P42261 (GRIA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate receptor 1
Short name=GluR-1

Alternative name(s):
AMPA-selective glutamate receptor 1
GluR-A
GluR-K1
Glutamate receptor ionotropic, AMPA 1
Short name=GluA1

Gene names

Name:	GRIA1
Synonyms:	GLUH1, GLUR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	906 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Ref.8 Ref.9
Subunit structure	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with SYNDIG1 and GRIA2 By similarity. Interacts with LRFN1 By similarity. Interacts with HIP1 and RASGRF2 By similarity. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity. Interacts with CACNG5 By similarity. Interacts with CNIH2 and CACNG2. Ref.9
Subcellular location	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell projection › dendrite By similarity. Cell projection › dendritic spine By similarity. Note: Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression By similarity.
Tissue specificity	Widely expressed in brain.
Post-translational modification	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis By similarity.
Miscellaneous	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
Sequence similarities	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Cell projection Endoplasmic reticulum Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	long-term memory Inferred from electronic annotation. Source: Compara receptor internalization Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Inferred from sequence or structural similarity. Source: UniProtKB cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from sequence or structural similarity. Source: BHF-UCL dendrite membrane Inferred from electronic annotation. Source: Compara endocytic vesicle membrane Traceable author statement. Source: Reactome endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell neuronal cell body Inferred from sequence or structural similarity. Source: BHF-UCL postsynaptic density Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	PDZ domain binding Inferred from sequence or structural similarity. Source: BHF-UCL alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from direct assay Ref.9Ref.8. Source: UniProtKB extracellular-glutamate-gated ion channel activity Inferred from electronic annotation. Source: InterPro kainate selective glutamate receptor activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform Flop (identifier: P42261-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Flip (identifier: P42261-2)

The sequence of this isoform differs from the canonical sequence as follows:
     758-758: N → G
     768-768: N → S
     772-772: L → V
     778-778: N → S
     790-793: GGGD → KDSG

Isoform 3 (identifier: P42261-3)

The sequence of this isoform differs from the canonical sequence as follows:
     74-154: FCSQFSKGVY...FVYIYDADRG → C

