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Protein

Glutamate receptor 3

Gene

GRIA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei480GlutamateBy similarity1
Binding sitei515GlutamateBy similarity1
Binding sitei737GlutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: Reactome
  • glutamate receptor signaling pathway Source: ProtInc
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125675-MONOMER.
ReactomeiR-HSA-399710. Activation of AMPA receptors.
R-HSA-399719. Trafficking of AMPA receptors.
R-HSA-416993. Trafficking of GluR2-containing AMPA receptors.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiP42263.

Protein family/group databases

TCDBi1.A.10.1.4. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor 3
Short name:
GluR-3
Alternative name(s):
AMPA-selective glutamate receptor 3
GluR-C
GluR-K3
Glutamate receptor ionotropic, AMPA 3
Short name:
GluA3
Gene namesi
Name:GRIA3
Synonyms:GLUR3, GLURC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4573. GRIA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 552ExtracellularBy similarityAdd BLAST524
Transmembranei553 – 573HelicalBy similarityAdd BLAST21
Topological domaini574 – 602CytoplasmicBy similarityAdd BLAST29
Intramembranei603 – 618Helical; Pore-formingBy similarityAdd BLAST16
Intramembranei619 – 621By similarity3
Topological domaini622 – 627CytoplasmicBy similarity6
Transmembranei628 – 648HelicalBy similarityAdd BLAST21
Topological domaini649 – 823ExtracellularBy similarityAdd BLAST175
Transmembranei824 – 844Helical; Name=M4By similarityAdd BLAST21
Topological domaini845 – 894CytoplasmicBy similarityAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 94 (MRX94)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia.
See also OMIM:300699
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043484450R → Q in MRX94. 1 PublicationCorresponds to variant rs368568228dbSNPEnsembl.1
Natural variantiVAR_043485631R → S in MRX94; homomers have minimal or no current; heteromers have altered desensitization kinetics. 1 PublicationCorresponds to variant rs137852351dbSNPEnsembl.1
Natural variantiVAR_043486706M → T in MRX94; homomers have minimal or no current; heteromers have altered desensitization kinetics. 1 PublicationCorresponds to variant rs137852352dbSNPEnsembl.1
Natural variantiVAR_043487833G → R in MRX94; reduced receptor expression possibly due to rapid degradation. 1 PublicationCorresponds to variant rs137852350dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi2892.
MalaCardsiGRIA3.
MIMi300699. phenotype.
OpenTargetsiENSG00000125675.
Orphaneti364028. X-linked intellectual disability due to GRIA3 anomalies.
PharmGKBiPA28968.

Chemistry databases

ChEMBLiCHEMBL3595.
DrugBankiDB00898. Ethanol.
DB01356. Lithium.
GuidetoPHARMACOLOGYi446.

Polymorphism and mutation databases

BioMutaiGRIA3.
DMDMi77416864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001153629 – 894Glutamate receptor 3Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 340By similarity
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi380N-linked (GlcNAc...)Sequence analysis1
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1
Glycosylationi422N-linked (GlcNAc...)Sequence analysis1
Lipidationi621S-palmitoyl cysteineBy similarity1
Modified residuei663PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Disulfide bondi750 ↔ 805By similarity
Lipidationi847S-palmitoyl cysteineBy similarity1
Modified residuei877PhosphotyrosineBy similarity1
Modified residuei887PhosphotyrosineBy similarity1

Post-translational modificationi

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP42263.
PaxDbiP42263.
PeptideAtlasiP42263.
PRIDEiP42263.

PTM databases

iPTMnetiP42263.
PhosphoSitePlusiP42263.
SwissPalmiP42263.

Expressioni

Gene expression databases

BgeeiENSG00000125675.
CleanExiHS_GRIA3.
ExpressionAtlasiP42263. baseline and differential.
GenevisibleiP42263. HS.

Organism-specific databases

HPAiHPA058659.

