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P42270 (HPCG_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxo-hepta-3-ene-1,7-dioic acid hydratase

Short name=OHED hydratase
EC=4.2.-.-
Gene names
Name:hpcG
OrganismEscherichia coli
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transforms 2-oxo-hept-3-ene-1,7-dioate (OHED) into 2,4-dihydroxy-hept-2-ene-1,7-dioic acid (HHED).

Pathway

Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7.

Sequence similarities

Belongs to the hydratase/decarboxylase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlyase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2642642-oxo-hepta-3-ene-1,7-dioic acid hydratase
PRO_0000084042

Sequences

Sequence LengthMass (Da)Tools
P42270 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: E1D7CFF9F872751C

FASTA26429,603
        10         20         30         40         50         60 
MFDKHTHTLI AQRLDQAEKQ REQIRAISLD YPEITIEDAY AVQREWVRLK IAEGRTLKGH 

        70         80         90        100        110        120 
KIGLTSKAMQ ASSQISEPDY GALLHDNVLP RWQRYRFIVP RIEVELAFVL AKPLRGPNCT 

       130        140        150        160        170        180 
LFDVYNATDY VIPALELIDA RCHNIDPETQ RPRKVFDTIS DNAANSGVIL GGRPIKPDEL 

       190        200        210        220        230        240 
DLRWISALMY RNGVIEETGV AAGVLNHPAN GVAWLANKLA PYDVQLEAGQ IILGGSFTRP 

       250        260 
VPARKGDTFH VDYGNMGSIS CRFV 

« Hide

References

[1]"Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the analogous enzymes of the catechol pathway."
Roper D.I., Stringfellow J.M., Cooper R.A.
Gene 156:47-51(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81446 Genomic DNA. Translation: CAA57202.1.
PIRI41083.

3D structure databases

ProteinModelPortalP42270.
SMRP42270. Positions 1-264.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP42270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00208; UER00421.

Family and domain databases

Gene3D3.90.850.10. 1 hit.
InterProIPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR012690. HpaH.
[Graphical view]
PfamPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMSSF56529. SSF56529. 1 hit.
TIGRFAMsTIGR02312. HpaH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPCG_ECOLX
AccessionPrimary (citable) accession number: P42270
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways