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Protein

Acyl-CoA-binding protein homolog

Gene

Dbi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters (By similarity). May be involved in energy metabolism in a manner that depends on the substrate used for energy production. Dbi and its metabolites are involved in the regulation of multiple biological processes.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: FlyBase
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • cellular acyl-CoA homeostasis Source: FlyBase

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein homolog
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor homolog
Short name:
DBI
Gene namesi
Name:Dbi
ORF Names:CG8627
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010387 Dbi

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002140101 – 86Acyl-CoA-binding protein homologAdd BLAST86

Proteomic databases

PaxDbiP42281
PRIDEiP42281

Expressioni

Tissue specificityi

Expressed in larval and pupal brains. In adults, expressed in cardia, part of the Malpighian tubules, fat body, and gametes of both sexes.1 Publication

Developmental stagei

Expressed from the larval stage onwards throughout the adult stage.1 Publication

Gene expression databases

BgeeiFBgn0010387
ExpressionAtlasiP42281 baseline and differential
GenevisibleiP42281 DM

Interactioni

Protein-protein interaction databases

IntActiP42281, 1 interactor
STRINGi7227.FBpp0076624

Structurei

3D structure databases

ProteinModelPortaliP42281
SMRiP42281
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 86ACBPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
InParanoidiP42281
OMAiTDKPGMF
OrthoDBiEOG091G0NXJ
PhylomeDBiP42281

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEQFNAAA EKVKSLTKRP SDDEFLQLYA LFKQASVGDN DTAKPGLLDL
60 70 80
KGKAKWEAWN KQKGKSSEAA QQEYITFVEG LVAKYA
Length:86
Mass (Da):9,557
Last modified:November 1, 1995 - v1
Checksum:i623986B5566228E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55K → S in CAA53268 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04822 Genomic DNA Translation: AAA21649.1
U04823 mRNA Translation: AAA21650.1
X75596 mRNA Translation: CAA53268.1
AE014296 Genomic DNA Translation: AAF50607.1
AE014296 Genomic DNA Translation: AAN12074.1
AY070704 mRNA Translation: AAL48175.1
PIRiA56041
S38574
RefSeqiNP_523952.2, NM_079228.3
NP_729218.1, NM_168192.3
UniGeneiDm.20425

Genome annotation databases

EnsemblMetazoaiFBtr0076915; FBpp0076624; FBgn0010387
FBtr0076916; FBpp0076625; FBgn0010387
GeneIDi38784
KEGGidme:Dmel_CG8627

Similar proteinsi

Entry informationi

Entry nameiACBP_DROME
AccessioniPrimary (citable) accession number: P42281
Secondary accession number(s): A4V1K8, Q9VS23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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