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P42279

- TRYU_DROME

UniProt

P42279 - TRYU_DROME

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Protein

Trypsin eta

Gene

etaTry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay systemBy similarity
Active sitei120 – 1201Charge relay systemBy similarity
Sitei209 – 2091Required for specificityBy similarity
Active sitei215 – 2151Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: FlyBase

GO - Biological processi

  1. proteolysis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.117.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin eta (EC:3.4.21.4)
Gene namesi
Name:etaTry
ORF Names:CG12386
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011554. etaTry.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 275Activation peptidePRO_0000028283
Chaini28 – 262235Trypsin etaPRO_0000028284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Disulfide bondi185 ↔ 200PROSITE-ProRule annotation
Disulfide bondi211 ↔ 235PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP42279.

Expressioni

Gene expression databases

BgeeiP42279.
ExpressionAtlasiP42279. differential.

Interactioni

Protein-protein interaction databases

BioGridi62010. 1 interaction.
MINTiMINT-317423.

Structurei

3D structure databases

ProteinModelPortaliP42279.
SMRiP42279. Positions 28-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 259232Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00620000088101.
InParanoidiP42279.
KOiK01312.
OMAiYWRPISE.
OrthoDBiEOG75B84T.
PhylomeDBiP42279.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42279-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKVILRILA VLFLLGIYAV SAQSDGRIVG GADTSSYYTK YVVQLRRRSS
60 70 80 90 100
SSSSYAQTCG GCILDAVTIA TAAHCVYNRE AENFLVVAGD DSRGGMNGVV
110 120 130 140 150
VRVSKLIPHE LYNSSTMDND IALVVVDPPL PLDSFSTMEA IEIASEQPAV
160 170 180 190 200
GVQATISGWG YTKENGLSSD QLQQVKVPIV DSEKCQEAYY WRPISEGMLC
210 220 230 240 250
AGLSEGGKDA CQGDSGGPLV VANKLAGIVS WGEGCARPNY PGVYANVAYY
260
KDWIAKQRTS YV
Length:262
Mass (Da):28,088
Last modified:August 16, 2005 - v2
Checksum:iBE908F7602A611DC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81I → V in AAA17455. (PubMed:10486967)Curated
Sequence conflicti24 – 241S → P in AAA17455. (PubMed:10486967)Curated
Sequence conflicti88 – 881A → S in AAA17455. (PubMed:10486967)Curated
Sequence conflicti97 – 971N → Y in AAA17455. (PubMed:10486967)Curated
Sequence conflicti105 – 1051K → Q in AAA17455. (PubMed:10486967)Curated
Sequence conflicti142 – 1421E → V in AAA17455. (PubMed:10486967)Curated
Sequence conflicti149 – 1491A → P in AAA17455. (PubMed:10486967)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04853 Genomic DNA. Translation: AAA17455.1.
AE013599 Genomic DNA. Translation: AAF58662.1.
BT012306 mRNA. Translation: AAS77431.1.
RefSeqiNP_523692.1. NM_078968.2.
UniGeneiDm.23664.

Genome annotation databases

EnsemblMetazoaiFBtr0088163; FBpp0087259; FBgn0011554.
GeneIDi36217.
KEGGidme:Dmel_CG12386.
UCSCiCG12386-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04853 Genomic DNA. Translation: AAA17455.1 .
AE013599 Genomic DNA. Translation: AAF58662.1 .
BT012306 mRNA. Translation: AAS77431.1 .
RefSeqi NP_523692.1. NM_078968.2.
UniGenei Dm.23664.

3D structure databases

ProteinModelPortali P42279.
SMRi P42279. Positions 28-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62010. 1 interaction.
MINTi MINT-317423.

Protein family/group databases

MEROPSi S01.117.

Proteomic databases

PaxDbi P42279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088163 ; FBpp0087259 ; FBgn0011554 .
GeneIDi 36217.
KEGGi dme:Dmel_CG12386.
UCSCi CG12386-RA. d. melanogaster.

Organism-specific databases

CTDi 36217.
FlyBasei FBgn0011554. etaTry.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00620000088101.
InParanoidi P42279.
KOi K01312.
OMAi YWRPISE.
OrthoDBi EOG75B84T.
PhylomeDBi P42279.

Miscellaneous databases

GenomeRNAii 36217.
NextBioi 797389.

Gene expression databases

Bgeei P42279.
ExpressionAtlasi P42279. differential.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Concerted evolution within a trypsin gene cluster in Drosophila."
    Wang S., Magoulas C., Hickey D.A.
    Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-262.
    Strain: Berkeley.
    Tissue: Larva and Pupae.

Entry informationi

Entry nameiTRYU_DROME
AccessioniPrimary (citable) accession number: P42279
Secondary accession number(s): Q6NLM5, Q9V5X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3