Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-cystine-binding protein TcyA

Gene

tcyA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex TcyABC involved in L-cystine import.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU03610-MONOMER.
RETL1328306-WGS:GSTH-4098-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.14. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
L-cystine-binding protein TcyA
Gene namesi
Name:tcyA
Synonyms:yckK
Ordered Locus Names:BSU03610
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919PROSITE-ProRule annotationAdd
BLAST
Chaini20 – 268249L-cystine-binding protein TcyAPRO_0000031778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP42199.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (TcyC), two transmembrane proteins (TcyB) and a solute-binding protein (TcyA).Curated

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002048.

Structurei

3D structure databases

ProteinModelPortaliP42199.
SMRiP42199. Positions 37-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0834. LUCA.
HOGENOMiHOG000031895.
InParanoidiP42199.
KOiK02424.
OMAiQFIEGRW.
PhylomeDBiP42199.

Family and domain databases

InterProiIPR018313. SBP_3_CS.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF00497. SBP_bac_3. 1 hit.
[Graphical view]
SMARTiSM00062. PBPb. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS01039. SBP_BACTERIAL_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKALLALFM VVSIAALAAC GAGNDNQSKD NAKDGDLWAS IKKKGVLTVG
60 70 80 90 100
TEGTYEPFTY HDKDTDKLTG YDVEVITEVA KRLGLKVDFK ETQWDSMFAG
110 120 130 140 150
LNSKRFDVVA NQVGKTDRED KYDFSDKYTT SRAVVVTKKD NNDIKSEADV
160 170 180 190 200
KGKTSAQSLT SNYNKLATNA GAKVEGVEGM AQALQMIQQG RVDMTYNDKL
210 220 230 240 250
AVLNYLKTSG NKNVKIAFET GEPQSTYFTF RKGSGEVVDQ VNKALKEMKE
260
DGTLSKISKK WFGEDVSK
Length:268
Mass (Da):29,514
Last modified:June 16, 2009 - v3
Checksum:iE88B56676E8AD762
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 822KR → NS in CAA54724 (PubMed:7551042).Curated
Sequence conflicti95 – 951D → G in BAA08994 (PubMed:8969502).Curated
Sequence conflicti120 – 1212DK → NQ in CAA54724 (PubMed:7551042).Curated
Sequence conflicti190 – 1901G → A in BAA08994 (PubMed:8969502).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77636 Genomic DNA. Translation: CAA54724.1.
D50453 Genomic DNA. Translation: BAA08994.1.
AL009126 Genomic DNA. Translation: CAB12155.2.
PIRiE69761.
RefSeqiNP_388243.2. NC_000964.3.
WP_003246699.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12155; CAB12155; BSU03610.
GeneIDi938298.
KEGGibsu:BSU03610.
PATRICi18972289. VBIBacSub10457_0373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77636 Genomic DNA. Translation: CAA54724.1.
D50453 Genomic DNA. Translation: BAA08994.1.
AL009126 Genomic DNA. Translation: CAB12155.2.
PIRiE69761.
RefSeqiNP_388243.2. NC_000964.3.
WP_003246699.1. NZ_JNCM01000031.1.

3D structure databases

ProteinModelPortaliP42199.
SMRiP42199. Positions 37-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002048.

Protein family/group databases

TCDBi3.A.1.3.14. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP42199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12155; CAB12155; BSU03610.
GeneIDi938298.
KEGGibsu:BSU03610.
PATRICi18972289. VBIBacSub10457_0373.

Phylogenomic databases

eggNOGiCOG0834. LUCA.
HOGENOMiHOG000031895.
InParanoidiP42199.
KOiK02424.
OMAiQFIEGRW.
PhylomeDBiP42199.

Enzyme and pathway databases

BioCyciBSUB:BSU03610-MONOMER.
RETL1328306-WGS:GSTH-4098-MONOMER.

Family and domain databases

InterProiIPR018313. SBP_3_CS.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF00497. SBP_bac_3. 1 hit.
[Graphical view]
SMARTiSM00062. PBPb. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS01039. SBP_BACTERIAL_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCYA_BACSU
AccessioniPrimary (citable) accession number: P42199
Secondary accession number(s): P94402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 16, 2009
Last modified: September 7, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.