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Protein

Interferon gamma

Gene

IFNG

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  1. cytokine activity Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: UniProtKB-KW
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: GO_Central
  13. negative regulation of growth of symbiont in host Source: Ensembl
  14. negative regulation of interleukin-17 production Source: Ensembl
  15. negative regulation of myelination Source: Ensembl
  16. negative regulation of smooth muscle cell proliferation Source: Ensembl
  17. neutrophil apoptotic process Source: Ensembl
  18. neutrophil chemotaxis Source: Ensembl
  19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  20. positive regulation of chemokine biosynthetic process Source: Ensembl
  21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  24. positive regulation of interleukin-1 beta secretion Source: Ensembl
  25. positive regulation of interleukin-23 production Source: Ensembl
  26. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  27. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  28. positive regulation of killing of cells of other organism Source: Ensembl
  29. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  30. positive regulation of MHC class II biosynthetic process Source: Ensembl
  31. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  32. positive regulation of osteoclast differentiation Source: Ensembl
  33. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  34. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  35. positive regulation of T cell proliferation Source: Ensembl
  36. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  37. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  38. positive regulation of tumor necrosis factor production Source: Ensembl
  39. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  40. protein import into nucleus, translocation Source: Ensembl
  41. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_182563. Interferon gamma signaling.
REACT_182567. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 166143Interferon gammaPRO_0000016437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP42161.
SMRiP42161. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP42161.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42161-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS
60 70 80 90 100
LFVDILKKWR EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM
110 120 130 140 150
LGKFLNSSTS KREDFLKLIQ IPVNDLQVQR KAINELIKVM NDLSPRSNLR
160
KRKRSQNLFR GRRASK
Length:166
Mass (Da):19,395
Last modified:December 1, 2000 - v2
Checksum:i72179B0B637402DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → L in AAB22724. (PubMed:1640120)Curated
Sequence conflicti22 – 221N → Y in AAB22724. (PubMed:1640120)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126247 mRNA. Translation: AAD31423.1.
EF095772 mRNA. Translation: ABL01503.1.
S41201 mRNA. Translation: AAB22724.2.
RefSeqiNP_001003174.1. NM_001003174.1.
UniGeneiCfa.3900.

Genome annotation databases

EnsembliENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408.
GeneIDi403801.
KEGGicfa:403801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126247 mRNA. Translation: AAD31423.1.
EF095772 mRNA. Translation: ABL01503.1.
S41201 mRNA. Translation: AAB22724.2.
RefSeqiNP_001003174.1. NM_001003174.1.
UniGeneiCfa.3900.

3D structure databases

ProteinModelPortaliP42161.
SMRiP42161. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408.
GeneIDi403801.
KEGGicfa:403801.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP42161.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiREACT_182563. Interferon gamma signaling.
REACT_182567. Regulation of IFNG signaling.

Miscellaneous databases

NextBioi20817298.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of canine interferon-gamma."
    Boroughs K.L., Sim G.-K.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amplification and cloning of canine interferon gamma in mammalian expression vector."
    Salunkhe S.S., Rai A., Saxena A., Tiwari A.K., Ravindra P.V., Sandey M., Gupta P.K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of the cDNA for canine interferon-gamma."
    Zucker K., Lu P., Esquenazi V., Miller J.
    J. Interferon Res. 12:191-194(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-166.
    Tissue: Lymphocyte.

Entry informationi

Entry nameiIFNG_CANFA
AccessioniPrimary (citable) accession number: P42161
Secondary accession number(s): A1E294, Q9TVA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: February 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.