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P42276

- TRYDG_DROME

UniProt

P42276 - TRYDG_DROME

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Protein

Trypsin delta/gamma

Gene
deltaTry, CG12351
gammaTry, CG30028
CG30031
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Charge relay system By similarity
Active sitei116 – 1161Charge relay system By similarity
Sitei204 – 2041Required for specificity By similarity
Active sitei210 – 2101Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: FlyBase

GO - Biological processi

  1. proteolysis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.A84.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Trypsin delta/gamma (EC:3.4.21.4)
Gene namesi
Name:deltaTry
ORF Names:CG12351
AND
Name:gammaTry
ORF Names:CG30028
AND
ORF Names:CG30031
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R
FlyBaseiFBgn0050031. CG30031.
FBgn0010358. deltaTry.
FBgn0010359. gammaTry.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: FlyBase
  2. extracellular space Source: UniProtKB-SubCell

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 InferredAdd
BLAST
Propeptidei23 – 308Activation peptidePRO_0000028269
Chaini31 – 253223Trypsin delta/gammaPRO_0000028270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 72 By similarity
Disulfide bondi180 ↔ 197 By similarity
Disulfide bondi206 ↔ 230 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP42276.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087224.

Structurei

3D structure databases

ProteinModelPortaliP42276.
SMRiP42276. Positions 31-253.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 253223Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00620000088101.
InParanoidiP42276.
KOiK01312.
OMAiTIGSFPW.
OrthoDBiEOG7MKW6Q.
PhylomeDBiP42276.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42276-1 [UniParc]FASTAAdd to Basket

« Hide

MLKFVILLSA VACALGGTVP EGLLPQLDGR IVGGSATTIS SFPWQISLQR    50
SGSHSCGGSI YSSNVIVTAA HCLQSVSASV LQIRAGSSYW SSGGVTFSVS 100
SFKNHEGYNA NTMVNDIAII KINGALTFSS TIKAIGLASS NPANGAAASV 150
SGWGTLSYGS SSIPSQLQYV NVNIVSQSQC ASSTYGYGSQ IRSTMICAAA 200
SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA DVAALRSWVI 250
SNA 253
Length:253
Mass (Da):25,680
Last modified:August 16, 2005 - v2
Checksum:iF77D47E0CCC78F92
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181A → V in AAA17449. 1 Publication
Sequence conflicti118 – 1181A → V in AAA17450. 1 Publication
Sequence conflicti148 – 1481A → G in AAA17449. 1 Publication
Sequence conflicti148 – 1481A → G in AAA17450. 1 Publication
Sequence conflicti240 – 2401A → S in AAA17449. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04853 Genomic DNA. Translation: AAA17449.1.
U04853 Genomic DNA. Translation: AAA17450.1.
AE013599 Genomic DNA. Translation: AAF58657.2.
AE013599 Genomic DNA. Translation: AAM68730.1.
AE013599 Genomic DNA. Translation: AAM68731.1.
AY075487 mRNA. Translation: AAL68297.1.
RefSeqiNP_523694.2. NM_078970.4.
NP_725034.1. NM_165823.3.
NP_725035.1. NM_165824.3.
UniGeneiDm.14041.
Dm.21711.
Dm.30904.

Genome annotation databases

EnsemblMetazoaiFBtr0088123; FBpp0087224; FBgn0050031.
FBtr0088124; FBpp0087225; FBgn0010358.
FBtr0088159; FBpp0087255; FBgn0010359.
GeneIDi246404.
36221.
48343.
KEGGidme:Dmel_CG12351.
dme:Dmel_CG30028.
dme:Dmel_CG30031.
UCSCiCG12351-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04853 Genomic DNA. Translation: AAA17449.1 .
U04853 Genomic DNA. Translation: AAA17450.1 .
AE013599 Genomic DNA. Translation: AAF58657.2 .
AE013599 Genomic DNA. Translation: AAM68730.1 .
AE013599 Genomic DNA. Translation: AAM68731.1 .
AY075487 mRNA. Translation: AAL68297.1 .
RefSeqi NP_523694.2. NM_078970.4.
NP_725034.1. NM_165823.3.
NP_725035.1. NM_165824.3.
UniGenei Dm.14041.
Dm.21711.
Dm.30904.

3D structure databases

ProteinModelPortali P42276.
SMRi P42276. Positions 31-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0087224.

Protein family/group databases

MEROPSi S01.A84.

Proteomic databases

PaxDbi P42276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088123 ; FBpp0087224 ; FBgn0050031 .
FBtr0088124 ; FBpp0087225 ; FBgn0010358 .
FBtr0088159 ; FBpp0087255 ; FBgn0010359 .
GeneIDi 246404.
36221.
48343.
KEGGi dme:Dmel_CG12351.
dme:Dmel_CG30028.
dme:Dmel_CG30031.
UCSCi CG12351-RA. d. melanogaster.

Organism-specific databases

CTDi 36221.
48343.
FlyBasei FBgn0050031. CG30031.
FBgn0010358. deltaTry.
FBgn0010359. gammaTry.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00620000088101.
InParanoidi P42276.
KOi K01312.
OMAi TIGSFPW.
OrthoDBi EOG7MKW6Q.
PhylomeDBi P42276.

Miscellaneous databases

NextBioi 842323.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Concerted evolution within a trypsin gene cluster in Drosophila."
    Wang S., Magoulas C., Hickey D.A.
    Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (DELTATRY AND GAMMATRY).
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CG30031; DELTATRY AND GAMMATRY).
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (GAMMATRY).
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiTRYDG_DROME
AccessioniPrimary (citable) accession number: P42276
Secondary accession number(s): P42277, Q8SXZ4, Q9V5Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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