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P42338

- PK3CB_HUMAN

UniProt

P42338 - PK3CB_HUMAN

Protein

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Gene

PIK3CB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.4 Publications

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

    Pathwayi

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. phosphatidylinositol 3-kinase activity Source: UniProtKB
    5. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome
    6. protein binding Source: IntAct

    GO - Biological processi

    1. activation of MAPK activity Source: ProtInc
    2. autophagy Source: UniProtKB-KW
    3. blood coagulation Source: Reactome
    4. cell migration Source: UniProtKB
    5. cellular calcium ion homeostasis Source: Ensembl
    6. chemotaxis Source: ProtInc
    7. embryonic cleavage Source: Ensembl
    8. epidermal growth factor receptor signaling pathway Source: Reactome
    9. Fc-epsilon receptor signaling pathway Source: Reactome
    10. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    11. fibroblast growth factor receptor signaling pathway Source: Reactome
    12. G-protein coupled receptor signaling pathway Source: UniProtKB
    13. homophilic cell adhesion Source: Ensembl
    14. innate immune response Source: Reactome
    15. insulin receptor signaling pathway Source: Reactome
    16. leukocyte migration Source: Reactome
    17. neurotrophin TRK receptor signaling pathway Source: Reactome
    18. phosphatidylinositol 3-kinase signaling Source: UniProtKB
    19. phosphatidylinositol biosynthetic process Source: Reactome
    20. phosphatidylinositol-mediated signaling Source: Reactome
    21. phospholipid metabolic process Source: Reactome
    22. platelet activation Source: UniProtKB
    23. platelet aggregation Source: UniProtKB
    24. positive regulation of autophagy Source: UniProtKB
    25. regulation of cell-matrix adhesion Source: Ensembl
    26. regulation of clathrin-mediated endocytosis Source: UniProtKB
    27. signal transduction Source: ProtInc
    28. small molecule metabolic process Source: Reactome
    29. T cell receptor signaling pathway Source: Reactome
    30. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Autophagy, Cell adhesion, Endocytosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS00644-MONOMER.
    ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.
    REACT_12464. PI3K/AKT activation.
    REACT_12555. Downstream TCR signaling.
    REACT_12621. Tie2 Signaling.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_147814. DAP12 signaling.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_1695. GPVI-mediated activation cascade.
    REACT_17025. Downstream signal transduction.
    REACT_23787. Regulation of signaling by CBL.
    REACT_23832. Nephrin interactions.
    REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
    REACT_23891. Interleukin receptor SHC signaling.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_976. PI3K Cascade.
    SignaLinkiP42338.
    UniPathwayiUPA00220.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC:2.7.1.153)
    Short name:
    PI3-kinase subunit beta
    Short name:
    PI3K-beta
    Short name:
    PI3Kbeta
    Short name:
    PtdIns-3-kinase subunit beta
    Alternative name(s):
    Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
    Short name:
    PtdIns-3-kinase subunit p110-beta
    Short name:
    p110beta
    Gene namesi
    Name:PIK3CB
    Synonyms:PIK3C1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8976. PIK3CB.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Interaction with PIK3R2 is required for nuclear localization and export.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB-SubCell
    3. phosphatidylinositol 3-kinase complex Source: RefGenome
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi342 – 3421K → N: Enhanced inhibition by PIK3R1 leading to reduced lipid kinase activity and reduced oncogenicity. Does not modify regulation by GPCRs. 1 Publication
    Mutagenesisi805 – 8051K → R: Loss of lipid kinase activity. May not affect insulin signaling and cell proliferation. Partially affects oncogene-induced trasformation. 1 Publication

    Organism-specific databases

    PharmGKBiPA33309.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10701070Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPRO_0000088787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1070 – 10701Phosphoserine; by autocatalysis1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-1070 down-regulates lipid kinase activity.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP42338.
    PaxDbiP42338.
    PeptideAtlasiP42338.
    PRIDEiP42338.

    PTM databases

    PhosphoSiteiP42338.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously.

    Gene expression databases

    ArrayExpressiP42338.
    BgeeiP42338.
    CleanExiHS_PIK3CB.
    GenevestigatoriP42338.

    Organism-specific databases

    HPAiCAB031938.

    Interactioni

    Subunit structurei

    Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 By similarity. Interacts with BECN1, ATG14 and RAB5A By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HCKP086312EBI-2609540,EBI-346340
    PIK3R2O004593EBI-2609540,EBI-346930

    Protein-protein interaction databases

    BioGridi111309. 16 interactions.
    DIPiDIP-44775N.
    IntActiP42338. 14 interactions.
    MINTiMINT-1505441.
    STRINGi9606.ENSP00000289153.

