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P42116

- NURM_NEUCR

UniProt

P42116 - NURM_NEUCR

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Protein
NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial
Gene
nuo17.8, B20J13.200, NCU00969
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-17.8kD
Short name:
CI-17.8kD
Gene namesi
Name:nuo17.8
ORF Names:B20J13.200, NCU00969
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion1 Publication
Add
BLAST
Chaini27 – 186160NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial
PRO_0000020040Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits.

Structurei

3D structure databases

ProteinModelPortaliP42116.

Family & Domainsi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG130674.
OrthoDBiEOG7BP8FQ.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42116-1 [UniParc]FASTAAdd to Basket

« Hide

MSSFRLGVSR VARQVRAPCV RNTRRYASDS HAPADHTHSA AGHGEHHHAN    50
AADANEELGT AFYVIFGAIP AFGALYYFSR PGKDGQPNSI TKWLQKWEEH 100
QEALADKNAL VTAALEQAAH DKHLFYYVDQ LRSGHYEMKY PEVFQHGSAR 150
NVPAGTYIPL DKVVEVYRKQ HLDEEERKAK KLAAAN 186
Length:186
Mass (Da):20,895
Last modified:November 1, 1995 - v1
Checksum:i6A3E738708D37EEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71414 mRNA. Translation: CAA50537.1.
BX842629 Genomic DNA. Translation: CAE76339.1.
CM002236 Genomic DNA. Translation: EAA35926.1.
PIRiS35057.
RefSeqiXP_965162.1. XM_960069.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000000759; EFNCRP00000000759; EFNCRG00000000759.
GeneIDi3881298.
KEGGincr:NCU00969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71414 mRNA. Translation: CAA50537.1 .
BX842629 Genomic DNA. Translation: CAE76339.1 .
CM002236 Genomic DNA. Translation: EAA35926.1 .
PIRi S35057.
RefSeqi XP_965162.1. XM_960069.2.

3D structure databases

ProteinModelPortali P42116.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000000759 ; EFNCRP00000000759 ; EFNCRG00000000759 .
GeneIDi 3881298.
KEGGi ncr:NCU00969.

Phylogenomic databases

eggNOGi NOG130674.
OrthoDBi EOG7BP8FQ.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, in vitro mitochondrial import and membrane assembly of the 17.8 kDa subunit of complex I from Neurospora crassa."
    Azevedo J.E., Abrolat-Scharff J., Eckerskorn C., Werner S.
    Biochem. J. 293:501-506(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 27-45.
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiNURM_NEUCR
AccessioniPrimary (citable) accession number: P42116
Secondary accession number(s): Q7SGF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

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