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Protein

Alcohol dehydrogenase

Gene
N/A
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thermophilic NAD+-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Temperature dependencei

Thermostable.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Zinc 1; catalyticBy similarity
Metal bindingi61 – 611Zinc 1; catalyticBy similarity
Metal bindingi92 – 921Zinc 2By similarity
Metal bindingi95 – 951Zinc 2By similarity
Metal bindingi98 – 981Zinc 2By similarity
Metal bindingi106 – 1061Zinc 2By similarity
Metal bindingi148 – 1481Zinc 1; catalyticBy similarity
Binding sitei195 – 1951NADBy similarity
Binding sitei200 – 2001NADBy similarity
Binding sitei331 – 3311NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi172 – 1776NADBy similarity
Nucleotide bindingi260 – 2623NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1196-MONOMER.
BRENDAi1.1.1.1. 623.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Alternative name(s):
ADH-HT
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Alcohol dehydrogenasePRO_0000160738Add
BLAST

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Beta strandi14 – 174Combined sources
Beta strandi27 – 3711Combined sources
Helixi39 – 468Combined sources
Beta strandi49 – 513Combined sources
Beta strandi55 – 573Combined sources
Beta strandi63 – 708Combined sources
Beta strandi82 – 854Combined sources
Beta strandi87 – 904Combined sources
Beta strandi93 – 953Combined sources
Helixi96 – 994Combined sources
Helixi103 – 1053Combined sources
Turni112 – 1143Combined sources
Beta strandi119 – 1279Combined sources
Helixi128 – 1303Combined sources
Helixi140 – 1434Combined sources
Helixi144 – 1463Combined sources
Helixi149 – 16012Combined sources
Beta strandi167 – 1715Combined sources
Helixi177 – 18610Combined sources
Beta strandi190 – 1945Combined sources
Helixi198 – 2069Combined sources
Beta strandi210 – 2134Combined sources
Turni215 – 2173Combined sources
Helixi220 – 2289Combined sources
Beta strandi229 – 23810Combined sources
Helixi241 – 25010Combined sources
Beta strandi251 – 2599Combined sources
Beta strandi264 – 2707Combined sources
Helixi271 – 2766Combined sources
Beta strandi280 – 2834Combined sources
Helixi289 – 30012Combined sources
Beta strandi308 – 3125Combined sources
Helixi313 – 3153Combined sources
Helixi316 – 3249Combined sources
Beta strandi329 – 3357Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJWX-ray2.35A/B/C/D1-339[»]
3PIIX-ray2.90A/B/C/D1-339[»]
ProteinModelPortaliP42328.
SMRiP42328. Positions 1-339.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42328.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVVEQFK EPLKIKEVEK PTISYGEVLV RIKACGVCHT DLHAAHGDWP
60 70 80 90 100
VKPKLPLIPG HEGVGIVEEV GPGVTHLKVG DRVGIPWLYS ACGHCDYCLS
110 120 130 140 150
GQETLCEHQK NAGYSVDGGY AEYCRAAADY VVKIPDNLSF EEAAPIFCAG
160 170 180 190 200
VTTYKALKVT GAKPGEWVAI YGIGGLGHVA VQYAKAMGLN VVAVDIGDEK
210 220 230 240 250
LELAKELGAD LVVNPLKEDA AKFMKEKVGG VHAAVVTAVS KPAFQSAYNS
260 270 280 290 300
IRRGGACVLV GLPPEEMPIP IFDTVLNGIK IIGSIVGTRK DLQEALQFAA
310 320 330
EGKVKTIIEV QPLEKINEVF DRMLKGQING RVVLTLEDK
Length:339
Mass (Da):36,338
Last modified:November 1, 1995 - v1
Checksum:iAED17E4A34163430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27089 Genomic DNA. Translation: CAA81612.1.
PIRiS45605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27089 Genomic DNA. Translation: CAA81612.1.
PIRiS45605.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJWX-ray2.35A/B/C/D1-339[»]
3PIIX-ray2.90A/B/C/D1-339[»]
ProteinModelPortaliP42328.
SMRiP42328. Positions 1-339.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1196-MONOMER.
BRENDAi1.1.1.1. 623.

Miscellaneous databases

EvolutionaryTraceiP42328.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH3_GEOSE
AccessioniPrimary (citable) accession number: P42328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.