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Protein

Alcohol dehydrogenase

Gene
N/A
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thermophilic NAD+-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Temperature dependencei

Thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi61Zinc 1; catalyticBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi148Zinc 1; catalyticBy similarity1
Binding sitei195NADBy similarity1
Binding sitei200NADBy similarity1
Binding sitei331NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi172 – 177NADBy similarity6
Nucleotide bindingi260 – 262NADBy similarity3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1. 623.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Alternative name(s):
ADH-HT
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607381 – 339Alcohol dehydrogenaseAdd BLAST339

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Beta strandi14 – 17Combined sources4
Beta strandi27 – 37Combined sources11
Helixi39 – 46Combined sources8
Beta strandi49 – 51Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi63 – 70Combined sources8
Beta strandi82 – 85Combined sources4
Beta strandi87 – 90Combined sources4
Beta strandi93 – 95Combined sources3
Helixi96 – 99Combined sources4
Helixi103 – 105Combined sources3
Turni112 – 114Combined sources3
Beta strandi119 – 127Combined sources9
Helixi128 – 130Combined sources3
Helixi140 – 143Combined sources4
Helixi144 – 146Combined sources3
Helixi149 – 160Combined sources12
Beta strandi167 – 171Combined sources5
Helixi177 – 186Combined sources10
Beta strandi190 – 194Combined sources5
Helixi198 – 206Combined sources9
Beta strandi210 – 213Combined sources4
Turni215 – 217Combined sources3
Helixi220 – 228Combined sources9
Beta strandi229 – 238Combined sources10
Helixi241 – 250Combined sources10
Beta strandi251 – 259Combined sources9
Beta strandi264 – 270Combined sources7
Helixi271 – 276Combined sources6
Beta strandi280 – 283Combined sources4
Helixi289 – 300Combined sources12
Beta strandi308 – 312Combined sources5
Helixi313 – 315Combined sources3
Helixi316 – 324Combined sources9
Beta strandi329 – 335Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RJWX-ray2.35A/B/C/D1-339[»]
3PIIX-ray2.90A/B/C/D1-339[»]
ProteinModelPortaliP42328.
SMRiP42328.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42328.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVVEQFK EPLKIKEVEK PTISYGEVLV RIKACGVCHT DLHAAHGDWP
60 70 80 90 100
VKPKLPLIPG HEGVGIVEEV GPGVTHLKVG DRVGIPWLYS ACGHCDYCLS
110 120 130 140 150
GQETLCEHQK NAGYSVDGGY AEYCRAAADY VVKIPDNLSF EEAAPIFCAG
160 170 180 190 200
VTTYKALKVT GAKPGEWVAI YGIGGLGHVA VQYAKAMGLN VVAVDIGDEK
210 220 230 240 250
LELAKELGAD LVVNPLKEDA AKFMKEKVGG VHAAVVTAVS KPAFQSAYNS
260 270 280 290 300
IRRGGACVLV GLPPEEMPIP IFDTVLNGIK IIGSIVGTRK DLQEALQFAA
310 320 330
EGKVKTIIEV QPLEKINEVF DRMLKGQING RVVLTLEDK
Length:339
Mass (Da):36,338
Last modified:November 1, 1995 - v1
Checksum:iAED17E4A34163430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27089 Genomic DNA. Translation: CAA81612.1.
PIRiS45605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27089 Genomic DNA. Translation: CAA81612.1.
PIRiS45605.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RJWX-ray2.35A/B/C/D1-339[»]
3PIIX-ray2.90A/B/C/D1-339[»]
ProteinModelPortaliP42328.
SMRiP42328.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.1.1.1. 623.

Miscellaneous databases

EvolutionaryTraceiP42328.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH3_GEOSE
AccessioniPrimary (citable) accession number: P42328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.