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Protein

Glutamate receptor 2

Gene

GRIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei471Glutamate2 Publications1
Binding sitei506Glutamate2 Publications1
Binding sitei726Glutamate2 Publications1

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • ionotropic glutamate receptor signaling pathway Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120251-MONOMER.
ReactomeiR-HSA-399710. Activation of AMPA receptors.
R-HSA-416993. Trafficking of GluR2-containing AMPA receptors.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
SignaLinkiP42262.
SIGNORiP42262.

Protein family/group databases

TCDBi1.A.10.1.13. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor 2
Short name:
GluR-2
Alternative name(s):
AMPA-selective glutamate receptor 2
GluR-B
GluR-K2
Glutamate receptor ionotropic, AMPA 2
Short name:
GluA2
Gene namesi
Name:GRIA2
Synonyms:GLUR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4572. GRIA2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 543ExtracellularBy similarityAdd BLAST519
Transmembranei544 – 564HelicalBy similarityAdd BLAST21
Topological domaini565 – 591CytoplasmicBy similarityAdd BLAST27
Intramembranei592 – 607Helical; Pore-formingBy similarityAdd BLAST16
Intramembranei608 – 610By similarity3
Topological domaini611 – 616CytoplasmicBy similarity6
Transmembranei617 – 637HelicalBy similarityAdd BLAST21
Topological domaini638 – 812ExtracellularBy similarityAdd BLAST175
Transmembranei813 – 833Helical; Name=M4Add BLAST21
Topological domaini834 – 883CytoplasmicBy similarityAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2891.
OpenTargetsiENSG00000120251.
PharmGKBiPA28967.

Chemistry databases

ChEMBLiCHEMBL4016.
DrugBankiDB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB00898. Ethanol.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB01346. Quinidine barbiturate.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
GuidetoPHARMACOLOGYi445.

Polymorphism and mutation databases

BioMutaiGRIA2.
DMDMi23831146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001153225 – 883Glutamate receptor 2Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 330
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)1 Publication1
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Lipidationi610S-palmitoyl cysteineBy similarity1
Modified residuei683Phosphoserine; by PKCBy similarity1
Modified residuei717Phosphoserine; by PKGBy similarity1
Disulfide bondi739 ↔ 794
Lipidationi836S-palmitoyl cysteineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1
Modified residuei876PhosphotyrosineBy similarity1
Modified residuei880PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP42262.
PeptideAtlasiP42262.
PRIDEiP42262.

PTM databases

iPTMnetiP42262.
PhosphoSitePlusiP42262.
SwissPalmiP42262.

Expressioni

Gene expression databases

BgeeiENSG00000120251.
CleanExiHS_GRIA2.
ExpressionAtlasiP42262. baseline and differential.
GenevisibleiP42262. HS.

Organism-specific databases

HPAiCAB006830.
CAB007812.
CAB012981.
HPA008441.

Interactioni

Subunit structurei

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly (By similarity). Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2 (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). Interacts with OLFM2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NSFP464592EBI-3909876,EBI-712251

Protein-protein interaction databases

BioGridi109148. 30 interactors.
DIPiDIP-42852N.
IntActiP42262. 12 interactors.
MINTiMINT-2791741.
STRINGi9606.ENSP00000264426.

Chemistry databases

BindingDBiP42262.

