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P42196

- BACS2_NATPH

UniProt

P42196 - BACS2_NATPH

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Protein

Sensory rhodopsin-2

Gene

sop2

Organism
Natronomonas pharaonis (Natronobacterium pharaonis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Photophobic photoreceptor responsible for the negative phototaxis. Activates the sensory rhodopsin II transducer (HTR-II) in response to blue light.3 Publications

GO - Molecular functioni

  1. ion channel activity Source: InterPro
  2. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phototransduction Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Photoreceptor protein, Receptor, Retinal protein

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Protein family/group databases

TCDBi3.E.1.3.3. the ion-translocating microbial rhodopsin (mr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory rhodopsin-2
Alternative name(s):
Sensory rhodopsin II
Short name:
SR-II
Gene namesi
Name:sop2
Synonyms:sopII
OrganismiNatronomonas pharaonis (Natronobacterium pharaonis)
Taxonomic identifieri2257 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Extracellular
Transmembranei4 – 2522Helical; Name=Helix AAdd
BLAST
Topological domaini26 – 338Cytoplasmic
Transmembranei34 – 5522Helical; Name=Helix BAdd
BLAST
Topological domaini56 – 6914ExtracellularAdd
BLAST
Transmembranei70 – 9122Helical; Name=Helix CAdd
BLAST
Topological domaini92 – 943Cytoplasmic
Transmembranei95 – 11723Helical; Name=Helix DAdd
BLAST
Topological domaini118 – 1214Extracellular
Transmembranei122 – 14928Helical; Name=Helix EAdd
BLAST
Topological domaini150 – 1534Cytoplasmic
Transmembranei154 – 18128Helical; Name=Helix FAdd
BLAST
Topological domaini182 – 1898Extracellular
Transmembranei190 – 22233Helical; Name=Helix GAdd
BLAST
Topological domaini223 – 23917CytoplasmicAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Sensory rhodopsin-2PRO_0000196282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051N6-(retinylidene)lysine

Interactioni

Subunit structurei

Homodimer. Interacts with HTR-II.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
htr2P422591EBI-1034509,EBI-1034515

Protein-protein interaction databases

DIPiDIP-35282N.
IntActiP42196. 1 interaction.
MINTiMINT-248654.

Structurei

Secondary structure

1
239
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2625Combined sources
Turni31 – 333Combined sources
Helixi34 – 5522Combined sources
Turni56 – 594Combined sources
Beta strandi60 – 634Combined sources
Beta strandi66 – 694Combined sources
Helixi70 – 9122Combined sources
Helixi95 – 11723Combined sources
Helixi123 – 14220Combined sources
Helixi144 – 1496Combined sources
Helixi154 – 17118Combined sources
Helixi173 – 1808Combined sources
Turni182 – 1854Combined sources
Helixi190 – 21829Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GU8X-ray2.27A1-239[»]
1GUEX-ray2.27A1-239[»]
1H2SX-ray1.93A1-225[»]
1H68X-ray2.10A1-239[»]
1JGJX-ray2.40A1-217[»]
2F93X-ray2.00A2-239[»]
2F95X-ray2.20A2-239[»]
3QAPX-ray1.90A1-239[»]
3QDCX-ray2.50A1-239[»]
4GYCX-ray2.05A1-239[»]
ProteinModelPortaliP42196.
SMRiP42196. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42196.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001425. Arc/bac/fun_rhod.
IPR029730. Arc/bac/fun_rhod-like.
IPR017452. GPCR_Rhodpsn_7TM.
IPR018229. Rhodopsin_retinal_BS.
[Graphical view]
PfamiPF01036. Bac_rhodopsin. 1 hit.
[Graphical view]
PRINTSiPR00251. BACTRLOPSIN.
SMARTiSM01021. Bac_rhodopsin. 1 hit.
[Graphical view]
PROSITEiPS00950. BACTERIAL_OPSIN_1. 1 hit.
PS00327. BACTERIAL_OPSIN_RET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42196-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGLTTLFWL GAIGMLVGTL AFAWAGRDAG SGERRYYVTL VGISGIAAVA
60 70 80 90 100
YVVMALGVGW VPVAERTVFA PRYIDWILTT PLIVYFLGLL AGLDSREFGI
110 120 130 140 150
VITLNTVVML AGFAGAMVPG IERYALFGMG AVAFLGLVYY LVGPMTESAS
160 170 180 190 200
QRSSGIKSLY VRLRNLTVIL WAIYPFIWLL GPPGVALLTP TVDVALIVYL
210 220 230
DLVTKVGFGF IALDAAATLR AEHGESLAGV DTDAPAVAD
Length:239
Mass (Da):25,355
Last modified:November 1, 1995 - v1
Checksum:iC0E93EAF341B6B19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35086 Genomic DNA. Translation: CAA84469.1.
PIRiS55300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35086 Genomic DNA. Translation: CAA84469.1 .
PIRi S55300.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GU8 X-ray 2.27 A 1-239 [» ]
1GUE X-ray 2.27 A 1-239 [» ]
1H2S X-ray 1.93 A 1-225 [» ]
1H68 X-ray 2.10 A 1-239 [» ]
1JGJ X-ray 2.40 A 1-217 [» ]
2F93 X-ray 2.00 A 2-239 [» ]
2F95 X-ray 2.20 A 2-239 [» ]
3QAP X-ray 1.90 A 1-239 [» ]
3QDC X-ray 2.50 A 1-239 [» ]
4GYC X-ray 2.05 A 1-239 [» ]
ProteinModelPortali P42196.
SMRi P42196. Positions 1-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35282N.
IntActi P42196. 1 interaction.
MINTi MINT-248654.

Protein family/group databases

TCDBi 3.E.1.3.3. the ion-translocating microbial rhodopsin (mr) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P42196.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001425. Arc/bac/fun_rhod.
IPR029730. Arc/bac/fun_rhod-like.
IPR017452. GPCR_Rhodpsn_7TM.
IPR018229. Rhodopsin_retinal_BS.
[Graphical view ]
Pfami PF01036. Bac_rhodopsin. 1 hit.
[Graphical view ]
PRINTSi PR00251. BACTRLOPSIN.
SMARTi SM01021. Bac_rhodopsin. 1 hit.
[Graphical view ]
PROSITEi PS00950. BACTERIAL_OPSIN_1. 1 hit.
PS00327. BACTERIAL_OPSIN_RET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The primary structure of sensory rhodopsin II: a member of an additional retinal protein subgroup is coexpressed with its transducer, the halobacterial transducer of rhodopsin II."
    Seidel R., Scharf B., Gautel M., Kleine K., Oesterhelt D., Engelhard M.
    Proc. Natl. Acad. Sci. U.S.A. 92:3036-3040(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SP-1 / 28.
  2. "Biochemical and photochemical properties of the photophobic receptors from Halobacterium halobium and Natronobacterium pharaonis."
    Scharf B., Pevec B., Hess B., Engelhard M.
    Eur. J. Biochem. 206:359-366(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
    Strain: SP-1 / 28.
  3. "Heterologous coexpression of the blue light receptor psRII and its transducer pHtrII from Natronobacterium pharaonis in the Halobacterium salinarium strain Pho81/w restores negative phototaxis."
    Luttenberg B., Wolff E.K., Engelhard M.
    FEBS Lett. 426:117-120(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Crystal structure of sensory rhodopsin II at 2.4 Angstroms: insights into color tuning and transducer interaction."
    Luecke H., Schobert B., Lanyi J.K., Spudich E.N., Spudich J.L.
    Science 293:1499-1503(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-217, RETINAL-BINDING SITE.
  5. "Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex."
    Gordeliy V.I., Labahn J., Moukhametzianov R., Efremov R., Granzin J., Schlesinger R., Bueldt G., Savopol T., Scheidig A.J., Klare J.P., Engelhard M.
    Nature 419:484-487(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-225, FUNCTION, INTERACTION WITH HTR-II, RETINAL-BINDING SITE.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2-219, SUBUNIT, RETINAL-BINDING SITE.
  7. "Early structural rearrangements in the photocycle of an integral membrane sensory receptor."
    Edman K., Royant A., Nollert P., Maxwell C.A., Pebay-Peyroula E., Navarro J., Neutze R., Landau E.M.
    Structure 10:473-482(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 2-219, SUBCELLULAR LOCATION, RETINAL-BINDING SITE.

Entry informationi

Entry nameiBACS2_NATPH
AccessioniPrimary (citable) accession number: P42196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3