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Protein

Interleukin-13

Gene

Il13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

  • interleukin-13 receptor binding Source: RGD

GO - Biological processi

  • cellular response to cytokine stimulus Source: Ensembl
  • cellular response to mechanical stimulus Source: RGD
  • immune response Source: InterPro
  • inflammatory response Source: Ensembl
  • microglial cell activation Source: RGD
  • negative regulation of complement-dependent cytotoxicity Source: Ensembl
  • negative regulation of endothelial cell apoptotic process Source: Ensembl
  • negative regulation of NAD(P)H oxidase activity Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of transforming growth factor beta production Source: RGD
  • positive regulation of B cell proliferation Source: RGD
  • positive regulation of connective tissue growth factor production Source: RGD
  • positive regulation of immunoglobulin production Source: RGD
  • positive regulation of ion transport Source: RGD
  • positive regulation of macrophage activation Source: Ensembl
  • positive regulation of mast cell degranulation Source: Ensembl
  • positive regulation of pancreatic stellate cell proliferation Source: RGD
  • positive regulation of protein secretion Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of tyrosine phosphorylation of Stat6 protein Source: RGD
  • regulation of proton transport Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nicotine Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Alternative name(s):
T-cell activation protein P600
Gene namesi
Name:Il13
Synonyms:Il-13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68949. Il13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 131110Interleukin-13PRO_0000015553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi52 ↔ 80By similarity
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi68 ↔ 94By similarity
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP42203.
PRIDEiP42203.

Expressioni

Gene expression databases

GenevisibleiP42203. RN.

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

  • interleukin-13 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010121.

Structurei

3D structure databases

ProteinModelPortaliP42203.
SMRiP42203. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP42203.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
PhylomeDBiP42203.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWVTAVLA LACLGGLATP GPVRRSTSPP VALRELIEEL SNITQDQKTS
60 70 80 90 100
LCNSSMVWSV DLTAGGFCAA LESLTNISSC NAIHRTQRIL NGLCNQKASD
110 120 130
VASSPPDTKI EVAQFISKLL NYSKQLFRYG H
Length:131
Mass (Da):14,093
Last modified:November 1, 1995 - v1
Checksum:iE5008CAB8DE8C201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26913 mRNA. Translation: AAA16478.1.
PIRiI52290.
RefSeqiNP_446280.1. NM_053828.1.
UniGeneiRn.9921.

Genome annotation databases

EnsembliENSRNOT00000010121; ENSRNOP00000010121; ENSRNOG00000007652.
GeneIDi116553.
KEGGirno:116553.
UCSCiRGD:68949. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26913 mRNA. Translation: AAA16478.1.
PIRiI52290.
RefSeqiNP_446280.1. NM_053828.1.
UniGeneiRn.9921.

3D structure databases

ProteinModelPortaliP42203.
SMRiP42203. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010121.

Proteomic databases

PaxDbiP42203.
PRIDEiP42203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010121; ENSRNOP00000010121; ENSRNOG00000007652.
GeneIDi116553.
KEGGirno:116553.
UCSCiRGD:68949. rat.

Organism-specific databases

CTDi3596.
RGDi68949. Il13.

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP42203.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
PhylomeDBiP42203.
TreeFamiTF336383.

Miscellaneous databases

NextBioi619195.
PROiP42203.

Gene expression databases

GenevisibleiP42203. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis."
    Lakkis F.G., Cruet E.N.
    Biochem. Biophys. Res. Commun. 197:612-618(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney cortex.

Entry informationi

Entry nameiIL13_RAT
AccessioniPrimary (citable) accession number: P42203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.