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Protein

Interleukin-4

Gene

IL4

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell stimulatory factor 1
Short name:
BSF-1
Lymphocyte stimulatory factor 1
Gene namesi
Name:IL4
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001553124 – 134Interleukin-4Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 133By similarity
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi48 ↔ 88By similarity
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP42202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000290.
InParanoidiP42202.
KOiK05430.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTYQLLPA LVCLLACTSF IQGCKYDITL QEIIKTLNLT DGKGKNSCME
60 70 80 90 100
LTVADAFGPK NTDGKEICRA AKVLQQYKRH DRSLIKECLS GLDRNLKGMA
110 120 130
NGTCCTVNEA KKSTLKDFLE RLKTIMKEKY SKCS
Length:134
Mass (Da):14,921
Last modified:April 12, 2005 - v2
Checksum:iCD609F0083B90F32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5Y → S in AAA21299 (PubMed:8042287).Curated1
Sequence conflicti8L → I in AAG21896 (Ref. 3) Curated1
Sequence conflicti19S → SN in AAG21896 (Ref. 3) Curated1
Sequence conflicti25K → I in AAB87701 (Ref. 2) Curated1
Sequence conflicti35K → I in AAB87701 (Ref. 2) Curated1
Sequence conflicti38N → NN in AAG21896 (Ref. 3) Curated1
Sequence conflicti58G → AG (Ref. 3) Curated1
Sequence conflicti76Q → QL in AAG21896 (Ref. 3) Curated1
Sequence conflicti96Missing in AAA21299 (PubMed:8042287).Curated1
Sequence conflicti116Missing in AAA21299 (PubMed:8042287).Curated1
Sequence conflicti127K → R in AAA21299 (PubMed:8042287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06010 mRNA. Translation: AAA21299.1.
AF035404 mRNA. Translation: AAB87701.1.
AF305617 mRNA. Translation: AAG21896.1.
RefSeqiNP_001075988.1. NM_001082519.1.
UniGeneiEca.11253.

Genome annotation databases

GeneIDi100034225.
KEGGiecb:100034225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06010 mRNA. Translation: AAA21299.1.
AF035404 mRNA. Translation: AAB87701.1.
AF305617 mRNA. Translation: AAG21896.1.
RefSeqiNP_001075988.1. NM_001082519.1.
UniGeneiEca.11253.

3D structure databases

ProteinModelPortaliP42202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034225.
KEGGiecb:100034225.

Organism-specific databases

CTDi3565.

Phylogenomic databases

HOVERGENiHBG000290.
InParanoidiP42202.
KOiK05430.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL4_HORSE
AccessioniPrimary (citable) accession number: P42202
Secondary accession number(s): O46393, Q9GL85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 12, 2005
Last modified: May 11, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.