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Protein

Interferon gamma

Gene

IFNG

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:18951 IFNG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001644324 – 166Interferon gammaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP42160

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSECAG00000016021

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013836

Structurei

3D structure databases

ProteinModelPortaliP42160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP42160
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
TreeFamiTF336308

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTSFILAF QLCAILGSST YYCQAAFFKE IENLKEYFNA SNPDVGDGGP
60 70 80 90 100
LFLDILKNWK EDSDKKIIQS QIVSFYFKLF ENLKDNQVIQ KSMDTIKEDL
110 120 130 140 150
FVKFFNSSTS KLEDFQKLIQ IPVNDLKVQR KAISELIKVM NDLSPKANLR
160
KRKRSQNPFR GRRALQ
Length:166
Mass (Da):19,338
Last modified:November 1, 1995 - v1
Checksum:iA335A51057812FAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2N → K in BAA05876 (PubMed:7841464).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04050 mRNA Translation: AAA59061.1
D28520 mRNA Translation: BAA05876.1
RefSeqiNP_001075418.1, NM_001081949.1
UniGeneiEca.721

Genome annotation databases

EnsembliENSECAT00000017076; ENSECAP00000013836; ENSECAG00000016021
GeneIDi100034181
KEGGiecb:100034181

Similar proteinsi

Entry informationi

Entry nameiIFNG_HORSE
AccessioniPrimary (citable) accession number: P42160
Secondary accession number(s): Q28387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome