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P42196

- BACS2_NATPH

UniProt

P42196 - BACS2_NATPH

Protein

Sensory rhodopsin-2

Gene

sop2

Organism
Natronomonas pharaonis (Natronobacterium pharaonis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Photophobic photoreceptor responsible for the negative phototaxis. Activates the sensory rhodopsin II transducer (HTR-II) in response to blue light.3 Publications

    GO - Molecular functioni

    1. ion channel activity Source: InterPro
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Photoreceptor protein, Receptor, Retinal protein

    Keywords - Biological processi

    Keywords - Ligandi

    Chromophore

    Protein family/group databases

    TCDBi3.E.1.3.3. the ion-translocating microbial rhodopsin (mr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sensory rhodopsin-2
    Alternative name(s):
    Sensory rhodopsin II
    Short name:
    SR-II
    Gene namesi
    Name:sop2
    Synonyms:sopII
    OrganismiNatronomonas pharaonis (Natronobacterium pharaonis)
    Taxonomic identifieri2257 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Sensory rhodopsin-2PRO_0000196282Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051N6-(retinylidene)lysine

    Interactioni

    Subunit structurei

    Homodimer. Interacts with HTR-II.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    htr2P422591EBI-1034509,EBI-1034515

    Protein-protein interaction databases

    DIPiDIP-35282N.
    IntActiP42196. 1 interaction.
    MINTiMINT-248654.

    Structurei

    Secondary structure

    1
    239
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 2625
    Turni31 – 333
    Helixi34 – 5522
    Turni56 – 594
    Beta strandi60 – 634
    Beta strandi66 – 694
    Helixi70 – 9122
    Helixi95 – 11723
    Helixi123 – 14220
    Helixi144 – 1496
    Helixi154 – 17118
    Helixi173 – 1808
    Turni182 – 1854
    Helixi190 – 21829

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GU8X-ray2.27A1-239[»]
    1GUEX-ray2.27A1-239[»]
    1H2SX-ray1.93A1-225[»]
    1H68X-ray2.10A1-239[»]
    1JGJX-ray2.40A1-217[»]
    2F93X-ray2.00A2-239[»]
    2F95X-ray2.20A2-239[»]
    3QAPX-ray1.90A1-239[»]
    3QDCX-ray2.50A1-239[»]
    4GYCX-ray2.05A1-239[»]
    ProteinModelPortaliP42196.
    SMRiP42196. Positions 1-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42196.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33Extracellular
    Topological domaini26 – 338Cytoplasmic
    Topological domaini56 – 6914ExtracellularAdd
    BLAST
    Topological domaini92 – 943Cytoplasmic
    Topological domaini118 – 1214Extracellular
    Topological domaini150 – 1534Cytoplasmic
    Topological domaini182 – 1898Extracellular
    Topological domaini223 – 23917CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2522Helical; Name=Helix AAdd
    BLAST
    Transmembranei34 – 5522Helical; Name=Helix BAdd
    BLAST
    Transmembranei70 – 9122Helical; Name=Helix CAdd
    BLAST
    Transmembranei95 – 11723Helical; Name=Helix DAdd
    BLAST
    Transmembranei122 – 14928Helical; Name=Helix EAdd
    BLAST
    Transmembranei154 – 18128Helical; Name=Helix FAdd
    BLAST
    Transmembranei190 – 22233Helical; Name=Helix GAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001425. Arc/bac/fun_rhod.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR018229. Rhodopsin_retinal_BS.
    [Graphical view]
    PRINTSiPR00251. BACTRLOPSIN.
    PROSITEiPS00950. BACTERIAL_OPSIN_1. 1 hit.
    PS00327. BACTERIAL_OPSIN_RET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGLTTLFWL GAIGMLVGTL AFAWAGRDAG SGERRYYVTL VGISGIAAVA    50
    YVVMALGVGW VPVAERTVFA PRYIDWILTT PLIVYFLGLL AGLDSREFGI 100
    VITLNTVVML AGFAGAMVPG IERYALFGMG AVAFLGLVYY LVGPMTESAS 150
    QRSSGIKSLY VRLRNLTVIL WAIYPFIWLL GPPGVALLTP TVDVALIVYL 200
    DLVTKVGFGF IALDAAATLR AEHGESLAGV DTDAPAVAD 239
    Length:239
    Mass (Da):25,355
    Last modified:November 1, 1995 - v1
    Checksum:iC0E93EAF341B6B19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35086 Genomic DNA. Translation: CAA84469.1.
    PIRiS55300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35086 Genomic DNA. Translation: CAA84469.1 .
    PIRi S55300.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GU8 X-ray 2.27 A 1-239 [» ]
    1GUE X-ray 2.27 A 1-239 [» ]
    1H2S X-ray 1.93 A 1-225 [» ]
    1H68 X-ray 2.10 A 1-239 [» ]
    1JGJ X-ray 2.40 A 1-217 [» ]
    2F93 X-ray 2.00 A 2-239 [» ]
    2F95 X-ray 2.20 A 2-239 [» ]
    3QAP X-ray 1.90 A 1-239 [» ]
    3QDC X-ray 2.50 A 1-239 [» ]
    4GYC X-ray 2.05 A 1-239 [» ]
    ProteinModelPortali P42196.
    SMRi P42196. Positions 1-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-35282N.
    IntActi P42196. 1 interaction.
    MINTi MINT-248654.

