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Protein

Trypsin delta/gamma

Gene

deltaTry

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Charge relay systemBy similarity1
Active sitei116Charge relay systemBy similarity1
Sitei204Required for specificityBy similarity1
Active sitei210Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.A84.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin delta/gamma (EC:3.4.21.4)
Gene namesi
ORF Names:CG12351
AND
ORF Names:CG30028
AND
ORF Names:CG30031
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0050031. CG30031.
FBgn0010358. deltaTry.
FBgn0010359. gammaTry.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: FlyBase
  • extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22CuratedAdd BLAST22
PropeptideiPRO_000002826923 – 30Activation peptide8
ChainiPRO_000002827031 – 253Trypsin delta/gammaAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
Disulfide bondi180 ↔ 197PROSITE-ProRule annotation
Disulfide bondi206 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP42276.
PRIDEiP42276.

Expressioni

Gene expression databases

BgeeiFBgn0010359.
ExpressionAtlasiP42276. baseline.
GenevisibleiP42276. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087255.

Structurei

3D structure databases

ProteinModelPortaliP42276.
SMRiP42276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 253Peptidase S1PROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00840000130039.
InParanoidiP42276.
KOiK01312.
OMAiYSNNIIV.
OrthoDBiEOG091G0AH5.
PhylomeDBiP42276.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFVILLSA VACALGGTVP EGLLPQLDGR IVGGSATTIS SFPWQISLQR
60 70 80 90 100
SGSHSCGGSI YSSNVIVTAA HCLQSVSASV LQIRAGSSYW SSGGVTFSVS
110 120 130 140 150
SFKNHEGYNA NTMVNDIAII KINGALTFSS TIKAIGLASS NPANGAAASV
160 170 180 190 200
SGWGTLSYGS SSIPSQLQYV NVNIVSQSQC ASSTYGYGSQ IRSTMICAAA
210 220 230 240 250
SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA DVAALRSWVI

SNA
Length:253
Mass (Da):25,680
Last modified:August 16, 2005 - v2
Checksum:iF77D47E0CCC78F92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118A → V in AAA17449 (PubMed:10486967).Curated1
Sequence conflicti118A → V in AAA17450 (PubMed:10486967).Curated1
Sequence conflicti148A → G in AAA17449 (PubMed:10486967).Curated1
Sequence conflicti148A → G in AAA17450 (PubMed:10486967).Curated1
Sequence conflicti240A → S in AAA17449 (PubMed:10486967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA. Translation: AAA17449.1.
U04853 Genomic DNA. Translation: AAA17450.1.
AE013599 Genomic DNA. Translation: AAF58657.2.
AE013599 Genomic DNA. Translation: AAM68730.1.
AE013599 Genomic DNA. Translation: AAM68731.1.
AY075487 mRNA. Translation: AAL68297.1.
RefSeqiNP_523694.2. NM_078970.4.
NP_725034.1. NM_165823.3.
NP_725035.1. NM_165824.3.
UniGeneiDm.14041.
Dm.21711.
Dm.30904.

Genome annotation databases

EnsemblMetazoaiFBtr0088123; FBpp0087224; FBgn0050031.
FBtr0088124; FBpp0087225; FBgn0010358.
FBtr0088159; FBpp0087255; FBgn0010359.
GeneIDi246404.
36221.
48343.
KEGGidme:Dmel_CG12351.
dme:Dmel_CG30028.
dme:Dmel_CG30031.
UCSCiCG12351-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA. Translation: AAA17449.1.
U04853 Genomic DNA. Translation: AAA17450.1.
AE013599 Genomic DNA. Translation: AAF58657.2.
AE013599 Genomic DNA. Translation: AAM68730.1.
AE013599 Genomic DNA. Translation: AAM68731.1.
AY075487 mRNA. Translation: AAL68297.1.
RefSeqiNP_523694.2. NM_078970.4.
NP_725034.1. NM_165823.3.
NP_725035.1. NM_165824.3.
UniGeneiDm.14041.
Dm.21711.
Dm.30904.

3D structure databases

ProteinModelPortaliP42276.
SMRiP42276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087255.

Protein family/group databases

MEROPSiS01.A84.

Proteomic databases

PaxDbiP42276.
PRIDEiP42276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088123; FBpp0087224; FBgn0050031.
FBtr0088124; FBpp0087225; FBgn0010358.
FBtr0088159; FBpp0087255; FBgn0010359.
GeneIDi246404.
36221.
48343.
KEGGidme:Dmel_CG12351.
dme:Dmel_CG30028.
dme:Dmel_CG30031.
UCSCiCG12351-RA. d. melanogaster.

Organism-specific databases

CTDi36221.
48343.
FlyBaseiFBgn0050031. CG30031.
FBgn0010358. deltaTry.
FBgn0010359. gammaTry.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00840000130039.
InParanoidiP42276.
KOiK01312.
OMAiYSNNIIV.
OrthoDBiEOG091G0AH5.
PhylomeDBiP42276.

Miscellaneous databases

PROiP42276.

Gene expression databases

BgeeiFBgn0010359.
ExpressionAtlasiP42276. baseline.
GenevisibleiP42276. DM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRYDG_DROME
AccessioniPrimary (citable) accession number: P42276
Secondary accession number(s): P42277, Q8SXZ4, Q9V5Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.