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Protein

Septin-1

Gene

Sept1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661GTPBy similarity
Binding sitei92 – 921GTP; via amide nitrogenBy similarity
Binding sitei229 – 2291GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei244 – 2441GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398GTPBy similarity
Nucleotide bindingi171 – 1799GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic metaphase plate congression Source: MGI
  • spindle assembly involved in female meiosis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Alternative name(s):
Differentiation protein 6
Short name:
Protein Diff6
Peanut-like protein 3
Gene namesi
Name:Sept1
Synonyms:Diff6, Pnutl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858916. Sept1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • meiotic spindle Source: MGI
  • microtubule organizing center Source: UniProtKB-SubCell
  • midbody Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Septin-1PRO_0000173514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061PhosphoserineCombined sources
Modified residuei247 – 2471PhosphoserineCombined sources
Modified residuei250 – 2501PhosphothreonineCombined sources
Modified residuei306 – 3061Phosphoserine; by AURKBBy similarity
Modified residuei314 – 3141Phosphoserine; by AURKBBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP42209.
MaxQBiP42209.
PaxDbiP42209.
PeptideAtlasiP42209.
PRIDEiP42209.

2D gel databases

REPRODUCTION-2DPAGEP42209.

PTM databases

iPTMnetiP42209.
PhosphoSiteiP42209.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000486.
CleanExiMM_SEPT1.
ExpressionAtlasiP42209. baseline and differential.
GenevisibleiP42209. MM.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity).By similarity

Protein-protein interaction databases

IntActiP42209. 1 interaction.
STRINGi10090.ENSMUSP00000101921.

Structurei

3D structure databases

ProteinModelPortaliP42209.
SMRiP42209. Positions 22-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 295274Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiP42209.
KOiK13737.
OMAiVEVENPH.
OrthoDBiEOG091G07TS.
TreeFamiTF101079.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPDAS ARTAQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVRFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPRET QALKQKIRDQ LKEEEINIYQ
210 220 230 240 250
FPECDSDEDE EFKKQNEEMK ENIPFAVVGS CEVVRDGTRP VRGRRYSWGT
260 270 280 290 300
VEVENPHHCD FLNLRRMLVQ THLQDLKEVT HDLLYEGYRA RCLQSLARPG
310 320 330 340 350
ARDRASRSKL SRQSATEIPL PMLPLADTEK LIREKDEELR RMQEMLEKMQ
360
AQMQQSQAQG EQSDVL
Length:366
Mass (Da):42,020
Last modified:November 3, 2009 - v2
Checksum:iAB619C08D8C74184
GO

Sequence cautioni

The sequence AAA37803 differs from that shown. Reason: Frameshift at positions 147 and 155. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991C → F in AAA37803 (PubMed:2174398).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37030 mRNA. Translation: AAA37803.1. Frameshift.
BC140998 mRNA. Translation: AAI40999.1.
BC145081 mRNA. Translation: AAI45082.1.
CCDSiCCDS40141.1.
PIRiJU0319.
RefSeqiNP_059489.2. NM_017461.2.
UniGeneiMm.18.

Genome annotation databases

EnsembliENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486.
GeneIDi54204.
KEGGimmu:54204.
UCSCiuc009juq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37030 mRNA. Translation: AAA37803.1. Frameshift.
BC140998 mRNA. Translation: AAI40999.1.
BC145081 mRNA. Translation: AAI45082.1.
CCDSiCCDS40141.1.
PIRiJU0319.
RefSeqiNP_059489.2. NM_017461.2.
UniGeneiMm.18.

3D structure databases

ProteinModelPortaliP42209.
SMRiP42209. Positions 22-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP42209. 1 interaction.
STRINGi10090.ENSMUSP00000101921.

PTM databases

iPTMnetiP42209.
PhosphoSiteiP42209.

2D gel databases

REPRODUCTION-2DPAGEP42209.

Proteomic databases

EPDiP42209.
MaxQBiP42209.
PaxDbiP42209.
PeptideAtlasiP42209.
PRIDEiP42209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486.
GeneIDi54204.
KEGGimmu:54204.
UCSCiuc009juq.1. mouse.

Organism-specific databases

CTDi1731.
MGIiMGI:1858916. Sept1.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiP42209.
KOiK13737.
OMAiVEVENPH.
OrthoDBiEOG091G07TS.
TreeFamiTF101079.

Miscellaneous databases

PROiP42209.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000486.
CleanExiMM_SEPT1.
ExpressionAtlasiP42209. baseline and differential.
GenevisibleiP42209. MM.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT1_MOUSE
AccessioniPrimary (citable) accession number: P42209
Secondary accession number(s): B2RU74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 3, 2009
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.