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Protein

Interferon gamma

Gene

IFNG

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_327823. Interferon gamma signaling.
REACT_341601. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 166143Interferon gammaPRO_0000016437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000588.

Structurei

3D structure databases

ProteinModelPortaliP42161.
SMRiP42161. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP42161.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS
60 70 80 90 100
LFVDILKKWR EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM
110 120 130 140 150
LGKFLNSSTS KREDFLKLIQ IPVNDLQVQR KAINELIKVM NDLSPRSNLR
160
KRKRSQNLFR GRRASK
Length:166
Mass (Da):19,395
Last modified:December 1, 2000 - v2
Checksum:i72179B0B637402DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → L in AAB22724 (PubMed:1640120).Curated
Sequence conflicti22 – 221N → Y in AAB22724 (PubMed:1640120).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126247 mRNA. Translation: AAD31423.1.
EF095772 mRNA. Translation: ABL01503.1.
S41201 mRNA. Translation: AAB22724.2.
RefSeqiNP_001003174.1. NM_001003174.1.
UniGeneiCfa.3900.

Genome annotation databases

EnsembliENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408.
GeneIDi403801.
KEGGicfa:403801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126247 mRNA. Translation: AAD31423.1.
EF095772 mRNA. Translation: ABL01503.1.
S41201 mRNA. Translation: AAB22724.2.
RefSeqiNP_001003174.1. NM_001003174.1.
UniGeneiCfa.3900.

3D structure databases

ProteinModelPortaliP42161.
SMRiP42161. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408.
GeneIDi403801.
KEGGicfa:403801.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP42161.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiREACT_327823. Interferon gamma signaling.
REACT_341601. Regulation of IFNG signaling.

Miscellaneous databases

NextBioi20817298.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of canine interferon-gamma."
    Boroughs K.L., Sim G.-K.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amplification and cloning of canine interferon gamma in mammalian expression vector."
    Salunkhe S.S., Rai A., Saxena A., Tiwari A.K., Ravindra P.V., Sandey M., Gupta P.K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of the cDNA for canine interferon-gamma."
    Zucker K., Lu P., Esquenazi V., Miller J.
    J. Interferon Res. 12:191-194(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-166.
    Tissue: Lymphocyte.

Entry informationi

Entry nameiIFNG_CANFA
AccessioniPrimary (citable) accession number: P42161
Secondary accession number(s): A1E294, Q9TVA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: June 24, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.