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P42335 (IP3KB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol-trisphosphate 3-kinase B
EC=2.7.1.127
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase B
Short name=IP3 3-kinase B
Short name=IP3K B
Short name=InsP 3-kinase B
Gene names
Name:Itpkb
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulation

IP3K is activated by calmodulin.

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence caution

The sequence CAA52298.1 differs from that shown. Reason: Frameshift at position 175.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 934934Inositol-trisphosphate 3-kinase B
PRO_0000066869

Regions

Nucleotide binding718 – 7203ATP By similarity
Region756 – 7649Calmodulin-binding By similarity
Region781 – 7888Substrate binding By similarity

Sites

Binding site6671ATP By similarity
Binding site6781ATP By similarity
Binding site7311ATP By similarity
Binding site7331Substrate By similarity
Binding site7541Substrate By similarity
Binding site8051ATP By similarity
Binding site8851ATP By similarity
Binding site8881Substrate By similarity

Amino acid modifications

Modified residue421Phosphoserine By similarity
Modified residue481Phosphoserine By similarity
Modified residue641Phosphoserine By similarity
Modified residue701Phosphoserine By similarity
Modified residue1791Phosphoserine By similarity
Modified residue1811Phosphoserine By similarity

Experimental info

Sequence conflict63 – 686LSLEEP → ATKVPW Ref.2

Secondary structure

1 ................................................... 934
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P42335 [UniParc].

Last modified July 19, 2004. Version 3.
Checksum: C844B79747E1A117

FASTA934101,819
        10         20         30         40         50         60 
MAVYCYALNS LVIMNSTNEL KSGSPLPSGS ETPQPSGRAA LSPGSVFSPG RGASFLFPPA 

        70         80         90        100        110        120 
ESLSLEEPGS AGGWRSGRRR LNSSSGSGGG SSSSNSSSSS GVGSPSWAGR LRGDAQQVVA 

       130        140        150        160        170        180 
TRILSPPGPE EAQRKLRILQ RELQNVQVNQ KVGMFEAQIQ AQTSAIQAPR SPRLGRARSP 

       190        200        210        220        230        240 
SPCPFRSSSQ PPERVLAPCS PSEERRTKSW GEQCTETPDA NSRRRSRLST HPSKDKEGVA 

       250        260        270        280        290        300 
PLLGPASPTR LGTQSPSTSV RMERGSPASP RCGSPTPMEI DKRTAPSLEH FGTSLTLATK 

       310        320        330        340        350        360 
VAASAASAGP HPGHDSVLME ADCELGAMRP WEAHLERRGQ FLGRETGSAP EPIRTHIREP 

       370        380        390        400        410        420 
PGRVERVHSV GGQGSWTPEV IKRPEEGTVD AQSSELSENP RWSRLPGDPG SVGPEKGGSR 

       430        440        450        460        470        480 
IPGIRGPQQT LDSMREGSSA LGLLGGSQAA QPGSMDVETG ISCGRMLEPL PPGEVTTNLK 

       490        500        510        520        530        540 
EPQCLPGDRM GMQPESSIVW PSAVEEAPLI WTCDTGIQLK GTWRSQDGDA HPSCQEKSPD 

       550        560        570        580        590        600 
QKDKACSPSN IPAIPAVIIT DMGAQEDGGL EEIQGSPRGP LPLRKLSSSS ASSTGFSSSY 

       610        620        630        640        650        660 
EDSEEDISSD PERTLDPNSA FLHTLDQQKP RVSKSWRKIK NMVQWSPFVM SFKKKYPWIQ 

       670        680        690        700        710        720 
LAGHAGSFKA AANGRILKKH CESEQRCLDR LMADVLRPFV PAYHGDVVKD GERYNQMDDL 

       730        740        750        760        770        780 
LADFDSPCVM DCKMGIRTYL EEELTKARKK PSLRKDMYQK MVEVDPEAPT EEEKAQRAVT 

       790        800        810        820        830        840 
KPRYMQWRET ISSTATLGFR IEGIKKEDGS VNRDFKKTKT REQVTEAFRE FTKGNQNILI 

       850        860        870        880        890        900 
AYRDRLKAIR ETLEVSPFFK CHEVIGSSLL FIHDKKEQAK VWMIDFGKTT PLPEGQTLQH 

       910        920        930 
DVPWQEGNRE DGYLSGLNNL IDILTEMSQG SPLT

« Hide

References

[1]"Cloning of the complete protein coding regions for inositol 1,4,5-trisphosphate 3-kinase B-isoforms from rat and human."
Bertsch U., Suesse S., Frerk S., Fanick W.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase."
Thomas S., Brake B., Luzio J.P., Stanley K., Banting G.
Biochim. Biophys. Acta 1220:219-222(1994) [PubMed: 8312366] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-934.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ242781 mRNA. Translation: CAC40660.1.
X74227 mRNA. Translation: CAA52298.1. Frameshift.
IPIIPI00231739.
PIRS41053.
RefSeqNP_062185.2. NM_019312.2.
UniGeneRn.22498.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2AQXX-ray2.50A/B642-930[»]
ProteinModelPortalP42335.
SMRP42335. Positions 642-930.
ModBaseSearch...

Protein-protein interaction databases

STRINGP42335.

Proteomic databases

PRIDEP42335.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004032; ENSRNOP00000004032; ENSRNOG00000002969.
GeneID54260.
KEGGrno:54260.
UCSCAJ242781. rat.

Organism-specific databases

CTD3707.
RGD2932. Itpkb.

Phylogenomic databases

eggNOGroNOG11709.
GeneTreeENSGT00390000017438.
HOVERGENHBG052139.
InParanoidP42335.
OMAQGQFLGS.
OrthoDBEOG4Q2DG1.
PhylomeDBP42335.

Enzyme and pathway databases

BRENDA2.7.1.127. 5301.

Gene expression databases

ArrayExpressP42335.
GenevestigatorP42335.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
KOK00911.
PANTHERPTHR12400. IPK. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610782.

Entry information

Entry nameIP3KB_RAT
AccessionPrimary (citable) accession number: P42335
Secondary accession number(s): Q91XW1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 19, 2004
Last modified: November 16, 2011
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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