Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform

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Reviewed, UniProtKB/Swiss-Prot P42338 (PK3CB_HUMAN)

Last modified November 3, 2009. Version 91. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    EC=2.7.1.153
Alternative name(s):
    PI3-kinase p110 subunit beta
    PtdIns-3-kinase p110
    PI3Kbeta
      Short name=PI3K

Gene names

Name:	PIK3CB
Synonyms:	PIK3C1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1070 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
Pathway	Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
Subunit structure	Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.
Tissue specificity	Expressed ubiquitously.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Traceable author statement. Source: ProtInc activation of MAPK activity Traceable author statement. Source: ProtInc chemotaxis Traceable author statement. Source: ProtInc phosphoinositide phosphorylation Inferred from electronic annotation. Source: InterPro phosphoinositide-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular component	phosphoinositide 3-kinase complex Inferred from electronic annotation. Source: InterPro
Molecular function	1-phosphatidylinositol-3-kinase activity Traceable author statement. Source: ProtInc ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-4,5-bisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1070

1070

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform

PRO_0000088787

Regions

Domain

800 – 1050

251

PI3K/PI4K

Natural variations

Natural variant

672

Q → H: dbSNP rs2230462.

VAR_050530

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Sequences

Sequence

Length

Mass (Da)

Tools

P42338-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 81135FE93452C00E
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FASTA

1,070

122,762

        10         20         30         40         50         60 
MCFSFIMPPA MADILDIWAV DSQIASDGSI PVDFLLPTGI YIQLEVPREA TISYIKQMLW 

        70         80         90        100        110        120 
KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC DVRPFLPVLK LVTRSCDPGE 

       130        140        150        160        170        180 
KLDSKIGVLI GKGLHEFDSL KDPEVNEFRR KMRKFSEEKI LSLVGLSWMD WLKQTYPPEH 

       190        200        210        220        230        240 
EPSIPENLED KLYGGKLIVA VHFENCQDVF SFQVSPNMNP IKVNELAIQK RLTIHGKEDE 

       250        260        270        280        290        300 
VSPYDYVLQV SGRVEYVFGD HPLIQFQYIR NCVMNRALPH FILVECCKIK KMYEQEMIAI 

       310        320        330        340        350        360 
EAAINRNSSN LPLPLPPKKT RIISHVWENN NPFQIVLVKG NKLNTEETVK VHVRAGLFHG 

       370        380        390        400        410        420 
TELLCKTIVS SEVSGKNDHI WNEPLEFDIN ICDLPRMARL CFAVYAVLDK VKTKKSTKTI 

       430        440        450        460        470        480 
NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG QLRTGDIILH SWSSFPDELE EMLNPMGTVQ 

       490        500        510        520        530        540 
TNPYTENATA LHVKFPENKK QPYYYPPFDK IIEKAAEIAS SDSANVSSRG GKKFLPVLKE 

       550        560        570        580        590        600 
ILDRDPLSQL CENEMDLIWT LRQDCREIFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK 

       610        620        630        640        650        660 
LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP FLDCALSRFL 

       670        680        690        700        710        720 
LERALGNRRI GQFLFWHLRS EVHIPAVSVQ FGVILEAYCR GSVGHMKVLS KQVEALNKLK 

       730        740        750        760        770        780 
TLNSLIKLNA VKLNRAKGKE AMHTCLKQSA YREALSDLQS PLNPCVILSE LYVEKCKYMD 

       790        800        810        820        830        840 
SKMKPLWLVY NNKVFGEDSV GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG 

       850        860        870        880        890        900 
CLATGDRSGL IEVVSTSETI ADIQLNSSNV AAAAAFNKDA LLNWLKEYNS GDDLDRAIEE 

       910        920        930        940        950        960 
FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG IKRERVPFIL 

       970        980        990       1000       1010       1020 
TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF ITLFALMLTA GLPELTSVKD 

      1030       1040       1050       1060       1070 
IQYLKDSLAL GKSEEEALKQ FKQKFDEALR ESWTTKVNWM AHTVRKDYRS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85." Hu P., Mondino A., Skolnik E.Y., Schlessinger J. Mol. Cell. Biol. 13:7677-7688(1993) [PubMed: 8246984] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes." Kossila M., Sinkovic M., Karkkainen P., Laukkanen M.O., Miettinen R., Rissanen J., Kekalainen P., Kuusisto J., Yla-Herttuala S., Laakso M. Diabetes 49:1740-1743(2000) [PubMed: 11016459] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	S67334 mRNA. Translation: AAB29081.1. AJ297549 AJ297560 Genomic DNA. Translation: CAC21449.1. BC114432 mRNA. Translation: AAI14433.1.
IPI	IPI00031388.
PIR	A54600.
RefSeq	NP_006210.1.
UniGene	Hs.239818
3D structure databases
HSSP	HSSP built from PDB template 1E8Y based on UniProtKB P48736.
ModBase	Search...
Protein-protein interaction databases
STRING	P42338.
PTM databases
PhosphoSite	P42338.
Proteomic databases
PeptideAtlas	P42338.
PRIDE	P42338.
Genome annotation databases
Ensembl	ENST00000289153; ENSP00000289153; ENSG00000051382; Homo sapiens. [Genome view]
GeneID	5291.
KEGG	hsa:5291.
UCSC	uc003esu.1. human.
Organism-specific databases
CTD	5291.
GeneCards	GC03M139855.
H-InvDB	HIX0030788.
HGNC	HGNC:8976. PIK3CB.
MIM	602925. gene.
PharmGKB	PA33309.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P42338.
HOVERGEN	P42338.
OMA	VKGNKLN.
Enzyme and pathway databases
BRENDA	2.7.1.137. 247.
Pathway_Interaction_DB	pi3kcipathway. Class I PI3K signaling events. lysophospholipid_pathway. LPA receptor mediated events. trail_pathway. TRAIL signaling pathway.
Reactome	REACT_11061. Signalling by NGF. REACT_16888. Signaling by PDGF. REACT_498. Signaling by Insulin receptor. REACT_604. Hemostasis. REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	P42338.
Bgee	P42338.
CleanEx	HS_PIK3CB.
Genevestigator	P42338.
GermOnline	ENSG00000051382. Homo sapiens.
Family and domain databases
InterPro	IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR002420. PI3K_C2. IPR003113. PI3K_p85_bd. IPR000341. PI3K_ras_bd. IPR001263. PI3Ka. IPR015433. PI_Kinase. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. G3DSA:1.25.40.70. PI3Ka. 1 hit.
PANTHER	PTHR10048. PI_Kinase. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF02192. PI3K_p85B. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
SMART	SM00142. PI3K_C2. 1 hit. SM00143. PI3K_p85B. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20446.
SOURCE	Search...

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Entry information

Entry name

PK3CB_HUMAN

Accession

Primary (citable) accession number: P42338
Secondary accession number(s): Q24JU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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