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Protein

Probable aldehyde dehydrogenase YcbD

Gene

ycbD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei255 – 2551By similarity
Active sitei289 – 2891By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi233 – 2386NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU02470-MONOMER.
RETL1328306-WGS:GSTH-3212-MONOMER.
SABIO-RKP42236.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aldehyde dehydrogenase YcbD (EC:1.2.1.3)
Gene namesi
Name:ycbD
Ordered Locus Names:BSU02470
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU02470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Probable aldehyde dehydrogenase YcbDPRO_0000056444Add
BLAST

Proteomic databases

PaxDbiP42236.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU02470.

Structurei

3D structure databases

ProteinModelPortaliP42236.
SMRiP42236. Positions 7-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
InParanoidiP42236.
KOiK00128.
OMAiWEVNQEE.
OrthoDBiEOG6BS8QW.
PhylomeDBiP42236.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVITEQNTY LNFINGEWVK SQSGDMVKVE NPADVNDIVG YVQNSTAEDV
60 70 80 90 100
ERAVTAANEA KTAWRKLTGA ERGQYLYKTA DIMEQRLEEI AACATREMGK
110 120 130 140 150
TLPEAKGETA RGIAILRYYA GEGMRKTGDV IPSTDKDALM FTTRVPLGVV
160 170 180 190 200
GVISPWNFPV AIPIWKMAPA LVYGNTVVIK PATETAVTCA KIIACFEEAG
210 220 230 240 250
LPAGVINLVT GPGSVVGQGL AEHDGVNAVT FTGSNQVGKI IGQAALARGA
260 270 280 290 300
KYQLEMGGKN PVIVADDADL EAAAEAVITG AFRSTGQKCT ATSRVIVQSG
310 320 330 340 350
IYERFKEKLL QRTKDITIGD SLKEDVWMGP IASKNQLDNC LSYIEKGKQE
360 370 380 390 400
GASLLIGGEK LENGKYQNGY YVQPAIFDNV TSEMTIAQEE IFGPVIALIK
410 420 430 440 450
VDSIEEALNI ANDVKFGLSA SIFTENIGRM LSFIDEIDAG LVRINAESAG
460 470 480
VELQAPFGGM KQSSSHSREQ GEAAKDFFTA IKTVFVKP
Length:488
Mass (Da):52,415
Last modified:November 1, 1995 - v1
Checksum:i9C37B32EF51D59B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30808 Genomic DNA. Translation: BAA06468.1.
AL009126 Genomic DNA. Translation: CAB12041.1.
PIRiG69752.
RefSeqiNP_388129.1. NC_000964.3.
WP_003246263.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12041; CAB12041; BSU02470.
GeneIDi938406.
KEGGibsu:BSU02470.
PATRICi18972045. VBIBacSub10457_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30808 Genomic DNA. Translation: BAA06468.1.
AL009126 Genomic DNA. Translation: CAB12041.1.
PIRiG69752.
RefSeqiNP_388129.1. NC_000964.3.
WP_003246263.1. NZ_JNCM01000030.1.

3D structure databases

ProteinModelPortaliP42236.
SMRiP42236. Positions 7-487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU02470.

Proteomic databases

PaxDbiP42236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12041; CAB12041; BSU02470.
GeneIDi938406.
KEGGibsu:BSU02470.
PATRICi18972045. VBIBacSub10457_0251.

Organism-specific databases

GenoListiBSU02470.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
InParanoidiP42236.
KOiK00128.
OMAiWEVNQEE.
OrthoDBiEOG6BS8QW.
PhylomeDBiP42236.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BioCyciBSUB:BSU02470-MONOMER.
RETL1328306-WGS:GSTH-3212-MONOMER.
SABIO-RKP42236.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Determination of a 21548 bp nucleotide sequence around the 24 degrees region of the Bacillus subtilis chromosome."
    Ogawa K., Akagawa E., Nakamura K., Yamane K.
    Microbiology 141:269-275(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiALDH1_BACSU
AccessioniPrimary (citable) accession number: P42236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.