Interactioni

Subunit structurei

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity). Found in a complex with GRIA1, GRIA2, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi109149. 20 interactors.
DIPiDIP-46195N.
STRINGi9606.ENSP00000264357.

Chemistry databases

BindingDBiP42263.

Structurei

3D structure databases

ProteinModelPortaliP42263.
SMRiP42263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni508 – 510Glutamate bindingBy similarity3
Regioni686 – 687Glutamate bindingBy similarity2

Domaini

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOVERGENiHBG051839.
InParanoidiP42263.
KOiK05199.
OMAiDQLPSND.
OrthoDBiEOG091G11CB.
PhylomeDBiP42263.
TreeFamiTF315232.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Flop (identifier: P42263-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA
60 70 80 90 100
FRFAVQLYNT NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA
110 120 130 140 150
IFGFYDQMSM NTLTSFCGAL HTSFVTPSFP TDADVQFVIQ MRPALKGAIL
160 170 180 190 200
SLLGHYKWEK FVYLYDTERG FSILQAIMEA AVQNNWQVTA RSVGNIKDVQ
210 220 230 240 250
EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS RGYHYMLANL
260 270 280 290 300
GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN
310 320 330 340 350
APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ
360 370 380 390 400
GIDIERALKM VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN
410 420 430 440 450
EYERFVPFSD QQISNDSASS ENRTIVVTTI LESPYVMYKK NHEQLEGNER
460 470 480 490 500
YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY GARDPETKIW NGMVGELVYG
510 520 530 540 550
RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS KPGVFSFLDP
560 570 580 590 600
LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP
610 620 630 640 650
NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA
660 670 680 690 700
NLAAFLTVER MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE
710 720 730 740 750
KMWSYMKSAE PSVFTKTTAD GVARVRKSKG KFAFLLESTM NEYIEQRKPC
760 770 780 790 800
DTMKVGGNLD SKGYGVATPK GSALRNAVNL AVLKLNEQGL LDKLKNKWWY
810 820 830 840 850
DKGECGSGGG DSKDKTSALS LSNVAGVFYI LVGGLGLAMM VALIEFCYKS
860 870 880 890
RAESKRMKLT KNTQNFKPAP ATNTQNYATY REGYNVYGTE SVKI
Length:894
Mass (Da):101,157
Last modified:October 11, 2005 - v2
Checksum:i178589A870E0D102
GO
Isoform Flip (identifier: P42263-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     776-811: NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD → TPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSG

Show »
Length:894
Mass (Da):101,228
Checksum:iEB3ED4EBBA353021
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195N → H in AAF61847 (PubMed:10644433).Curated1
Sequence conflicti775R → G in AAA67922 (PubMed:7918660).Curated1
Sequence conflicti775R → G in AAA67923 (PubMed:7918660).Curated1
Sequence conflicti775R → G in CAA57567 (Ref. 2) Curated1
Sequence conflicti775R → G in AAF61847 (PubMed:10644433).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043484450R → Q in MRX94. 1 PublicationCorresponds to variant rs368568228dbSNPEnsembl.1
Natural variantiVAR_023579525F → L.3 PublicationsCorresponds to variant rs1052538dbSNPEnsembl.1
Natural variantiVAR_043485631R → S in MRX94; homomers have minimal or no current; heteromers have altered desensitization kinetics. 1 PublicationCorresponds to variant rs137852351dbSNPEnsembl.1
Natural variantiVAR_043486706M → T in MRX94; homomers have minimal or no current; heteromers have altered desensitization kinetics. 1 PublicationCorresponds to variant rs137852352dbSNPEnsembl.1
Natural variantiVAR_043487833G → R in MRX94; reduced receptor expression possibly due to rapid degradation. 1 PublicationCorresponds to variant rs137852350dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053351776 – 811NAVNL…SGGGD → TPVNLAVLKLSEQGILDKLK NKWWYDKGECGAKDSG in isoform Flip. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10302 mRNA. Translation: AAA67923.1.
U10301 mRNA. Translation: AAA67922.1.
X82068 mRNA. Translation: CAA57567.1.
AF159277
, AF159262, AF159263, AF159264, AF159265, AF159266, AF159267, AF159268, AF159269, AF159270, AF159271, AF159272, AF159273, AF159274, AF159275 Genomic DNA. Translation: AAF61847.1.
AF166365
, AF166362, AF166363, AF166364 Genomic DNA. Translation: AAF97857.1.
AF167332
, AF166366, AF166367, AF166368, AF166369, AF166370, AF166371, AF166372, AF166373, AF166375 Genomic DNA. Translation: AAF97858.1.
AF167332
, AF166366, AF166367, AF166368, AF166369, AF166370, AF166371, AF166372, AF166373, AF166374 Genomic DNA. Translation: AAF97859.1.
AL356213
, AL035426, AL590139, Z83848, Z82899 Genomic DNA. Translation: CAI95643.1.
AL356213
, AL035426, AL590139, Z83848, Z82899 Genomic DNA. Translation: CAI95644.1.
AL590139
, AL035426, AL356213, Z83848, Z82899 Genomic DNA. Translation: CAI95164.1.
AL590139
, AL035426, AL356213, Z83848, Z82899 Genomic DNA. Translation: CAI95165.1.
Z83848
, AL590139, AL356213, AL035426, Z82899 Genomic DNA. Translation: CAI95709.1.
Z83848
, AL590139, AL356213, AL035426, Z82899 Genomic DNA. Translation: CAI95710.1.
Z82899
, Z83848, AL590139, AL356213, AL035426 Genomic DNA. Translation: CAI95664.1.
Z82899
, Z83848, AL590139, AL356213, AL035426 Genomic DNA. Translation: CAI95665.1.
AL035426
, Z83848, Z82899, AL590139, AL356213 Genomic DNA. Translation: CAI95683.1.
AL035426
, Z83848, Z82899, AL590139, AL356213 Genomic DNA. Translation: CAI95684.1.
CH471107 Genomic DNA. Translation: EAX11865.1.
CH471107 Genomic DNA. Translation: EAX11867.1.
CCDSiCCDS14604.1. [P42263-1]
CCDS14605.1. [P42263-2]
PIRiS49460.
S50128.
S53696.
RefSeqiNP_000819.3. NM_000828.4.
NP_015564.4. NM_007325.4.
UniGeneiHs.377070.

Genome annotation databases

EnsembliENST00000541091; ENSP00000446440; ENSG00000125675. [P42263-1]
ENST00000620443; ENSP00000478489; ENSG00000125675. [P42263-2]
ENST00000622768; ENSP00000481554; ENSG00000125675. [P42263-1]
GeneIDi2892.
KEGGihsa:2892.
UCSCiuc033etl.2. human. [P42263-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10302 mRNA. Translation: AAA67923.1.
U10301 mRNA. Translation: AAA67922.1.
X82068 mRNA. Translation: CAA57567.1.
AF159277
, AF159262, AF159263, AF159264, AF159265, AF159266, AF159267, AF159268, AF159269, AF159270, AF159271, AF159272, AF159273, AF159274, AF159275 Genomic DNA. Translation: AAF61847.1.
AF166365
, AF166362, AF166363, AF166364 Genomic DNA. Translation: AAF97857.1.
AF167332
, AF166366, AF166367, AF166368, AF166369, AF166370, AF166371, AF166372, AF166373, AF166375 Genomic DNA. Translation: AAF97858.1.
AF167332
, AF166366, AF166367, AF166368, AF166369, AF166370, AF166371, AF166372, AF166373, AF166374 Genomic DNA. Translation: AAF97859.1.
AL356213
, AL035426, AL590139, Z83848, Z82899 Genomic DNA. Translation: CAI95643.1.
AL356213
, AL035426, AL590139, Z83848, Z82899 Genomic DNA. Translation: CAI95644.1.
AL590139
, AL035426, AL356213, Z83848, Z82899 Genomic DNA. Translation: CAI95164.1.
AL590139
, AL035426, AL356213, Z83848, Z82899 Genomic DNA. Translation: CAI95165.1.
Z83848
, AL590139, AL356213, AL035426, Z82899 Genomic DNA. Translation: CAI95709.1.
Z83848
, AL590139, AL356213, AL035426, Z82899 Genomic DNA. Translation: CAI95710.1.
Z82899
, Z83848, AL590139, AL356213, AL035426 Genomic DNA. Translation: CAI95664.1.
Z82899
, Z83848, AL590139, AL356213, AL035426 Genomic DNA. Translation: CAI95665.1.
AL035426
, Z83848, Z82899, AL590139, AL356213 Genomic DNA. Translation: CAI95683.1.
AL035426
, Z83848, Z82899, AL590139, AL356213 Genomic DNA. Translation: CAI95684.1.
CH471107 Genomic DNA. Translation: EAX11865.1.
CH471107 Genomic DNA. Translation: EAX11867.1.
CCDSiCCDS14604.1. [P42263-1]
CCDS14605.1. [P42263-2]
PIRiS49460.
S50128.
S53696.
RefSeqiNP_000819.3. NM_000828.4.
NP_015564.4. NM_007325.4.
UniGeneiHs.377070.

