P42270 (HPCG_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxo-hepta-3-ene-1,7-dioic acid hydratase
Short name=OHED hydratase
EC=4.2.-.-

Gene names

Name:

hpcG

Organism

Escherichia coli

Taxonomic identifier

562 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transforms 2-oxo-hept-3-ene-1,7-dioate (OHED) into 2,4-dihydoxy-hept-2-ene-1,7-dioic acid (HHED).
Pathway	Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7.
Sequence similarities	Belongs to the hydratase/decarboxylase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Molecular function	Lyase
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	2-oxo-hepta-3-ene-1,7-dioic acid hydratase		PRO_0000084042

Sequences

	Sequence		Length	Mass (Da)
	P42270 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: E1D7CFF9F872751C	FASTA	264	29,603
	10 20 30 40 50 60 MFDKHTHTLI AQRLDQAEKQ REQIRAISLD YPEITIEDAY AVQREWVRLK IAEGRTLKGH 70 80 90 100 110 120 KIGLTSKAMQ ASSQISEPDY GALLHDNVLP RWQRYRFIVP RIEVELAFVL AKPLRGPNCT 130 140 150 160 170 180 LFDVYNATDY VIPALELIDA RCHNIDPETQ RPRKVFDTIS DNAANSGVIL GGRPIKPDEL 190 200 210 220 230 240 DLRWISALMY RNGVIEETGV AAGVLNHPAN GVAWLANKLA PYDVQLEAGQ IILGGSFTRP 250 260 VPARKGDTFH VDYGNMGSIS CRFV

References

[1]

"Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the analogous enzymes of the catechol pathway." Roper D.I., Stringfellow J.M., Cooper R.A. Gene 156:47-51(1995) [PubMed: 7737515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81446 Genomic DNA. Translation: CAA57202.1.
PIR	I41083.
3D structure databases
ProteinModelPortal	P42270.
SMR	P42270. Positions 1-264.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002529. Fumarylacetoacetase_C. IPR011234. Fumarylacetoacetase_C-rel. IPR012690. HpaH. [Graphical view]
Gene3D	G3DSA:3.90.850.10. Fumarylacetoacetase_C-rel. 1 hit.
Pfam	PF01557. FAA_hydrolase. 1 hit. [Graphical view]
SUPFAM	SSF56529. Fumarylacetoacetase_C-rel. 1 hit.
TIGRFAMs	TIGR02312. HpaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPCG_ECOLX

Accession

Primary (citable) accession number: P42270

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 19, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program