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Protein

Sensory rhodopsin II transducer

Gene

htr2

Organism
Natronomonas pharaonis (Natronobacterium pharaonis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Photoreceptor protein, Receptor, Transducer

Keywords - Biological processi

Chemotaxis, Sensory transduction

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory rhodopsin II transducer
Alternative name(s):
HTR-II
Methyl-accepting phototaxis protein II
Short name:
MPP-II
Gene namesi
Name:htr2
Synonyms:htrII
OrganismiNatronomonas pharaonis (Natronobacterium pharaonis)
Taxonomic identifieri2257 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Add
BLAST
Topological domaini44 – 5916ExtracellularAdd
BLAST
Transmembranei60 – 8122Helical; Name=2Add
BLAST
Topological domaini82 – 534453CytoplasmicAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Sensory rhodopsin II transducerPRO_0000110555Add
BLAST

Keywords - PTMi

Methylation

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
sopIIQ3IMZ82EBI-1034515,EBI-7339190From a different organism.

Protein-protein interaction databases

DIPiDIP-35283N.
IntActiP42259. 2 interactions.
MINTiMINT-248664.
STRINGi348780.NP4832A.

Structurei

Secondary structure

1
534
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 5027Combined sources
Helixi53 – 8129Combined sources
Turni107 – 1093Combined sources
Beta strandi118 – 1203Combined sources
Turni124 – 1263Combined sources
Helixi127 – 1304Combined sources
Helixi135 – 15016Combined sources
Helixi151 – 1533Combined sources
Helixi157 – 1593Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H2SX-ray1.93B23-82[»]
2F93X-ray2.00B3-114[»]
2F95X-ray2.20B5-157[»]
2RM8NMR-A100-159[»]
4GYCX-ray2.05B1-135[»]
ProteinModelPortaliP42259.
SMRiP42259. Positions 23-82, 100-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42259.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 13653HAMP 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 21054HAMP 2PROSITE-ProRule annotationAdd
BLAST
Domaini229 – 465237Methyl-accepting transducerPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 HAMP domains.PROSITE-ProRule annotation
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG02320. Archaea.
COG0840. LUCA.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNVSRLLL PSRVRHSYTG KMGAVFIFVG ALTVLFGAIA YGEVTAAAAT
60 70 80 90 100
GDAAAVQEAA VSAILGLIIL LGINLGLVAA TLGGDTAASL STLAAKASRM
110 120 130 140 150
GDGDLDVELE TRREDEIGDL YAAFDEMRQS VRTSLEDAKN AREDAEQAQK
160 170 180 190 200
RAEEINTELQ AEAERFGEVM DRCADGDFTQ RLDAETDNEA MQSIEGSFNE
210 220 230 240 250
MMDGIEALVG RIERFADAVS EDAEAVRANA ESVMEASEDV NRAVQNISDA
260 270 280 290 300
AGDQTETVQQ IALEMDDVSA TTEEVAASAD DIAKTARQAA ETGEAGRETA
310 320 330 340 350
ETAITEMNEV ESRTEQAVAS MEELNEDVRE IGEVSEMIAD IAEQTNILAL
360 370 380 390 400
NASIEAARAD GNSEGFAVVA DEVKALAEET KAATEEIDDL IGTVQDRTQT
410 420 430 440 450
TVDDIRETSD QVSEGVETVE DTVDALERIV DSVERTNDGI QEINQSTDAQ
460 470 480 490 500
ADAAQKATTM VEDMAATSEQ TASDAETAAE TTETQAESVK EVFDLIDGLS
510 520 530
EQADSLSETL SRTDTEEASA ADLDDQPTLA AGDD
Length:534
Mass (Da):56,622
Last modified:November 1, 1995 - v1
Checksum:iCBE8012CC5F278E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35086 Genomic DNA. Translation: CAA84468.1.
PIRiS55299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35086 Genomic DNA. Translation: CAA84468.1.
PIRiS55299.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H2SX-ray1.93B23-82[»]
2F93X-ray2.00B3-114[»]
2F95X-ray2.20B5-157[»]
2RM8NMR-A100-159[»]
4GYCX-ray2.05B1-135[»]
ProteinModelPortaliP42259.
SMRiP42259. Positions 23-82, 100-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35283N.
IntActiP42259. 2 interactions.
MINTiMINT-248664.
STRINGi348780.NP4832A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiarCOG02320. Archaea.
COG0840. LUCA.

Miscellaneous databases

EvolutionaryTraceiP42259.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTR2_NATPH
AccessioniPrimary (citable) accession number: P42259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.