P42203 (IL13_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-13
Short name=IL-13

Alternative name(s):
T-cell activation protein P600

Gene names

Name:	Il13
Synonyms:	Il-13

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses By similarity.
Subunit structure	Interacts with IL13RA2 By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-4/IL-13 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to cytokine stimulus Inferred from electronic annotation. Source: Compara cellular response to mechanical stimulus Inferred from expression pattern PubMed 18362439. Source: RGD immune response Inferred from electronic annotation. Source: InterPro negative regulation of transforming growth factor beta production Inferred from direct assay PubMed 20100461. Source: RGD positive regulation of B cell proliferation Inferred from direct assay PubMed 10331006PubMed 11573960. Source: RGD positive regulation of connective tissue growth factor production Inferred from direct assay PubMed 21804025. Source: RGD positive regulation of immunoglobulin production Inferred from direct assay PubMed 11573960. Source: RGD positive regulation of macrophage activation Inferred from electronic annotation. Source: Compara positive regulation of pancreatic stellate cell proliferation Inferred from direct assay PubMed 20100461. Source: RGD positive regulation of protein secretion Inferred from direct assay PubMed 11739109. Source: RGD positive regulation of release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 20045483. Source: RGD positive regulation of smooth muscle cell proliferation Inferred from direct assay PubMed 20045483. Source: RGD positive regulation of tyrosine phosphorylation of Stat6 protein Inferred from direct assay PubMed 21804025. Source: RGD regulation of proton transport Inferred from direct assay PubMed 11739109. Source: RGD response to ethanol Inferred from expression pattern PubMed 16698589. Source: RGD response to lipopolysaccharide Inferred from expression pattern PubMed 16522370. Source: RGD response to nicotine Inferred from direct assay PubMed 18490768. Source: RGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay PubMed 17429054. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 131	110	Interleukin-13		PRO_0000015553
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	76	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Disulfide bond	52 ↔ 80		By similarity
	Disulfide bond	68 ↔ 94		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42203 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: E5008CAB8DE8C201	FASTA	131	14,093
	10 20 30 40 50 60 MALWVTAVLA LACLGGLATP GPVRRSTSPP VALRELIEEL SNITQDQKTS LCNSSMVWSV 70 80 90 100 110 120 DLTAGGFCAA LESLTNISSC NAIHRTQRIL NGLCNQKASD VASSPPDTKI EVAQFISKLL 130 NYSKQLFRYG H

References

[1]	"Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis." Lakkis F.G., Cruet E.N. Biochem. Biophys. Res. Commun. 197:612-618(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Kidney cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26913 mRNA. Translation: AAA16478.1.
IPI	IPI00194737.
PIR	I52290.
RefSeq	NP_446280.1. NM_053828.1.
UniGene	Rn.9921.
3D structure databases
ProteinModelPortal	P42203.
SMR	P42203. Positions 21-130.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000010121.
Proteomic databases
PRIDE	P42203.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000010121; ENSRNOP00000010121; ENSRNOG00000007652.
GeneID	116553.
KEGG	rno:116553.
UCSC	RGD:68949. rat.
Organism-specific databases
CTD	3596.
RGD	68949. Il13.
Phylogenomic databases
eggNOG	NOG42350.
GeneTree	ENSGT00390000003225.
HOGENOM	HOG000113028.
HOVERGEN	HBG006140.
InParanoid	P42203.
KO	K05435.
OMA	YCAALES.
OrthoDB	EOG437RGJ.
Gene expression databases
Genevestigator	P42203.
GermOnline	ENSRNOG00000007652. Rattus norvegicus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR020470. Interleukin-13. IPR018096. Interleukin-4/-13_CS. IPR001325. Interleukin-4/13. [Graphical view]
PANTHER	PTHR11322. PTHR11322. 1 hit.
Pfam	PF03487. IL13. 1 hit. [Graphical view]
PRINTS	PR01929. INTRLEUKIN13.
SMART	SM00190. IL4_13. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00838. INTERLEUKIN_4_13. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	619195.

Entry information

Entry name

IL13_RAT

Accession

Primary (citable) accession number: P42203

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program