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Reviewed, UniProtKB/Swiss-Prot P42125 (D3D2_MOUSE)

Last modified January 19, 2010. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3,2-trans-enoyl-CoA isomerase, mitochondrial
    EC=5.3.3.8
Alternative name(s):
    Dodecenoyl-CoA isomerase
    Delta(3),Delta(2)-enoyl-CoA isomerase
      Short name=D3,D2-enoyl-CoA isomerase
Gene names
Name: Dci
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.

Catalytic activity

(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Subunit structure

Homotrimer By similarity.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

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Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionIsomerase
   PTMAcetylation
Gene Ontology (GO)
   Biological processfatty acid beta-oxidation

Inferred from mutant phenotype. Source: MGI

   Cellular componentmitochondrial inner membrane

Inferred from direct assay. Source: MGI

mitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondodecenoyl-CoA delta-isomerase activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion By similarity
Chain29 – 2892613,2-trans-enoyl-CoA isomerase, mitochondrial
PRO_0000007421

Regions

Region93 – 975Substrate binding By similarity

Sites

Binding site1401Substrate; via amide nitrogen By similarity
Binding site1641Substrate By similarity
Site1651Important for catalytic activity By similarity

Amino acid modifications

Modified residue761N6-acetyllysine By similarity
Modified residue2701N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
P42125-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 804B4E731E422D06

FASTA28932,078
        10         20         30         40         50         60 
MALAAARRLL LHAGSRLGRR EAVDGARPFA NKRVLVETEG PAGVAVMKLR NPPVNSLSLE 

        70         80         90        100        110        120 
CLTEFTISLE KLENDKSIRG VILTSECPGI FSAGLDLLEM YGRNPAHYAE YWKNVQELWL 

       130        140        150        160        170        180 
RLYTSNMILV SAINGASPAG GCLLALCCDY RVMADNPKYT IGLNESLLGI VAPFWFKDMY 

       190        200        210        220        230        240 
VNTIGHREAD GALQLGTLFS PAEALKVGVV DEVVPEDQVH SKARSVMTKW LAIPDHSRQL 

       250        260        270        280 
TKNMMRKATA DNLIKQREAD IQNFTSFISK DSIQKSLHMY LEKLKQKKG

« Hide

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References

[1]"Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase."
Stoffel W., Dueker M., Hofmann K.O.
FEBS Lett. 333:119-122(1993) [PubMed: 8224148] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z14049 mRNA. Translation: CAA78417.1.
Z14050 expand/collapse EMBL AC list , Z14051, Z14052, Z14053, Z14054 Genomic DNA. Translation: CAA78418.1.
IPIIPI00114416.
PIRS38770.
UniGeneMm.291743

3D structure databases

SMRP42125. Positions 29-285.
ModBaseSearch...

Protein-protein interaction databases

STRINGP42125.

Proteomic databases

PRIDEP42125.

Genome annotation databases

EnsemblENSMUST00000024946; ENSMUSP00000024946; ENSMUSG00000024132; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:94871. Dci.

Phylogenomic databases

eggNOGroNOG07688.
HOGENOMHBG621614.
HOVERGENP42125.
InParanoidP42125.

Enzyme and pathway databases

BRENDA5.3.3.8. 244.

Gene expression databases

ArrayExpressP42125.
BgeeP42125.
GenevestigatorP42125.
GermOnlineENSMUSG00000024132. Mus musculus.

Family and domain databases

InterProIPR001753. Crotonase_core.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamPF00378. ECH. 1 hit.
[Graphical view]
PROSITEPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameD3D2_MOUSE
AccessionPrimary (citable) accession number: P42125
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 19, 2010
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents