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P42116

- NURM_NEUCR

UniProt

P42116 - NURM_NEUCR

Protein

NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial

Gene

nuo17.8

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-17.8kD
    Short name:
    CI-17.8kD
    Gene namesi
    Name:nuo17.8
    ORF Names:B20J13.200, NCU00969
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626Mitochondrion1 PublicationAdd
    BLAST
    Chaini27 – 186160NADH-ubiquinone oxidoreductase 17.8 kDa subunit, mitochondrialPRO_0000020040Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 40 different subunits.

    Structurei

    3D structure databases

    ProteinModelPortaliP42116.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG130674.
    OrthoDBiEOG7BP8FQ.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42116-1 [UniParc]FASTAAdd to Basket

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    MSSFRLGVSR VARQVRAPCV RNTRRYASDS HAPADHTHSA AGHGEHHHAN    50
    AADANEELGT AFYVIFGAIP AFGALYYFSR PGKDGQPNSI TKWLQKWEEH 100
    QEALADKNAL VTAALEQAAH DKHLFYYVDQ LRSGHYEMKY PEVFQHGSAR 150
    NVPAGTYIPL DKVVEVYRKQ HLDEEERKAK KLAAAN 186
    Length:186
    Mass (Da):20,895
    Last modified:November 1, 1995 - v1
    Checksum:i6A3E738708D37EEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71414 mRNA. Translation: CAA50537.1.
    BX842629 Genomic DNA. Translation: CAE76339.1.
    CM002236 Genomic DNA. Translation: EAA35926.1.
    PIRiS35057.
    RefSeqiXP_965162.1. XM_960069.2.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000000759; EFNCRP00000000759; EFNCRG00000000759.
    GeneIDi3881298.
    KEGGincr:NCU00969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71414 mRNA. Translation: CAA50537.1 .
    BX842629 Genomic DNA. Translation: CAE76339.1 .
    CM002236 Genomic DNA. Translation: EAA35926.1 .
    PIRi S35057.
    RefSeqi XP_965162.1. XM_960069.2.

    3D structure databases

    ProteinModelPortali P42116.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000000759 ; EFNCRP00000000759 ; EFNCRG00000000759 .
    GeneIDi 3881298.
    KEGGi ncr:NCU00969.

    Phylogenomic databases

    eggNOGi NOG130674.
    OrthoDBi EOG7BP8FQ.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning, in vitro mitochondrial import and membrane assembly of the 17.8 kDa subunit of complex I from Neurospora crassa."
      Azevedo J.E., Abrolat-Scharff J., Eckerskorn C., Werner S.
      Biochem. J. 293:501-506(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 27-45.
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNURM_NEUCR
    AccessioniPrimary (citable) accession number: P42116
    Secondary accession number(s): Q7SGF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    External Data

    Dasty 3