. Biol. 13:7677-7688(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes."
    Kossila M., Sinkovic M., Karkkainen P., Laukkanen M.O., Miettinen R., Rissanen J., Kekalainen P., Kuusisto J., Yla-Herttuala S., Laakso M.
    Diabetes 49:1740-1743(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma."
    Czupalla C., Culo M., Muller E.C., Brock C., Reusch H.P., Spicher K., Krause E., Nurnberg B.
    J. Biol. Chem. 278:11536-11545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-1070.
  6. "Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis."
    Jia S., Liu Z., Zhang S., Liu P., Zhang L., Lee S.H., Zhang J., Signoretti S., Loda M., Roberts T.M., Zhao J.J.
    Nature 454:776-779(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-805.
  7. Cited for: FUNCTION IN ONCOGENIC SIGNALING.
  8. Cited for: IDENTIFICATION IN A COMPLEX WITH PIK3R1 AND PTEN.
  9. "A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase."
    Dbouk H.A., Pang H., Fiser A., Backer J.M.
    Proc. Natl. Acad. Sci. U.S.A. 107:19897-19902(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-342.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival."
    Kumar A., Redondo-Munoz J., Perez-Garcia V., Cortes I., Chagoyen M., Carrera A.C.
    Mol. Cell. Biol. 31:2122-2133(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PIK3R2, SUBCELLULAR LOCATION, MOTIF NUCLEAR LOCALIZATION SIGNAL.
  12. "A beta version of life: p110beta takes center stage."
    Dbouk H.A., Backer J.M.
    Oncotarget 1:729-733(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  13. "Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions."
    Gratacap M.-P., Guillermet-Guibert J., Martin V., Chicanne G., Tronchere H., Gaits-Iacovoni F., Payrastre B.
    Adv. Enzyme Regul. 51:106-116(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.

Entry informationi

Entry nameiPK3CB_HUMAN
AccessioniPrimary (citable) accession number: P42338
Secondary accession number(s): D3DNF0, Q24JU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3