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P42226

- STAT6_HUMAN

UniProt

P42226 - STAT6_HUMAN

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Protein

Signal transducer and activator of transcription 6

Gene

STAT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. identical protein binding Source: IntAct
  3. protein phosphatase binding Source: UniProtKB
  4. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: ProtInc
  6. signal transducer activity Source: InterPro

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: Ensembl
  2. cellular response to reactive nitrogen species Source: Ensembl
  3. innate immune response Source: Reactome
  4. interleukin-4-mediated signaling pathway Source: UniProtKB
  5. mammary gland epithelial cell proliferation Source: Ensembl
  6. mammary gland morphogenesis Source: Ensembl
  7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. negative regulation of type 2 immune response Source: Ensembl
  9. positive regulation of isotype switching to IgE isotypes Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. positive regulation of type I interferon production Source: Reactome
  12. regulation of cell proliferation Source: Ensembl
  13. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  14. signal transduction Source: ProtInc
  15. T-helper 1 cell lineage commitment Source: Ensembl
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_163734. STAT6-mediated induction of chemokines.
REACT_17025. Downstream signal transduction.
SignaLinkiP42226.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 6
Alternative name(s):
IL-4 Stat
Gene namesi
Name:STAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:11368. STAT6.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocated into the nucleus in response to phosphorylation.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. membrane raft Source: Ensembl
  4. nuclear chromatin Source: Ensembl
  5. nucleoplasm Source: Reactome
  6. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi802 – 8021L → A: Abolishes the interaction with NCOA1; when associated with A-805. 1 Publication
Mutagenesisi805 – 8051L → A: Abolishes the interaction with NCOA1; when associated with A-802. 1 Publication

Organism-specific databases

Orphaneti2126. Solitary fibrous tumor.
PharmGKBiPA339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 847846Signal transducer and activator of transcription 6PRO_0000182433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei641 – 6411Phosphotyrosine; by JAKBy similarity

Post-translational modificationi

Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP42226.
PaxDbiP42226.
PRIDEiP42226.

PTM databases

PhosphoSiteiP42226.

Expressioni

Gene expression databases

BgeeiP42226.
CleanExiHS_STAT6.
ExpressionAtlasiP42226. baseline and differential.
GenevestigatoriP42226.

Organism-specific databases

HPAiHPA001861.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1186478,EBI-1186478
EP300Q094722EBI-1186478,EBI-447295
IL4RP243944EBI-1186478,EBI-367009
TBK1Q9UHD27EBI-1186478,EBI-356402
TMEM173Q86WV612EBI-1186478,EBI-2800345

Protein-protein interaction databases

BioGridi112655. 59 interactions.
IntActiP42226. 32 interactions.
MINTiMINT-8020389.
STRINGi9606.ENSP00000300134.

Structurei

Secondary structure

1
847
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi799 – 8079

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OJ5X-ray2.20B795-808[»]
ProteinModelPortaliP42226.
SMRiP42226. Positions 13-631.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini517 – 632116SH2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi802 – 8065LXXLL motif

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG278979.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiP42226.
KOiK11225.
OMAiKFQAGVR.
OrthoDBiEOG73JKTT.
PhylomeDBiP42226.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P42226-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC
60 70 80 90 100
NLASALLSDT VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR
110 120 130 140 150
QILQGEKKAV MEQFRHLPMP FHWKQEELKF KTGLRRLQHR VGEIHLLREA
160 170 180 190 200
LQKGAEAGQV SLHSLIETPA NGTGPSEALA MLLQETTGEL EAAKALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ EVGAAGGELE
260 270 280 290 300
PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR
310 320 330 340 350
FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS
360 370 380 390 400
IPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTNRGLL PEHFLFLAQK IFNDNSLSME AFQHRSVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV
660 670 680 690 700
ERDQPLPTPE LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI
710 720 730 740 750
PPYQGLSPEE SVNVLSAFQE PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ
760 770 780 790 800
EHAVSSPDPL LCSDVTMVED SCLSQPVTAF PQGTWIGEDI FPPLLPPTEQ
810 820 830 840
DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG QSGISMSHMD LRANPSW
Length:847
Mass (Da):94,135
Last modified:November 1, 1995 - v1
Checksum:iF35075F1C1F2A677
GO
Isoform 2 (identifier: P42226-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.
     175-177: PSE → MEQ

Show »
Length:673
Mass (Da):74,456
Checksum:i7A050ADF43A669BB
GO
Isoform 3 (identifier: P42226-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: No experimental confirmation available.

