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P42086 (PBUX_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xanthine permease
Gene names
Name:pbuX
Synonyms:ypaQ
Ordered Locus Names:BSU22060
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transport of xanthine in the cell.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Xanthine permease
PRO_0000165962

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane308 – 32821Helical; Potential
Transmembrane331 – 35121Helical; Potential
Transmembrane367 – 38721Helical; Potential
Transmembrane396 – 41621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P42086 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: AFB9EDFADFF12E29

FASTA43846,238
        10         20         30         40         50         60 
MRNGFGKTLS LGIQHVLAMY AGAIVVPLIV GKAMGLTVEQ LTYLVSIDIF MCGVATLLQV 

        70         80         90        100        110        120 
WSNRFFGIGL PVVLGCTFTA VSPMIAIGSE YGVSTVYGSI IASGILVILI SFFFGKLVSF 

       130        140        150        160        170        180 
FPPVVTGSVV TIIGITLMPV AMNNMAGGEG SADFGDLSNL ALAFTVLSII VLLYRFTKGF 

       190        200        210        220        230        240 
IKSVSILIGI LIGTFIAYFM GKVQFDNVSD AAVVQMIQPF YFGAPSFHAA PIITMSIVAI 

       250        260        270        280        290        300 
VSLVESTGVY FALGDLTNRR LTEIDLSKGY RAEGLAVLLG GIFNAFPYTA FSQNVGLVQL 

       310        320        330        340        350        360 
TGIKKNAVIV VTGVILMAFG LFPKIAAFTT IIPSAVLGGA MVAMFGMVIA YGIKMLSRID 

       370        380        390        400        410        420 
FAKQENLLIV ACSVGLGLGV TVVPDIFKQL PSALTLLTTN GIVAGSFTAV VLNIVYNVFS 

       430 
KAKKIEQEAD LAEQKTAV

« Hide

References

« Hide 'large scale' references
[1]"Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism."
Christiansen L.C., Schou S., Nygaard P., Saxild H.H.
J. Bacteriol. 179:2540-2550(1997) [PubMed: 9098051] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"Organization of the Bacillus subtilis 168 chromosome between kdg and the attachment site of the SP beta prophage: use of long accurate PCR and yeast artificial chromosomes for sequencing."
Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.
Microbiology 142:3005-3015(1996) [PubMed: 8969496] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X83878 Genomic DNA. Translation: CAA58759.1.
L77246 Genomic DNA. Translation: AAA96612.1.
AL009126 Genomic DNA. Translation: CAB14123.1.
PIRS51310.
RefSeqNP_390088.1. NC_000964.3.

3D structure databases

ProteinModelPortalP42086.
SMRP42086. Positions 1-419.
ModBaseSearch...

Protein family/group databases

TCDB2.A.40.3.1. nucleobase:cation symporter-2 (NCS2) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000003179; EBBACP00000003179; EBBACG00000003172.
GeneID939068.
GenomeReviewsGene locus BSU22060 in contig AL009126_GR.
KEGGbsu:BSU22060.
NMPDRfig|224308.1.peg.2211.
PATRIC18976219. VBIBacSub10457_2300.

Organism-specific databases

GenoListBSU22060. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000001001.
HOGENOMHBG470187.
OMACFLLWRA.
PhylomeDBP42086.
ProtClustDBCLSK887478.

Enzyme and pathway databases

BioCycBSUB:BSU22060-MONOMER.

Family and domain databases

InterProIPR017588. Xan_permease.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
KOK03458.
PANTHERPTHR11119. Xant/urac/vitC. 1 hit.
PfamPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsTIGR00801. Ncs2. 1 hit.
TIGR03173. PbuX. 1 hit.
PROSITEPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePBUX_BACSU
AccessionPrimary (citable) accession number: P42086
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

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