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Protein

HTH-type transcriptional regulator LrpA

Gene

lrpA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates its own transcription. Binds to a 46-base pair sequence that overlaps the transcriptional start site of its own promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 40H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator LrpA
Gene namesi
Name:lrpA
Ordered Locus Names:PF1601
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001117711 – 141HTH-type transcriptional regulator LrpAAdd BLAST141

Proteomic databases

PRIDEiP42180.

Interactioni

Subunit structurei

Binds DNA as a homotetramer.

Protein-protein interaction databases

STRINGi186497.PF1601.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 15Combined sources11
Helixi21 – 28Combined sources8
Helixi32 – 45Combined sources14
Helixi58 – 60Combined sources3
Beta strandi64 – 72Combined sources9
Helixi74 – 76Combined sources3
Helixi77 – 86Combined sources10
Beta strandi90 – 93Combined sources4
Beta strandi97 – 110Combined sources14
Helixi111 – 120Combined sources10
Turni121 – 124Combined sources4
Beta strandi128 – 135Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I1GX-ray2.90A/B1-141[»]
ProteinModelPortaliP42180.
SMRiP42180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42180.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 63HTH asnC-typePROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Contains 1 HTH asnC-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG01580. Archaea.
COG1522. LUCA.
HOGENOMiHOG000115326.
KOiK03718.
OMAiTKVCPAI.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.920. 1 hit.
InterProiIPR000485. AsnC-type_HTH_dom.
IPR011008. Dimeric_a/b-barrel.
IPR019888. Tscrpt_reg_AsnC-typ.
IPR019887. Tscrpt_reg_AsnC/Lrp_C.
IPR019885. Tscrpt_reg_HTH_AsnC-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01037. AsnC_trans_reg. 1 hit.
[Graphical view]
PRINTSiPR00033. HTHASNC.
SMARTiSM00344. HTH_ASNC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54909. SSF54909. 1 hit.
PROSITEiPS00519. HTH_ASNC_1. 1 hit.
PS50956. HTH_ASNC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDERDKIIL EILEKDARTP FTEIAKKLGI SETAVRKRVK ALEEKGIIEG
60 70 80 90 100
YTIKINPKKL GYSLVTITGV DTKPEKLFEV AEKLKEYDFV KELYLSSGDH
110 120 130 140
MIMAVIWAKD GEDLAEIISN KIGKIEGVTK VCPAIILEKL K
Length:141
Mass (Da):15,892
Last modified:September 26, 2001 - v2
Checksum:i41A74AD10119C925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97860 Genomic DNA. Translation: AAD20389.1.
AE009950 Genomic DNA. Translation: AAL81725.1.
PIRiT46972.
RefSeqiWP_011012747.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81725; AAL81725; PF1601.
GeneIDi1469477.
KEGGipfu:PF1601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97860 Genomic DNA. Translation: AAD20389.1.
AE009950 Genomic DNA. Translation: AAL81725.1.
PIRiT46972.
RefSeqiWP_011012747.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I1GX-ray2.90A/B1-141[»]
ProteinModelPortaliP42180.
SMRiP42180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1601.

Proteomic databases

PRIDEiP42180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81725; AAL81725; PF1601.
GeneIDi1469477.
KEGGipfu:PF1601.

Phylogenomic databases

eggNOGiarCOG01580. Archaea.
COG1522. LUCA.
HOGENOMiHOG000115326.
KOiK03718.
OMAiTKVCPAI.

Miscellaneous databases

EvolutionaryTraceiP42180.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.920. 1 hit.
InterProiIPR000485. AsnC-type_HTH_dom.
IPR011008. Dimeric_a/b-barrel.
IPR019888. Tscrpt_reg_AsnC-typ.
IPR019887. Tscrpt_reg_AsnC/Lrp_C.
IPR019885. Tscrpt_reg_HTH_AsnC-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01037. AsnC_trans_reg. 1 hit.
[Graphical view]
PRINTSiPR00033. HTHASNC.
SMARTiSM00344. HTH_ASNC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54909. SSF54909. 1 hit.
PROSITEiPS00519. HTH_ASNC_1. 1 hit.
PS50956. HTH_ASNC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREG7_PYRFU
AccessioniPrimary (citable) accession number: P42180
Secondary accession number(s): Q9Y8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.