Isoform 4 (identifier: P42261-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 906	888	Glutamate receptor 1		PRO_0000011529
Regions
	Topological domain	19 – 536	518	Extracellular By similarity
	Transmembrane	537 – 557	21	Helical; By similarity
	Topological domain	558 – 584	27	Cytoplasmic By similarity
	Intramembrane	585 – 600	16	Helical; Pore-forming; By similarity
	Intramembrane	601 – 603	3	By similarity
	Topological domain	604 – 609	6	Cytoplasmic By similarity
	Transmembrane	610 – 630	21	Helical; By similarity
	Topological domain	631 – 805	175	Extracellular By similarity
	Transmembrane	806 – 826	21	Helical; By similarity
	Topological domain	827 – 906	80	Cytoplasmic By similarity
Sites
	Binding site	464	1	Glutamate By similarity
	Binding site	499	1	Glutamate By similarity
	Binding site	719	1	Glutamate By similarity
Amino acid modifications
	Modified residue	645	1	Phosphoserine By similarity
	Modified residue	710	1	Phosphoserine By similarity
	Modified residue	849	1	Phosphoserine By similarity
	Modified residue	863	1	Phosphoserine By similarity
	Lipidation	603	1	S-palmitoyl cysteine By similarity
	Lipidation	829	1	S-palmitoyl cysteine By similarity
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	249	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	363	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential
	Glycosylation	406	1	N-linked (GlcNAc...) Potential
	Disulfide bond	75 ↔ 323		By similarity
	Disulfide bond	732 ↔ 787		By similarity
Natural variations
	Alternative sequence	1 – 69	69	Missing in isoform 4.		VSP_045119
	Alternative sequence	74 – 154	81	FCSQF…DADRG → C in isoform 3.		VSP_045120
	Alternative sequence	758	1	N → G in isoform Flip.		VSP_000092
	Alternative sequence	768	1	N → S in isoform Flip.		VSP_000093
	Alternative sequence	772	1	L → V in isoform Flip.		VSP_000094
	Alternative sequence	778	1	N → S in isoform Flip.		VSP_000095
	Alternative sequence	790 – 793	4	GGGD → KDSG in isoform Flip.		VSP_000096
	Natural variant	487	1	D → N. Corresponds to variant rs13166146 [ dbSNP | Ensembl ].		VAR_028071
	Natural variant	521	1	P → T. Corresponds to variant rs13166161 [ dbSNP | Ensembl ].		VAR_028072
	Natural variant	536	1	A → S. Corresponds to variant rs13166438 [ dbSNP | Ensembl ].		VAR_028073
	Natural variant	548	1	I → M. Corresponds to variant rs13186241 [ dbSNP | Ensembl ].		VAR_028074
	Natural variant	588	1	F → L. Corresponds to variant rs13186534 [ dbSNP | Ensembl ].		VAR_028075
Experimental info
	Sequence conflict	345	1	R → A in CAA41491. Ref.2
	Sequence conflict	375	1	G → S in AAA58395. Ref.3
	Sequence conflict	863	1	S → SA in AAA58613. Ref.1
	Sequence conflict	865 – 867	3	AGA → TAP in AAA58613. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Flop [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 03EA1E026D0A9A2F	FASTA	906	101,506
	10 20 30 40 50 60 MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 70 80 90 100 110 120 IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 130 140 150 160 170 180 FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT 190 200 210 220 230 240 TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL 250 260 270 280 290 300 NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM 310 320 330 340 350 360 AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 370 380 390 400 410 420 RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 430 440 450 460 470 480 MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 490 500 510 520 530 540 LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 550 560 570 580 590 600 MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 610 620 630 640 650 660 QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 670 680 690 700 710 720 YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 730 740 750 760 770 780 TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW 790 800 810 820 830 840 WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 850 860 870 880 890 900 GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP LGATGL
	Isoform Flip [UniParc]. Checksum: 4C1973DBFE98C979	FASTA	906	101,482
	10 20 30 40 50 60 MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 70 80 90 100 110 120 IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 130 140 150 160 170 180 FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT 190 200 210 220 230 240 TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL 250 260 270 280 290 300 NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM 310 320 330 340 350 360 AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 370 380 390 400 410 420 RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 430 440 450 460 470 480 MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 490 500 510 520 530 540 LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 550 560 570 580 590 600 MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 610 620 630 640 650 660 QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 670 680 690 700 710 720 YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 730 740 750 760 770 780 TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRGPV NLAVLKLSEQ GVLDKLKSKW 790 800 810 820 830 840 WYDKGECGSK DSGSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 850 860 870 880 890 900 GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP LGATGL
	Isoform 3 [UniParc]. Checksum: 53F69105FB85CFC9	FASTA	826	92,172
	10 20 30 40 50 60 MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 70 80 90 100 110 120 IVNISDSFEM TYRCLSVLQK VLDTAAEKNW QVTAVNILTT TEEGYRMLFQ DLEKKKERLV 130 140 150 160 170 180 VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL NKFKESGANV TGFQLVNYTD 190 200 210 220 230 240 TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM AEAFQSLRRQ RIDISRRGNA 250 260 270 280 290 300 GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR RTNYTLHVIE MKHDGIRKIG 310 320 330 340 350 360 YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV MLKKNANQFE GNDRYEGYCV 370 380 390 400 410 420 ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE LVYGRADVAV APLTITLVRE 430 440 450 460 470 480 EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW MCIVFAYIGV SVVLFLVSRF 490 500 510 520 530 540 SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ QGCDISPRSL SGRIVGGVWW 550 560 570 580 590 600 FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA YGTLEAGSTK EFFRRSKIAV 610 620 630 640 650 660 FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES TMNEYIEQRK PCDTMKVGGN 670 680 690 700 710 720 LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW WYDKGECGSG GGDSKDKTSA 730 740 750 760 770 780 LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK GFCLIPQQSI NEAIRTSTLP 790 800 810 820 RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP LGATGL
