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Protein

Hippocalcin-like protein 1

Gene

HPCAL1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Protein Rem-1
Gene namesi
Name:HPCAL1
Synonyms:REM1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737752 – 193Hippocalcin-like protein 1Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP42324.
PRIDEiP42324.

Expressioni

Tissue specificityi

Expressed in hemopoietic cells, but also in the fibroblasts, bone marrow, brain, eye and gut.1 Publication

Inductioni

By the MYB-ETS fusion oncogene.1 Publication

Gene expression databases

BgeeiENSGALG00000016443.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1636399,EBI-1635766

Protein-protein interaction databases

BioGridi676425. 1 interactor.
IntActiP42324. 1 interactor.
STRINGi9031.ENSGALP00000036116.

Structurei

3D structure databases

ProteinModelPortaliP42324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP42324.
OMAiLEIVQXK.
OrthoDBiEOG091G11T4.
PhylomeDBiP42324.
TreeFamiTF300009.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVEEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRGE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,269
Last modified:January 23, 2007 - v2
Checksum:i1EDDE87C53DCC29C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80875 mRNA. Translation: CAA56843.1.
PIRiI50676.
RefSeqiNP_990565.1. NM_205234.1.
XP_015131510.1. XM_015276024.1.
XP_015131512.1. XM_015276026.1.
XP_015131513.1. XM_015276027.1.
XP_015131514.1. XM_015276028.1.
UniGeneiGga.3776.

Genome annotation databases

EnsembliENSGALT00000036903; ENSGALP00000036116; ENSGALG00000016443.
ENSGALT00000063322; ENSGALP00000046009; ENSGALG00000016443.
GeneIDi396161.
KEGGigga:396161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80875 mRNA. Translation: CAA56843.1.
PIRiI50676.
RefSeqiNP_990565.1. NM_205234.1.
XP_015131510.1. XM_015276024.1.
XP_015131512.1. XM_015276026.1.
XP_015131513.1. XM_015276027.1.
XP_015131514.1. XM_015276028.1.
UniGeneiGga.3776.

3D structure databases

ProteinModelPortaliP42324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676425. 1 interactor.
IntActiP42324. 1 interactor.
STRINGi9031.ENSGALP00000036116.

Proteomic databases

PaxDbiP42324.
PRIDEiP42324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000036903; ENSGALP00000036116; ENSGALG00000016443.
ENSGALT00000063322; ENSGALP00000046009; ENSGALG00000016443.
GeneIDi396161.
KEGGigga:396161.

Organism-specific databases

CTDi3241.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP42324.
OMAiLEIVQXK.
OrthoDBiEOG091G11T4.
PhylomeDBiP42324.
TreeFamiTF300009.

Miscellaneous databases

PROiP42324.

Gene expression databases

BgeeiENSGALG00000016443.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHPCL1_CHICK
AccessioniPrimary (citable) accession number: P42324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.