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P42228

- STAT4_MOUSE

UniProt

P42228 - STAT4_MOUSE

Protein

Signal transducer and activator of transcription 4

Gene

Stat4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Carries out a dual function: signal transduction and activation of transcription.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: MGI
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: InterPro
    6. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: MGI
    2. cellular response to organic substance Source: MGI
    3. cytokine-mediated signaling pathway Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. protein phosphorylation Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 4
    Gene namesi
    Name:Stat4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:103062. Stat4.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Translocated into the nucleus in response to phosphorylation.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 749749Signal transducer and activator of transcription 4PRO_0000182421Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei694 – 6941Phosphotyrosine; by JAKBy similarity

    Post-translational modificationi

    Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP42228.
    PRIDEiP42228.

    PTM databases

    PhosphoSiteiP42228.

    Expressioni

    Gene expression databases

    GenevestigatoriP42228.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with ARL2BP.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Stat1P422252EBI-6253572,EBI-647118

    Protein-protein interaction databases

    BioGridi203524. 1 interaction.
    DIPiDIP-1170N.
    IntActiP42228. 1 interaction.

    Structurei

    Secondary structure

    1
    749
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 97
    Helixi12 – 143
    Helixi15 – 184
    Helixi19 – 213
    Helixi28 – 336
    Helixi35 – 406
    Helixi43 – 464
    Helixi50 – 7425
    Helixi77 – 9519
    Helixi98 – 11821

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BGFX-ray1.45A2-123[»]
    ProteinModelPortaliP42228.
    SMRiP42228. Positions 2-703.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42228.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini570 – 66596SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG267627.
    HOGENOMiHOG000220792.
    HOVERGENiHBG055669.
    InParanoidiP42228.
    KOiK11222.
    PhylomeDBiP42228.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42228-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIET QDWEVASNNE    50
    TMATILLQNL LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH 100
    VAVVISNCLR EERRILAAAN MPIQGPLEKS LQSSSVSERQ RNVEHKVSAI 150
    KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT MDQGDKNSIL VNQEVLTLLQ 200
    EMLNSLDFKR KEALSKMTQI VNETDLLMNS MLLEELQDWK KRQQIACIGG 250
    PLHNGLDQLQ NCFTLLAESL FQLRQQLEKL QEQSTKMTYE GDPIPAQRAH 300
    LLERATFLIY NLFKNSFVVE RQPCMPTHPQ RPMVLKTLIQ FTVKLRLLIK 350
    LPELNYQVKV KASIDKNVST LSNRRFVLCG THVKAMSSEE SSNGSLSVEF 400
    RHLQPKEMKC STGSKGNEGC HMVTEELHSI TFETQICLYG LTINLETSSL 450
    PVVMISNVSQ LPNAWASIIW YNVSTNDSQN LVFFNNPPSV TLGQLLEVMS 500
    WQFSSYVGRG LNSEQLNMLA EKLTVQSNYN DGHLTWAKFC KEHLPGKTFT 550
    FWTWLEAILD LIKKHILPLW IDGYIMGFVS KEKERLLLKD KMPGTFLLRF 600
    SESHLGGITF TWVDQSENGE VRFHSVEPYN KGRLSALAFA DILRDYKVIM 650
    AENIPENPLK YLYPDIPKDK AFGKHYSSQP CEVSRPTERG DKGYVPSVFI 700
    PISTIRSDST EPQSPSDLLP MSPSAYAVLR ENLSPTTIET AMNSPYSAE 749
    Length:749
    Mass (Da):85,941
    Last modified:November 1, 1995 - v1
    Checksum:iA88B837E49FCFEBC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991Missing in AAA19692. (PubMed:8007943)Curated
    Sequence conflicti638 – 6381A → P in AAA19692. (PubMed:8007943)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06923 mRNA. Translation: AAA19453.1.
    U09351 mRNA. Translation: AAA19692.1.
    PIRiA56047.
    RefSeqiNP_035617.1. NM_011487.4.
    UniGeneiMm.1550.

    Genome annotation databases

    GeneIDi20849.
    KEGGimmu:20849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06923 mRNA. Translation: AAA19453.1 .
    U09351 mRNA. Translation: AAA19692.1 .
    PIRi A56047.
    RefSeqi NP_035617.1. NM_011487.4.
    UniGenei Mm.1550.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BGF X-ray 1.45 A 2-123 [» ]
    ProteinModelPortali P42228.
    SMRi P42228. Positions 2-703.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203524. 1 interaction.
    DIPi DIP-1170N.
    IntActi P42228. 1 interaction.

    PTM databases

    PhosphoSitei P42228.

    Proteomic databases

    PaxDbi P42228.
    PRIDEi P42228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20849.
    KEGGi mmu:20849.

    Organism-specific databases

    CTDi 6775.
    MGIi MGI:103062. Stat4.

    Phylogenomic databases

    eggNOGi NOG267627.
    HOGENOMi HOG000220792.
    HOVERGENi HBG055669.
    InParanoidi P42228.
    KOi K11222.
    PhylomeDBi P42228.

    Miscellaneous databases

    EvolutionaryTracei P42228.
    NextBioi 299631.
    PROi P42228.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P42228.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Stat3 and Stat4: members of the family of signal transducers and activators of transcription."
      Zhong Z., Wen Z., Darnell J.E. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 91:4806-4810(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation."
      Yamamoto K., Quelle F.W., Thierfelder W.E., Kreider B.L., Gilbert D.J., Jenkins N.A., Copeland N.G., Silvennoinen O., Ihle J.N.
      Mol. Cell. Biol. 14:4342-4349(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Testis.
    3. Cited for: INTERACTION WITH ARL2BP.
    4. "Structure of the amino-terminal protein interaction domain of STAT-4."
      Vinkemeier U., Moarefi I., Darnell J.E. Jr., Kuriyan J.
      Science 279:1048-1052(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 1-123.

    Entry informationi

    Entry nameiSTAT4_MOUSE
    AccessioniPrimary (citable) accession number: P42228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3