	Isoform 4 [UniParc]. Checksum: 54246EAC4BFFB9F0	FASTA	837	93,900
	10 20 30 40 50 60 MTYRFCSQFS KGVYAIFGFY ERRTVNMLTS FCGALHVCFI TPSFPVDTSN QFVLQLRPEL 70 80 90 100 110 120 QDALISIIDH YKWQKFVYIY DADRGLSVLQ KVLDTAAEKN WQVTAVNILT TTEEGYRMLF 130 140 150 160 170 180 QDLEKKKERL VVVDCESERL NAILGQIIKL EKNGIGYHYI LANLGFMDID LNKFKESGAN 190 200 210 220 230 240 VTGFQLVNYT DTIPAKIMQQ WKNSDARDHT RVDWKRPKYT SALTYDGVKV MAEAFQSLRR 250 260 270 280 290 300 QRIDISRRGN AGDCLANPAV PWGQGIDIQR ALQQVRFEGL TGNVQFNEKG RRTNYTLHVI 310 320 330 340 350 360 EMKHDGIRKI GYWNEDDKFV PAATDAQAGG DNSSVQNRTY IVTTILEDPY VMLKKNANQF 370 380 390 400 410 420 EGNDRYEGYC VELAAEIAKH VGYSYRLEIV SDGKYGARDP DTKAWNGMVG ELVYGRADVA 430 440 450 460 470 480 VAPLTITLVR EEVIDFSKPF MSLGISIMIK KPQKSKPGVF SFLDPLAYEI WMCIVFAYIG 490 500 510 520 530 540 VSVVLFLVSR FSPYEWHSEE FEEGRDQTTS DQSNEFGIFN SLWFSLGAFM QQGCDISPRS 550 560 570 580 590 600 LSGRIVGGVW WFFTLIIISS YTANLAAFLT VERMVSPIES AEDLAKQTEI AYGTLEAGST 610 620 630 640 650 660 KEFFRRSKIA VFEKMWTYMK SAEPSVFVRT TEEGMIRVRK SKGKYAYLLE STMNEYIEQR 670 680 690 700 710 720 KPCDTMKVGG NLDSKGYGIA TPKGSALRNP VNLAVLKLNE QGLLDKLKNK WWYDKGECGS 730 740 750 760 770 780 GGGDSKDKTS ALSLSNVAGV FYILIGGLGL AMLVALIEFC YKSRSESKRM KGFCLIPQQS 790 800 810 820 830 INEAIRTSTL PRNSGAGASS GGSGENGRVV SHDFPKSMQS IPCMSHSSGM PLGATGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and chromosomal localization of one of the human glutamate receptor genes." Puckett C., Gomez C.M., Korenberg J.R., Tung H., Meier T.J., Chen X.N., Hood L.E. Proc. Natl. Acad. Sci. U.S.A. 88:7557-7561(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FLIP).
[2]	"The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5." Potier M.-C., Spillantini M.G., Carter N.P. DNA Seq. 2:211-218(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FLOP). Tissue: Hippocampus.
[3]	"Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors." Sun W., Ferrer-Montiel A.V., Schinder A.F., McPherson J.P., Evans G.A., Montal M. Proc. Natl. Acad. Sci. U.S.A. 89:1443-1447(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FLOP).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Brain and Hippocampus.
[5]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FLOP).
[8]	"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins." Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S. Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating." Shi Y., Suh Y.H., Milstein A.D., Isozaki K., Schmid S.M., Roche K.W., Nicoll R.A. Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CNIH2 AND CACNG2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64752 mRNA. Translation: AAA58613.1. X58633 mRNA. Translation: CAA41491.1. M81886 mRNA. Translation: AAA58395.1. AK295039 mRNA. Translation: BAH11956.1. AK295827 mRNA. Translation: BAH12192.1. AC010613 Genomic DNA. No translation available. AC025156 Genomic DNA. No translation available. AC091960 Genomic DNA. No translation available. AC091962 Genomic DNA. No translation available. CH471062 Genomic DNA. Translation: EAW61649.1. CH471062 Genomic DNA. Translation: EAW61650.1. BC111734 mRNA. Translation: AAI11735.1.
IPI	IPI00030880. IPI00219124.
PIR	A40222. A41273. S25852. S38723.
RefSeq	NP_000818.2. NM_000827.3. NP_001107655.1. NM_001114183.1. NP_001244948.1. NM_001258019.1. NP_001244950.1. NM_001258021.1. NP_001244952.1. NM_001258023.1.
UniGene	Hs.519693. Hs.737709.
3D structure databases
ProteinModelPortal	P42261.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-41487N.
MINT	MINT-271172.
STRING	9606.ENSP00000285900.
PTM databases
PhosphoSite	P42261.
Polymorphism databases
DMDM	116242505.
Proteomic databases
PaxDb	P42261.
PRIDE	P42261.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285900; ENSP00000285900; ENSG00000155511. ENST00000340592; ENSP00000339343; ENSG00000155511. ENST00000518142; ENSP00000427920; ENSG00000155511. ENST00000544403; ENSP00000444321; ENSG00000155511. ENST00000544794; ENSP00000442108; ENSG00000155511.
GeneID	2890.
KEGG	hsa:2890.
UCSC	uc003luy.4. human. uc003lva.4. human.
Organism-specific databases
CTD	2890.
GeneCards	GC05P152850.
H-InvDB	HIX0032120.
HGNC	HGNC:4571. GRIA1.
HPA	CAB001965.
MIM	138248. gene.
neXtProt	NX_P42261.
PharmGKB	PA28966.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316680.
HOGENOM	HOG000234372.
HOVERGEN	HBG051839.
KO	K05197.
OrthoDB	EOG479F6B.
PhylomeDB	P42261.
Enzyme and pathway databases
Pathway_Interaction_DB	ephbfwdpathway. EPHB forward signaling.
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	P42261.
Bgee	P42261.
CleanEx	HS_GRIA1.
Genevestigator	P42261.
GermOnline	ENSG00000155511. Homo sapiens.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR019594. Glu_rcpt_Glu/Gly-bd. IPR001320. Iontro_glu_rcpt. IPR001508. NMDA_rcpt. [Graphical view]
Pfam	PF01094. ANF_receptor. 1 hit. PF00060. Lig_chan. 1 hit. PF10613. Lig_chan-Glu_bd. 1 hit. [Graphical view]
PRINTS	PR00177. NMDARECEPTOR.
SMART	SM00918. Lig_chan-Glu_bd. 1 hit. SM00079. PBPe. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P42261.
ChEMBL	CHEMBL2009.
DrugBank	DB01189. Desflurane. DB00228. Enflurane. DB01159. Halothane. DB00753. Isoflurane. DB00142. L-Glutamic Acid. DB01028. Methoxyflurane. DB01236. Sevoflurane.
GenomeRNAi	2890.
NextBio	11425.
SOURCE	Search...

Entry information

Entry name

GRIA1_HUMAN

Accession

Primary (citable) accession number: P42261
Secondary accession number(s): B7Z2S0 , B7Z3F6, D3DQI4, Q2NKM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 140 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.