3D structure databases

ProteinModelPortaliP42263.
SMRiP42263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109149. 20 interactors.
DIPiDIP-46195N.
STRINGi9606.ENSP00000264357.

Chemistry databases

BindingDBiP42263.
ChEMBLiCHEMBL3595.
DrugBankiDB00898. Ethanol.
DB01356. Lithium.
GuidetoPHARMACOLOGYi446.

Protein family/group databases

TCDBi1.A.10.1.4. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

iPTMnetiP42263.
PhosphoSitePlusiP42263.
SwissPalmiP42263.

Polymorphism and mutation databases

BioMutaiGRIA3.
DMDMi77416864.

Proteomic databases

EPDiP42263.
PaxDbiP42263.
PeptideAtlasiP42263.
PRIDEiP42263.

Protocols and materials databases

DNASUi2892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541091; ENSP00000446440; ENSG00000125675. [P42263-1]
ENST00000620443; ENSP00000478489; ENSG00000125675. [P42263-2]
ENST00000622768; ENSP00000481554; ENSG00000125675. [P42263-1]
GeneIDi2892.
KEGGihsa:2892.
UCSCiuc033etl.2. human. [P42263-1]

Organism-specific databases

CTDi2892.
DisGeNETi2892.
GeneCardsiGRIA3.
HGNCiHGNC:4573. GRIA3.
HPAiHPA058659.
MalaCardsiGRIA3.
MIMi300699. phenotype.
305915. gene.
neXtProtiNX_P42263.
OpenTargetsiENSG00000125675.
Orphaneti364028. X-linked intellectual disability due to GRIA3 anomalies.
PharmGKBiPA28968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOVERGENiHBG051839.
InParanoidiP42263.
KOiK05199.
OMAiDQLPSND.
OrthoDBiEOG091G11CB.
PhylomeDBiP42263.
TreeFamiTF315232.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125675-MONOMER.
ReactomeiR-HSA-399710. Activation of AMPA receptors.
R-HSA-399719. Trafficking of AMPA receptors.
R-HSA-416993. Trafficking of GluR2-containing AMPA receptors.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiP42263.

Miscellaneous databases

ChiTaRSiGRIA3. human.
GeneWikiiGRIA3.
GenomeRNAii2892.
PROiP42263.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125675.
CleanExiHS_GRIA3.
ExpressionAtlasiP42263. baseline and differential.
GenevisibleiP42263. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRIA3_HUMAN
AccessioniPrimary (citable) accession number: P42263
Secondary accession number(s): D3DTF1
, Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2, Q9P0H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.