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P42207 (SEPT1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Septin-1
Alternative name(s):
DIFF6 protein homolog
Protein innocent bystander
Gene names
Name:Sep1
Synonyms:Diff6, iby
ORF Names:CG1403
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cytokinesis Potential.

Subunit structure

May assemble into a multicomponent structure.

Sequence similarities

Belongs to the septin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P42207-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P42207-2)

The sequence of this isoform differs from the canonical sequence as follows:
     158-165: LKPLDVEF → CVPFPFNF
     166-361: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Septin-1
PRO_0000173511

Regions

Nucleotide binding42 – 498GTP By similarity
Nucleotide binding181 – 1899GTP By similarity

Sites

Binding site761GTP By similarity
Binding site1021GTP; via amide nitrogen By similarity
Binding site2391GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2541GTP By similarity

Amino acid modifications

Modified residue3191Phosphoserine Ref.6

Natural variations

Alternative sequence158 – 1658LKPLDVEF → CVPFPFNF in isoform B.
VSP_038475
Alternative sequence166 – 361196Missing in isoform B.
VSP_038476

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: AE7D4860B625AB00

FASTA36141,131
        10         20         30         40         50         60 
MADTKGFSSI ETPGYVGFAN LPNQVHRKSV KKGFEFTLMV VGESGLGKST LVNSLFLTDL 

        70         80         90        100        110        120 
YPERIIPDAI EKQKQTVKLE ASTVEIEERG VKLRLTVVDT PGFGDAIDNS NSFGAILEYI 

       130        140        150        160        170        180 
DEQYERFLRD ESGLNRRNIV DNRIHCCFYF ISPFGHGLKP LDVEFMKKLH SKVNIVPVIA 

       190        200        210        220        230        240 
KADCLTKKEI LRLKCRIMQE IESHGIKIYP LPDCDSDEDE DYKEQVKQLK EAVPFAVCGA 

       250        260        270        280        290        300 
NTLLEVKGKK VRGRLYPWGV VEVENPDHCD FIKLRTMLIT HMQDLQEVTQ EVHYENYRSD 

       310        320        330        340        350        360 
RLAKGIKGKE NGVKAERDSS SQVVSNSVLG EKDRILQEKE AELRRMQEML AQMQARMQAQ 


Q 

« Hide

Isoform B [UniParc].

Checksum: 41671D3FE9F41B3F
Show »

FASTA16518,565

References

« Hide 'large scale' references
[1]"Localization and possible functions of Drosophila septins."
Fares H., Peifer M., Pringle J.R.
Mol. Biol. Cell 6:1843-1859(1995) [PubMed: 8590810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Embryo.
[2]Hayward D.C., Delaney S.J., Miklos G.L.G.
Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Tissue: Embryo.
[3]"Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila."
Maleszka R., de Couet H.G., Miklos G.L.G.
Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998) [PubMed: 9520435] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Canton-S.
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[6]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L33246 Genomic DNA. Translation: AAC34305.1.
X67202 mRNA. Translation: CAA47638.1.
AF017777 Genomic DNA. Translation: AAC28401.1.
AE014298 Genomic DNA. Translation: AAF50825.1.
AE014298 Genomic DNA. Translation: AAN09677.1.
PIRS25063.
RefSeqNP_523430.1. NM_078706.3.
UniGeneDm.2682.

3D structure databases

ProteinModelPortalP42207.
SMRP42207. Positions 32-302.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-18454N.
MINTMINT-305134.
STRINGP42207.

Proteomic databases

PRIDEP42207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0077198; FBpp0076897; FBgn0011710.
GeneID33114.
KEGGdme:Dmel_CG1403.

Organism-specific databases

CTD33114.
FlyBaseFBgn0011710. Sep1.

Phylogenomic databases

eggNOGinNOG08063.
InParanoidP42207.
OMAMQLQMQG.
OrthoDBEOG405QGN.
PhylomeDBP42207.

Gene expression databases

ArrayExpressP42207.
BgeeP42207.
GermOnlineCG1403. Drosophila melanogaster.

Family and domain databases

InterProIPR000038. Cell_div_GTP-bd.
IPR016491. Septin.
[Graphical view]
PANTHERPTHR18884. Cell_Div_GTP_bd. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
ProtoNetSearch...

Other

NextBio781972.

Entry information

Entry nameSEPT1_DROME
AccessionPrimary (citable) accession number: P42207
Secondary accession number(s): Q8IQ47, Q9VRH5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families