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Protein

Trypsin zeta

Gene

zetaTry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Charge relay systemBy similarity1
Active sitei134Charge relay systemBy similarity1
Sitei228Required for specificityBy similarity1
Active sitei234Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.116.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin zeta (EC:3.4.21.4)
Gene namesi
Name:zetaTry
ORF Names:CG12387
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011556. zetaTry.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22CuratedAdd BLAST22
PropeptideiPRO_000002828723 – 38Activation peptideAdd BLAST16
ChainiPRO_000002828839 – 280Trypsin zetaAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 88PROSITE-ProRule annotation
Disulfide bondi198 ↔ 218PROSITE-ProRule annotation
Disulfide bondi230 ↔ 254PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP42280.
PRIDEiP42280.

Expressioni

Gene expression databases

BgeeiFBgn0011556.
GenevisibleiP42280. DM.

Interactioni

Protein-protein interaction databases

BioGridi62009. 2 interactors.
IntActiP42280. 2 interactors.
MINTiMINT-297272.
STRINGi7227.FBpp0087260.

Structurei

3D structure databases

ProteinModelPortaliP42280.
SMRiP42280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 278Peptidase S1PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00860000133917.
InParanoidiP42280.
KOiK01312.
OMAiVSNELCD.
OrthoDBiEOG091G0DF7.
PhylomeDBiP42280.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSWIVGLL AFLVSLVALT QGLPLLEDLD EKSVPDGRIV GGYATDIAQV
60 70 80 90 100
PYQISLRYKG ITTPENPFRH RCGGSIFNET TIVTAAHCVI GTVASQYKVV
110 120 130 140 150
AGTNFQTGSD GVITNVKEIV MHEGYYSGAA YNNDIAILFV DPPLPLNNFT
160 170 180 190 200
IKAIKLALEQ PIEGTVSKVS GWGTTSPGGY SSNQLLAVDV PIVSNELCDQ
210 220 230 240 250
DYEDFGDETY RITSAMLCAG KRGVGGADAC QGDSGGPLAV RDELYGVVSW
260 270 280
GNSCALPNYP GVYANVAYLR PWIDAVLAGL
Length:280
Mass (Da):29,738
Last modified:August 16, 2005 - v2
Checksum:i99A2D76557C308FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86A → G in AAA17456 (PubMed:10486967).Curated1
Sequence conflicti145P → A in AAA17456 (PubMed:10486967).Curated1
Sequence conflicti153A → G in AAA17456 (PubMed:10486967).Curated1
Sequence conflicti158L → S in AAA17456 (PubMed:10486967).Curated1
Sequence conflicti222R → P in AAA17456 (PubMed:10486967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA. Translation: AAA17456.1.
AE013599 Genomic DNA. Translation: AAF58663.1.
AY113523 mRNA. Translation: AAM29528.1.
RefSeqiNP_523691.1. NM_078967.4.
UniGeneiDm.2633.

Genome annotation databases

EnsemblMetazoaiFBtr0088164; FBpp0087260; FBgn0011556.
GeneIDi36216.
KEGGidme:Dmel_CG12387.
UCSCiCG12387-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA. Translation: AAA17456.1.
AE013599 Genomic DNA. Translation: AAF58663.1.
AY113523 mRNA. Translation: AAM29528.1.
RefSeqiNP_523691.1. NM_078967.4.
UniGeneiDm.2633.

3D structure databases

ProteinModelPortaliP42280.
SMRiP42280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62009. 2 interactors.
IntActiP42280. 2 interactors.
MINTiMINT-297272.
STRINGi7227.FBpp0087260.

Protein family/group databases

MEROPSiS01.116.

Proteomic databases

PaxDbiP42280.
PRIDEiP42280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088164; FBpp0087260; FBgn0011556.
GeneIDi36216.
KEGGidme:Dmel_CG12387.
UCSCiCG12387-RA. d. melanogaster.

Organism-specific databases

CTDi36216.
FlyBaseiFBgn0011556. zetaTry.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00860000133917.
InParanoidiP42280.
KOiK01312.
OMAiVSNELCD.
OrthoDBiEOG091G0DF7.
PhylomeDBiP42280.

Miscellaneous databases

GenomeRNAii36216.
PROiP42280.

Gene expression databases

BgeeiFBgn0011556.
GenevisibleiP42280. DM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRYZ_DROME
AccessioniPrimary (citable) accession number: P42280
Secondary accession number(s): Q9V5X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.