Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P42170 (RIR2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:rnr-2
ORF Names:C03C10.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Ribonucleoside-diphosphate reductase small chain
PRO_0000190455

Sites

Active site1681 By similarity
Metal binding1301Iron 1 By similarity
Metal binding1611Iron 1 By similarity
Metal binding1611Iron 2 By similarity
Metal binding1641Iron 1 By similarity
Metal binding2241Iron 2 By similarity
Metal binding2581Iron 2 By similarity
Metal binding2611Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42170 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 75497147ABF36C59

FASTA38144,289
        10         20         30         40         50         60 
MTLTEIQNVE KENAGASVPK HSSNKLKLEK ELEKLEIVDQ TKAASAEETN NESEVNELDA 

        70         80         90        100        110        120 
DEPMLQDLDN RFVIFPLKHH DIWNFYKKAV ASFWTVEEVD LGKDMNDWEK MNGDEQYFIS 

       130        140        150        160        170        180 
RILAFFAASD GIVNENLCER FSNEVQVSEA RFFYGFQIAI ENIHSEMYSK LIETYIRDET 

       190        200        210        220        230        240 
ERNTLFNAVD EFEFIKKKAD WALRWISDKK ASFAERLIAF AAVEGIFFSG SFASIFWLKK 

       250        260        270        280        290        300 
RGLMPGLTHS NELISRDEGL HRDFACLLYS KLQKKLTQQR IYDIIKDAVA IEQEFLTEAL 

       310        320        330        340        350        360 
PVDMIGMNCR LMSQYIEFVA DHLLVELGCD KLYKSKNPFD FMENISIDGK TNFFEKRVSE 

       370        380 
YQRPGVMVNE AERQFDLEAD F 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z35637 Genomic DNA. Translation: CAA84688.1.
PIRT18876.
RefSeqNP_497821.1. NM_065420.5.
UniGeneCel.6650.

3D structure databases

ProteinModelPortalP42170.
SMRP42170. Positions 37-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40762. 6 interactions.
DIPDIP-24490N.
IntActP42170. 1 interaction.
MINTMINT-1055286.
STRING6239.C03C10.3.1.

Proteomic databases

PaxDbP42170.
PRIDEP42170.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC03C10.3.1; C03C10.3.1; C03C10.3.
C03C10.3.2; C03C10.3.2; C03C10.3.
GeneID175525.
KEGGcel:CELE_C03C10.3.
UCSCC03C10.3.1. c. elegans.

Organism-specific databases

CTD175525.
WormBaseC03C10.3; CE00874; WBGene00004392; rnr-2.

Phylogenomic databases

eggNOGCOG0208.
HOGENOMHOG000255975.
InParanoidP42170.
KOK10808.
OMAACANHWM.
PhylomeDBP42170.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio888524.
PROP42170.

Entry information

Entry nameRIR2_CAEEL
AccessionPrimary (citable) accession number: P42170
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase