Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trypsin theta

Gene

thetaTry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Sitei210Required for specificityBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.114

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin theta (EC:3.4.21.4)
Gene namesi
ORF Names:CG12385
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011555 thetaTry

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19CuratedAdd BLAST19
PropeptideiPRO_000002827920 – 34Activation peptideAdd BLAST15
ChainiPRO_000002828035 – 262Trypsin thetaAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 77PROSITE-ProRule annotation
Disulfide bondi186 ↔ 203PROSITE-ProRule annotation
Disulfide bondi212 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP42278
PRIDEiP42278

Expressioni

Gene expression databases

BgeeiFBgn0011555
ExpressionAtlasiP42278 baseline and differential
GenevisibleiP42278 DM

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087258

Structurei

3D structure databases

ProteinModelPortaliP42278
SMRiP42278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 260Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144439
InParanoidiP42278
KOiK01312
OMAiFWCMSLP
OrthoDBiEOG091G0AH5
PhylomeDBiP42278

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRLVVLLVC LAVGSACAGT VGVSNGDPFE REGRIVGGED TTIGAHPYQV
60 70 80 90 100
SLQTKSGSHF CGGSLINEDT VVTAAHCLVG RKVSKVFVRL GSTLYNEGGI
110 120 130 140 150
VVAVRELAYN EDYNSKTMEY DVGILKLDEK VKETENIRYI ELATETPPTG
160 170 180 190 200
TTAVVTGWGS KCYFWCMTLP KTLQEVYVNI VDWKTCASDE YKYGEIIYDS
210 220 230 240 250
MVCAYEKKKD ACQGDSGGPL AVGNTLVGIV SWGYACASNL LPGVYSDVPA
260
LRKWILNASE TL
Length:262
Mass (Da):28,378
Last modified:August 16, 2005 - v2
Checksum:i440A66F07037C985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45 – 46AH → GD in AAA17454 (PubMed:10486967).Curated2
Sequence conflicti73T → A in AAL48054 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA Translation: AAA17454.1
AE013599 Genomic DNA Translation: AAF58661.1
AY070583 mRNA Translation: AAL48054.1
RefSeqiNP_523693.1, NM_078969.5
UniGeneiDm.5696

Genome annotation databases

EnsemblMetazoaiFBtr0088162; FBpp0087258; FBgn0011555
GeneIDi36218
KEGGidme:Dmel_CG12385
UCSCiCG12385-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiTRYT_DROME
AccessioniPrimary (citable) accession number: P42278
Secondary accession number(s): Q8SZQ7, Q9V5Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 16, 2005
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health