UniProtKB - P42126 (ECI1_HUMAN)
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Protein
Enoyl-CoA delta isomerase 1, mitochondrial
Gene
ECI1
Organism
Homo sapiens (Human)
Status
Functioni
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
Catalytic activityi
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.1 Publication
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 153 | Substrate; via amide nitrogenCombined sources1 Publication | 1 | |
Binding sitei | 177 | SubstrateCombined sources1 Publication | 1 | |
Sitei | 178 | Important for catalytic activity1 Publication | 1 |
GO - Molecular functioni
- dodecenoyl-CoA delta-isomerase activity Source: Reactome
- enoyl-CoA hydratase activity Source: GO_Central
- intramolecular oxidoreductase activity Source: Reactome
GO - Biological processi
- fatty acid beta-oxidation Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 5.3.3.8. 2681. |
Reactomei | R-HSA-77288. mitochondrial fatty acid beta-oxidation of unsaturated fatty acids. |
UniPathwayi | UPA00659. |
Chemistry databases
SwissLipidsi | SLP:000001184. |
Names & Taxonomyi
Protein namesi | Recommended name: Enoyl-CoA delta isomerase 1, mitochondrial (EC:5.3.3.8)Alternative name(s): 3,2-trans-enoyl-CoA isomerase Delta(3),Delta(2)-enoyl-CoA isomerase Short name: D3,D2-enoyl-CoA isomerase Dodecenoyl-CoA isomerase |
Gene namesi | Name:ECI1 Synonyms:DCI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167969.12. |
HGNCi | HGNC:2703. ECI1. |
MIMi | 600305. gene. |
neXtProti | NX_P42126. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 178 | E → A: Loss of activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1632. |
OpenTargetsi | ENSG00000167969. |
PharmGKBi | PA27173. |
Chemistry databases
DrugBanki | DB03127. Benzamidine. DB02910. Octanoyl-Coenzyme A. |
Polymorphism and mutation databases
BioMutai | ECI1. |
DMDMi | 1169204. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 41 | MitochondrionBy similarityAdd BLAST | 41 | |
ChainiPRO_0000007420 | 42 – 302 | Enoyl-CoA delta isomerase 1, mitochondrialAdd BLAST | 261 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 61 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 84 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 89 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 283 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 283 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 288 | N6-succinyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P42126. |
MaxQBi | P42126. |
PaxDbi | P42126. |
PeptideAtlasi | P42126. |
PRIDEi | P42126. |
TopDownProteomicsi | P42126-1. [P42126-1] P42126-2. [P42126-2] |
2D gel databases
OGPi | P42126. |
PTM databases
iPTMneti | P42126. |
PhosphoSitePlusi | P42126. |
SwissPalmi | P42126. |
Expressioni
Gene expression databases
Bgeei | ENSG00000167969. |
CleanExi | HS_DCI. |
ExpressionAtlasi | P42126. baseline and differential. |
Genevisiblei | P42126. HS. |
Organism-specific databases
HPAi | HPA041746. HPA043227. |
Interactioni
Subunit structurei
Homotrimer.1 Publication
Protein-protein interaction databases
BioGridi | 108000. 10 interactors. |
IntActi | P42126. 5 interactors. |
MINTi | P42126. |
STRINGi | 9606.ENSP00000301729. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 46 – 52 | Combined sources | 7 | |
Turni | 53 – 56 | Combined sources | 4 | |
Beta strandi | 57 – 62 | Combined sources | 6 | |
Turni | 65 – 67 | Combined sources | 3 | |
Helixi | 72 – 87 | Combined sources | 16 | |
Beta strandi | 93 – 100 | Combined sources | 8 | |
Beta strandi | 102 – 104 | Combined sources | 3 | |
Helixi | 110 – 113 | Combined sources | 4 | |
Helixi | 118 – 136 | Combined sources | 19 | |
Beta strandi | 139 – 146 | Combined sources | 8 | |
Beta strandi | 148 – 150 | Combined sources | 3 | |
Helixi | 152 – 158 | Combined sources | 7 | |
Beta strandi | 161 – 167 | Combined sources | 7 | |
Helixi | 178 – 181 | Combined sources | 4 | |
Helixi | 187 – 197 | Combined sources | 11 | |
Helixi | 199 – 208 | Combined sources | 10 | |
Helixi | 214 – 219 | Combined sources | 6 | |
Beta strandi | 222 – 227 | Combined sources | 6 | |
Helixi | 229 – 231 | Combined sources | 3 | |
