Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P42228

- STAT4_MOUSE

UniProt

P42228 - STAT4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Signal transducer and activator of transcription 4

Gene

Stat4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
  5. signal transducer activity Source: InterPro

GO - Biological processi

  1. cell proliferation Source: MGI
  2. cellular response to organic substance Source: MGI
  3. cytokine-mediated signaling pathway Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. protein phosphorylation Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 4
Gene namesi
Name:Stat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:103062. Stat4.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocated into the nucleus in response to phosphorylation.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Signal transducer and activator of transcription 4PRO_0000182421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei694 – 6941Phosphotyrosine; by JAKBy similarity

Post-translational modificationi

Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP42228.
PRIDEiP42228.

PTM databases

PhosphoSiteiP42228.

Expressioni

Gene expression databases

GenevestigatoriP42228.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with ARL2BP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat1P422252EBI-6253572,EBI-647118

Protein-protein interaction databases

BioGridi203524. 1 interaction.
DIPiDIP-1170N.
IntActiP42228. 1 interaction.

Structurei

Secondary structure

1
749
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Helixi12 – 143Combined sources
Helixi15 – 184Combined sources
Helixi19 – 213Combined sources
Helixi28 – 336Combined sources
Helixi35 – 406Combined sources
Helixi43 – 464Combined sources
Helixi50 – 7425Combined sources
Helixi77 – 9519Combined sources
Helixi98 – 11821Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BGFX-ray1.45A2-123[»]
ProteinModelPortaliP42228.
SMRiP42228. Positions 2-703.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42228.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 66596SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG267627.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
InParanoidiP42228.
KOiK11222.
PhylomeDBiP42228.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42228-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIET QDWEVASNNE
60 70 80 90 100
TMATILLQNL LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH
110 120 130 140 150
VAVVISNCLR EERRILAAAN MPIQGPLEKS LQSSSVSERQ RNVEHKVSAI
160 170 180 190 200
KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT MDQGDKNSIL VNQEVLTLLQ
210 220 230 240 250
EMLNSLDFKR KEALSKMTQI VNETDLLMNS MLLEELQDWK KRQQIACIGG
260 270 280 290 300
PLHNGLDQLQ NCFTLLAESL FQLRQQLEKL QEQSTKMTYE GDPIPAQRAH
310 320 330 340 350
LLERATFLIY NLFKNSFVVE RQPCMPTHPQ RPMVLKTLIQ FTVKLRLLIK
360 370 380 390 400
LPELNYQVKV KASIDKNVST LSNRRFVLCG THVKAMSSEE SSNGSLSVEF
410 420 430 440 450
RHLQPKEMKC STGSKGNEGC HMVTEELHSI TFETQICLYG LTINLETSSL
460 470 480 490 500
PVVMISNVSQ LPNAWASIIW YNVSTNDSQN LVFFNNPPSV TLGQLLEVMS
510 520 530 540 550
WQFSSYVGRG LNSEQLNMLA EKLTVQSNYN DGHLTWAKFC KEHLPGKTFT
560 570 580 590 600
FWTWLEAILD LIKKHILPLW IDGYIMGFVS KEKERLLLKD KMPGTFLLRF
610 620 630 640 650
SESHLGGITF TWVDQSENGE VRFHSVEPYN KGRLSALAFA DILRDYKVIM
660 670 680 690 700
AENIPENPLK YLYPDIPKDK AFGKHYSSQP CEVSRPTERG DKGYVPSVFI
710 720 730 740
PISTIRSDST EPQSPSDLLP MSPSAYAVLR ENLSPTTIET AMNSPYSAE
Length:749
Mass (Da):85,941
Last modified:November 1, 1995 - v1
Checksum:iA88B837E49FCFEBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991Missing in AAA19692. (PubMed:8007943)Curated
Sequence conflicti638 – 6381A → P in AAA19692. (PubMed:8007943)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06923 mRNA. Translation: AAA19453.1.
U09351 mRNA. Translation: AAA19692.1.
PIRiA56047.
RefSeqiNP_035617.1. NM_011487.4.
UniGeneiMm.1550.

Genome annotation databases

GeneIDi20849.
KEGGimmu:20849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06923 mRNA. Translation: AAA19453.1 .
U09351 mRNA. Translation: AAA19692.1 .
PIRi A56047.
RefSeqi NP_035617.1. NM_011487.4.
UniGenei Mm.1550.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BGF X-ray 1.45 A 2-123 [» ]
ProteinModelPortali P42228.
SMRi P42228. Positions 2-703.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203524. 1 interaction.
DIPi DIP-1170N.
IntActi P42228. 1 interaction.

PTM databases

PhosphoSitei P42228.

Proteomic databases

PaxDbi P42228.
PRIDEi P42228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20849.
KEGGi mmu:20849.

Organism-specific databases

CTDi 6775.
MGIi MGI:103062. Stat4.

Phylogenomic databases

eggNOGi NOG267627.
HOGENOMi HOG000220792.
HOVERGENi HBG055669.
InParanoidi P42228.
KOi K11222.
PhylomeDBi P42228.

Miscellaneous databases

EvolutionaryTracei P42228.
NextBioi 299631.
PROi P42228.
SOURCEi Search...

Gene expression databases

Genevestigatori P42228.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stat3 and Stat4: members of the family of signal transducers and activators of transcription."
    Zhong Z., Wen Z., Darnell J.E. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 91:4806-4810(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation."
    Yamamoto K., Quelle F.W., Thierfelder W.E., Kreider B.L., Gilbert D.J., Jenkins N.A., Copeland N.G., Silvennoinen O., Ihle J.N.
    Mol. Cell. Biol. 14:4342-4349(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Testis.
  3. Cited for: INTERACTION WITH ARL2BP.
  4. "Structure of the amino-terminal protein interaction domain of STAT-4."
    Vinkemeier U., Moarefi I., Darnell J.E. Jr., Kuriyan J.
    Science 279:1048-1052(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 1-123.

Entry informationi

Entry nameiSTAT4_MOUSE
AccessioniPrimary (citable) accession number: P42228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3