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P42170

- RIR2_CAEEL

UniProt

P42170 - RIR2_CAEEL

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

rnr-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi130 – 1301Iron 1PROSITE-ProRule annotation
    Metal bindingi161 – 1611Iron 1PROSITE-ProRule annotation
    Metal bindingi161 – 1611Iron 2By similarity
    Metal bindingi164 – 1641Iron 1PROSITE-ProRule annotation
    Active sitei168 – 1681PROSITE-ProRule annotation
    Metal bindingi224 – 2241Iron 2By similarity
    Metal bindingi258 – 2581Iron 2By similarity
    Metal bindingi261 – 2611Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway
    3. embryo development Source: WormBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_183103. G1/S-Specific Transcription.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:rnr-2
    ORF Names:C03C10.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC03C10.3; CE00874; WBGene00004392; rnr-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Ribonucleoside-diphosphate reductase small chainPRO_0000190455Add
    BLAST

    Proteomic databases

    PaxDbiP42170.
    PRIDEiP42170.

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.

    Protein-protein interaction databases

    BioGridi40762. 6 interactions.
    DIPiDIP-24490N.
    IntActiP42170. 1 interaction.
    MINTiMINT-1055286.
    STRINGi6239.C03C10.3.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP42170.
    SMRiP42170. Positions 24-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    GeneTreeiENSGT00390000013305.
    HOGENOMiHOG000255975.
    InParanoidiP42170.
    KOiK10808.
    OMAiGVMNSTK.
    PhylomeDBiP42170.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42170-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLTEIQNVE KENAGASVPK HSSNKLKLEK ELEKLEIVDQ TKAASAEETN    50
    NESEVNELDA DEPMLQDLDN RFVIFPLKHH DIWNFYKKAV ASFWTVEEVD 100
    LGKDMNDWEK MNGDEQYFIS RILAFFAASD GIVNENLCER FSNEVQVSEA 150
    RFFYGFQIAI ENIHSEMYSK LIETYIRDET ERNTLFNAVD EFEFIKKKAD 200
    WALRWISDKK ASFAERLIAF AAVEGIFFSG SFASIFWLKK RGLMPGLTHS 250
    NELISRDEGL HRDFACLLYS KLQKKLTQQR IYDIIKDAVA IEQEFLTEAL 300
    PVDMIGMNCR LMSQYIEFVA DHLLVELGCD KLYKSKNPFD FMENISIDGK 350
    TNFFEKRVSE YQRPGVMVNE AERQFDLEAD F 381
    Length:381
    Mass (Da):44,289
    Last modified:November 1, 1995 - v1
    Checksum:i75497147ABF36C59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35637 Genomic DNA. Translation: CAA84688.1.
    PIRiT18876.
    RefSeqiNP_497821.1. NM_065420.5.
    UniGeneiCel.6650.

    Genome annotation databases

    EnsemblMetazoaiC03C10.3; C03C10.3; WBGene00004392.
    GeneIDi175525.
    KEGGicel:CELE_C03C10.3.
    UCSCiC03C10.3.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35637 Genomic DNA. Translation: CAA84688.1 .
    PIRi T18876.
    RefSeqi NP_497821.1. NM_065420.5.
    UniGenei Cel.6650.

    3D structure databases

    ProteinModelPortali P42170.
    SMRi P42170. Positions 24-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40762. 6 interactions.
    DIPi DIP-24490N.
    IntActi P42170. 1 interaction.
    MINTi MINT-1055286.
    STRINGi 6239.C03C10.3.1.

    Proteomic databases

    PaxDbi P42170.
    PRIDEi P42170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C03C10.3 ; C03C10.3 ; WBGene00004392 .
    GeneIDi 175525.
    KEGGi cel:CELE_C03C10.3.
    UCSCi C03C10.3.1. c. elegans.

    Organism-specific databases

    CTDi 175525.
    WormBasei C03C10.3 ; CE00874 ; WBGene00004392 ; rnr-2.

    Phylogenomic databases

    eggNOGi COG0208.
    GeneTreei ENSGT00390000013305.
    HOGENOMi HOG000255975.
    InParanoidi P42170.
    KOi K10808.
    OMAi GVMNSTK.
    PhylomeDBi P42170.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    Reactomei REACT_183103. G1/S-Specific Transcription.

    Miscellaneous databases

    NextBioi 888524.
    PROi P42170.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiRIR2_CAEEL
    AccessioniPrimary (citable) accession number: P42170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3