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P42227

- STAT3_MOUSE

UniProt

P42227 - STAT3_MOUSE

Protein

Signal transducer and activator of transcription 3

Gene

Stat3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G.3 Publications

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: MGI
    3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    4. protein binding Source: UniProtKB
    5. protein dimerization activity Source: MGI
    6. protein kinase binding Source: UniProtKB
    7. sequence-specific DNA binding Source: MGI
    8. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    9. signal transducer activity Source: InterPro
    10. transcription factor binding Source: UniProtKB
    11. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. astrocyte differentiation Source: UniProtKB
    3. cell proliferation Source: MGI
    4. cytokine-mediated signaling pathway Source: UniProtKB
    5. eating behavior Source: MGI
    6. eye photoreceptor cell differentiation Source: MGI
    7. glucose homeostasis Source: MGI
    8. interleukin-6-mediated signaling pathway Source: UniProtKB
    9. JAK-STAT cascade Source: UniProtKB
    10. JAK-STAT cascade involved in growth hormone signaling pathway Source: BHF-UCL
    11. negative regulation of cell death Source: Ensembl
    12. negative regulation of cell proliferation Source: MGI
    13. negative regulation of glycolytic process Source: MGI
    14. negative regulation of neuron migration Source: MGI
    15. phosphorylation Source: UniProtKB
    16. positive regulation of Notch signaling pathway Source: UniProtKB
    17. positive regulation of transcription, DNA-templated Source: UniProtKB
    18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    19. protein import into nucleus Source: UniProtKB
    20. radial glial cell differentiation Source: UniProtKB
    21. regulation of multicellular organism growth Source: MGI
    22. regulation of transcription, DNA-templated Source: UniProtKB
    23. response to drug Source: Ensembl
    24. response to estradiol Source: Ensembl
    25. response to ethanol Source: Ensembl
    26. sexual reproduction Source: MGI
    27. stem cell maintenance Source: MGI
    28. temperature homeostasis Source: MGI
    29. transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Acute phase, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_169390. Signaling by Leptin.
    REACT_188529. Signaling by Leptin.
    REACT_188578. Signaling by SCF-KIT.
    REACT_196460. Signaling by FGFR1 fusion mutants.
    REACT_198614. Growth hormone receptor signaling.
    REACT_199118. Interleukin-6 signaling.
    REACT_212952. Signalling to STAT3.
    REACT_216222. Transcriptional regulation of pluripotent stem cells.
    REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 3
    Alternative name(s):
    Acute-phase response factor
    Gene namesi
    Name:Stat3
    Synonyms:Aprf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:103038. Stat3.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 By similarity. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi77 – 771V → A: No effect on nuclear import; when associated with A-78 and W-174. 2 Publications
    Mutagenesisi78 – 781L → A: No effect on nuclear import; when associated with A-77 and W-174. 2 Publications
    Mutagenesisi174 – 1741F → W: No effect on nuclear import; when associated with A-77 and A-78. 2 Publications
    Mutagenesisi609 – 6091R → A: Nuclear localization to the same extent as wild-type; when associated with F-705. 2 Publications
    Mutagenesisi705 – 7051Y → F: Nuclear localization to the same extent as wild-type; when associated with A-609. 2 Publications
    Mutagenesisi727 – 7271S → A: Decreased transcriptional activation. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 770769Signal transducer and activator of transcription 3PRO_0000182418Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei705 – 7051Phosphotyrosine; by FER and PTK63 Publications
    Modified residuei727 – 7271Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCE4 Publications

    Post-translational modificationi

    Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1 By similarity. Upon UV-A treatment, phosphorylated on Ser-727 by RPS6KA5 By similarity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling By similarity. Phosphoryation at Tyr-705 by FER or PTK6 leads to an increase of its transcriptional activity.By similarity9 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP42227.
    PaxDbiP42227.
    PRIDEiP42227.

    PTM databases

    PhosphoSiteiP42227.

    Expressioni

    Tissue specificityi

    STAT3A is seen in the liver, spleen, and kidney. STAT3B is also detected in the liver, although in a much less abundant manner. Expressed in the lung and an increase in expression levels seen during methicillin-resistant S.aureus infection.1 Publication

    Gene expression databases

    ArrayExpressiP42227.
    BgeeiP42227.
    GenevestigatoriP42227.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import. Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation. Interacts with ARL2BP; interaction is enhanced with ARL2. Binds to CDK9 when activated and nuclear By similarity. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression. Interacts with NEK6. Interacts with BMX By similarity. Interacts with ZIPK/DAPK3 By similarity. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the 'Lys-129' acetylated form of BIRC5/survivin By similarity. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Bank1Q80VH04EBI-602878,EBI-646949
    Cdk6Q642613EBI-602878,EBI-847380
    ECHS1P300843EBI-602878,EBI-719602From a different organism.
    Erbb2P704244EBI-602878,EBI-2945468
    GADD45GIP1Q8TAE83EBI-602878,EBI-372506From a different organism.
    Hax1O3538711EBI-602878,EBI-642449
    IL6STP401896EBI-602878,EBI-1030834From a different organism.
    PgrQ001754EBI-602878,EBI-346821

    Protein-protein interaction databases

    BioGridi203523. 23 interactions.
    DIPiDIP-442N.
    IntActiP42227. 22 interactions.
    MINTiMINT-4135802.

