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Protein

Interferon gamma

Gene

IFNG

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-CFA-877300 Interferon gamma signaling
R-CFA-877312 Regulation of IFNG signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:41879 IFNG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001643724 – 166Interferon gammaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP42161
PRIDEiP42161

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSCAFG00000000408

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000588

Structurei

3D structure databases

ProteinModelPortaliP42161
SMRiP42161
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP42161
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
TreeFamiTF336308

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS
60 70 80 90 100
LFVDILKKWR EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM
110 120 130 140 150
LGKFLNSSTS KREDFLKLIQ IPVNDLQVQR KAINELIKVM NDLSPRSNLR
160
KRKRSQNLFR GRRASK
Length:166
Mass (Da):19,395
Last modified:December 1, 2000 - v2
Checksum:i72179B0B637402DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → L in AAB22724 (PubMed:1640120).Curated1
Sequence conflicti22N → Y in AAB22724 (PubMed:1640120).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126247 mRNA Translation: AAD31423.1
EF095772 mRNA Translation: ABL01503.1
S41201 mRNA Translation: AAB22724.2
RefSeqiNP_001003174.1, NM_001003174.1
UniGeneiCfa.3900

Genome annotation databases

EnsembliENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408
GeneIDi403801
KEGGicfa:403801

Similar proteinsi

Entry informationi

Entry nameiIFNG_CANLF
AccessioniPrimary (citable) accession number: P42161
Secondary accession number(s): A1E294, Q9TVA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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