Reviewed, UniProtKB/Swiss-Prot P42236 (ALDH1_BACSU)

Names and origin

Protein names

Recommended name:
    Probable aldehyde dehydrogenase ycbD
    EC=1.2.1.3

Gene names

Name:	ycbD
Ordered Locus Names:	BSU02470

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Probable aldehyde dehydrogenase ycbD		PRO_0000056444
Regions
	Nucleotide binding	233 – 238	6	NAD By similarity
Sites
	Active site	255	1	By similarity
	Active site	289	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42236-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 9C37B32EF51D59B2	FASTA	488	52,415
	10 20 30 40 50 60 MSVITEQNTY LNFINGEWVK SQSGDMVKVE NPADVNDIVG YVQNSTAEDV ERAVTAANEA 70 80 90 100 110 120 KTAWRKLTGA ERGQYLYKTA DIMEQRLEEI AACATREMGK TLPEAKGETA RGIAILRYYA 130 140 150 160 170 180 GEGMRKTGDV IPSTDKDALM FTTRVPLGVV GVISPWNFPV AIPIWKMAPA LVYGNTVVIK 190 200 210 220 230 240 PATETAVTCA KIIACFEEAG LPAGVINLVT GPGSVVGQGL AEHDGVNAVT FTGSNQVGKI 250 260 270 280 290 300 IGQAALARGA KYQLEMGGKN PVIVADDADL EAAAEAVITG AFRSTGQKCT ATSRVIVQSG 310 320 330 340 350 360 IYERFKEKLL QRTKDITIGD SLKEDVWMGP IASKNQLDNC LSYIEKGKQE GASLLIGGEK 370 380 390 400 410 420 LENGKYQNGY YVQPAIFDNV TSEMTIAQEE IFGPVIALIK VDSIEEALNI ANDVKFGLSA 430 440 450 460 470 480 SIFTENIGRM LSFIDEIDAG LVRINAESAG VELQAPFGGM KQSSSHSREQ GEAAKDFFTA IKTVFVKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Determination of a 21548 bp nucleotide sequence around the 24 degrees region of the Bacillus subtilis chromosome." Ogawa K., Akagawa E., Nakamura K., Yamane K. Microbiology 141:269-275(1995) [PubMed: 7704254] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D30808 Genomic DNA. Translation: BAA06468.1. AL009126 Genomic DNA. Translation: CAB12041.1.
PIR	G69752.
RefSeq	NP_388129.1.
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Genome annotation databases
GeneID	938406.
GenomeReviews	Gene locus BSU02470 in contig AL009126_GR.
KEGG	bsu:BSU02470.
NMPDR	fig|224308.1.peg.248.
Organism-specific databases
SubtiList	BG11159. ycbD. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P42236.
OMA	P42236. SEALMFT.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU0248-MON.
BRENDA	1.2.1.3. 150.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH1_BACSU

Accession

Primary (citable) accession number: P42236

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)