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P42280

- TRYZ_DROME

UniProt

P42280 - TRYZ_DROME

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Protein

Trypsin zeta

Gene

zetaTry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Charge relay systemBy similarity
Active sitei134 – 1341Charge relay systemBy similarity
Sitei228 – 2281Required for specificityBy similarity
Active sitei234 – 2341Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: FlyBase

GO - Biological processi

  1. proteolysis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.116.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin zeta (EC:3.4.21.4)
Gene namesi
Name:zetaTry
ORF Names:CG12387
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011556. zetaTry.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222CuratedAdd
BLAST
Propeptidei23 – 3816Activation peptidePRO_0000028287Add
BLAST
Chaini39 – 280242Trypsin zetaPRO_0000028288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 88PROSITE-ProRule annotation
Disulfide bondi198 ↔ 218PROSITE-ProRule annotation
Disulfide bondi230 ↔ 254PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP42280.

Expressioni

Gene expression databases

BgeeiP42280.

Interactioni

Protein-protein interaction databases

BioGridi62009. 2 interactions.
IntActiP42280. 2 interactions.
MINTiMINT-297272.
STRINGi7227.FBpp0087260.

Structurei

3D structure databases

ProteinModelPortaliP42280.
SMRiP42280. Positions 39-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 278240Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00620000088101.
InParanoidiP42280.
KOiK01312.
OrthoDBiEOG75B84T.
PhylomeDBiP42280.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42280-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSWIVGLL AFLVSLVALT QGLPLLEDLD EKSVPDGRIV GGYATDIAQV
60 70 80 90 100
PYQISLRYKG ITTPENPFRH RCGGSIFNET TIVTAAHCVI GTVASQYKVV
110 120 130 140 150
AGTNFQTGSD GVITNVKEIV MHEGYYSGAA YNNDIAILFV DPPLPLNNFT
160 170 180 190 200
IKAIKLALEQ PIEGTVSKVS GWGTTSPGGY SSNQLLAVDV PIVSNELCDQ
210 220 230 240 250
DYEDFGDETY RITSAMLCAG KRGVGGADAC QGDSGGPLAV RDELYGVVSW
260 270 280
GNSCALPNYP GVYANVAYLR PWIDAVLAGL
Length:280
Mass (Da):29,738
Last modified:August 16, 2005 - v2
Checksum:i99A2D76557C308FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861A → G in AAA17456. (PubMed:10486967)Curated
Sequence conflicti145 – 1451P → A in AAA17456. (PubMed:10486967)Curated
Sequence conflicti153 – 1531A → G in AAA17456. (PubMed:10486967)Curated
Sequence conflicti158 – 1581L → S in AAA17456. (PubMed:10486967)Curated
Sequence conflicti222 – 2221R → P in AAA17456. (PubMed:10486967)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04853 Genomic DNA. Translation: AAA17456.1.
AE013599 Genomic DNA. Translation: AAF58663.1.
AY113523 mRNA. Translation: AAM29528.1.
RefSeqiNP_523691.1. NM_078967.4.
UniGeneiDm.2633.

Genome annotation databases

EnsemblMetazoaiFBtr0088164; FBpp0087260; FBgn0011556.
GeneIDi36216.
KEGGidme:Dmel_CG12387.
UCSCiCG12387-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04853 Genomic DNA. Translation: AAA17456.1 .
AE013599 Genomic DNA. Translation: AAF58663.1 .
AY113523 mRNA. Translation: AAM29528.1 .
RefSeqi NP_523691.1. NM_078967.4.
UniGenei Dm.2633.

3D structure databases

ProteinModelPortali P42280.
SMRi P42280. Positions 39-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62009. 2 interactions.
IntActi P42280. 2 interactions.
MINTi MINT-297272.
STRINGi 7227.FBpp0087260.

Protein family/group databases

MEROPSi S01.116.

Proteomic databases

PaxDbi P42280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088164 ; FBpp0087260 ; FBgn0011556 .
GeneIDi 36216.
KEGGi dme:Dmel_CG12387.
UCSCi CG12387-RA. d. melanogaster.

Organism-specific databases

CTDi 36216.
FlyBasei FBgn0011556. zetaTry.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00620000088101.
InParanoidi P42280.
KOi K01312.
OrthoDBi EOG75B84T.
PhylomeDBi P42280.

Miscellaneous databases

GenomeRNAii 36216.
NextBioi 797384.

Gene expression databases

Bgeei P42280.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Concerted evolution within a trypsin gene cluster in Drosophila."
    Wang S., Magoulas C., Hickey D.A.
    Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiTRYZ_DROME
AccessioniPrimary (citable) accession number: P42280
Secondary accession number(s): Q9V5X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3