    Structurei

    3D structure databases

    ProteinModelPortaliP42338.
    SMRiP42338. Positions 123-1067.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 11590PI3K-ABDPROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 28592PI3K-RBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini327 – 496170C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini524 – 701178PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini800 – 1067268PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi410 – 4189Nuclear localization signal

    Domaini

    The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K-ABD domain.PROSITE-ProRule annotation
    Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    HOGENOMiHOG000252911.
    HOVERGENiHBG052721.
    InParanoidiP42338.
    KOiK00922.
    OMAiAMHTCLK.
    OrthoDBiEOG70CR65.
    PhylomeDBiP42338.
    TreeFamiTF102031.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42338-1 [UniParc]FASTAAdd to Basket

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    MCFSFIMPPA MADILDIWAV DSQIASDGSI PVDFLLPTGI YIQLEVPREA     50
    TISYIKQMLW KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC 100
    DVRPFLPVLK LVTRSCDPGE KLDSKIGVLI GKGLHEFDSL KDPEVNEFRR 150
    KMRKFSEEKI LSLVGLSWMD WLKQTYPPEH EPSIPENLED KLYGGKLIVA 200
    VHFENCQDVF SFQVSPNMNP IKVNELAIQK RLTIHGKEDE VSPYDYVLQV 250
    SGRVEYVFGD HPLIQFQYIR NCVMNRALPH FILVECCKIK KMYEQEMIAI 300
    EAAINRNSSN LPLPLPPKKT RIISHVWENN NPFQIVLVKG NKLNTEETVK 350
    VHVRAGLFHG TELLCKTIVS SEVSGKNDHI WNEPLEFDIN ICDLPRMARL 400
    CFAVYAVLDK VKTKKSTKTI NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG 450
    QLRTGDIILH SWSSFPDELE EMLNPMGTVQ TNPYTENATA LHVKFPENKK 500
    QPYYYPPFDK IIEKAAEIAS SDSANVSSRG GKKFLPVLKE ILDRDPLSQL 550
    CENEMDLIWT LRQDCREIFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK 600
    LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP 650
    FLDCALSRFL LERALGNRRI GQFLFWHLRS EVHIPAVSVQ FGVILEAYCR 700
    GSVGHMKVLS KQVEALNKLK TLNSLIKLNA VKLNRAKGKE AMHTCLKQSA 750
    YREALSDLQS PLNPCVILSE LYVEKCKYMD SKMKPLWLVY NNKVFGEDSV 800
    GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG CLATGDRSGL 850
    IEVVSTSETI ADIQLNSSNV AAAAAFNKDA LLNWLKEYNS GDDLDRAIEE 900
    FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG 950
    IKRERVPFIL TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF 1000
    ITLFALMLTA GLPELTSVKD IQYLKDSLAL GKSEEEALKQ FKQKFDEALR 1050
    ESWTTKVNWM AHTVRKDYRS 1070
    Length:1,070
    Mass (Da):122,762
    Last modified:November 1, 1995 - v1
    Checksum:i81135FE93452C00E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti672 – 6721Q → H.
    Corresponds to variant rs2230462 [ dbSNP | Ensembl ].
    VAR_050530

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67334 mRNA. Translation: AAB29081.1.
    AJ297549
    , AJ297550, AJ297551, AJ297552, AJ297553, AJ297554, AJ297555, AJ297556, AJ297557, AJ297558, AJ297559, AJ297560 Genomic DNA. Translation: CAC21449.1.
    CH471052 Genomic DNA. Translation: EAW79053.1.
    CH471052 Genomic DNA. Translation: EAW79055.1.
    BC114432 mRNA. Translation: AAI14433.1.
    CCDSiCCDS3104.1.
    PIRiA54600.
    RefSeqiNP_006210.1. NM_006219.2.
    XP_005247587.1. XM_005247530.1.
    XP_005247588.1. XM_005247531.1.
    XP_006713722.1. XM_006713659.1.
    UniGeneiHs.239818.

    Genome annotation databases

    EnsembliENST00000289153; ENSP00000289153; ENSG00000051382.
    ENST00000477593; ENSP00000418143; ENSG00000051382.
    GeneIDi5291.
    KEGGihsa:5291.
    UCSCiuc011bmq.3. human.

    Polymorphism databases

    DMDMi1171955.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67334 mRNA. Translation: AAB29081.1 .
    AJ297549
    , AJ297550 , AJ297551 , AJ297552 , AJ297553 , AJ297554 , AJ297555 , AJ297556 , AJ297557 , AJ297558 , AJ297559 , AJ297560 Genomic DNA. Translation: CAC21449.1 .
    CH471052 Genomic DNA. Translation: EAW79053.1 .
    CH471052 Genomic DNA. Translation: EAW79055.1 .
    BC114432 mRNA. Translation: AAI14433.1 .
    CCDSi CCDS3104.1.
    PIRi A54600.
    RefSeqi NP_006210.1. NM_006219.2.
    XP_005247587.1. XM_005247530.1.
    XP_005247588.1. XM_005247531.1.
    XP_006713722.1. XM_006713659.1.
    UniGenei Hs.239818.

