Reviewed,
UniProtKB/Swiss-Prot P42280 (TRYZ_DROME)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Trypsin zeta EC=3.4.21.4 | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 280 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Zymogen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Non-traceable author statement. Source: FlyBase |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct serine-type endopeptidase activityNon-traceable author statement. Source: FlyBase |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Q9VKB5 | 1 | EBI-186721,EBI-88710 | ||
| alphaPS5 | Q9W1M8 | 1 | EBI-186721,EBI-106628 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Probable | ||||||||
| Propeptide | 23 – 38 | 16 | Activation peptide | PRO_0000028287 | |||||||
| Chain | 39 – 280 | 242 | Trypsin zeta | PRO_0000028288 | |||||||
Regions | |||||||||||
| Domain | 39 – 278 | 240 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 87 | 1 | Charge relay system By similarity | ||||||||
| Active site | 134 | 1 | Charge relay system By similarity | ||||||||
| Active site | 234 | 1 | Charge relay system By similarity | ||||||||
| Site | 228 | 1 | Required for specificity By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 72 ↔ 88 | By similarity | |||||||||
| Disulfide bond | 198 ↔ 218 | By similarity | |||||||||
| Disulfide bond | 230 ↔ 254 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 86 | 1 | A → G in AAA17456. Ref.1 | ||||||||
| Sequence conflict | 145 | 1 | P → A in AAA17456. Ref.1 | ||||||||
| Sequence conflict | 153 | 1 | A → G in AAA17456. Ref.1 | ||||||||
| Sequence conflict | 158 | 1 | L → S in AAA17456. Ref.1 | ||||||||
| Sequence conflict | 222 | 1 | R → P in AAA17456. Ref.1 | ||||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| U04853 Genomic DNA. Translation: AAA17456.1. AE013599 Genomic DNA. Translation: AAF58663.1. AY113523 mRNA. Translation: AAM29528.1. | |
| RefSeq | NP_523691.1. |
| UniGene | Dm.2633 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EZX based on UniProtKB P00760. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P42280. 2 interactions. |
Protein family/group databases | |
| MEROPS | S01.116. |
Genome annotation databases | |
| Ensembl | FBgn0011556. Drosophila melanogaster. [Contig view] |
| GeneID | 36216. |
| KEGG | dme:Dmel_CG12387. |
| NMPDR | fig|7227.3.peg.4633. |
Organism-specific databases | |
| FlyBase | FBgn0011556. zetaTry. |
Phylogenomic databases | |
| HOGENOM | P42280. |
| OMA | P42280. AYNNDIA. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.4. 48. |
Gene expression databases | |
| GermOnline | CG12387. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 797384. |
Entry information
| Entry name | TRYZ_DROME | ||||||||
| Accession | Primary (citable) accession number: P42280 Secondary accession number(s): Q9V5X8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

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