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P42276

- TRYDG_DROME

UniProt

P42276 - TRYDG_DROME

Protein

Trypsin delta/gamma

Gene

deltaTry

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711Charge relay systemBy similarity
    Active sitei116 – 1161Charge relay systemBy similarity
    Sitei204 – 2041Required for specificityBy similarity
    Active sitei210 – 2101Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: FlyBase

    GO - Biological processi

    1. proteolysis Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.A84.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin delta/gamma (EC:3.4.21.4)
    Gene namesi
    Name:deltaTry
    ORF Names:CG12351
    AND
    Name:gammaTry
    ORF Names:CG30028
    AND
    ORF Names:CG30031
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0050031. CG30031.
    FBgn0010358. deltaTry.
    FBgn0010359. gammaTry.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: FlyBase
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222CuratedAdd
    BLAST
    Propeptidei23 – 308Activation peptidePRO_0000028269
    Chaini31 – 253223Trypsin delta/gammaPRO_0000028270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi180 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi206 ↔ 230PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP42276.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0087224.

    Structurei

    3D structure databases

    ProteinModelPortaliP42276.
    SMRiP42276. Positions 31-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 253223Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00620000088101.
    InParanoidiP42276.
    KOiK01312.
    OMAiTIGSFPW.
    OrthoDBiEOG7MKW6Q.
    PhylomeDBiP42276.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42276-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKFVILLSA VACALGGTVP EGLLPQLDGR IVGGSATTIS SFPWQISLQR    50
    SGSHSCGGSI YSSNVIVTAA HCLQSVSASV LQIRAGSSYW SSGGVTFSVS 100
    SFKNHEGYNA NTMVNDIAII KINGALTFSS TIKAIGLASS NPANGAAASV 150
    SGWGTLSYGS SSIPSQLQYV NVNIVSQSQC ASSTYGYGSQ IRSTMICAAA 200
    SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA DVAALRSWVI 250
    SNA 253
    Length:253
    Mass (Da):25,680
    Last modified:August 16, 2005 - v2
    Checksum:iF77D47E0CCC78F92
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181A → V in AAA17449. (PubMed:10486967)Curated
    Sequence conflicti118 – 1181A → V in AAA17450. (PubMed:10486967)Curated
    Sequence conflicti148 – 1481A → G in AAA17449. (PubMed:10486967)Curated
    Sequence conflicti148 – 1481A → G in AAA17450. (PubMed:10486967)Curated
    Sequence conflicti240 – 2401A → S in AAA17449. (PubMed:10486967)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04853 Genomic DNA. Translation: AAA17449.1.
    U04853 Genomic DNA. Translation: AAA17450.1.
    AE013599 Genomic DNA. Translation: AAF58657.2.
    AE013599 Genomic DNA. Translation: AAM68730.1.
    AE013599 Genomic DNA. Translation: AAM68731.1.
    AY075487 mRNA. Translation: AAL68297.1.
    RefSeqiNP_523694.2. NM_078970.4.
    NP_725034.1. NM_165823.3.
    NP_725035.1. NM_165824.3.
    UniGeneiDm.14041.
    Dm.21711.
    Dm.30904.

    Genome annotation databases

    EnsemblMetazoaiFBtr0088123; FBpp0087224; FBgn0050031.
    FBtr0088124; FBpp0087225; FBgn0010358.
    FBtr0088159; FBpp0087255; FBgn0010359.
    GeneIDi246404.
    36221.
    48343.
    KEGGidme:Dmel_CG12351.
    dme:Dmel_CG30028.
    dme:Dmel_CG30031.
    UCSCiCG12351-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04853 Genomic DNA. Translation: AAA17449.1 .
    U04853 Genomic DNA. Translation: AAA17450.1 .
    AE013599 Genomic DNA. Translation: AAF58657.2 .
    AE013599 Genomic DNA. Translation: AAM68730.1 .
    AE013599 Genomic DNA. Translation: AAM68731.1 .
    AY075487 mRNA. Translation: AAL68297.1 .
    RefSeqi NP_523694.2. NM_078970.4.
    NP_725034.1. NM_165823.3.
    NP_725035.1. NM_165824.3.
    UniGenei Dm.14041.
    Dm.21711.
    Dm.30904.

    3D structure databases

    ProteinModelPortali P42276.
    SMRi P42276. Positions 31-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0087224.

    Protein family/group databases

    MEROPSi S01.A84.

    Proteomic databases

    PaxDbi P42276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0088123 ; FBpp0087224 ; FBgn0050031 .
    FBtr0088124 ; FBpp0087225 ; FBgn0010358 .
    FBtr0088159 ; FBpp0087255 ; FBgn0010359 .
    GeneIDi 246404.
    36221.
    48343.
    KEGGi dme:Dmel_CG12351.
    dme:Dmel_CG30028.
    dme:Dmel_CG30031.
    UCSCi CG12351-RA. d. melanogaster.

    Organism-specific databases

    CTDi 36221.
    48343.
    FlyBasei FBgn0050031. CG30031.
    FBgn0010358. deltaTry.
    FBgn0010359. gammaTry.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00620000088101.
    InParanoidi P42276.
    KOi K01312.
    OMAi TIGSFPW.
    OrthoDBi EOG7MKW6Q.
    PhylomeDBi P42276.

    Miscellaneous databases

    NextBioi 842323.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Concerted evolution within a trypsin gene cluster in Drosophila."
      Wang S., Magoulas C., Hickey D.A.
      Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (DELTATRY AND GAMMATRY).
      Strain: Oregon-R.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CG30031; DELTATRY AND GAMMATRY).
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (GAMMATRY).
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiTRYDG_DROME
    AccessioniPrimary (citable) accession number: P42276
    Secondary accession number(s): P42277, Q8SXZ4, Q9V5Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3