Helixi | 232 – 244 | Combined sources | 13 | |
Helixi | 248 – 267 | Combined sources | 20 | |
Helixi | 270 – 281 | Combined sources | 12 | |
Helixi | 284 – 290 | Combined sources | 7 | |
Helixi | 293 – 299 | Combined sources | 7 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SG4 | X-ray | 1.30 | A/B/C | 43-302 | [»] | |
ProteinModelPortali | P42126. | |||||
SMRi | P42126. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42126. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 110 | Substrate bindingCombined sources1 Publication | 5 |
Sequence similaritiesi
Belongs to the enoyl-CoA hydratase/isomerase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG410ISNQ. Eukaryota. COG1024. LUCA. |
GeneTreei | ENSGT00390000005678. |
HOVERGENi | HBG001112. |
InParanoidi | P42126. |
KOi | K13238. |
OMAi | TMHHAGI. |
OrthoDBi | EOG091G0I32. |
PhylomeDBi | P42126. |
TreeFami | TF314436. |
Family and domain databases
InterProi | View protein in InterPro IPR029045. ClpP/crotonase-like_dom_sf. IPR018376. Enoyl-CoA_hyd/isom_CS. IPR001753. Enoyl-CoA_hydra/iso. |
Pfami | View protein in Pfam PF00378. ECH_1. 1 hit. |
SUPFAMi | SSF52096. SSF52096. 1 hit. |
PROSITEi | View protein in PROSITE PS00166. ENOYL_COA_HYDRATASE. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P42126-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE
60 70 80 90 100
PDAGAGVAVM KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR
110 120 130 140 150
PGVFSAGLDL TEMCGRSPAH YAGYWKAVQE LWLRLYQSNL VLVSAINGAC
160 170 180 190 200
PAGGCLVALT CDYRILADNP RYCIGLNETQ LGIIAPFWLK DTLENTIGHR
210 220 230 240 250
AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI AQWMAIPDHA
260 270 280 290 300
RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE
KG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | L → P in AAH00762 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 14 | L → P in AAH19316 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 41 | R → P in CAA81065 (PubMed:7829074).Curated | 1 | |
Sequence conflicti | 44 | S → C AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 54 | G → A in CAA81065 (PubMed:7829074).Curated | 1 | |
Sequence conflicti | 78 | L → F AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 93 | G → V in AAA35485 (PubMed:8198519).Curated | 1 | |
Sequence conflicti | 114 | Missing AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 192 – 193 | TL → PY AA sequence (PubMed:7818490).Curated | 2 | |
Sequence conflicti | 204 – 207 | RALQ → SAPE in AAA35485 (PubMed:8198519).Curated | 4 | |
Sequence conflicti | 210 | L → S AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 213 – 215 | PPA → RRP in AAA35485 (PubMed:8198519).Curated | 3 | |
Sequence conflicti | 242 | Q → K AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 245 | A → T AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 248 | D → E AA sequence (PubMed:7818490).Curated | 1 | |
Sequence conflicti | 291 | Q → E AA sequence (PubMed:7818490).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001358 | 172 – 188 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z25820 mRNA. Translation: CAA81065.1. Z25821 Z25824 Genomic DNA. Translation: CAA81066.1. AK291127 mRNA. Translation: BAF83816.1. CH471112 Genomic DNA. Translation: EAW85524.1. BC000762 mRNA. Translation: AAH00762.1. BC002746 mRNA. Translation: AAH02746.1. BC020228 mRNA. Translation: AAH20228.1. BC019316 mRNA. Translation: AAH19316.1. L24774 mRNA. Translation: AAA35485.1. |
CCDSi | CCDS10464.1. [P42126-1] CCDS58410.1. [P42126-2] |
PIRi | A55723. |
RefSeqi | NP_001171500.1. NM_001178029.1. [P42126-2] NP_001910.2. NM_001919.3. [P42126-1] |
UniGenei | Hs.403436. |
Genome annotation databases
Ensembli | ENST00000301729; ENSP00000301729; ENSG00000167969. [P42126-1] ENST00000562238; ENSP00000456319; ENSG00000167969. [P42126-2] |
GeneIDi | 1632. |
KEGGi | hsa:1632. |
UCSCi | uc002cpr.4. human. [P42126-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | ECI1_HUMAN | |
Accessioni | P42126Primary (citable) accession number: P42126 Secondary accession number(s): A8K512 Q9UDG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |