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Protein

Interleukin-13

Gene

Il13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-13 receptor binding Source: RGD

GO - Biological processi

  • cellular response to cytokine stimulus Source: GO_Central
  • cellular response to mechanical stimulus Source: RGD
  • immune response Source: InterPro
  • inflammatory response Source: GO_Central
  • microglial cell activation Source: RGD
  • negative regulation of complement-dependent cytotoxicity Source: Ensembl
  • negative regulation of endothelial cell apoptotic process Source: Ensembl
  • negative regulation of NAD(P)H oxidase activity Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of transforming growth factor beta production Source: RGD
  • positive regulation of B cell proliferation Source: RGD
  • positive regulation of connective tissue growth factor production Source: RGD
  • positive regulation of immunoglobulin production Source: RGD
  • positive regulation of ion transport Source: RGD
  • positive regulation of macrophage activation Source: GO_Central
  • positive regulation of mast cell degranulation Source: GO_Central
  • positive regulation of pancreatic stellate cell proliferation Source: RGD
  • positive regulation of protein secretion Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of tyrosine phosphorylation of Stat6 protein Source: RGD
  • regulation of proton transport Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nicotine Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-RNO-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Alternative name(s):
T-cell activation protein P600
Gene namesi
Name:Il13
Synonyms:Il-13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68949. Il13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 131110Interleukin-13PRO_0000015553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi52 ↔ 80By similarity
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi68 ↔ 94By similarity
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP42203.
PRIDEiP42203.

Expressioni

Gene expression databases

GenevisibleiP42203. RN.

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-13 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010121.

Structurei

3D structure databases

ProteinModelPortaliP42203.
SMRiP42203. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP42203.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
PhylomeDBiP42203.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWVTAVLA LACLGGLATP GPVRRSTSPP VALRELIEEL SNITQDQKTS
60 70 80 90 100
LCNSSMVWSV DLTAGGFCAA LESLTNISSC NAIHRTQRIL NGLCNQKASD
110 120 130
VASSPPDTKI EVAQFISKLL NYSKQLFRYG H
Length:131
Mass (Da):14,093
Last modified:November 1, 1995 - v1
Checksum:iE5008CAB8DE8C201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26913 mRNA. Translation: AAA16478.1.
PIRiI52290.
RefSeqiNP_446280.1. NM_053828.1.
UniGeneiRn.9921.

Genome annotation databases

EnsembliENSRNOT00000010121; ENSRNOP00000010121; ENSRNOG00000007652.
GeneIDi116553.
KEGGirno:116553.
UCSCiRGD:68949. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26913 mRNA. Translation: AAA16478.1.
PIRiI52290.
RefSeqiNP_446280.1. NM_053828.1.
UniGeneiRn.9921.

3D structure databases

ProteinModelPortaliP42203.
SMRiP42203. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010121.

Proteomic databases

PaxDbiP42203.
PRIDEiP42203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010121; ENSRNOP00000010121; ENSRNOG00000007652.
GeneIDi116553.
KEGGirno:116553.
UCSCiRGD:68949. rat.

Organism-specific databases

CTDi3596.
RGDi68949. Il13.

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP42203.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
PhylomeDBiP42203.
TreeFamiTF336383.

Enzyme and pathway databases

ReactomeiR-RNO-449147. Signaling by Interleukins.

Miscellaneous databases

PROiP42203.

Gene expression databases

GenevisibleiP42203. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis."
    Lakkis F.G., Cruet E.N.
    Biochem. Biophys. Res. Commun. 197:612-618(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney cortex.

Entry informationi

Entry nameiIL13_RAT
AccessioniPrimary (citable) accession number: P42203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.