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P42270

- HPCG_ECOLX

UniProt

P42270 - HPCG_ECOLX

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Protein

2-oxo-hepta-3-ene-1,7-dioic acid hydratase

Gene

hpcG

Organism
Escherichia coli
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transforms 2-oxo-hept-3-ene-1,7-dioate (OHED) into 2,4-dihydroxy-hept-2-ene-1,7-dioic acid (HHED).

Pathwayi

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-KW

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2308-MONOMER.
UniPathwayiUPA00208; UER00421.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxo-hepta-3-ene-1,7-dioic acid hydratase (EC:4.2.-.-)
Short name:
OHED hydratase
Gene namesi
Name:hpcG
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2642642-oxo-hepta-3-ene-1,7-dioic acid hydratasePRO_0000084042Add
BLAST

Proteomic databases

PRIDEiP42270.

Structurei

3D structure databases

ProteinModelPortaliP42270.
SMRiP42270. Positions 1-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hydratase/decarboxylase family.Curated

Family and domain databases

Gene3Di3.90.850.10. 1 hit.
InterProiIPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR012690. HpaH.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.
TIGRFAMsiTIGR02312. HpaH. 1 hit.

Sequencei

Sequence statusi: Complete.

P42270-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDKHTHTLI AQRLDQAEKQ REQIRAISLD YPEITIEDAY AVQREWVRLK
60 70 80 90 100
IAEGRTLKGH KIGLTSKAMQ ASSQISEPDY GALLHDNVLP RWQRYRFIVP
110 120 130 140 150
RIEVELAFVL AKPLRGPNCT LFDVYNATDY VIPALELIDA RCHNIDPETQ
160 170 180 190 200
RPRKVFDTIS DNAANSGVIL GGRPIKPDEL DLRWISALMY RNGVIEETGV
210 220 230 240 250
AAGVLNHPAN GVAWLANKLA PYDVQLEAGQ IILGGSFTRP VPARKGDTFH
260
VDYGNMGSIS CRFV
Length:264
Mass (Da):29,603
Last modified:November 1, 1995 - v1
Checksum:iE1D7CFF9F872751C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81446 Genomic DNA. Translation: CAA57202.1.
PIRiI41083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81446 Genomic DNA. Translation: CAA57202.1 .
PIRi I41083.

3D structure databases

ProteinModelPortali P42270.
SMRi P42270. Positions 1-264.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P42270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00208 ; UER00421 .
BioCyci RETL1328306-WGS:GSTH-2308-MONOMER.

Family and domain databases

Gene3Di 3.90.850.10. 1 hit.
InterProi IPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR012690. HpaH.
[Graphical view ]
Pfami PF01557. FAA_hydrolase. 1 hit.
[Graphical view ]
SUPFAMi SSF56529. SSF56529. 1 hit.
TIGRFAMsi TIGR02312. HpaH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the analogous enzymes of the catechol pathway."
    Roper D.I., Stringfellow J.M., Cooper R.A.
    Gene 156:47-51(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C.

Entry informationi

Entry nameiHPCG_ECOLX
AccessioniPrimary (citable) accession number: P42270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3