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P42228

- STAT4_MOUSE

UniProt

P42228 - STAT4_MOUSE

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Protein
Signal transducer and activator of transcription 4
Gene
Stat4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. calcium ion binding Source: InterPro
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
  6. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell proliferation Source: MGI
  2. cellular response to organic substance Source: MGI
  3. cytokine-mediated signaling pathway Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. protein phosphorylation Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 4
Gene namesi
Name:Stat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:103062. Stat4.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocated into the nucleus in response to phosphorylation.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Signal transducer and activator of transcription 4
PRO_0000182421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei694 – 6941Phosphotyrosine; by JAK By similarity

Post-translational modificationi

Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP42228.
PRIDEiP42228.

PTM databases

PhosphoSiteiP42228.

Expressioni

Gene expression databases

GenevestigatoriP42228.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with ARL2BP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat1P422252EBI-6253572,EBI-647118

Protein-protein interaction databases

BioGridi203524. 1 interaction.
DIPiDIP-1170N.
IntActiP42228. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97
Helixi12 – 143
Helixi15 – 184
Helixi19 – 213
Helixi28 – 336
Helixi35 – 406
Helixi43 – 464
Helixi50 – 7425
Helixi77 – 9519
Helixi98 – 11821

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BGFX-ray1.45A2-123[»]
ProteinModelPortaliP42228.
SMRiP42228. Positions 2-703.

Miscellaneous databases

EvolutionaryTraceiP42228.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 66596SH2
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG267627.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
InParanoidiP42228.
KOiK11222.
PhylomeDBiP42228.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42228-1 [UniParc]FASTAAdd to Basket

« Hide

MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIET QDWEVASNNE    50
TMATILLQNL LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH 100
VAVVISNCLR EERRILAAAN MPIQGPLEKS LQSSSVSERQ RNVEHKVSAI 150
KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT MDQGDKNSIL VNQEVLTLLQ 200
EMLNSLDFKR KEALSKMTQI VNETDLLMNS MLLEELQDWK KRQQIACIGG 250
PLHNGLDQLQ NCFTLLAESL FQLRQQLEKL QEQSTKMTYE GDPIPAQRAH 300
LLERATFLIY NLFKNSFVVE RQPCMPTHPQ RPMVLKTLIQ FTVKLRLLIK 350
LPELNYQVKV KASIDKNVST LSNRRFVLCG THVKAMSSEE SSNGSLSVEF 400
RHLQPKEMKC STGSKGNEGC HMVTEELHSI TFETQICLYG LTINLETSSL 450
PVVMISNVSQ LPNAWASIIW YNVSTNDSQN LVFFNNPPSV TLGQLLEVMS 500
WQFSSYVGRG LNSEQLNMLA EKLTVQSNYN DGHLTWAKFC KEHLPGKTFT 550
FWTWLEAILD LIKKHILPLW IDGYIMGFVS KEKERLLLKD KMPGTFLLRF 600
SESHLGGITF TWVDQSENGE VRFHSVEPYN KGRLSALAFA DILRDYKVIM 650
AENIPENPLK YLYPDIPKDK AFGKHYSSQP CEVSRPTERG DKGYVPSVFI 700
PISTIRSDST EPQSPSDLLP MSPSAYAVLR ENLSPTTIET AMNSPYSAE 749
Length:749
Mass (Da):85,941
Last modified:November 1, 1995 - v1
Checksum:iA88B837E49FCFEBC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991Missing in AAA19692. 1 Publication
Sequence conflicti638 – 6381A → P in AAA19692. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06923 mRNA. Translation: AAA19453.1.
U09351 mRNA. Translation: AAA19692.1.
PIRiA56047.
RefSeqiNP_035617.1. NM_011487.4.
UniGeneiMm.1550.

Genome annotation databases

GeneIDi20849.
KEGGimmu:20849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06923 mRNA. Translation: AAA19453.1 .
U09351 mRNA. Translation: AAA19692.1 .
PIRi A56047.
RefSeqi NP_035617.1. NM_011487.4.
UniGenei Mm.1550.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BGF X-ray 1.45 A 2-123 [» ]
ProteinModelPortali P42228.
SMRi P42228. Positions 2-703.
ModBasei Search...

Protein-protein interaction databases

BioGridi 203524. 1 interaction.
DIPi DIP-1170N.
IntActi P42228. 1 interaction.

PTM databases

PhosphoSitei P42228.

Proteomic databases

PaxDbi P42228.
PRIDEi P42228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20849.
KEGGi mmu:20849.

Organism-specific databases

CTDi 6775.
MGIi MGI:103062. Stat4.

Phylogenomic databases

eggNOGi NOG267627.
HOGENOMi HOG000220792.
HOVERGENi HBG055669.
InParanoidi P42228.
KOi K11222.
PhylomeDBi P42228.

Miscellaneous databases

EvolutionaryTracei P42228.
NextBioi 299631.
PROi P42228.
SOURCEi Search...

Gene expression databases

Genevestigatori P42228.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stat3 and Stat4: members of the family of signal transducers and activators of transcription."
    Zhong Z., Wen Z., Darnell J.E. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 91:4806-4810(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation."
    Yamamoto K., Quelle F.W., Thierfelder W.E., Kreider B.L., Gilbert D.J., Jenkins N.A., Copeland N.G., Silvennoinen O., Ihle J.N.
    Mol. Cell. Biol. 14:4342-4349(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Testis.
  3. Cited for: INTERACTION WITH ARL2BP.
  4. "Structure of the amino-terminal protein interaction domain of STAT-4."
    Vinkemeier U., Moarefi I., Darnell J.E. Jr., Kuriyan J.
    Science 279:1048-1052(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 1-123.

Entry informationi

Entry nameiSTAT4_MOUSE
AccessioniPrimary (citable) accession number: P42228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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