    3D structure databases

    ProteinModelPortali P42338.
    SMRi P42338. Positions 123-1067.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111309. 16 interactions.
    DIPi DIP-44775N.
    IntActi P42338. 14 interactions.
    MINTi MINT-1505441.
    STRINGi 9606.ENSP00000289153.

    Chemistry

    BindingDBi P42338.
    ChEMBLi CHEMBL3145.
    GuidetoPHARMACOLOGYi 2154.

    PTM databases

    PhosphoSitei P42338.

    Polymorphism databases

    DMDMi 1171955.

    Proteomic databases

    MaxQBi P42338.
    PaxDbi P42338.
    PeptideAtlasi P42338.
    PRIDEi P42338.

    Protocols and materials databases

    DNASUi 5291.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289153 ; ENSP00000289153 ; ENSG00000051382 .
    ENST00000477593 ; ENSP00000418143 ; ENSG00000051382 .
    GeneIDi 5291.
    KEGGi hsa:5291.
    UCSCi uc011bmq.3. human.

    Organism-specific databases

    CTDi 5291.
    GeneCardsi GC03M138372.
    HGNCi HGNC:8976. PIK3CB.
    HPAi CAB031938.
    MIMi 602925. gene.
    neXtProti NX_P42338.
    PharmGKBi PA33309.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5032.
    HOGENOMi HOG000252911.
    HOVERGENi HBG052721.
    InParanoidi P42338.
    KOi K00922.
    OMAi AMHTCLK.
    OrthoDBi EOG70CR65.
    PhylomeDBi P42338.
    TreeFami TF102031.

    Enzyme and pathway databases

    UniPathwayi UPA00220 .
    BioCyci MetaCyc:HS00644-MONOMER.
    Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.
    REACT_12464. PI3K/AKT activation.
    REACT_12555. Downstream TCR signaling.
    REACT_12621. Tie2 Signaling.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_147814. DAP12 signaling.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_1695. GPVI-mediated activation cascade.
    REACT_17025. Downstream signal transduction.
    REACT_23787. Regulation of signaling by CBL.
    REACT_23832. Nephrin interactions.
    REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
    REACT_23891. Interleukin receptor SHC signaling.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_976. PI3K Cascade.
    SignaLinki P42338.

    Miscellaneous databases

    GeneWikii PIK3CB.
    GenomeRNAii 5291.
    NextBioi 20446.
    PROi P42338.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42338.
    Bgeei P42338.
    CleanExi HS_PIK3CB.
    Genevestigatori P42338.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85."
      Hu P., Mondino A., Skolnik E.Y., Schlessinger J.
      Mol. Cell. Biol. 13:7677-7688(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes."
      Kossila M., Sinkovic M., Karkkainen P., Laukkanen M.O., Miettinen R., Rissanen J., Kekalainen P., Kuusisto J., Yla-Herttuala S., Laakso M.
      Diabetes 49:1740-1743(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma."
      Czupalla C., Culo M., Muller E.C., Brock C., Reusch H.P., Spicher K., Krause E., Nurnberg B.
      J. Biol. Chem. 278:11536-11545(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-1070.
    6. "Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis."
      Jia S., Liu Z., Zhang S., Liu P., Zhang L., Lee S.H., Zhang J., Signoretti S., Loda M., Roberts T.M., Zhao J.J.
      Nature 454:776-779(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF LYS-805.
    7. Cited for: FUNCTION IN ONCOGENIC SIGNALING.
    8. Cited for: IDENTIFICATION IN A COMPLEX WITH PIK3R1 AND PTEN.
    9. "A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase."
      Dbouk H.A., Pang H., Fiser A., Backer J.M.
      Proc. Natl. Acad. Sci. U.S.A. 107:19897-19902(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF LYS-342.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival."
      Kumar A., Redondo-Munoz J., Perez-Garcia V., Cortes I., Chagoyen M., Carrera A.C.
      Mol. Cell. Biol. 31:2122-2133(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PIK3R2, SUBCELLULAR LOCATION, MOTIF NUCLEAR LOCALIZATION SIGNAL.
    12. "A beta version of life: p110beta takes center stage."
      Dbouk H.A., Backer J.M.
      Oncotarget 1:729-733(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    13. "Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions."
      Gratacap M.-P., Guillermet-Guibert J., Martin V., Chicanne G., Tronchere H., Gaits-Iacovoni F., Payrastre B.
      Adv. Enzyme Regul. 51:106-116(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.

    Entry informationi

    Entry nameiPK3CB_HUMAN
    AccessioniPrimary (citable) accession number: P42338
    Secondary accession number(s): D3DNF0, Q24JU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3