Reviewed,
UniProtKB/Swiss-Prot P42207 (SEPT1_DROME)
Last modified
June 16, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Septin-1 Alternative name(s): DIFF6 protein homolog Protein innocent bystander | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 361 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in cytokinesis Potential. |
| Subunit structure | May assemble into a multicomponent structure. |
| Sequence similarities | Belongs to the septin family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW cellularizationTraceable author statement. Source: FlyBase positive regulation of apoptosisInferred from direct assay. Source: FlyBase |
| Cellular component | germline ring canal Non-traceable author statement. Source: FlyBase septin complexInferred from electronic annotation. Source: InterPro |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin protein ligase bindingInferred from physical interaction. Source: FlyBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 361 | 361 | Septin-1 | PRO_0000173511 | |||||
Regions | |||||||||
| Nucleotide binding | 42 – 49 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 183 – 189 | 7 | GTP By similarity | ||||||
Sites | |||||||||
| Binding site | 239 | 1 | GTP; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Binding site | 256 | 1 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 319 | 1 | Phosphoserine Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Hayward D.C., Delaney S.J., Miklos G.L.G. Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo. |
| [2] | Fares H.F., Peifer M.A., Pringle J.R. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila." Maleszka R., de Couet H.G., Miklos G.L.G. Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998) [PubMed: 9520435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S. |
| [4] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [5] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. |
| [6] | "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells." Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A. Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X67202 mRNA. Translation: CAA47638.1. L33246 Genomic DNA. Translation: AAC34305.1. AF017777 Genomic DNA. Translation: AAC28401.1. AE014298 Genomic DNA. Translation: AAF50825.1. | |
| PIR | S25063. |
| RefSeq | NP_523430.1. |
| UniGene | Dm.2682 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:18454N. |
| IntAct | P42207. 10 interactions. |
Proteomic databases | |
| PRIDE | P42207. |
Genome annotation databases | |
| Ensembl | FBgn0011710. Drosophila melanogaster. [Contig view] |
| GeneID | 33114. |
| KEGG | dme:Dmel_CG1403. |
Organism-specific databases | |
| FlyBase | FBgn0011710. Sep1. |
Phylogenomic databases | |
| HOGENOM | P42207. |
| OMA | P42207. AQMQLQM. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-002860-MON. |
Gene expression databases | |
| ArrayExpress | P42207. |
| GermOnline | CG1403. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR000038. Cell_Div_GTP_bd. IPR016491. Septin. [Graphical view] |
| PANTHER | PTHR18884. Cell_Div_GTP_bd. 1 hit. |
| Pfam | PF00735. Septin. 1 hit. [Graphical view] |
| PIRSF | PIRSF006698. Septin. 1 hit. |
| ProDom | PD002565. GTP_Cell_Div. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 781972. |
Entry information
| Entry name | SEPT1_DROME | ||||||||
| Accession | Primary (citable) accession number: P42207 Secondary accession number(s): Q9VRH5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