    Structurei

    Secondary structure

    1
    770
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi139 – 18042
    Helixi199 – 23739
    Helixi239 – 25113
    Helixi261 – 29030
    Turni297 – 3015
    Helixi302 – 32019
    Beta strandi321 – 3288
    Beta strandi338 – 3403
    Beta strandi345 – 3539
    Helixi356 – 3583
    Turni359 – 3613
    Beta strandi363 – 3697
    Helixi371 – 3733
    Beta strandi375 – 3773
    Beta strandi384 – 3885
    Beta strandi391 – 3933
    Helixi400 – 4023
    Beta strandi404 – 41512
    Beta strandi418 – 4203
    Helixi426 – 4283
    Helixi432 – 4343
    Beta strandi439 – 4479
    Beta strandi450 – 4578
    Beta strandi461 – 4666
    Helixi467 – 4693
    Helixi470 – 48314
    Helixi492 – 4943
    Helixi501 – 51515
    Helixi522 – 53312
    Helixi546 – 5494
    Beta strandi557 – 5593
    Helixi561 – 57414
    Beta strandi575 – 5773
    Helixi578 – 5814
    Helixi593 – 5953
    Turni596 – 6005
    Beta strandi608 – 6103
    Beta strandi619 – 6213
    Beta strandi626 – 6283
    Helixi642 – 6454
    Helixi650 – 6534
    Beta strandi664 – 6663
    Beta strandi671 – 6733
    Turni674 – 6763
    Turni679 – 6835
    Helixi684 – 6863

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BG1X-ray2.25A127-723[»]
    3CWGX-ray3.05A/B127-688[»]
    4E68X-ray2.58A127-723[»]
    ProteinModelPortaliP42227.
    SMRiP42227. Positions 2-715.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42227.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini580 – 67091SH2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi150 – 16213Essential for nuclear importAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG303257.
    GeneTreeiENSGT00750000117596.
    HOGENOMiHOG000220792.
    HOVERGENiHBG055669.
    InParanoidiA2A5D1.
    KOiK04692.
    OMAiNKESHAT.
    OrthoDBiEOG73JKTT.
    PhylomeDBiP42227.
    TreeFamiTF318648.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Stat3A (identifier: P42227-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE    50
    SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 100
    IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 150
    VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 200
    QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 250
    CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 300
    HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 350
    LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 400
    NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 450
    KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 500
    WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 550
    KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 600
    KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 650
    AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 700
    SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG 750
    QFESLTFDMD LTSECATSPM 770
    Length:770
    Mass (Da):88,054
    Last modified:October 1, 1996 - v2
    Checksum:i6C00626711C8012D
    GO
    Isoform Stat3B (identifier: P42227-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         716-770: TTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM → FIDAVWK

    Show »
    Length:722
    Mass (Da):83,126
    Checksum:i09226A697966D947
    GO
    Isoform Del-701 (identifier: P42227-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         701-701: Missing.

    Show »
    Length:769
    Mass (Da):87,967
    Checksum:iA374A26FB9D28077
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161E → K in AAA19452. (PubMed:7523373)Curated
    Sequence conflicti25 – 251S → T in AAA19452. (PubMed:7523373)Curated
    Sequence conflicti25 – 251S → T in AAC52612. (PubMed:7568080)Curated
    Sequence conflicti394 – 3941M → I in AAA37254. (PubMed:7512451)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei701 – 7011Missing in isoform Del-701. 1 PublicationVSP_010475
    Alternative sequencei716 – 77055TTCSN…ATSPM → FIDAVWK in isoform Stat3B. 1 PublicationVSP_006287Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29278 mRNA. Translation: AAA37254.1.
    U08378 mRNA. Translation: AAA56668.1.
    U06922 mRNA. Translation: AAA19452.1.
    U30709 mRNA. Translation: AAC52612.1.
    AF246978 Genomic DNA. Translation: AAL59017.1.
    AY299489 mRNA. Translation: AAQ75418.1.
    AY299490 mRNA. Translation: AAQ75419.1.
    AL591466 Genomic DNA. Translation: CAM19461.1.
    AL591466 Genomic DNA. Translation: CAX15620.1.
    BC003806 mRNA. Translation: AAH03806.1.
    CCDSiCCDS25440.1. [P42227-1]
    CCDS25441.1. [P42227-2]
    CCDS48934.1. [P42227-3]
    PIRiI49508.
    RefSeqiNP_035616.1. NM_011486.4. [P42227-2]
    NP_998824.1. NM_213659.2. [P42227-1]
    NP_998825.1. NM_213660.2. [P42227-3]
    UniGeneiMm.249934.

    Genome annotation databases

    EnsembliENSMUST00000092671; ENSMUSP00000090342; ENSMUSG00000004040. [P42227-3]
    ENSMUST00000103114; ENSMUSP00000099403; ENSMUSG00000004040. [P42227-2]
    ENSMUST00000127638; ENSMUSP00000120152; ENSMUSG00000004040. [P42227-1]
    GeneIDi20848.
    KEGGimmu:20848.
    UCSCiuc007lmp.1. mouse. [P42227-1]
    uc007lmq.1. mouse. [P42227-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29278 mRNA. Translation: AAA37254.1 .
    U08378 mRNA. Translation: AAA56668.1 .
    U06922 mRNA. Translation: AAA19452.1 .
    U30709 mRNA. Translation: AAC52612.1 .
    AF246978 Genomic DNA. Translation: AAL59017.1 .
    AY299489 mRNA. Translation: AAQ75418.1 .
    AY299490 mRNA. Translation: AAQ75419.1 .
    AL591466 Genomic DNA. Translation: CAM19461.1 .
    AL591466 Genomic DNA. Translation: CAX15620.1 .
    BC003806 mRNA. Translation: AAH03806.1 .
    CCDSi CCDS25440.1. [P42227-1 ]
    CCDS25441.1. [P42227-2 ]
    CCDS48934.1. [P42227-3 ]
    PIRi I49508.
    RefSeqi NP_035616.1. NM_011486.4. [P42227-2 ]
    NP_998824.1. NM_213659.2. [P42227-1 ]
    NP_998825.1. NM_213660.2. [P42227-3 ]
    UniGenei Mm.249934.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BG1 X-ray 2.25 A 127-723 [» ]
    3CWG X-ray 3.05 A/B 127-688 [» ]
    4E68 X-ray 2.58 A 127-723 [» ]
    ProteinModelPortali P42227.
    SMRi P42227. Positions 2-715.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203523. 23 interactions.
    DIPi DIP-442N.
    IntActi P42227. 22 interactions.
    MINTi MINT-4135802.

    Chemistry

    BindingDBi P42227.
    ChEMBLi CHEMBL5402.

    PTM databases

    PhosphoSitei P42227.

    Proteomic databases

    MaxQBi P42227.
    PaxDbi P42227.
    PRIDEi P42227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092671 ; ENSMUSP00000090342 ; ENSMUSG00000004040 . [P42227-3 ]
    ENSMUST00000103114 ; ENSMUSP00000099403 ; ENSMUSG00000004040 . [P42227-2 ]
    ENSMUST00000127638 ; ENSMUSP00000120152 ; ENSMUSG00000004040 . [P42227-1 ]
    GeneIDi 20848.
    KEGGi mmu:20848.
    UCSCi uc007lmp.1. mouse. [P42227-1 ]
    uc007lmq.1. mouse. [P42227-3 ]

    Organism-specific databases

    CTDi 6774.
    MGIi MGI:103038. Stat3.

    Phylogenomic databases

    eggNOGi NOG303257.
    GeneTreei ENSGT00750000117596.
    HOGENOMi HOG000220792.
    HOVERGENi HBG055669.
    InParanoidi A2A5D1.
    KOi K04692.
    OMAi NKESHAT.
    OrthoDBi EOG73JKTT.
    PhylomeDBi P42227.
    TreeFami TF318648.

    Enzyme and pathway databases

    Reactomei REACT_169390. Signaling by Leptin.
    REACT_188529. Signaling by Leptin.
    REACT_188578. Signaling by SCF-KIT.
    REACT_196460. Signaling by FGFR1 fusion mutants.
    REACT_198614. Growth hormone receptor signaling.
    REACT_199118. Interleukin-6 signaling.
    REACT_212952. Signalling to STAT3.
    REACT_216222. Transcriptional regulation of pluripotent stem cells.
    REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

    Miscellaneous databases

    ChiTaRSi STAT3. mouse.
    EvolutionaryTracei P42227.
    NextBioi 299623.
    PROi P42227.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42227.
    Bgeei P42227.
    Genevestigatori P42227.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway."
      Akira S., Nishio Y., Inoue M., Wang X.-J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T.
      Cell 77:63-71(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3A), PROTEIN SEQUENCE OF 154-158; 181-185 AND 632-640.
      Strain: BALB/c.
      Tissue: Liver.
    2. "Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors."
      Raz R., Durbin J.E., Levy D.E.
      J. Biol. Chem. 269:24391-24395(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DEL-701).
      Tissue: Brain.
    3. "Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6."
      Zhong Z., Wen Z., Darnell J.E. Jr.
      Science 264:95-98(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3A).
      Tissue: Thymus.
    4. "Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3."
      Schaefer T.S., Sanders L.K., Nathans D.
      Proc. Natl. Acad. Sci. U.S.A. 92:9097-9101(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3B).
      Strain: BALB/c and C57BL/6.
      Tissue: Liver.
    5. "Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse."
      Miyoshi K., Cui Y., Riedlinger G., Robinson P., Lehoczky J., Zon L., Oka T., Dewar K., Hennighausen L.
      Genomics 71:150-155(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM STAT3A).
      Strain: 129/SvJ.
    6. "A mutant Stat5b with weaker DNA binding defines a key defective pathway in non-obese diabetic (NOD) mice."
      Davoodi-Semiromi A., She J.-X.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3A).
      Strain: C57BL/6J and NOD/LtJ.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM STAT3A).
      Strain: FVB/N.
      Tissue: Mammary gland.
    9. "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation."
      Wen Z., Zhong Z., Darnell J.E. Jr.
      Cell 82:241-250(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-727, MUTAGENESIS.
    10. "Specific inhibition of Stat3 signal transduction by PIAS3."
      Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K.
      Science 278:1803-1805(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PIAS3.
      Tissue: Thymus.
    11. Cited for: PHOSPHORYLATION BY FER, INTERACTION WITH FER.
    12. "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction."
      Collum R.G., Brutsaert S., Lee G., Schindler C.
      Proc. Natl. Acad. Sci. U.S.A. 97:10120-10125(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STATIP1.
    13. "MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells."
      Zhang Y., Liu G., Dong Z.
      J. Biol. Chem. 276:42534-42542(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-705 AND SER-727.
    14. "Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation."
      Hart K.C., Robertson S.C., Donoghue D.J.
      Mol. Biol. Cell 12:931-942(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT TYR-705.
    15. "Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction."
      Ohkawara B., Shirakabe K., Hyodo-Miura J., Matsuo R., Ueno N., Matsumoto K., Shibuya H.
      Genes Dev. 18:381-386(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NLK, PHOSPHORYLATION AT SER-727, MUTAGENESIS OF SER-727.
    16. "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3."
      Liu L., McBride K.M., Reich N.C.
      Proc. Natl. Acad. Sci. U.S.A. 102:8150-8155(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF VAL-77; LEU-78; PHE-174; ARG-609 AND TYR-705, INTERACTION WITH KPNA4 AND KPNA5, NUCLEAR IMPORT MOTIF.
    17. "SIPAR interacts with STAT3 to regulate its signal pathway."
      Ning H., Rong Y., Zhang Y., Chang Z.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 32:173-179(2005)
      Cited for: INTERACTION WITH SIPAR.
      Strain: Swiss Webster / NIH.
    18. "Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin."
      Ng D.C., Lin B.H., Lim C.P., Huang G., Zhang T., Poli V., Cao X.
      J. Cell Biol. 172:245-257(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STMN3.
    19. Cited for: INTERACTION WITH ARL2BP.
    20. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    21. "Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells."
      Jeon Y.J., Lee K.Y., Cho Y.Y., Pugliese A., Kim H.G., Jeong C.H., Bode A.M., Dong Z.
      J. Biol. Chem. 285:28126-28133(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-727, INTERACTION WITH NEK6.
    22. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
      Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.
      J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION IN RESPONSE TO KIT SIGNALING.
    23. Cited for: FUNCTION.
    24. "Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia."
      Choi S.M., McAleer J.P., Zheng M., Pociask D.A., Kaplan M.H., Qin S., Reinhart T.A., Kolls J.K.
      J. Exp. Med. 210:551-561(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.
    25. "Three-dimensional structure of the Stat3beta homodimer bound to DNA."
      Becker S., Groner B., Mueller C.W.
      Nature 394:145-151(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 136-716.

    Entry informationi

    Entry nameiSTAT3_MOUSE
    AccessioniPrimary (citable) accession number: P42227
    Secondary accession number(s): A2A5D1, B7ZC17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 167 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Involved in the gp130-mediated signaling pathway.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3