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P42227

- STAT3_MOUSE

UniProt

P42227 - STAT3_MOUSE

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Protein

Signal transducer and activator of transcription 3

Gene

Stat3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G.3 Publications

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. DNA binding Source: MGI
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  4. protein dimerization activity Source: MGI
  5. protein kinase binding Source: UniProtKB
  6. sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  8. signal transducer activity Source: InterPro
  9. transcription factor binding Source: UniProtKB
  10. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. astrocyte differentiation Source: UniProtKB
  3. cell proliferation Source: MGI
  4. cytokine-mediated signaling pathway Source: UniProtKB
  5. eating behavior Source: MGI
  6. eye photoreceptor cell differentiation Source: MGI
  7. glucose homeostasis Source: MGI
  8. interleukin-6-mediated signaling pathway Source: UniProtKB
  9. JAK-STAT cascade Source: UniProtKB
  10. JAK-STAT cascade involved in growth hormone signaling pathway Source: BHF-UCL
  11. negative regulation of cell death Source: Ensembl
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of glycolytic process Source: MGI
  14. negative regulation of neuron migration Source: MGI
  15. phosphorylation Source: UniProtKB
  16. positive regulation of Notch signaling pathway Source: UniProtKB
  17. positive regulation of transcription, DNA-templated Source: UniProtKB
  18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  19. protein import into nucleus Source: UniProtKB
  20. radial glial cell differentiation Source: UniProtKB
  21. regulation of multicellular organism growth Source: MGI
  22. regulation of transcription, DNA-templated Source: UniProtKB
  23. response to drug Source: Ensembl
  24. response to estradiol Source: Ensembl
  25. response to ethanol Source: Ensembl
  26. sexual reproduction Source: MGI
  27. stem cell maintenance Source: MGI
  28. temperature homeostasis Source: MGI
  29. transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Acute phase, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_169390. Signaling by Leptin.
REACT_188529. Signaling by Leptin.
REACT_188578. Signaling by SCF-KIT.
REACT_196460. Signaling by FGFR1 fusion mutants.
REACT_198614. Growth hormone receptor signaling.
REACT_199118. Interleukin-6 signaling.
REACT_212952. Signalling to STAT3.
REACT_216222. Transcriptional regulation of pluripotent stem cells.
REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 3
Alternative name(s):
Acute-phase response factor
Gene namesi
Name:Stat3
Synonyms:Aprf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:103038. Stat3.

Subcellular locationi

Cytoplasm. Nucleus
Note: Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 By similarity. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi77 – 771V → A: No effect on nuclear import; when associated with A-78 and W-174. 1 Publication
Mutagenesisi78 – 781L → A: No effect on nuclear import; when associated with A-77 and W-174. 1 Publication
Mutagenesisi174 – 1741F → W: No effect on nuclear import; when associated with A-77 and A-78. 1 Publication
Mutagenesisi609 – 6091R → A: Nuclear localization to the same extent as wild-type; when associated with F-705. 1 Publication
Mutagenesisi705 – 7051Y → F: Nuclear localization to the same extent as wild-type; when associated with A-609. 1 Publication
Mutagenesisi727 – 7271S → A: Decreased transcriptional activation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 770769Signal transducer and activator of transcription 3PRO_0000182418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei705 – 7051Phosphotyrosine; by FER and PTK63 Publications
Modified residuei727 – 7271Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCE4 Publications

Post-translational modificationi

Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1 By similarity. Upon UV-A treatment, phosphorylated on Ser-727 by RPS6KA5 By similarity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling By similarity. Phosphoryation at Tyr-705 by FER or PTK6 leads to an increase of its transcriptional activity.By similarity9 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP42227.
PaxDbiP42227.
PRIDEiP42227.

PTM databases

PhosphoSiteiP42227.

Expressioni

Tissue specificityi

STAT3A is seen in the liver, spleen, and kidney. STAT3B is also detected in the liver, although in a much less abundant manner. Expressed in the lung and an increase in expression levels seen during methicillin-resistant S.aureus infection.1 Publication

