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P42170

- RIR2_CAEEL

UniProt

P42170 - RIR2_CAEEL

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

rnr-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Iron 1PROSITE-ProRule annotation
Metal bindingi161 – 1611Iron 1PROSITE-ProRule annotation
Metal bindingi161 – 1611Iron 2By similarity
Metal bindingi164 – 1641Iron 1PROSITE-ProRule annotation
Active sitei168 – 1681PROSITE-ProRule annotation
Metal bindingi224 – 2241Iron 2By similarity
Metal bindingi258 – 2581Iron 2By similarity
Metal bindingi261 – 2611Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
  3. embryo development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_183103. G1/S-Specific Transcription.
REACT_237648. E2F mediated regulation of DNA replication.
REACT_245077. Synthesis and interconversion of nucleotide di- and triphosphates.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:rnr-2
ORF Names:C03C10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC03C10.3; CE00874; WBGene00004392; rnr-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Ribonucleoside-diphosphate reductase small chainPRO_0000190455Add
BLAST

Proteomic databases

PaxDbiP42170.
PRIDEiP42170.

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

BioGridi40762. 6 interactions.
DIPiDIP-24490N.
IntActiP42170. 1 interaction.
MINTiMINT-1055286.
STRINGi6239.C03C10.3.1.

Structurei

3D structure databases

ProteinModelPortaliP42170.
SMRiP42170. Positions 24-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
GeneTreeiENSGT00390000013305.
HOGENOMiHOG000255975.
InParanoidiP42170.
KOiK10808.
OMAiGVMNSTK.
PhylomeDBiP42170.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42170-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLTEIQNVE KENAGASVPK HSSNKLKLEK ELEKLEIVDQ TKAASAEETN
60 70 80 90 100
NESEVNELDA DEPMLQDLDN RFVIFPLKHH DIWNFYKKAV ASFWTVEEVD
110 120 130 140 150
LGKDMNDWEK MNGDEQYFIS RILAFFAASD GIVNENLCER FSNEVQVSEA
160 170 180 190 200
RFFYGFQIAI ENIHSEMYSK LIETYIRDET ERNTLFNAVD EFEFIKKKAD
210 220 230 240 250
WALRWISDKK ASFAERLIAF AAVEGIFFSG SFASIFWLKK RGLMPGLTHS
260 270 280 290 300
NELISRDEGL HRDFACLLYS KLQKKLTQQR IYDIIKDAVA IEQEFLTEAL
310 320 330 340 350
PVDMIGMNCR LMSQYIEFVA DHLLVELGCD KLYKSKNPFD FMENISIDGK
360 370 380
TNFFEKRVSE YQRPGVMVNE AERQFDLEAD F
Length:381
Mass (Da):44,289
Last modified:November 1, 1995 - v1
Checksum:i75497147ABF36C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35637 Genomic DNA. Translation: CAA84688.1.
PIRiT18876.
RefSeqiNP_497821.1. NM_065420.5.
UniGeneiCel.6650.

Genome annotation databases

EnsemblMetazoaiC03C10.3; C03C10.3; WBGene00004392.
GeneIDi175525.
KEGGicel:CELE_C03C10.3.
UCSCiC03C10.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35637 Genomic DNA. Translation: CAA84688.1 .
PIRi T18876.
RefSeqi NP_497821.1. NM_065420.5.
UniGenei Cel.6650.

3D structure databases

ProteinModelPortali P42170.
SMRi P42170. Positions 24-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40762. 6 interactions.
DIPi DIP-24490N.
IntActi P42170. 1 interaction.
MINTi MINT-1055286.
STRINGi 6239.C03C10.3.1.

Proteomic databases

PaxDbi P42170.
PRIDEi P42170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C03C10.3 ; C03C10.3 ; WBGene00004392 .
GeneIDi 175525.
KEGGi cel:CELE_C03C10.3.
UCSCi C03C10.3.1. c. elegans.

Organism-specific databases

CTDi 175525.
WormBasei C03C10.3 ; CE00874 ; WBGene00004392 ; rnr-2.

Phylogenomic databases

eggNOGi COG0208.
GeneTreei ENSGT00390000013305.
HOGENOMi HOG000255975.
InParanoidi P42170.
KOi K10808.
OMAi GVMNSTK.
PhylomeDBi P42170.

Enzyme and pathway databases

UniPathwayi UPA00326 .
Reactomei REACT_183103. G1/S-Specific Transcription.
REACT_237648. E2F mediated regulation of DNA replication.
REACT_245077. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

NextBioi 888524.
PROi P42170.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiRIR2_CAEEL
AccessioniPrimary (citable) accession number: P42170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3