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Protein

Acyl-CoA-binding protein homolog

Gene

Dbi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters (By similarity). May be involved in energy metabolism in a manner that depends on the substrate used for energy production. Dbi and its metabolites are involved in the regulation of multiple biological processes.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: FlyBase
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • cellular acyl-CoA homeostasis Source: FlyBase
  • transport Source: UniProtKB-KW

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein homolog
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor homolog
Short name:
DBI
Gene namesi
Name:Dbi
ORF Names:CG8627
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010387. Dbi.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002140101 – 86Acyl-CoA-binding protein homologAdd BLAST86

Proteomic databases

PaxDbiP42281.
PRIDEiP42281.

Expressioni

Tissue specificityi

Expressed in larval and pupal brains. In adults, expressed in cardia, part of the Malpighian tubules, fat body, and gametes of both sexes.1 Publication

Developmental stagei

Expressed from the larval stage onwards throughout the adult stage.1 Publication

Gene expression databases

BgeeiFBgn0010387.
ExpressionAtlasiP42281. differential.
GenevisibleiP42281. DM.

Interactioni

Protein-protein interaction databases

IntActiP42281. 1 interactor.
STRINGi7227.FBpp0076624.

Structurei

3D structure databases

ProteinModelPortaliP42281.
SMRiP42281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 86ACBPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
InParanoidiP42281.
OMAiAQQEYIT.
OrthoDBiEOG091G0NXJ.
PhylomeDBiP42281.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiView protein in InterPro
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
PfamiView protein in Pfam
PF00887. ACBP. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiView protein in PROSITE
PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P42281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEQFNAAA EKVKSLTKRP SDDEFLQLYA LFKQASVGDN DTAKPGLLDL
60 70 80
KGKAKWEAWN KQKGKSSEAA QQEYITFVEG LVAKYA
Length:86
Mass (Da):9,557
Last modified:November 1, 1995 - v1
Checksum:i623986B5566228E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55K → S in CAA53268 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04822 Genomic DNA. Translation: AAA21649.1.
U04823 mRNA. Translation: AAA21650.1.
X75596 mRNA. Translation: CAA53268.1.
AE014296 Genomic DNA. Translation: AAF50607.1.
AE014296 Genomic DNA. Translation: AAN12074.1.
AY070704 mRNA. Translation: AAL48175.1.
PIRiA56041.
S38574.
RefSeqiNP_523952.2. NM_079228.3.
NP_729218.1. NM_168192.3.
UniGeneiDm.20425.

Genome annotation databases

EnsemblMetazoaiFBtr0076915; FBpp0076624; FBgn0010387.
FBtr0076916; FBpp0076625; FBgn0010387.
GeneIDi38784.
KEGGidme:Dmel_CG8627.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACBP_DROME
AccessioniPrimary (citable) accession number: P42281
Secondary accession number(s): A4V1K8, Q9VS23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families