Gene expression databases

BgeeiP42227.
ExpressionAtlasiP42227. baseline and differential.
GenevestigatoriP42227.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import. Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation. Interacts with ARL2BP; interaction is enhanced with ARL2. Binds to CDK9 when activated and nuclear By similarity. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression. Interacts with NEK6. Interacts with BMX By similarity. Interacts with ZIPK/DAPK3 By similarity. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the 'Lys-129' acetylated form of BIRC5/survivin By similarity. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Bank1Q80VH04EBI-602878,EBI-646949
Cdk6Q642613EBI-602878,EBI-847380
Dapk3O547848EBI-602878,EBI-77359
ECHS1P300843EBI-602878,EBI-719602From a different organism.
Erbb2P704244EBI-602878,EBI-2945468
GADD45GIP1Q8TAE83EBI-602878,EBI-372506From a different organism.
Hax1O3538711EBI-602878,EBI-642449
IL6STP401896EBI-602878,EBI-1030834From a different organism.
PgrQ001754EBI-602878,EBI-346821

Protein-protein interaction databases

BioGridi203523. 23 interactions.
DIPiDIP-442N.
IntActiP42227. 23 interactions.
MINTiMINT-4135802.

Structurei

Secondary structure

1
770
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi139 – 18042
Helixi199 – 23739
Helixi239 – 25113
Helixi261 – 29030
Turni297 – 3015
Helixi302 – 32019
Beta strandi321 – 3288
Beta strandi338 – 3403
Beta strandi345 – 3539
Helixi356 – 3583
Turni359 – 3613
Beta strandi363 – 3697
Helixi371 – 3733
Beta strandi375 – 3773
Beta strandi384 – 3885
Beta strandi391 – 3933
Helixi400 – 4023
Beta strandi404 – 41512
Beta strandi418 – 4203
Helixi426 – 4283
Helixi432 – 4343
Beta strandi439 – 4479
Beta strandi450 – 4578
Beta strandi461 – 4666
Helixi467 – 4693
Helixi470 – 48314
Helixi492 – 4943
Helixi501 – 51515
Helixi522 – 53312
Helixi546 – 5494
Beta strandi557 – 5593
Helixi561 – 57414
Beta strandi575 – 5773
Helixi578 – 5814
Helixi593 – 5953
Turni596 – 6005
Beta strandi608 – 6103
Beta strandi619 – 6213
Beta strandi626 – 6283
Helixi642 – 6454
Helixi650 – 6534
Beta strandi664 – 6663
Beta strandi671 – 6733
Turni674 – 6763
Turni679 – 6835
Helixi684 – 6863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BG1X-ray2.25A127-723[»]
3CWGX-ray3.05A/B127-688[»]
4E68X-ray2.58A127-723[»]
ProteinModelPortaliP42227.
SMRiP42227. Positions 2-715.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42227.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini580 – 67091SH2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi150 – 16213Essential for nuclear importAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG303257.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
InParanoidiP42227.
KOiK04692.
OMAiNKESHAT.
OrthoDBiEOG73JKTT.
PhylomeDBiP42227.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Stat3A (identifier: P42227-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL
460 470 480 490 500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT
510 520 530 540 550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC
560 570 580 590 600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF
660 670 680 690 700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG
710 720 730 740 750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG
760 770
QFESLTFDMD LTSECATSPM
Length:770
Mass (Da):88,054
Last modified:October 1, 1996 - v2
Checksum:i6C00626711C8012D
GO
Isoform Stat3B (identifier: P42227-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-770: TTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM → FIDAVWK

Show »
Length:722
Mass (Da):83,126
Checksum:i09226A697966D947
GO
Isoform Del-701 (identifier: P42227-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: Missing.

Show »
Length:769
Mass (Da):87,967
Checksum:iA374A26FB9D28077
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161E → K in AAA19452. (PubMed:7523373)Curated
Sequence conflicti25 – 251S → T in AAA19452. (PubMed:7523373)Curated
Sequence conflicti25 – 251S → T in AAC52612. (PubMed:7568080)Curated
Sequence conflicti394 – 3941M → I in AAA37254. (PubMed:7512451)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei701 – 7011Missing in isoform Del-701. 1 PublicationVSP_010475
Alternative sequencei716 – 77055TTCSN…ATSPM → FIDAVWK in isoform Stat3B. 1 PublicationVSP_006287Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29278 mRNA. Translation: AAA37254.1.
U08378 mRNA. Translation: AAA56668.1.
U06922 mRNA. Translation: AAA19452.1.
U30709 mRNA. Translation: AAC52612.1.
AF246978 Genomic DNA. Translation: AAL59017.1.
AY299489 mRNA. Translation: AAQ75418.1.
AY299490 mRNA. Translation: AAQ75419.1.
AL591466 Genomic DNA. Translation: CAM19461.1.
AL591466 Genomic DNA. Translation: CAX15620.1.
BC003806 mRNA. Translation: AAH03806.1.
CCDSiCCDS25440.1. [P42227-1]
CCDS25441.1. [P42227-2]
CCDS48934.1. [P42227-3]
PIRiI49508.
RefSeqiNP_035616.1. NM_011486.4. [P42227-2]
NP_998824.1. NM_213659.2. [P42227-1]
NP_998825.1. NM_213660.2. [P42227-3]
UniGeneiMm.249934.

Genome annotation databases

EnsembliENSMUST00000092671; ENSMUSP00000090342; ENSMUSG00000004040. [P42227-3]
ENSMUST00000103114; ENSMUSP00000099403; ENSMUSG00000004040. [P42227-2]
ENSMUST00000127638; ENSMUSP00000120152; ENSMUSG00000004040. [P42227-1]
GeneIDi20848.
KEGGimmu:20848.
UCSCiuc007lmp.1. mouse. [P42227-1]
uc007lmq.1. mouse. [P42227-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29278 mRNA. Translation: AAA37254.1 .
U08378 mRNA. Translation: AAA56668.1 .
U06922 mRNA. Translation: AAA19452.1 .
U30709 mRNA. Translation: AAC52612.1 .
AF246978 Genomic DNA. Translation: AAL59017.1 .
AY299489 mRNA. Translation: AAQ75418.1 .
AY299490 mRNA. Translation: AAQ75419.1 .
AL591466 Genomic DNA. Translation: CAM19461.1 .
AL591466 Genomic DNA. Translation: CAX15620.1 .
BC003806 mRNA. Translation: AAH03806.1 .
CCDSi CCDS25440.1. [P42227-1 ]
CCDS25441.1. [P42227-2 ]
CCDS48934.1. [P42227-3 ]
PIRi I49508.
RefSeqi NP_035616.1. NM_011486.4. [P42227-2 ]
NP_998824.1. NM_213659.2. [P42227-1 ]
NP_998825.1. NM_213660.2. [P42227-3 ]
UniGenei Mm.249934.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BG1 X-ray 2.25 A 127-723 [» ]
3CWG X-ray 3.05 A/B 127-688 [» ]
4E68 X-ray 2.58 A 127-723 [» ]
ProteinModelPortali P42227.
SMRi P42227. Positions 2-715.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203523. 23 interactions.
DIPi DIP-442N.
IntActi P42227. 23 interactions.
MINTi MINT-4135802.

Chemistry

BindingDBi P42227.
ChEMBLi CHEMBL5402.

PTM databases

PhosphoSitei P42227.

Proteomic databases

MaxQBi P42227.
PaxDbi P42227.
PRIDEi P42227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092671 ; ENSMUSP00000090342 ; ENSMUSG00000004040 . [P42227-3 ]
ENSMUST00000103114 ; ENSMUSP00000099403 ; ENSMUSG00000004040 . [P42227-2 ]
ENSMUST00000127638 ; ENSMUSP00000120152 ; ENSMUSG00000004040 . [P42227-1 ]
GeneIDi 20848.
KEGGi mmu:20848.
UCSCi uc007lmp.1. mouse. [P42227-1 ]
uc007lmq.1. mouse. [P42227-3 ]

Organism-specific databases

CTDi 6774.
MGIi MGI:103038. Stat3.

Phylogenomic databases

eggNOGi NOG303257.
GeneTreei ENSGT00760000119236.
HOGENOMi HOG000220792.
HOVERGENi HBG055669.
InParanoidi P42227.
KOi K04692.
OMAi NKESHAT.
OrthoDBi EOG73JKTT.
PhylomeDBi P42227.
TreeFami TF318648.

Enzyme and pathway databases

Reactomei REACT_169390. Signaling by Leptin.
REACT_188529. Signaling by Leptin.
REACT_188578. Signaling by SCF-KIT.
REACT_196460. Signaling by FGFR1 fusion mutants.
REACT_198614. Growth hormone receptor signaling.
REACT_199118. Interleukin-6 signaling.
REACT_212952. Signalling to STAT3.
REACT_216222. Transcriptional regulation of pluripotent stem cells.
REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

ChiTaRSi STAT3. mouse.
EvolutionaryTracei P42227.
NextBioi 299623.
PROi P42227.
SOURCEi Search...

Gene expression databases

Bgeei P42227.
ExpressionAtlasi P42227. baseline and differential.
Genevestigatori P42227.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway."
    Akira S., Nishio Y., Inoue M., Wang X.-J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T.
    Cell 77:63-71(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3A), PROTEIN SEQUENCE OF 154-158; 181-185 AND 632-640.
    Strain: BALB/c.
    Tissue: Liver.
  2. "Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors."
    Raz R., Durbin J.E., Levy D.E.
    J. Biol. Chem. 269:24391-24395(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DEL-701).
    Tissue: Brain.
  3. "Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6."
    Zhong Z., Wen Z., Darnell J.E. Jr.
    Science 264:95-98(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3A).
    Tissue: Thymus.
  4. "Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3."
    Schaefer T.S., Sanders L.K., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 92:9097-9101(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3B).
    Strain: BALB/c and C57BL/6.
    Tissue: Liver.
  5. "Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse."
    Miyoshi K., Cui Y., Riedlinger G., Robinson P., Lehoczky J., Zon L., Oka T., Dewar K., Hennighausen L.
    Genomics 71:150-155(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM STAT3A).
    Strain: 129/SvJ.
  6. "A mutant Stat5b with weaker DNA binding defines a key defective pathway in non-obese diabetic (NOD) mice."
    Davoodi-Semiromi A., She J.-X.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM STAT3A).
    Strain: C57BL/6J and NOD/LtJ.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM STAT3A).
    Strain: FVB/N.
    Tissue: Mammary gland.
  9. "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation."
    Wen Z., Zhong Z., Darnell J.E. Jr.
    Cell 82:241-250(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-727, MUTAGENESIS.
  10. "Specific inhibition of Stat3 signal transduction by PIAS3."
    Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K.
    Science 278:1803-1805(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIAS3.
    Tissue: Thymus.
  11. Cited for: PHOSPHORYLATION BY FER, INTERACTION WITH FER.
  12. "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction."
    Collum R.G., Brutsaert S., Lee G., Schindler C.
    Proc. Natl. Acad. Sci. U.S.A. 97:10120-10125(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STATIP1.
  13. "MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells."
    Zhang Y., Liu G., Dong Z.
    J. Biol. Chem. 276:42534-42542(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-705 AND SER-727.
  14. "Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation."
    Hart K.C., Robertson S.C., Donoghue D.J.
    Mol. Biol. Cell 12:931-942(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT TYR-705.
  15. "Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction."
    Ohkawara B., Shirakabe K., Hyodo-Miura J., Matsuo R., Ueno N., Matsumoto K., Shibuya H.
    Genes Dev. 18:381-386(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NLK, PHOSPHORYLATION AT SER-727, MUTAGENESIS OF SER-727.
  16. "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3."
    Liu L., McBride K.M., Reich N.C.
    Proc. Natl. Acad. Sci. U.S.A. 102:8150-8155(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF VAL-77; LEU-78; PHE-174; ARG-609 AND TYR-705, INTERACTION WITH KPNA4 AND KPNA5, NUCLEAR IMPORT MOTIF.
  17. "SIPAR interacts with STAT3 to regulate its signal pathway."
    Ning H., Rong Y., Zhang Y., Chang Z.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 32:173-179(2005)
    Cited for: INTERACTION WITH SIPAR.
    Strain: Swiss Webster / NIH.
  18. "Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin."
    Ng D.C., Lin B.H., Lim C.P., Huang G., Zhang T., Poli V., Cao X.
    J. Cell Biol. 172:245-257(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STMN3.
  19. Cited for: INTERACTION WITH ARL2BP.
  20. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  21. "Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells."
    Jeon Y.J., Lee K.Y., Cho Y.Y., Pugliese A., Kim H.G., Jeong C.H., Bode A.M., Dong Z.
    J. Biol. Chem. 285:28126-28133(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-727, INTERACTION WITH NEK6.
  22. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
    Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.
    J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION IN RESPONSE TO KIT SIGNALING.
  23. Cited for: FUNCTION.
  24. "Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia."
    Choi S.M., McAleer J.P., Zheng M., Pociask D.A., Kaplan M.H., Qin S., Reinhart T.A., Kolls J.K.
    J. Exp. Med. 210:551-561(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.
  25. "Three-dimensional structure of the Stat3beta homodimer bound to DNA."
    Becker S., Groner B., Mueller C.W.
    Nature 394:145-151(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 136-716.

Entry informationi

Entry nameiSTAT3_MOUSE
AccessioniPrimary (citable) accession number: P42227
Secondary accession number(s): A2A5D1, B7ZC17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Involved in the gp130-mediated signaling pathway.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3