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P42116 (NURM_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-17.8kD
Short name=CI-17.8kD
Gene names
Name:nuo17.8
ORF Names:B20J13.200, NCU00969
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Subunit structure

Complex I is composed of about 40 different subunits.

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion Ref.1
Chain27 – 186160NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial
PRO_0000020040

Regions

Transmembrane58 – 7821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P42116 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6A3E738708D37EEE

FASTA18620,895
        10         20         30         40         50         60 
MSSFRLGVSR VARQVRAPCV RNTRRYASDS HAPADHTHSA AGHGEHHHAN AADANEELGT 

        70         80         90        100        110        120 
AFYVIFGAIP AFGALYYFSR PGKDGQPNSI TKWLQKWEEH QEALADKNAL VTAALEQAAH 

       130        140        150        160        170        180 
DKHLFYYVDQ LRSGHYEMKY PEVFQHGSAR NVPAGTYIPL DKVVEVYRKQ HLDEEERKAK 


KLAAAN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, in vitro mitochondrial import and membrane assembly of the 17.8 kDa subunit of complex I from Neurospora crassa."
Azevedo J.E., Abrolat-Scharff J., Eckerskorn C., Werner S.
Biochem. J. 293:501-506(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 27-45.
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71414 mRNA. Translation: CAA50537.1.
BX842629 Genomic DNA. Translation: CAE76339.1.
CM002236 Genomic DNA. Translation: EAA35926.1.
PIRS35057.
RefSeqXP_965162.1. XM_960069.2.

3D structure databases

ProteinModelPortalP42116.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000000759; EFNCRP00000000759; EFNCRG00000000759.
GeneID3881298.
KEGGncr:NCU00969.

Phylogenomic databases

eggNOGNOG130674.
OrthoDBEOG7BP8FQ.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameNURM_NEUCR
AccessionPrimary (citable) accession number: P42116
Secondary accession number(s): Q7SGF3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program