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P42232

- STA5B_MOUSE

UniProt

P42232 - STA5B_MOUSE

Protein

Signal transducer and activator of transcription 5B

Gene

Stat5b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. chromatin binding Source: UniProtKB
    3. DNA binding Source: MGI
    4. double-stranded DNA binding Source: Ensembl
    5. protein binding Source: UniProtKB
    6. protein dimerization activity Source: UniProtKB
    7. protein phosphatase binding Source: UniProtKB
    8. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    9. sequence-specific DNA binding transcription factor activity Source: Ensembl
    10. signal transducer activity Source: MGI

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: BHF-UCL
    2. acute-phase response Source: Ensembl
    3. allantoin metabolic process Source: BHF-UCL
    4. cellular response to epidermal growth factor stimulus Source: UniProtKB
    5. cellular response to growth factor stimulus Source: UniProtKB
    6. citrate metabolic process Source: BHF-UCL
    7. creatine metabolic process Source: BHF-UCL
    8. creatinine metabolic process Source: BHF-UCL
    9. cytokine-mediated signaling pathway Source: MGI
    10. development of secondary female sexual characteristics Source: MGI
    11. development of secondary male sexual characteristics Source: MGI
    12. fatty acid metabolic process Source: BHF-UCL
    13. female pregnancy Source: MGI
    14. isoleucine metabolic process Source: BHF-UCL
    15. JAK-STAT cascade Source: MGI
    16. JAK-STAT cascade involved in growth hormone signaling pathway Source: BHF-UCL
    17. lactation Source: MGI
    18. lipid storage Source: MGI
    19. liver development Source: Ensembl
    20. luteinization Source: MGI
    21. natural killer cell differentiation Source: MGI
    22. negative regulation of apoptotic process Source: MGI
    23. negative regulation of erythrocyte differentiation Source: MGI
    24. oxaloacetate metabolic process Source: BHF-UCL
    25. Peyer's patch development Source: MGI
    26. positive regulation of activated T cell proliferation Source: MGI
    27. positive regulation of B cell differentiation Source: MGI
    28. positive regulation of cell proliferation Source: MGI
    29. positive regulation of cellular component movement Source: Ensembl
    30. positive regulation of gamma-delta T cell differentiation Source: MGI
    31. positive regulation of inflammatory response Source: MGI
    32. positive regulation of interleukin-2 biosynthetic process Source: MGI
    33. positive regulation of lymphocyte differentiation Source: MGI
    34. positive regulation of mitotic cell cycle Source: MGI
    35. positive regulation of multicellular organism growth Source: MGI
    36. positive regulation of natural killer cell differentiation Source: MGI
    37. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
    38. positive regulation of natural killer cell proliferation Source: MGI
    39. positive regulation of smooth muscle cell proliferation Source: Ensembl
    40. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    41. progesterone metabolic process Source: MGI
    42. prolactin signaling pathway Source: UniProtKB
    43. regulation of cell adhesion Source: MGI
    44. regulation of epithelial cell differentiation Source: MGI
    45. regulation of multicellular organism growth Source: BHF-UCL
    46. regulation of steroid metabolic process Source: MGI
    47. regulation of transcription from RNA polymerase II promoter Source: MGI
    48. response to estradiol Source: Ensembl
    49. response to ethanol Source: Ensembl
    50. response to hypoxia Source: Ensembl
    51. response to interleukin-15 Source: MGI
    52. response to interleukin-2 Source: MGI
    53. response to interleukin-4 Source: MGI
    54. response to lipopolysaccharide Source: Ensembl
    55. sex differentiation Source: MGI
    56. succinate metabolic process Source: BHF-UCL
    57. taurine metabolic process Source: BHF-UCL
    58. T cell differentiation in thymus Source: MGI
    59. T cell homeostasis Source: MGI
    60. transcription from RNA polymerase II promoter Source: Ensembl
    61. valine metabolic process Source: BHF-UCL

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_169390. Signaling by Leptin.
    REACT_188529. Signaling by Leptin.
    REACT_188578. Signaling by SCF-KIT.
    REACT_196460. Signaling by FGFR1 fusion mutants.
    REACT_198561. Prolactin receptor signaling.
    REACT_198614. Growth hormone receptor signaling.
    REACT_198701. Interleukin-7 signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 5B
    Gene namesi
    Name:Stat5b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:103035. Stat5b.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Translocated into the nucleus in response to phosphorylation.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi684 – 6841T → A: Fails to interact with INSR. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 786786Signal transducer and activator of transcription 5BPRO_0000182430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281PhosphoserineBy similarity
    Modified residuei699 – 6991Phosphotyrosine; by HCK, JAK and PTK6By similarity

    Post-translational modificationi

    Tyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 By similarity. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity By similarity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.By similarity4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP42232.
    PaxDbiP42232.
    PRIDEiP42232.

    PTM databases

    PhosphoSiteiP42232.

    Expressioni

    Tissue specificityi

    In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.

    Developmental stagei

    Detected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation.

    Gene expression databases

    ArrayExpressiP42232.
    BgeeiP42232.
    GenevestigatoriP42232.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member. Interacts with SOCS7 By similarity. Binds NR3C1 and NCOA1. Interacts (via SH2 domain) with INSR.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DNAJA3Q96EY13EBI-617454,EBI-356767From a different organism.
    DNAJA3Q96EY1-12EBI-617454,EBI-4322330From a different organism.
    DNAJA3Q96EY1-22EBI-617454,EBI-3952284From a different organism.
    GHRP199416EBI-617454,EBI-7526279From a different organism.

    Protein-protein interaction databases

    BioGridi203526. 6 interactions.
    DIPiDIP-898N.
    IntActiP42232. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP42232.
    SMRiP42232. Positions 2-686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini589 – 68698SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG245085.
    GeneTreeiENSGT00740000115175.
    HOVERGENiHBG107486.
    InParanoidiQ9R0X8.
    KOiK11224.
    OMAiVREATNS.
    OrthoDBiEOG73JKTT.
    PhylomeDBiP42232.
    TreeFamiTF318648.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42232-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN    50
    PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQSTYDR 100
    CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE 150
    LRLITQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLG QLNPQERMSR 200
    ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 250
    ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300
    QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA 350
    TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC 400
    CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFDSQFSV 450
    GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD 500
    KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNI SSNHLEDYNS 550
    MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 600
    QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD 650
    FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCEP ATAKAADGYV 700
    KPQIKQVVPE FANASTDAGS GATYMDQAPS PVVCPQAHYN MYPPNPDSVL 750
    DTDGDFDLED TMDVARRVEE LLGRPMDSQW IPHAQS 786
    Length:786
    Mass (Da):90,002
    Last modified:November 1, 1995 - v1
    Checksum:iA8FE76405E41B2EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti210 – 2101S → P in CAB51862. (PubMed:10835485)Curated
    Sequence conflicti433 – 4331E → G in AAC52282. (PubMed:7568026)Curated
    Sequence conflicti433 – 4331E → G in AAL05590. (PubMed:14701862)Curated
    Sequence conflicti433 – 4331E → G in AAK97791. (PubMed:14701862)Curated
    Sequence conflicti433 – 4331E → G in AAK97792. (PubMed:14701862)Curated
    Sequence conflicti433 – 4331E → G in AAK97793. (PubMed:14701862)Curated

    Polymorphismi

    The polymorphism at position 327 in strain NOD reduces DNA-binding affinity.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti327 – 3271L → M in strain: NOD. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48539 mRNA. Translation: CAA88420.1.
    U21110 mRNA. Translation: AAC52282.1.
    AF234171 Genomic DNA. Translation: AAF62911.2.
    AY040231 mRNA. Translation: AAK74074.1.
    AY042906 mRNA. Translation: AAL05590.1.
    AY044901 mRNA. Translation: AAK97791.1.
    AY044902 mRNA. Translation: AAK97792.1.
    AY044903 mRNA. Translation: AAK97793.1.
    AK150098 mRNA. Translation: BAE29305.1.
    AK154014 mRNA. Translation: BAE32317.1.
    AK154664 mRNA. Translation: BAE32752.1.
    AL591466 Genomic DNA. Translation: CAM19465.1.
    BC024319 mRNA. Translation: AAH24319.1.
    AJ237939 Genomic DNA. Translation: CAB51862.1.
    CCDSiCCDS25438.1.
    PIRiI49274.
    RefSeqiNP_001107035.1. NM_001113563.1.
    NP_035619.3. NM_011489.3.
    UniGeneiMm.34064.

    Genome annotation databases

    EnsembliENSMUST00000004143; ENSMUSP00000004143; ENSMUSG00000020919.
    ENSMUST00000107358; ENSMUSP00000102981; ENSMUSG00000020919.
    GeneIDi20851.
    KEGGimmu:20851.
    UCSCiuc007lmi.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48539 mRNA. Translation: CAA88420.1 .
    U21110 mRNA. Translation: AAC52282.1 .
    AF234171 Genomic DNA. Translation: AAF62911.2 .
    AY040231 mRNA. Translation: AAK74074.1 .
    AY042906 mRNA. Translation: AAL05590.1 .
    AY044901 mRNA. Translation: AAK97791.1 .
    AY044902 mRNA. Translation: AAK97792.1 .
    AY044903 mRNA. Translation: AAK97793.1 .
    AK150098 mRNA. Translation: BAE29305.1 .
    AK154014 mRNA. Translation: BAE32317.1 .
    AK154664 mRNA. Translation: BAE32752.1 .
    AL591466 Genomic DNA. Translation: CAM19465.1 .
    BC024319 mRNA. Translation: AAH24319.1 .
    AJ237939 Genomic DNA. Translation: CAB51862.1 .
    CCDSi CCDS25438.1.
    PIRi I49274.
    RefSeqi NP_001107035.1. NM_001113563.1.
    NP_035619.3. NM_011489.3.
    UniGenei Mm.34064.

    3D structure databases

    ProteinModelPortali P42232.
    SMRi P42232. Positions 2-686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203526. 6 interactions.
    DIPi DIP-898N.
    IntActi P42232. 3 interactions.

    PTM databases

    PhosphoSitei P42232.

    Proteomic databases

    MaxQBi P42232.
    PaxDbi P42232.
    PRIDEi P42232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004143 ; ENSMUSP00000004143 ; ENSMUSG00000020919 .
    ENSMUST00000107358 ; ENSMUSP00000102981 ; ENSMUSG00000020919 .
    GeneIDi 20851.
    KEGGi mmu:20851.
    UCSCi uc007lmi.2. mouse.

    Organism-specific databases

    CTDi 6777.
    MGIi MGI:103035. Stat5b.

    Phylogenomic databases

    eggNOGi NOG245085.
    GeneTreei ENSGT00740000115175.
    HOVERGENi HBG107486.
    InParanoidi Q9R0X8.
    KOi K11224.
    OMAi VREATNS.
    OrthoDBi EOG73JKTT.
    PhylomeDBi P42232.
    TreeFami TF318648.

    Enzyme and pathway databases

    Reactomei REACT_169390. Signaling by Leptin.
    REACT_188529. Signaling by Leptin.
    REACT_188578. Signaling by SCF-KIT.
    REACT_196460. Signaling by FGFR1 fusion mutants.
    REACT_198561. Prolactin receptor signaling.
    REACT_198614. Growth hormone receptor signaling.
    REACT_198701. Interleukin-7 signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Miscellaneous databases

    ChiTaRSi STAT5B. mouse.
    NextBioi 299639.
    PROi P42232.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42232.
    Bgeei P42232.
    Genevestigatori P42232.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs."
      Mui A.L.-F., Wakao H., O'Farrell A.-M., Harada N., Miyajima A.
      EMBO J. 14:1166-1175(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X A/J.
      Tissue: Liver.
    2. "Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue."
      Liu X., Robinson G.W., Gouilleux F., Groner B., Hennighausen L.
      Proc. Natl. Acad. Sci. U.S.A. 92:8831-8835(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse."
      Miyoshi K., Cui Y., Riedlinger G., Robinson P., Lehoczky J., Zon L., Oka T., Dewar K., Hennighausen L.
      Genomics 71:150-155(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    4. "A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in non-obese diabetic (NOD) mice."
      Davoodi-Semiromi A., Laloraya M., Kumar G.P., Purohit S., Jha R.K., She J.-X.
      J. Biol. Chem. 279:11553-11561(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-327.
      Strain: BALB/c, C3H, C57BL/6, CBA and NOD.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Dendritic cell and Thymus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    8. "Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains."
      Seyfert H.-M., Pitra C., Meyer L., Brunner R.M., Wheeler T.T., Molenaar A., McCracken J.Y., Herrmann J., Thiesen H.-J., Schwerin M.
      J. Mol. Evol. 50:550-561(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-389.
    9. Cited for: INTERACTION WITH INRS, MUTAGENESIS OF THR-684.
    10. "Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells."
      Cella N., Groner B., Hynes N.E.
      Mol. Cell. Biol. 18:1783-1792(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NR3C1.
    11. "Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways."
      Mizuki M., Fenski R., Halfter H., Matsumura I., Schmidt R., Muller C., Gruning W., Kratz-Albers K., Serve S., Steur C., Buchner T., Kienast J., Kanakura Y., Berdel W.E., Serve H.
      Blood 96:3907-3914(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING.
    12. "A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus."
      Aoki N., Matsuda T.
      Mol. Endocrinol. 16:58-69(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PROLACTIN SIGNALING PATHWAY, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.
    13. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
      Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.
      J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION IN RESPONSE TO KIT SIGNALING.
    14. Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING.

    Entry informationi

    Entry nameiSTA5B_MOUSE
    AccessioniPrimary (citable) accession number: P42232
    Secondary accession number(s): A2A5D5
    , Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3