P42165 (IFNA1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon type A1/A2

Gene names

Name:	IFNA1
AND
Name:	IFNA2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antiviral activities.
Subcellular location	Secreted Probable.
Developmental stage	Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	defense response Inferred from electronic annotation. Source: InterPro response to virus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW cytokine receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 193	162	Interferon type A1/A2		PRO_0000016428
Amino acid modifications
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Disulfide bond	32 ↔ 129		By similarity
	Disulfide bond	61 ↔ 155		Potential
	Disulfide bond	68 ↔ 168		By similarity
Natural variations
	Natural variant	65	1	N → S.

Sequences

	Sequence		Length	Mass (Da)
	P42165 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 35AF74479C450A15	FASTA	193	22,116
	10 20 30 40 50 60 MAVPASPQHP RGYGILLLTL LLKALATTAS ACNHLRPQDA TFSHDSLQLL RDMAPTLPQL 70 80 90 100 110 120 CPQHNASCSF NDTILDTSNT RQADKTTHDI LQHLFKILSS PSTPAHWNDS QRQSLLNRIH 130 140 150 160 170 180 RYTQHLEQCL DSSDTRSRTR WPRNLHLTIK KHFSCLHTFL QDNDYSACAW EHVRLQARAW 190 FLHIHNLTGN TRT

References

[1]	"Chicken interferon gene: cloning, expression, and analysis." Sekellick M.J., Ferrandino A.F., Hopkins D.A., Marcus P.I. J. Interferon Res. 14:71-79(1994) [PubMed: 7521382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A family of genes coding for two serologically distinct chicken interferons." Sick C., Schultz U., Staeheli P. J. Biol. Chem. 271:7635-7639(1996) [PubMed: 8631799] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: White leghorn. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07868 mRNA. Translation: AAA50213.1. X92477 Genomic DNA. Translation: CAA63215.1. X92476 Genomic DNA. Translation: CAA63214.1.
IPI	IPI00603629.
PIR	I50693.
RefSeq	NP_990758.1. NM_205427.1.
UniGene	Gga.801.
3D structure databases
ProteinModelPortal	P42165.
ModBase	Search...
Protein-protein interaction databases
STRING	P42165.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000021627; ENSGALP00000021594; ENSGALG00000013245.
GeneID	396398.
KEGG	gga:396398.
Organism-specific databases
CTD	396398.
Phylogenomic databases
HOGENOM	HBG281128.
HOVERGEN	HBG052087.
InParanoid	P42165.
OMA	FISKDSF.
PhylomeDB	P42165.
Family and domain databases
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000471. Interferon_alpha/beta/delta. IPR015587. Interferon_alpha_precursor. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
KO	K05414.
PANTHER	PTHR11691:SF2. IFNa_like. 1 hit. PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
SMART	SM00076. IFabd. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IFNA1_CHICK

Accession

Primary (citable) accession number: P42165

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program