ID   YKCA_CAEEL              Reviewed;         441 AA.
AC   P42083; Q2V4X3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 3.
DT   27-MAR-2024, entry version 133.
DE   RecName: Full=Putative tyrosine-protein phosphatase B0280.11;
DE            EC=3.1.3.48;
GN   ORFNames=B0280.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class dual specificity subfamily. {ECO:0000305}.
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DR   EMBL; FO080148; CCD61607.1; -; Genomic_DNA.
DR   PIR; T15305; T15305.
DR   RefSeq; NP_498560.2; NM_066159.2.
DR   AlphaFoldDB; P42083; -.
DR   SMR; P42083; -.
DR   STRING; 6239.B0280.11.1; -.
DR   PaxDb; 6239-B0280-11; -.
DR   EnsemblMetazoa; B0280.11.1; B0280.11.1; WBGene00015106.
DR   GeneID; 175997; -.
DR   KEGG; cel:CELE_B0280.11; -.
DR   UCSC; B0280.11; c. elegans.
DR   AGR; WB:WBGene00015106; -.
DR   WormBase; B0280.11; CE39312; WBGene00015106; -.
DR   eggNOG; KOG0789; Eukaryota.
DR   GeneTree; ENSGT00970000195861; -.
DR   HOGENOM; CLU_596184_0_0_1; -.
DR   InParanoid; P42083; -.
DR   OMA; FETFACA; -.
DR   OrthoDB; 5606224at2759; -.
DR   PhylomeDB; P42083; -.
DR   PRO; PR:P42083; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015106; Expressed in adult organism and 1 other cell type or tissue.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00047; PTPc; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   PANTHER; PTHR23219:SF12; TYROSINE-PROTEIN PHOSPHATASE B0280.11-RELATED; 1.
DR   PANTHER; PTHR23219; TYROSINE-PROTEIN PHOSPHATASE C15H7.3-RELATED; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..441
FT                   /note="Putative tyrosine-protein phosphatase B0280.11"
FT                   /id="PRO_0000094926"
FT   DOMAIN          142..400
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        337
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   441 AA;  49492 MW;  D5AC5DB5F506F43E CRC64;
     MEKKKSKTNL LQKFADKFKK KKRSRSAPTS KERTSEISKR KSRSPSKSKV TTGNSHGAST
     DNKTKTDTNR MEVTAKGFKK AKDAKKLEKK KEETGPSKTP STIALRRAES QMELSGNRKN
     VEKGVKTWVE QLEKLVEIRK LLEADFKPID TMKVDLEKCQ AFKKNIDYCQ SENVELYDAN
     RVKGGGEADF FYHATVTSIP SISTKSTILA QLPLSDSPHS LESFWLMVAA QKIQRLFILI
     GEDELDKAAL SEYFPEDFKE FKTIRVNNRK TVSKSDEQPN TQLYYEVVPK DCAEAPFAMI
     EICDFWPDGK IPTVSYGRIA ATAASVFDSD IDSDATCAIV SNYGAGRAGS FLVGVQAIEK
     LQAGDAPNIK EIAMSIRSQR PCAIETLPQY VFTYIIALTY GLKHVKDPVL KSKTEKVISQ
     LEQFACEKMM EEDEEDNTTC E
//