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P42161

- IFNG_CANFA

UniProt

P42161 - IFNG_CANFA

Protein

Interferon gamma

Gene

IFNG

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. antigen processing and presentation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. defense response to bacterium Source: Ensembl
    8. defense response to protozoan Source: Ensembl
    9. defense response to virus Source: UniProtKB-KW
    10. endoplasmic reticulum unfolded protein response Source: Ensembl
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: RefGenome
    13. negative regulation of growth of symbiont in host Source: Ensembl
    14. negative regulation of interleukin-17 production Source: Ensembl
    15. negative regulation of myelination Source: Ensembl
    16. negative regulation of smooth muscle cell proliferation Source: Ensembl
    17. neutrophil apoptotic process Source: Ensembl
    18. neutrophil chemotaxis Source: Ensembl
    19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    20. positive regulation of chemokine biosynthetic process Source: Ensembl
    21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    24. positive regulation of interleukin-12 production Source: Ensembl
    25. positive regulation of interleukin-1 beta secretion Source: Ensembl
    26. positive regulation of interleukin-23 production Source: Ensembl
    27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
    28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    29. positive regulation of killing of cells of other organism Source: Ensembl
    30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    31. positive regulation of MHC class II biosynthetic process Source: Ensembl
    32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    33. positive regulation of osteoclast differentiation Source: Ensembl
    34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
    35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    36. positive regulation of T cell proliferation Source: Ensembl
    37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    39. positive regulation of tumor necrosis factor production Source: Ensembl
    40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    41. positive regulation of vitamin D biosynthetic process Source: Ensembl
    42. protein import into nucleus, translocation Source: Ensembl
    43. regulation of insulin secretion Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Growth regulation

    Enzyme and pathway databases

    ReactomeiREACT_182563. Interferon gamma signaling.
    REACT_182567. Regulation of IFNG signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gamma
    Short name:
    IFN-gamma
    Gene namesi
    Name:IFNG
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 10

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 166143Interferon gammaPRO_0000016437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Released primarily from activated T lymphocytes.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP42161.
    SMRiP42161. Positions 24-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45353.
    GeneTreeiENSGT00390000007831.
    HOGENOMiHOG000254784.
    HOVERGENiHBG056912.
    InParanoidiP42161.
    KOiK04687.
    OMAiKEYFNAS.
    OrthoDBiEOG7VHSZM.
    TreeFamiTF336308.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42161-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS    50
    LFVDILKKWR EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM 100
    LGKFLNSSTS KREDFLKLIQ IPVNDLQVQR KAINELIKVM NDLSPRSNLR 150
    KRKRSQNLFR GRRASK 166
    Length:166
    Mass (Da):19,395
    Last modified:December 1, 2000 - v2
    Checksum:i72179B0B637402DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191S → L in AAB22724. (PubMed:1640120)Curated
    Sequence conflicti22 – 221N → Y in AAB22724. (PubMed:1640120)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF126247 mRNA. Translation: AAD31423.1.
    EF095772 mRNA. Translation: ABL01503.1.
    S41201 mRNA. Translation: AAB22724.2.
    RefSeqiNP_001003174.1. NM_001003174.1.
    UniGeneiCfa.3900.

    Genome annotation databases

    EnsembliENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408.
    GeneIDi403801.
    KEGGicfa:403801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF126247 mRNA. Translation: AAD31423.1 .
    EF095772 mRNA. Translation: ABL01503.1 .
    S41201 mRNA. Translation: AAB22724.2 .
    RefSeqi NP_001003174.1. NM_001003174.1.
    UniGenei Cfa.3900.

    3D structure databases

    ProteinModelPortali P42161.
    SMRi P42161. Positions 24-144.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000000643 ; ENSCAFP00000000588 ; ENSCAFG00000000408 .
    GeneIDi 403801.
    KEGGi cfa:403801.

    Organism-specific databases

    CTDi 3458.

    Phylogenomic databases

    eggNOGi NOG45353.
    GeneTreei ENSGT00390000007831.
    HOGENOMi HOG000254784.
    HOVERGENi HBG056912.
    InParanoidi P42161.
    KOi K04687.
    OMAi KEYFNAS.
    OrthoDBi EOG7VHSZM.
    TreeFami TF336308.

    Enzyme and pathway databases

    Reactomei REACT_182563. Interferon gamma signaling.
    REACT_182567. Regulation of IFNG signaling.

    Miscellaneous databases

    NextBioi 20817298.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of canine interferon-gamma."
      Boroughs K.L., Sim G.-K.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Amplification and cloning of canine interferon gamma in mammalian expression vector."
      Salunkhe S.S., Rai A., Saxena A., Tiwari A.K., Ravindra P.V., Sandey M., Gupta P.K.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of the cDNA for canine interferon-gamma."
      Zucker K., Lu P., Esquenazi V., Miller J.
      J. Interferon Res. 12:191-194(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-166.
      Tissue: Lymphocyte.

    Entry informationi

    Entry nameiIFNG_CANFA
    AccessioniPrimary (citable) accession number: P42161
    Secondary accession number(s): A1E294, Q9TVA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3