Structurei

Secondary structure

1883
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 34Combined sources8
Helixi38 – 51Combined sources14
Beta strandi58 – 65Combined sources8
Helixi70 – 83Combined sources14
Beta strandi88 – 90Combined sources3
Turni94 – 96Combined sources3
Helixi97 – 107Combined sources11
Beta strandi111 – 113Combined sources3
Beta strandi125 – 127Combined sources3
Helixi133 – 142Combined sources10
Beta strandi147 – 152Combined sources6
Helixi159 – 171Combined sources13
Beta strandi174 – 179Combined sources6
Helixi188 – 191Combined sources4
Helixi193 – 201Combined sources9
Beta strandi206 – 211Combined sources6
Helixi213 – 225Combined sources13
Helixi230 – 232Combined sources3
Beta strandi234 – 237Combined sources4
Beta strandi239 – 241Combined sources3
Helixi247 – 249Combined sources3
Beta strandi256 – 262Combined sources7
Helixi268 – 277Combined sources10
Turni282 – 284Combined sources3
Beta strandi289 – 291Combined sources3
Helixi295 – 316Combined sources22
Helixi341 – 349Combined sources9
Beta strandi353 – 355Combined sources3
Beta strandi358 – 360Combined sources3
Beta strandi366 – 368Combined sources3
Beta strandi373 – 379Combined sources7
Beta strandi382 – 390Combined sources9
Turni391 – 393Combined sources3
Beta strandi394 – 397Combined sources4
Beta strandi416 – 420Combined sources5
Turni424 – 426Combined sources3
Beta strandi427 – 429Combined sources3
Helixi433 – 435Combined sources3
Helixi438 – 441Combined sources4
Beta strandi442 – 444Combined sources3
Helixi445 – 457Combined sources13
Beta strandi461 – 465Combined sources5
Turni476 – 478Combined sources3
Helixi483 – 489Combined sources7
Beta strandi494 – 496Combined sources3
Helixi504 – 507Combined sources4
Beta strandi510 – 512Combined sources3
Beta strandi516 – 519Combined sources4
Beta strandi521 – 526Combined sources6
Helixi657 – 661Combined sources5
Beta strandi664 – 671Combined sources8
Helixi675 – 682Combined sources8
Helixi686 – 697Combined sources12
Beta strandi704 – 706Combined sources3
Helixi707 – 716Combined sources10
Turni717 – 719Combined sources3
Beta strandi720 – 726Combined sources7
Helixi727 – 734Combined sources8
Beta strandi741 – 745Combined sources5
Beta strandi751 – 753Combined sources3
Beta strandi756 – 758Combined sources3
Helixi764 – 776Combined sources13
Helixi779 – 788Combined sources10
Turni789 – 791Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WJWX-ray1.80A25-412[»]
2WJXX-ray4.10A/B/C25-412[»]
2XHDX-ray1.80A/B413-527[»]
A/B653-796[»]
3R7XX-ray2.10A/B413-527[»]
A/B653-796[»]
3RN8X-ray1.70A/B/C413-527[»]
A/B/C653-812[»]
3RNNX-ray1.75A/B/C413-527[»]
A/B/C653-812[»]
3UA8X-ray1.90A413-527[»]
A653-796[»]
5H8SX-ray1.70A/B/C413-527[»]
A/B/C653-796[»]
ProteinModelPortaliP42262.
SMRiP42262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42262.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni499 – 501Glutamate binding3
Regioni675 – 676Glutamate binding2

Domaini

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234372.
HOVERGENiHBG051839.
InParanoidiP42262.
KOiK05198.
OMAiIQRWSTL.
OrthoDBiEOG091G11CB.
PhylomeDBiP42262.
TreeFamiTF315232.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Flop (identifier: P42262-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ
60 70 80 90 100
FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI
110 120 130 140 150
TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY
160 170 180 190 200
LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE MYRSLFQDLE
210 220 230 240 250
LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI
260 270 280 290 300
QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT TTIKYTSALT
310 320 330 340 350
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ
360 370 380 390 400
VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT
410 420 430 440 450
ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA
460 470 480 490 500
AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL
510 520 530 540 550
TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI
560 570 580 590 600
VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF
610 620 630 640 650
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM
660 670 680 690 700
VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP
710 720 730 740 750
SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS
760 770 780 790 800
KGYGIATPKG SSLRNAVNLA VLKLNEQGLL DKLKNKWWYD KGECGSGGGD
810 820 830 840 850
SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK
860 870 880
NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI
Length:883
Mass (Da):98,821
Last modified:October 10, 2002 - v3
Checksum:i6DAB96C76D1D8448
GO
Isoform Flip (identifier: P42262-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-800: NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD → TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSG

Show »
Length:883
Mass (Da):98,878
Checksum:i882141AC054254F8
GO
Isoform 3 (identifier: P42262-3) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     848-883: VAKNAQNINP...NVYGIESVKI → MTLNDAMRNK...GMNVSVTDLS

Show »
Length:901
Mass (Da):100,594
Checksum:i6E668073D621EFBB
GO
Isoform 4 (identifier: P42262-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     765-800: NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD → TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSG

Note: No experimental confirmation available.
Show »
Length:836
Mass (Da):93,775
Checksum:i1B3F13BC745D4A45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140I → V in AAH10574 (PubMed:15489334).Curated1
Sequence conflicti241G → E in AAA58631 (PubMed:8003671).Curated1
Sequence conflicti415T → I in AAH28736 (PubMed:15489334).Curated1
Sequence conflicti764R → G in AAA58631 (PubMed:8003671).Curated1

RNA editingi

Edited at position 607.1 Publication
Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable to divalent ions.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_000303607Q → R in RNA edited version. 2 PublicationsCorresponds to variant rs17850674dbSNPEnsembl.1
Natural variantiVAR_037055608Q → R.1 PublicationCorresponds to variant rs17850675dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559201 – 47Missing in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_053350765 – 800NAVNL…SGGGD → TPVNLAVLKLSEQGVLDKLK NKWWYDKGECGAKDSG in isoform Flip and isoform 4. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_029309848 – 883VAKNA…ESVKI → MTLNDAMRNKARLSITGSTG ENGRVMTPEFPKAVHAVPYV SPGMGMNVSVTDLS in isoform 3. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20814 mRNA. Translation: AAA58631.1.
AC079233 Genomic DNA. No translation available.
AC112240 Genomic DNA. No translation available.
BC010574 mRNA. Translation: AAH10574.1.
BC028736 mRNA. Translation: AAH28736.2.
CCDSiCCDS3797.1. [P42262-2]
CCDS43274.1. [P42262-1]
CCDS43275.1. [P42262-4]
PIRiI58181.
RefSeqiNP_000817.2. NM_000826.3.
NP_001077088.1. NM_001083619.1.
NP_001077089.1. NM_001083620.1.
XP_016863605.1. XM_017008116.1. [P42262-4]
XP_016863606.1. XM_017008117.1. [P42262-4]
UniGeneiHs.32763.

Genome annotation databases

EnsembliENST00000264426; ENSP00000264426; ENSG00000120251. [P42262-1]
ENST00000296526; ENSP00000296526; ENSG00000120251. [P42262-2]
ENST00000393815; ENSP00000377403; ENSG00000120251. [P42262-4]
ENST00000507898; ENSP00000426845; ENSG00000120251. [P42262-4]
GeneIDi2891.
KEGGihsa:2891.
UCSCiuc003ipk.5. human. [P42262-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20814 mRNA. Translation: AAA58631.1.
AC079233 Genomic DNA. No translation available.
AC112240 Genomic DNA. No translation available.
BC010574 mRNA. Translation: AAH10574.1.
BC028736 mRNA. Translation: AAH28736.2.
CCDSiCCDS3797.1. [P42262-2]
CCDS43274.1. [P42262-1]
CCDS43275.1. [P42262-4]
PIRiI58181.
RefSeqiNP_000817.2. NM_000826.3.
NP_001077088.1. NM_001083619.1.
NP_001077089.1. NM_001083620.1.
XP_016863605.1. XM_017008116.1. [P42262-4]
XP_016863606.1. XM_017008117.1. [P42262-4]
UniGeneiHs.32763.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WJWX-ray1.80A25-412[»]
2WJXX-ray4.10A/B/C25-412[»]
2XHDX-ray1.80A/B413-527[»]
A/B653-796[»]
3R7XX-ray2.10A/B413-527[»]
A/B653-796[»]
3RN8X-ray1.70A/B/C413-527[»]
A/B/C653-812[»]
3RNNX-ray1.75A/B/C413-527[»]
A/B/C653-812[»]
3UA8X-ray1.90A413-527[»]
A653-796[»]
5H8SX-ray1.70A/B/C413-527[»]
A/B/C653-796[»]
ProteinModelPortaliP42262.
SMRiP42262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109148. 30 interactors.
DIPiDIP-42852N.
IntActiP42262. 12 interactors.
MINTiMINT-2791741.
STRINGi9606.ENSP00000264426.

Chemistry databases

BindingDBiP42262.
ChEMBLiCHEMBL4016.
DrugBankiDB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB00898. Ethanol.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB01346. Quinidine barbiturate.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
GuidetoPHARMACOLOGYi445.

Protein family/group databases

TCDBi1.A.10.1.13. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

iPTMnetiP42262.
PhosphoSitePlusiP42262.
SwissPalmiP42262.

Polymorphism and mutation databases

BioMutaiGRIA2.
DMDMi23831146.

Proteomic databases

PaxDbiP42262.
PeptideAtlasiP42262.
PRIDEiP42262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264426; ENSP00000264426; ENSG00000120251. [P42262-1]
ENST00000296526; ENSP00000296526; ENSG00000120251. [P42262-2]
ENST00000393815; ENSP00000377403; ENSG00000120251. [P42262-4]
ENST00000507898; ENSP00000426845; ENSG00000120251. [P42262-4]
GeneIDi2891.
KEGGihsa:2891.
UCSCiuc003ipk.5. human. [P42262-1]

Organism-specific databases

CTDi2891.
DisGeNETi2891.
GeneCardsiGRIA2.
HGNCiHGNC:4572. GRIA2.
HPAiCAB006830.
CAB007812.
CAB012981.
HPA008441.
MIMi138247. gene.
neXtProtiNX_P42262.
OpenTargetsiENSG00000120251.
PharmGKBiPA28967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234372.
HOVERGENiHBG051839.
InParanoidiP42262.
KOiK05198.
OMAiIQRWSTL.
OrthoDBiEOG091G11CB.
PhylomeDBiP42262.
TreeFamiTF315232.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120251-MONOMER.
ReactomeiR-HSA-399710. Activation of AMPA receptors.
R-HSA-416993. Trafficking of GluR2-containing AMPA receptors.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
SignaLinkiP42262.
SIGNORiP42262.

Miscellaneous databases

ChiTaRSiGRIA2. human.
EvolutionaryTraceiP42262.
GeneWikiiGRIA2.
GenomeRNAii2891.
PROiP42262.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120251.
CleanExiHS_GRIA2.
ExpressionAtlasiP42262. baseline and differential.
GenevisibleiP42262. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRIA2_HUMAN
AccessioniPrimary (citable) accession number: P42262
Secondary accession number(s): A8MT92, I6L997, Q96FP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2002
Last modified: November 2, 2016
This is version 179 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.