P42207 (SEPT1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Septin-1

Alternative name(s):
DIFF6 protein homolog
Protein innocent bystander

Gene names

Name:	Sep1
Synonyms:	Diff6, iby
ORF Names:	CG1403

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cytokinesis Potential.
Subunit structure	May assemble into a multicomponent structure.
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellularization Traceable author statement. Source: FlyBase positive regulation of apoptotic process Inferred from direct assay. Source: FlyBase
Cellular component	germline ring canal Non-traceable author statement. Source: FlyBase microtubule associated complex Inferred from direct assay. Source: FlyBase septin complex Inferred from direct assay. Source: FlyBase
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from direct assay. Source: FlyBase ubiquitin protein ligase binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P42207-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P42207-2)

The sequence of this isoform differs from the canonical sequence as follows:
     158-165: LKPLDVEF → CVPFPFNF
     166-361: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Septin-1		PRO_0000173511
Regions
	Nucleotide binding	42 – 49	8	GTP By similarity
	Nucleotide binding	181 – 189	9	GTP By similarity
Sites
	Binding site	76	1	GTP By similarity
	Binding site	102	1	GTP; via amide nitrogen By similarity
	Binding site	239	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	254	1	GTP By similarity
Amino acid modifications
	Modified residue	319	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	158 – 165	8	LKPLDVEF → CVPFPFNF in isoform B.		VSP_038475
	Alternative sequence	166 – 361	196	Missing in isoform B.		VSP_038476

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified November 1, 1995. Version 1. Checksum: AE7D4860B625AB00	FASTA	361	41,131
	10 20 30 40 50 60 MADTKGFSSI ETPGYVGFAN LPNQVHRKSV KKGFEFTLMV VGESGLGKST LVNSLFLTDL 70 80 90 100 110 120 YPERIIPDAI EKQKQTVKLE ASTVEIEERG VKLRLTVVDT PGFGDAIDNS NSFGAILEYI 130 140 150 160 170 180 DEQYERFLRD ESGLNRRNIV DNRIHCCFYF ISPFGHGLKP LDVEFMKKLH SKVNIVPVIA 190 200 210 220 230 240 KADCLTKKEI LRLKCRIMQE IESHGIKIYP LPDCDSDEDE DYKEQVKQLK EAVPFAVCGA 250 260 270 280 290 300 NTLLEVKGKK VRGRLYPWGV VEVENPDHCD FIKLRTMLIT HMQDLQEVTQ EVHYENYRSD 310 320 330 340 350 360 RLAKGIKGKE NGVKAERDSS SQVVSNSVLG EKDRILQEKE AELRRMQEML AQMQARMQAQ Q
	Isoform B [UniParc]. Checksum: 41671D3FE9F41B3F	FASTA	165	18,565
	10 20 30 40 50 60 MADTKGFSSI ETPGYVGFAN LPNQVHRKSV KKGFEFTLMV VGESGLGKST LVNSLFLTDL 70 80 90 100 110 120 YPERIIPDAI EKQKQTVKLE ASTVEIEERG VKLRLTVVDT PGFGDAIDNS NSFGAILEYI 130 140 150 160 DEQYERFLRD ESGLNRRNIV DNRIHCCFYF ISPFGHGCVP FPFNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Localization and possible functions of Drosophila septins." Fares H., Peifer M., Pringle J.R. Mol. Biol. Cell 6:1843-1859(1995) [PubMed: 8590810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Embryo.
[2]	Hayward D.C., Delaney S.J., Miklos G.L.G. Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Tissue: Embryo.
[3]	"Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila." Maleszka R., de Couet H.G., Miklos G.L.G. Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998) [PubMed: 9520435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[6]	"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells." Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A. Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L33246 Genomic DNA. Translation: AAC34305.1. X67202 mRNA. Translation: CAA47638.1. AF017777 Genomic DNA. Translation: AAC28401.1. AE014298 Genomic DNA. Translation: AAF50825.1. AE014298 Genomic DNA. Translation: AAN09677.1.
PIR	S25063.
RefSeq	NP_523430.1. NM_078706.3.
UniGene	Dm.2682.
3D structure databases
ProteinModelPortal	P42207.
SMR	P42207. Positions 32-302.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-18454N.
MINT	MINT-305134.
STRING	P42207.
Proteomic databases
PRIDE	P42207.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077198; FBpp0076897; FBgn0011710.
GeneID	33114.
KEGG	dme:Dmel_CG1403.
Organism-specific databases
CTD	33114.
FlyBase	FBgn0011710. Sep1.
Phylogenomic databases
eggNOG	inNOG08063.
InParanoid	P42207.
OMA	MQLQMQG.
OrthoDB	EOG405QGN.
PhylomeDB	P42207.
Gene expression databases
ArrayExpress	P42207.
Bgee	P42207.
GermOnline	CG1403. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. IPR016491. Septin. [Graphical view]
PANTHER	PTHR18884. Cell_Div_GTP_bd. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
ProtoNet	Search...
Other
NextBio	781972.

Entry information

Entry name

SEPT1_DROME

Accession

Primary (citable) accession number: P42207
Secondary accession number(s): Q8IQ47, Q9VRH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project