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Protein

Septin-1

Gene

Sept1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66GTPBy similarity1
Binding sitei92GTP; via amide nitrogenBy similarity1
Binding sitei229GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei244GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi171 – 179GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic metaphase plate congression Source: MGI
  • spindle assembly involved in female meiosis Source: MGI

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Alternative name(s):
Differentiation protein 6
Short name:
Protein Diff6
Peanut-like protein 3
Gene namesi
Name:Sept1
Synonyms:Diff6, Pnutl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858916. Sept1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • meiotic spindle Source: MGI
  • microtubule organizing center Source: UniProtKB-SubCell
  • midbody Source: MGI

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735141 – 366Septin-1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei250PhosphothreonineCombined sources1
Modified residuei306Phosphoserine; by AURKBBy similarity1
Modified residuei314Phosphoserine; by AURKBBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP42209.
MaxQBiP42209.
PaxDbiP42209.
PeptideAtlasiP42209.
PRIDEiP42209.

2D gel databases

REPRODUCTION-2DPAGEiP42209.

PTM databases

iPTMnetiP42209.
PhosphoSitePlusiP42209.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000486.
CleanExiMM_SEPT1.
ExpressionAtlasiP42209. baseline and differential.
GenevisibleiP42209. MM.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP42209. 1 interactor.
STRINGi10090.ENSMUSP00000101921.

Structurei

3D structure databases

ProteinModelPortaliP42209.
SMRiP42209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 295Septin-type GAdd BLAST274

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00880000137871.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiP42209.
KOiK13737.
OMAiEVENPHH.
OrthoDBiEOG091G07TS.
TreeFamiTF101079.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
InterProiView protein in InterPro
IPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiView protein in Pfam
PF00735. Septin. 1 hit.
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51719. G_SEPTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P42209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPDAS ARTAQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVRFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPRET QALKQKIRDQ LKEEEINIYQ
210 220 230 240 250
FPECDSDEDE EFKKQNEEMK ENIPFAVVGS CEVVRDGTRP VRGRRYSWGT
260 270 280 290 300
VEVENPHHCD FLNLRRMLVQ THLQDLKEVT HDLLYEGYRA RCLQSLARPG
310 320 330 340 350
ARDRASRSKL SRQSATEIPL PMLPLADTEK LIREKDEELR RMQEMLEKMQ
360
AQMQQSQAQG EQSDVL
Length:366
Mass (Da):42,020
Last modified:November 3, 2009 - v2
Checksum:iAB619C08D8C74184
GO

Sequence cautioni

The sequence AAA37803 differs from that shown. Reason: Frameshift at positions 147 and 155.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99C → F in AAA37803 (PubMed:2174398).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37030 mRNA. Translation: AAA37803.1. Frameshift.
BC140998 mRNA. Translation: AAI40999.1.
BC145081 mRNA. Translation: AAI45082.1.
CCDSiCCDS40141.1.
PIRiJU0319.
RefSeqiNP_059489.2. NM_017461.2.
UniGeneiMm.18.

Genome annotation databases

EnsembliENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486.
GeneIDi54204.
KEGGimmu:54204.
UCSCiuc009juq.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSEPT1_MOUSE
AccessioniPrimary (citable) accession number: P42209
Secondary accession number(s): B2RU74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 3, 2009
Last modified: June 7, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families