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Protein

Putative tyrosine-protein phosphatase B0280.11

Gene

B0280.11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei337 – 3371Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase B0280.11 (EC:3.1.3.48)
Gene namesi
ORF Names:B0280.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0280.11; CE39312; WBGene00015106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Putative tyrosine-protein phosphatase B0280.11PRO_0000094926Add
BLAST

Proteomic databases

PRIDEiP42083.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0280.11.

Structurei

3D structure databases

ProteinModelPortaliP42083.
SMRiP42083. Positions 173-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 400259Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 9189Lys-richAdd
BLAST
Compositional biasi17 – 226Poly-Lys

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG270825.
GeneTreeiENSGT00530000064500.
HOGENOMiHOG000125385.
InParanoidiP42083.
OMAiFETFACA.
OrthoDBiEOG74N5MR.
PhylomeDBiP42083.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42083-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKKKSKTNL LQKFADKFKK KKRSRSAPTS KERTSEISKR KSRSPSKSKV
60 70 80 90 100
TTGNSHGAST DNKTKTDTNR MEVTAKGFKK AKDAKKLEKK KEETGPSKTP
110 120 130 140 150
STIALRRAES QMELSGNRKN VEKGVKTWVE QLEKLVEIRK LLEADFKPID
160 170 180 190 200
TMKVDLEKCQ AFKKNIDYCQ SENVELYDAN RVKGGGEADF FYHATVTSIP
210 220 230 240 250
SISTKSTILA QLPLSDSPHS LESFWLMVAA QKIQRLFILI GEDELDKAAL
260 270 280 290 300
SEYFPEDFKE FKTIRVNNRK TVSKSDEQPN TQLYYEVVPK DCAEAPFAMI
310 320 330 340 350
EICDFWPDGK IPTVSYGRIA ATAASVFDSD IDSDATCAIV SNYGAGRAGS
360 370 380 390 400
FLVGVQAIEK LQAGDAPNIK EIAMSIRSQR PCAIETLPQY VFTYIIALTY
410 420 430 440
GLKHVKDPVL KSKTEKVISQ LEQFACEKMM EEDEEDNTTC E
Length:441
Mass (Da):49,492
Last modified:May 2, 2006 - v3
Checksum:iD5AC5DB5F506F43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080148 Genomic DNA. Translation: CCD61607.1.
PIRiT15305.
RefSeqiNP_498560.2. NM_066159.2.
UniGeneiCel.34018.

Genome annotation databases

EnsemblMetazoaiB0280.11; B0280.11; WBGene00015106.
GeneIDi175997.
KEGGicel:CELE_B0280.11.
UCSCiB0280.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080148 Genomic DNA. Translation: CCD61607.1.
PIRiT15305.
RefSeqiNP_498560.2. NM_066159.2.
UniGeneiCel.34018.

3D structure databases

ProteinModelPortaliP42083.
SMRiP42083. Positions 173-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0280.11.

Proteomic databases

PRIDEiP42083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0280.11; B0280.11; WBGene00015106.
GeneIDi175997.
KEGGicel:CELE_B0280.11.
UCSCiB0280.11. c. elegans.

Organism-specific databases

CTDi175997.
WormBaseiB0280.11; CE39312; WBGene00015106.

Phylogenomic databases

eggNOGiNOG270825.
GeneTreeiENSGT00530000064500.
HOGENOMiHOG000125385.
InParanoidiP42083.
OMAiFETFACA.
OrthoDBiEOG74N5MR.
PhylomeDBiP42083.

Miscellaneous databases

NextBioi890662.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYKCA_CAEEL
AccessioniPrimary (citable) accession number: P42083
Secondary accession number(s): Q2V4X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 2, 2006
Last modified: January 7, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.