Show »
Length:737
Mass (Da):81,748
Checksum:i8A076ABC6053A831
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491E → Q in AAC67525. (PubMed:9782085)Curated
Sequence conflicti246 – 2461G → D in BAH14513. (PubMed:14702039)Curated
Sequence conflicti733 – 7331S → N in AAC67525. (PubMed:9782085)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811M → R.1 Publication
Corresponds to variant rs3024952 [ dbSNP | Ensembl ].
VAR_013094
Natural varianti419 – 4191D → N.
Corresponds to variant rs11172102 [ dbSNP | Ensembl ].
VAR_059812

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 174174Missing in isoform 2. 1 PublicationVSP_031871Add
BLAST
Alternative sequencei1 – 110110Missing in isoform 3. 1 PublicationVSP_045282Add
BLAST
Alternative sequencei175 – 1773PSE → MEQ in isoform 2. 1 PublicationVSP_031872

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16031 mRNA. Translation: AAA57193.1.
AF067575, AF067572, AF067573 Genomic DNA. Translation: AAC67525.1.
AB103089 mRNA. Translation: BAD89432.1.
AK290431 mRNA. Translation: BAF83120.1.
AK316142 mRNA. Translation: BAH14513.1.
AF417842 Genomic DNA. Translation: AAL06595.1.
AC023237 Genomic DNA. No translation available.
BC075852 mRNA. Translation: AAH75852.1.
CCDSiCCDS53804.1. [P42226-3]
CCDS8931.1. [P42226-1]
PIRiA54740.
RefSeqiNP_001171549.1. NM_001178078.1. [P42226-1]
NP_001171550.1. NM_001178079.1. [P42226-1]
NP_001171551.1. NM_001178080.1. [P42226-3]
NP_003144.3. NM_003153.4. [P42226-1]
XP_006719636.1. XM_006719573.1. [P42226-1]
XP_006719637.1. XM_006719574.1. [P42226-1]
XP_006719638.1. XM_006719575.1. [P42226-1]
UniGeneiHs.524518.

Genome annotation databases

EnsembliENST00000300134; ENSP00000300134; ENSG00000166888. [P42226-1]
ENST00000454075; ENSP00000401486; ENSG00000166888. [P42226-1]
ENST00000537215; ENSP00000444530; ENSG00000166888. [P42226-3]
ENST00000538913; ENSP00000445409; ENSG00000166888. [P42226-3]
ENST00000543873; ENSP00000438451; ENSG00000166888. [P42226-1]
ENST00000556155; ENSP00000451742; ENSG00000166888. [P42226-1]
GeneIDi6778.
KEGGihsa:6778.
UCSCiuc001sna.3. human. [P42226-1]

Polymorphism databases

DMDMi1174459.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16031 mRNA. Translation: AAA57193.1 .
AF067575 , AF067572 , AF067573 Genomic DNA. Translation: AAC67525.1 .
AB103089 mRNA. Translation: BAD89432.1 .
AK290431 mRNA. Translation: BAF83120.1 .
AK316142 mRNA. Translation: BAH14513.1 .
AF417842 Genomic DNA. Translation: AAL06595.1 .
AC023237 Genomic DNA. No translation available.
BC075852 mRNA. Translation: AAH75852.1 .
CCDSi CCDS53804.1. [P42226-3 ]
CCDS8931.1. [P42226-1 ]
PIRi A54740.
RefSeqi NP_001171549.1. NM_001178078.1. [P42226-1 ]
NP_001171550.1. NM_001178079.1. [P42226-1 ]
NP_001171551.1. NM_001178080.1. [P42226-3 ]
NP_003144.3. NM_003153.4. [P42226-1 ]
XP_006719636.1. XM_006719573.1. [P42226-1 ]
XP_006719637.1. XM_006719574.1. [P42226-1 ]
XP_006719638.1. XM_006719575.1. [P42226-1 ]
UniGenei Hs.524518.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OJ5 X-ray 2.20 B 795-808 [» ]
ProteinModelPortali P42226.
SMRi P42226. Positions 13-631.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112655. 59 interactions.
IntActi P42226. 32 interactions.
MINTi MINT-8020389.
STRINGi 9606.ENSP00000300134.

