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Protein

Xanthine permease

Gene

pbuX

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transport of xanthine in the cell.

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciBSUB:BSU22060-MONOMER.

Protein family/group databases

TCDBi2.A.40.3.1. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine permease
Gene namesi
Name:pbuX
Synonyms:ypaQ
Ordered Locus Names:BSU22060
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU22060. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Xanthine permeasePRO_0000165962Add
BLAST

Proteomic databases

PaxDbiP42086.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU22060.

Structurei

3D structure databases

ProteinModelPortaliP42086.
SMRiP42086. Positions 1-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2233.
HOGENOMiHOG000038199.
InParanoidiP42086.
KOiK16169.
OMAiSCYDIPF.
OrthoDBiEOG6M6JJK.
PhylomeDBiP42086.

Family and domain databases

InterProiIPR017588. UacT-like.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF12. PTHR11119:SF12. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00801. ncs2. 1 hit.
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42086-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNGFGKTLS LGIQHVLAMY AGAIVVPLIV GKAMGLTVEQ LTYLVSIDIF
60 70 80 90 100
MCGVATLLQV WSNRFFGIGL PVVLGCTFTA VSPMIAIGSE YGVSTVYGSI
110 120 130 140 150
IASGILVILI SFFFGKLVSF FPPVVTGSVV TIIGITLMPV AMNNMAGGEG
160 170 180 190 200
SADFGDLSNL ALAFTVLSII VLLYRFTKGF IKSVSILIGI LIGTFIAYFM
210 220 230 240 250
GKVQFDNVSD AAVVQMIQPF YFGAPSFHAA PIITMSIVAI VSLVESTGVY
260 270 280 290 300
FALGDLTNRR LTEIDLSKGY RAEGLAVLLG GIFNAFPYTA FSQNVGLVQL
310 320 330 340 350
TGIKKNAVIV VTGVILMAFG LFPKIAAFTT IIPSAVLGGA MVAMFGMVIA
360 370 380 390 400
YGIKMLSRID FAKQENLLIV ACSVGLGLGV TVVPDIFKQL PSALTLLTTN
410 420 430
GIVAGSFTAV VLNIVYNVFS KAKKIEQEAD LAEQKTAV
Length:438
Mass (Da):46,238
Last modified:November 1, 1995 - v1
Checksum:iAFB9EDFADFF12E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83878 Genomic DNA. Translation: CAA58759.1.
L77246 Genomic DNA. Translation: AAA96612.1.
AL009126 Genomic DNA. Translation: CAB14123.1.
PIRiS51310.
RefSeqiNP_390088.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14123; CAB14123; BSU22060.
GeneIDi939068.
KEGGibsu:BSU22060.
PATRICi18976219. VBIBacSub10457_2300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83878 Genomic DNA. Translation: CAA58759.1.
L77246 Genomic DNA. Translation: AAA96612.1.
AL009126 Genomic DNA. Translation: CAB14123.1.
PIRiS51310.
RefSeqiNP_390088.1. NC_000964.3.

3D structure databases

ProteinModelPortaliP42086.
SMRiP42086. Positions 1-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU22060.

Protein family/group databases

TCDBi2.A.40.3.1. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Proteomic databases

PaxDbiP42086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14123; CAB14123; BSU22060.
GeneIDi939068.
KEGGibsu:BSU22060.
PATRICi18976219. VBIBacSub10457_2300.

Organism-specific databases

GenoListiBSU22060. [Micado]

Phylogenomic databases

eggNOGiCOG2233.
HOGENOMiHOG000038199.
InParanoidiP42086.
KOiK16169.
OMAiSCYDIPF.
OrthoDBiEOG6M6JJK.
PhylomeDBiP42086.

Enzyme and pathway databases

BioCyciBSUB:BSU22060-MONOMER.

Family and domain databases

InterProiIPR017588. UacT-like.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF12. PTHR11119:SF12. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00801. ncs2. 1 hit.
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism."
    Christiansen L.C., Schou S., Nygaard P., Saxild H.H.
    J. Bacteriol. 179:2540-2550(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "Organization of the Bacillus subtilis 168 chromosome between kdg and the attachment site of the SP beta prophage: use of long accurate PCR and yeast artificial chromosomes for sequencing."
    Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.
    Microbiology 142:3005-3015(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiPBUX_BACSU
AccessioniPrimary (citable) accession number: P42086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.