    Protein family/group databases

    TCDBi 3.E.1.3.3. the ion-translocating microbial rhodopsin (mr) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P42196.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001425. Arc/bac/fun_rhod.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR018229. Rhodopsin_retinal_BS.
    [Graphical view ]
    PRINTSi PR00251. BACTRLOPSIN.
    PROSITEi PS00950. BACTERIAL_OPSIN_1. 1 hit.
    PS00327. BACTERIAL_OPSIN_RET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of sensory rhodopsin II: a member of an additional retinal protein subgroup is coexpressed with its transducer, the halobacterial transducer of rhodopsin II."
      Seidel R., Scharf B., Gautel M., Kleine K., Oesterhelt D., Engelhard M.
      Proc. Natl. Acad. Sci. U.S.A. 92:3036-3040(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SP-1 / 28.
    2. "Biochemical and photochemical properties of the photophobic receptors from Halobacterium halobium and Natronobacterium pharaonis."
      Scharf B., Pevec B., Hess B., Engelhard M.
      Eur. J. Biochem. 206:359-366(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
      Strain: SP-1 / 28.
    3. "Heterologous coexpression of the blue light receptor psRII and its transducer pHtrII from Natronobacterium pharaonis in the Halobacterium salinarium strain Pho81/w restores negative phototaxis."
      Luttenberg B., Wolff E.K., Engelhard M.
      FEBS Lett. 426:117-120(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Crystal structure of sensory rhodopsin II at 2.4 Angstroms: insights into color tuning and transducer interaction."
      Luecke H., Schobert B., Lanyi J.K., Spudich E.N., Spudich J.L.
      Science 293:1499-1503(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-217, RETINAL-BINDING SITE.
    5. "Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex."
      Gordeliy V.I., Labahn J., Moukhametzianov R., Efremov R., Granzin J., Schlesinger R., Bueldt G., Savopol T., Scheidig A.J., Klare J.P., Engelhard M.
      Nature 419:484-487(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-225, FUNCTION, INTERACTION WITH HTR-II, RETINAL-BINDING SITE.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2-219, SUBUNIT, RETINAL-BINDING SITE.
    7. "Early structural rearrangements in the photocycle of an integral membrane sensory receptor."
      Edman K., Royant A., Nollert P., Maxwell C.A., Pebay-Peyroula E., Navarro J., Neutze R., Landau E.M.
      Structure 10:473-482(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 2-219, SUBCELLULAR LOCATION, RETINAL-BINDING SITE.

    Entry informationi

    Entry nameiBACS2_NATPH
    AccessioniPrimary (citable) accession number: P42196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3