Chemistry

BindingDBi P42226.
ChEMBLi CHEMBL5401.

PTM databases

PhosphoSitei P42226.

Polymorphism databases

DMDMi 1174459.

Proteomic databases

MaxQBi P42226.
PaxDbi P42226.
PRIDEi P42226.

Protocols and materials databases

DNASUi 6778.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300134 ; ENSP00000300134 ; ENSG00000166888 . [P42226-1 ]
ENST00000454075 ; ENSP00000401486 ; ENSG00000166888 . [P42226-1 ]
ENST00000537215 ; ENSP00000444530 ; ENSG00000166888 . [P42226-3 ]
ENST00000538913 ; ENSP00000445409 ; ENSG00000166888 . [P42226-3 ]
ENST00000543873 ; ENSP00000438451 ; ENSG00000166888 . [P42226-1 ]
ENST00000556155 ; ENSP00000451742 ; ENSG00000166888 . [P42226-1 ]
GeneIDi 6778.
KEGGi hsa:6778.
UCSCi uc001sna.3. human. [P42226-1 ]

Organism-specific databases

CTDi 6778.
GeneCardsi GC12M057489.
HGNCi HGNC:11368. STAT6.
HPAi HPA001861.
MIMi 601512. gene.
neXtProti NX_P42226.
Orphaneti 2126. Solitary fibrous tumor.
PharmGKBi PA339.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278979.
GeneTreei ENSGT00760000119236.
HOGENOMi HOG000230988.
HOVERGENi HBG107486.
InParanoidi P42226.
KOi K11225.
OMAi KFQAGVR.
OrthoDBi EOG73JKTT.
PhylomeDBi P42226.
TreeFami TF318648.

Enzyme and pathway databases

Reactomei REACT_163734. STAT6-mediated induction of chemokines.
REACT_17025. Downstream signal transduction.
SignaLinki P42226.

Miscellaneous databases

ChiTaRSi STAT6. human.
EvolutionaryTracei P42226.
GeneWikii STAT6.
GenomeRNAii 6778.
NextBioi 26458.
PROi P42226.
SOURCEi Search...

Gene expression databases

Bgeei P42226.
CleanExi HS_STAT6.
ExpressionAtlasi P42226. baseline and differential.
Genevestigatori P42226.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An interleukin-4-induced transcription factor: IL-4 Stat."
    Hou J., Schindler U., Henzel W.J., Ho T., Brasseur M., McKnight S.L.
    Science 265:1701-1706(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors."
    Patel B.K., Keck C.L., O'Leary R.S., Popescu N.C., LaRochelle W.J.
    Genomics 52:192-200(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "STAT6 mRNA, nirs splice variant 2."
    Tabata Y., Sameshima E., Hayashi A., Iida K., Mitsuyama M., Kanai S., Furuya T., Saito T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Tongue.
  5. SeattleSNPs variation discovery resource
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-181.
  6. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  8. "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1."
    Litterst C.M., Pfitzner E.
    J. Biol. Chem. 277:36052-36060(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCOA1, MUTAGENESIS OF LEU-802 AND LEU-805.
  9. "T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."
    Lu X., Chen J., Sasmono R.T., Hsi E.D., Sarosiek K.A., Tiganis T., Lossos I.S.
    Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN IL4 SIGNALING, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain."
    Razeto A., Ramakrishnan V., Litterst C.M., Giller K., Griesinger C., Carlomagno T., Lakomek N., Heimburg T., Lodrini M., Pfitzner E., Becker S.
    J. Mol. Biol. 336:319-329(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 795-808 IN COMPLEX WITH 257-385 OF NCOA1.

Entry informationi

Entry nameiSTAT6_HUMAN
AccessioniPrimary (citable) accession number: P42226
Secondary accession number(s): A8K316
, B7ZA27, F5GXI9, Q5FBW5, Q71UP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3