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Protein

Arabinan endo-1,5-alpha-L-arabinosidase A

Gene

abnA

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Its preferred substrate is linear 1,5-alpha-L-arabinan. The enzyme activity is progressively reduced as 1,5-alpha-chains become shorter or more highly substituted.

Catalytic activityi

Endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5)-arabinans.

Pathway:iL-arabinan degradation

This protein is involved in the pathway L-arabinan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway L-arabinan degradation and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16541.
UniPathwayiUPA00667.

Protein family/group databases

CAZyiGH43. Glycoside Hydrolase Family 43.
mycoCLAPiABN43A_ASPNG.

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinan endo-1,5-alpha-L-arabinosidase A (EC:3.2.1.99)
Alternative name(s):
Endo-1,5-alpha-L-arabinanase A
Short name:
ABN A
Gene namesi
Name:abnA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 321302Arabinan endo-1,5-alpha-L-arabinosidase APRO_0000012204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By L-araban, arabinogalactan and L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00007516.

Structurei

3D structure databases

ProteinModelPortaliP42256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 43 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3507.

Family and domain databases

Gene3Di2.115.10.20. 1 hit.
InterProiIPR006710. Glyco_hydro_43.
IPR016840. Glyco_hydro_43_endo_a_Ara-ase.
IPR023296. Glyco_hydro_beta-prop.
[Graphical view]
PANTHERiPTHR22925. PTHR22925. 1 hit.
PfamiPF04616. Glyco_hydro_43. 1 hit.
[Graphical view]
PIRSFiPIRSF026534. Endo_alpha-L-arabinosidase. 1 hit.
SUPFAMiSSF75005. SSF75005. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQLLSVASV PLLASLVHGY ADPGACSGVC TTHDPGLIRR ESDGTYFLFS
60 70 80 90 100
TGNKISYVSA SSIEGPWTSV GSMLPDGSSI DLDGNDDLWA PDVSYVDGLY
110 120 130 140 150
YVYYAVSTFG SQDSAIGLAT SETMEYGSWT DHGSTGIASS SAKIYNAIDP
160 170 180 190 200
NLIYADGTYY INFGSFWDDI YQVPMKSTPT AAASSSYNLA YDPSGTHAEE
210 220 230 240 250
GSYMFQYGDY YYLFYSAGIC CGYDTSMPAS GEEYHIKVCR STSPTGDFVD
260 270 280 290 300
SDGTACTDGG GTMVLESHGE VYGPGGQGVY DDPNLGPVLY YHYMNTTIGY
310 320
ADSDAQFGWN TIDFSSGWPV V
Length:321
Mass (Da):34,455
Last modified:November 1, 1995 - v1
Checksum:i3087D7D0592A0B20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23430 Genomic DNA. Translation: AAA32682.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23430 Genomic DNA. Translation: AAA32682.1.

3D structure databases

ProteinModelPortaliP42256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00007516.

Protein family/group databases

CAZyiGH43. Glycoside Hydrolase Family 43.
mycoCLAPiABN43A_ASPNG.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG3507.

Enzyme and pathway databases

UniPathwayiUPA00667.
BioCyciMetaCyc:MONOMER-16541.

Family and domain databases

Gene3Di2.115.10.20. 1 hit.
InterProiIPR006710. Glyco_hydro_43.
IPR016840. Glyco_hydro_43_endo_a_Ara-ase.
IPR023296. Glyco_hydro_beta-prop.
[Graphical view]
PANTHERiPTHR22925. PTHR22925. 1 hit.
PfamiPF04616. Glyco_hydro_43. 1 hit.
[Graphical view]
PIRSFiPIRSF026534. Endo_alpha-L-arabinosidase. 1 hit.
SUPFAMiSSF75005. SSF75005. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression and structure of the endo-1,5-alpha-L-arabinase gene of Aspergillus niger."
    Flipphi M.J.A., Panneman H., van der Veen P., Visser J., de Graaff L.H.
    Appl. Microbiol. Biotechnol. 40:318-326(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20-32 AND 125-139.
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Entry informationi

Entry nameiABNA_ASPNG
AccessioniPrimary (citable) accession number: P42256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.