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Protein

Enoyl-CoA delta isomerase 1, mitochondrial

Gene

Eci1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.

Catalytic activityi

A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140Substrate; via amide nitrogenBy similarity1
Binding sitei164SubstrateBy similarity1
Sitei165Important for catalytic activityBy similarity1

GO - Molecular functioni

  • dodecenoyl-CoA delta-isomerase activity Source: MGI
  • enoyl-CoA hydratase activity Source: GO_Central

GO - Biological processi

  • fatty acid beta-oxidation Source: MGI

Keywordsi

Molecular functionIsomerase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-CoA delta isomerase 1, mitochondrial (EC:5.3.3.8)
Alternative name(s):
3,2-trans-enoyl-CoA isomerase
Delta(3),Delta(2)-enoyl-CoA isomerase
Short name:
D3,D2-enoyl-CoA isomerase
Dodecenoyl-CoA isomerase
Gene namesi
Name:Eci1
Synonyms:Dci
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:94871 Eci1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
ChainiPRO_000000742129 – 289Enoyl-CoA delta isomerase 1, mitochondrialAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-acetyllysine; alternateCombined sources1
Modified residuei48N6-succinyllysine; alternateCombined sources1
Modified residuei71N6-succinyllysineCombined sources1
Modified residuei76N6-acetyllysineCombined sources1
Modified residuei222N6-acetyllysine; alternateCombined sources1
Modified residuei222N6-succinyllysine; alternateCombined sources1
Modified residuei229N6-acetyllysine; alternateCombined sources1
Modified residuei229N6-succinyllysine; alternateCombined sources1
Modified residuei255N6-acetyllysine; alternateCombined sources1
Modified residuei255N6-succinyllysine; alternateCombined sources1
Modified residuei270N6-acetyllysine; alternateCombined sources1
Modified residuei270N6-succinyllysine; alternateCombined sources1
Modified residuei275N6-succinyllysineCombined sources1
Modified residuei283N6-acetyllysine; alternateCombined sources1
Modified residuei283N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP42125
PaxDbiP42125
PeptideAtlasiP42125
PRIDEiP42125

PTM databases

iPTMnetiP42125
PhosphoSitePlusiP42125
SwissPalmiP42125

Expressioni

Gene expression databases

BgeeiENSMUSG00000024132
GenevisibleiP42125 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi199065, 1 interactor
STRINGi10090.ENSMUSP00000024946

Structurei

3D structure databases

ProteinModelPortaliP42125
SMRiP42125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 97Substrate bindingBy similarity5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410ISNQ Eukaryota
COG1024 LUCA
GeneTreeiENSGT00390000005678
HOVERGENiHBG001112
InParanoidiP42125
KOiK13238
OMAiTMHHAGI
OrthoDBiEOG091G0I32
TreeFamiTF314436

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAAARRLL LHAGSRLGRR EAVDGARRFA NKRVLVETEG PAGVAVMKLR
60 70 80 90 100
NPPVNSLSLE CLTEFTISLE KLENDKSIRG VILTSECPGI FSAGLDLLEM
110 120 130 140 150
YGRNPAHYAE YWKNVQELWL RLYTSNMILV SAINGASPAG GCLLALCCDY
160 170 180 190 200
RVMADNPKYT IGLNESLLGI VAPFWFKDMY VNTIGHREAE RALQLGTLFS
210 220 230 240 250
PAEALKVGVV DEVVPEDQVH SKARSVMTKW LAIPDHSRQL TKNMMRKATA
260 270 280
DNLIKQREAD IQNFTSFISK DSIQKSLHMY LEKLKQKKG
Length:289
Mass (Da):32,250
Last modified:October 3, 2012 - v2
Checksum:i950B7A39D9458B91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28R → P in CAA78417 (PubMed:8224148).Curated1
Sequence conflicti28R → P in CAA78418 (PubMed:8224148).Curated1
Sequence conflicti190 – 191ER → DG in CAA78417 (PubMed:8224148).Curated2
Sequence conflicti190 – 191ER → DG in CAA78418 (PubMed:8224148).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14049 mRNA Translation: CAA78417.1
Z14050
, Z14051, Z14052, Z14053, Z14054 Genomic DNA Translation: CAA78418.1
AK029481 mRNA Translation: BAC26469.1
AC154237 Genomic DNA No translation available.
CH466606 Genomic DNA Translation: EDL22317.1
BC022712 mRNA Translation: AAH22712.1
BC054444 mRNA Translation: AAH54444.1
CCDSiCCDS28480.1
PIRiS38770
RefSeqiNP_034153.2, NM_010023.4
UniGeneiMm.291743

Genome annotation databases

EnsembliENSMUST00000024946; ENSMUSP00000024946; ENSMUSG00000024132
GeneIDi13177
KEGGimmu:13177
UCSCiuc008avv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiECI1_MOUSE
AccessioniPrimary (citable) accession number: P42125
Secondary accession number(s): Q8QZV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 3, 2012
Last modified: April 25, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health