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P42083

- YKCA_CAEEL

UniProt

P42083 - YKCA_CAEEL

Protein

Putative tyrosine-protein phosphatase B0280.11

Gene

B0280.11

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (02 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei337 – 3371Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative tyrosine-protein phosphatase B0280.11 (EC:3.1.3.48)
    Gene namesi
    ORF Names:B0280.11
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiB0280.11; CE39312; WBGene00015106.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Putative tyrosine-protein phosphatase B0280.11PRO_0000094926Add
    BLAST

    Proteomic databases

    PRIDEiP42083.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.B0280.11.

    Structurei

    3D structure databases

    ProteinModelPortaliP42083.
    SMRiP42083. Positions 136-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini142 – 400259Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 9189Lys-richAdd
    BLAST
    Compositional biasi17 – 226Poly-Lys

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG270825.
    GeneTreeiENSGT00530000064500.
    HOGENOMiHOG000125385.
    InParanoidiP42083.
    OMAiFETFACA.
    OrthoDBiEOG74N5MR.
    PhylomeDBiP42083.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42083-1 [UniParc]FASTAAdd to Basket

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    MEKKKSKTNL LQKFADKFKK KKRSRSAPTS KERTSEISKR KSRSPSKSKV    50
    TTGNSHGAST DNKTKTDTNR MEVTAKGFKK AKDAKKLEKK KEETGPSKTP 100
    STIALRRAES QMELSGNRKN VEKGVKTWVE QLEKLVEIRK LLEADFKPID 150
    TMKVDLEKCQ AFKKNIDYCQ SENVELYDAN RVKGGGEADF FYHATVTSIP 200
    SISTKSTILA QLPLSDSPHS LESFWLMVAA QKIQRLFILI GEDELDKAAL 250
    SEYFPEDFKE FKTIRVNNRK TVSKSDEQPN TQLYYEVVPK DCAEAPFAMI 300
    EICDFWPDGK IPTVSYGRIA ATAASVFDSD IDSDATCAIV SNYGAGRAGS 350
    FLVGVQAIEK LQAGDAPNIK EIAMSIRSQR PCAIETLPQY VFTYIIALTY 400
    GLKHVKDPVL KSKTEKVISQ LEQFACEKMM EEDEEDNTTC E 441
    Length:441
    Mass (Da):49,492
    Last modified:May 2, 2006 - v3
    Checksum:iD5AC5DB5F506F43E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080148 Genomic DNA. Translation: CCD61607.1.
    PIRiT15305.
    RefSeqiNP_498560.2. NM_066159.2.
    UniGeneiCel.34018.

    Genome annotation databases

    EnsemblMetazoaiB0280.11; B0280.11; WBGene00015106.
    GeneIDi175997.
    KEGGicel:CELE_B0280.11.
    UCSCiB0280.11. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080148 Genomic DNA. Translation: CCD61607.1 .
    PIRi T15305.
    RefSeqi NP_498560.2. NM_066159.2.
    UniGenei Cel.34018.

    3D structure databases

    ProteinModelPortali P42083.
    SMRi P42083. Positions 136-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0280.11.

    Proteomic databases

    PRIDEi P42083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0280.11 ; B0280.11 ; WBGene00015106 .
    GeneIDi 175997.
    KEGGi cel:CELE_B0280.11.
    UCSCi B0280.11. c. elegans.

    Organism-specific databases

    CTDi 175997.
    WormBasei B0280.11 ; CE39312 ; WBGene00015106 .

    Phylogenomic databases

    eggNOGi NOG270825.
    GeneTreei ENSGT00530000064500.
    HOGENOMi HOG000125385.
    InParanoidi P42083.
    OMAi FETFACA.
    OrthoDBi EOG74N5MR.
    PhylomeDBi P42083.

    Miscellaneous databases

    NextBioi 890662.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiYKCA_CAEEL
    AccessioniPrimary (citable) accession number: P42083
    Secondary accession number(s): Q2V4X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3