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Protein

Longitudinals lacking protein, isoforms H/M/V

Gene

lola

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.2 Publications

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • antimicrobial humoral response Source: FlyBase
  • axon guidance Source: UniProtKB
  • axon midline choice point recognition Source: UniProtKB
  • axonogenesis Source: UniProtKB
  • dendrite morphogenesis Source: FlyBase
  • gonad development Source: FlyBase
  • inter-male aggressive behavior Source: FlyBase
  • larval lymph gland hemopoiesis Source: FlyBase
  • larval somatic muscle development Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • R3/R4 cell fate commitment Source: FlyBase
  • R7 cell development Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of imaginal disc-derived wing size Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Longitudinals lacking protein, isoforms H/M/V
Gene namesi
Name:lolaImported
ORF Names:CG12052Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0283521. lola.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi107A → V in ORE120; defective in embryonic axon guidance. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470731 – 549Longitudinals lacking protein, isoforms H/M/VAdd BLAST549

Proteomic databases

PaxDbiP42284.
PRIDEiP42284.

Expressioni

Tissue specificityi

Mostly neuronal.1 Publication

Developmental stagei

Expressed both maternally and zygotically. At least one isoform is present at each developmental stage.3 Publications

Gene expression databases

BgeeiFBgn0005630.
ExpressionAtlasiP42284. differential.
GenevisibleiP42284. DM.

Interactioni

Protein-protein interaction databases

BioGridi69126. 44 interactors.

Structurei

3D structure databases

ProteinModelPortaliP42284.
SMRiP42284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 97BTBPROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG410IXYF. Eukaryota.
ENOG4111M67. LUCA.
GeneTreeiENSGT00530000064321.
OrthoDBiEOG091G0WNB.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequences (22)i

Sequence statusi: Complete.

This entry describes 22 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Some isoforms may be generated by alternative trans-splicing of exons sequentially encoded by the same DNA strand.
Isoform V (identifier: P42284-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-G

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL
60 70 80 90 100
SACSPYFATL LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL
110 120 130 140 150
AALLKAAESL QIKGLSDNRT GGGVAPKPES SGHHRGGKLS GAYTLEQTKR
160 170 180 190 200
ARLATGGAMD TSGDVSGSRE GSSSPSRRRR KVRRRSMEND AHDNSNSSVL
210 220 230 240 250
QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS STQQQQPLTS
260 270 280 290 300
TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN
310 320 330 340 350
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV
360 370 380 390 400
KQLASVVDKS SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL
410 420 430 440 450
TLDEEDMTME ELDQTAGTSQ GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ
460 470 480 490 500
RDPQDVSTNQ TVVLPHYSIY HYYSNIYYLL SHTTIYEADR TVSVSCPGKL
510 520 530 540
NCLPQRNDLQ ETKSVTVLYT IHFFLYILMI YIFVLCKILP RIVFVWVST
Length:549
Mass (Da):59,323
Last modified:August 30, 2005 - v2
Checksum:i0FB6C88602ADAB49
GO
Isoform H (identifier: P42284-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-M

The sequence of this isoform differs from the canonical sequence as follows:
     455-518: DVSTNQTVVL...LQETKSVTVL → DEAGQNEGGE...IIQSFIDKIY
     519-549: Missing.

Show »
Length:518
Mass (Da):55,409
Checksum:i9740E942EA33752E
GO
Isoform M (identifier: P42284-1) [UniParc]FASTAAdd to basket
Also known as: Short, Ohsako-A

The sequence of this isoform differs from the canonical sequence as follows:
     455-465: DVSTNQTVVLP → GECLLPLKSII
     466-549: Missing.

Show »
Length:465
Mass (Da):49,320
Checksum:i7CD2FA1169C4732C
GO
Isoform A (identifier: Q7KQZ4-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-D
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:706
Mass (Da):75,751
GO
Isoform B (identifier: Q7KQZ4-1) [UniParc]FASTAAdd to basket
Also known as: C, Ohsako-L
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: C-terminal exons may be joined by a trans-splicing event. The exons are coded by the same DNA strand.
Length:787
Mass (Da):82,173
GO
Isoform D (identifier: Q7KQZ4-3) [UniParc]FASTAAdd to basket
Also known as: E, Ohsako-F
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:748
Mass (Da):79,439
GO
Isoform F (identifier: Q867Z4-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-I
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:565
Mass (Da):60,740
GO
Isoform G (identifier: P42283-1) [UniParc]FASTAAdd to basket
Also known as: Long, Ohsako-T, R
The sequence of this isoform can be found in the external entry P42283.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: C-terminal exons may be joined by a trans-splicing event. The exons are coded by the same DNA strand.
Length:891
Mass (Da):96,254
GO
Isoform I (identifier: Q867Z4-1) [UniParc]FASTAAdd to basket
Also known as: Ohsako-K
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:970
Mass (Da):105,812
GO
Isoform J (identifier: Q9V5M6-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-O
The sequence of this isoform can be found in the external entry Q9V5M6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:757
Mass (Da):78,690
GO
Isoform K (identifier: Q867Z4-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-H
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:546
Mass (Da):58,945
GO
Isoform L (identifier: Q7KQZ4-4) [UniParc]FASTAAdd to basket
Also known as: Ohsako-C
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:608
Mass (Da):65,412
GO
Isoform N (identifier: Q9V5M3-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:878
Mass (Da):96,207
GO
Isoform O (identifier: Q9V5M3-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-P
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:668
Mass (Da):71,801
GO
Isoform P (identifier: Q9V5M6-1) [UniParc]FASTAAdd to basket
Also known as: Ohsako-N
The sequence of this isoform can be found in the external entry Q9V5M6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:963
Mass (Da):102,734
GO
Isoform Q (identifier: Q9V5M6-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-B
The sequence of this isoform can be found in the external entry Q9V5M6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:603
Mass (Da):64,685
GO
Isoform S (identifier: Q9V5M6-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9V5M6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:720
Mass (Da):77,050
GO
Isoform T (identifier: Q867Z4-5) [UniParc]FASTAAdd to basket
Also known as: U, Ohsako-J
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:575
Mass (Da):61,917
GO
Isoform W (identifier: Q9V5M3-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-Q
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:771
Mass (Da):83,526
GO
Isoform X (identifier: Q9V5M3-4) [UniParc]FASTAAdd to basket
Also known as: Ohsako-S
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:602
Mass (Da):64,422
GO
Isoform Y (identifier: Q9V5M3-5) [UniParc]FASTAAdd to basket
Also known as: Ohsako-R
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:577
Mass (Da):62,746
GO
Isoform Z (identifier: Q9V5M6-5) [UniParc]FASTAAdd to basket
Also known as: Ohsako-E
The sequence of this isoform can be found in the external entry Q9V5M6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:665
Mass (Da):70,896
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform M (identifier: P42284-1)
Sequence conflicti465I → YEL in AAA19592 (PubMed:8050351).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015404455 – 518DVSTN…SVTVL → DEAGQNEGGESRIRVRNWLM LADKSIIGKSSDEPSVLHIV LLLSTHRHIISFLLIIQSFI DKIY in isoform H. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_015403455 – 465DVSTNQTVVLP → GECLLPLKSII in isoform M. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_015405466 – 549Missing in isoform M. 2 PublicationsAdd BLAST84
Alternative sequenceiVSP_015406519 – 549Missing in isoform H. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07606 mRNA. Translation: AAA19592.1.
AB107272 mRNA. Translation: BAC67577.1.
AB107278 mRNA. Translation: BAC67583.1.
AB107284 mRNA. Translation: BAC67589.1.
AB107292 mRNA. Translation: BAC67597.1.
AB107298 mRNA. Translation: BAC67603.1.
AB107304 mRNA. Translation: BAC67609.1.
AB107312 mRNA. Translation: BAC67617.1.
AB107318 mRNA. Translation: BAC67623.1.
AB107324 mRNA. Translation: BAC67629.1.
AB107332 mRNA. Translation: BAC67637.1.
AB107338 mRNA. Translation: BAC67643.1.
AB107344 mRNA. Translation: BAC67649.1.
AE013599 Genomic DNA. Translation: AAF58777.2.
AE013599 Genomic DNA. Translation: AAO41431.1.
AE013599 Genomic DNA. Translation: AAS64877.1.
RefSeqiNP_724945.1. NM_170617.5. [P42284-3]
NP_788320.1. NM_176140.4. [P42284-1]
NP_995807.1. NM_206085.4. [P42284-2]
UniGeneiDm.11710.

Genome annotation databases

EnsemblMetazoaiFBtr0089346; FBpp0088380; FBgn0005630. [P42284-3]
FBtr0089362; FBpp0088396; FBgn0005630. [P42284-1]
FBtr0089363; FBpp0088949; FBgn0005630. [P42284-2]
GeneIDi44548.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLOLA2_DROME
AccessioniPrimary (citable) accession number: P42284
Secondary accession number(s): Q867M9, Q867R1, Q868A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 30, 2005
Last modified: October 25, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase