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P42082

- CD86_MOUSE

UniProt

P42082 - CD86_MOUSE

Protein

T-lymphocyte activation antigen CD86

Gene

Cd86

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.

    GO - Biological processi

    1. aging Source: Ensembl
    2. B cell activation Source: MGI
    3. cellular response to cytokine stimulus Source: Ensembl
    4. cellular response to lipopolysaccharide Source: Ensembl
    5. cellular response to metal ion Source: Ensembl
    6. defense response to virus Source: MGI
    7. myeloid dendritic cell differentiation Source: Ensembl
    8. negative regulation of T cell anergy Source: Ensembl
    9. positive regulation of activated T cell proliferation Source: Ensembl
    10. positive regulation of T cell proliferation Source: MGI
    11. response to drug Source: Ensembl
    12. response to interferon-gamma Source: Ensembl
    13. response to yeast Source: Ensembl
    14. T cell proliferation involved in immune response Source: Ensembl
    15. toll-like receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_204081. CD28 co-stimulation.
    REACT_226151. CD28 dependent PI3K/Akt signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-lymphocyte activation antigen CD86
    Alternative name(s):
    Activation B7-2 antigen
    Early T-cell costimulatory molecule 1
    Short name:
    ETC-1
    CD_antigen: CD86
    Gene namesi
    Name:Cd86
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:101773. Cd86.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 309286T-lymphocyte activation antigen CD86PRO_0000014551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 216PROSITE-ProRule annotation
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP42082.

    PTM databases

    PhosphoSiteiP42082.

    Expressioni

    Tissue specificityi

    Expressed on activated B-cells.

    Gene expression databases

    ArrayExpressiP42082.
    BgeeiP42082.
    CleanExiMM_CD86.
    GenevestigatoriP42082.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with MARCH8 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198617. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP42082.
    SMRiP42082. Positions 26-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 244221ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini266 – 30944CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 12896Ig-like V-typeAdd
    BLAST
    Domaini150 – 22374Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79621.
    HOVERGENiHBG004093.
    KOiK05413.
    OMAiIANFSEP.
    OrthoDBiEOG70PC0G.
    PhylomeDBiP42082.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P42082-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPRCTMGLA ILIFVTVLLI SDAVSVETQA YFNGTAYLPC PFTKAQNISL    50
    SELVVFWQDQ QKLVLYEHYL GTEKLDSVNA KYLGRTSFDR NNWTLRLHNV 100
    QIKDMGSYDC FIQKKPPTGS IILQQTLTEL SVIANFSEPE IKLAQNVTGN 150
    SGINLTCTSK QGHPKPKKMY FLITNSTNEY GDNMQISQDN VTELFSISNS 200
    LSLSFPDGVW HMTVVCVLET ESMKISSKPL NFTQEFPSPQ TYWKEITASV 250
    TVALLLVMLL IIVCHKKPNQ PSRPSNTASK LERDSNADRE TINLKELEPQ 300
    IASAKPNAE 309
    Length:309
    Mass (Da):34,666
    Last modified:November 1, 1995 - v1
    Checksum:i8F58DCD1FB81D5EA
    GO
    Isoform 2 (identifier: P42082-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: Missing.

    Show »
    Length:303
    Mass (Da):33,962
    Checksum:i92526096A8C6F249
    GO

    Sequence cautioni

    The sequence AAB30744.2 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66Missing in isoform 2. CuratedVSP_023125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25606 mRNA. Translation: AAA79770.1.
    S70108 mRNA. Translation: AAB30744.2. Different initiation.
    U39456
    , U39459, U39461, U39462, U39463, U39464, U39465, U39466 Genomic DNA. Translation: AAC52334.1.
    U39456
    , U39461, U39462, U39463, U39464, U39465, U39466 Genomic DNA. Translation: AAC52336.1.
    CCDSiCCDS28155.1. [P42082-1]
    PIRiI49522.
    RefSeqiNP_062261.3. NM_019388.3. [P42082-1]
    XP_006521805.1. XM_006521742.1. [P42082-2]
    UniGeneiMm.1452.

    Genome annotation databases

    EnsembliENSMUST00000089620; ENSMUSP00000087047; ENSMUSG00000022901. [P42082-1]
    GeneIDi12524.
    KEGGimmu:12524.
    UCSCiuc007zcq.2. mouse. [P42082-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25606 mRNA. Translation: AAA79770.1 .
    S70108 mRNA. Translation: AAB30744.2 . Different initiation.
    U39456
    , U39459 , U39461 , U39462 , U39463 , U39464 , U39465 , U39466 Genomic DNA. Translation: AAC52334.1 .
    U39456
    , U39461 , U39462 , U39463 , U39464 , U39465 , U39466 Genomic DNA. Translation: AAC52336.1 .
    CCDSi CCDS28155.1. [P42082-1 ]
    PIRi I49522.
    RefSeqi NP_062261.3. NM_019388.3. [P42082-1 ]
    XP_006521805.1. XM_006521742.1. [P42082-2 ]
    UniGenei Mm.1452.

    3D structure databases

    ProteinModelPortali P42082.
    SMRi P42082. Positions 26-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198617. 1 interaction.

    PTM databases

    PhosphoSitei P42082.

    Proteomic databases

    PRIDEi P42082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089620 ; ENSMUSP00000087047 ; ENSMUSG00000022901 . [P42082-1 ]
    GeneIDi 12524.
    KEGGi mmu:12524.
    UCSCi uc007zcq.2. mouse. [P42082-1 ]

    Organism-specific databases

    CTDi 942.
    MGIi MGI:101773. Cd86.

    Phylogenomic databases

    eggNOGi NOG79621.
    HOVERGENi HBG004093.
    KOi K05413.
    OMAi IANFSEP.
    OrthoDBi EOG70PC0G.
    PhylomeDBi P42082.
    TreeFami TF331083.

    Enzyme and pathway databases

    Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_204081. CD28 co-stimulation.
    REACT_226151. CD28 dependent PI3K/Akt signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    NextBioi 281542.
    PROi P42082.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42082.
    Bgeei P42082.
    CleanExi MM_CD86.
    Genevestigatori P42082.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production."
      Freeman G.J., Borriello F., Hodes R.J., Reiser H., Gribben J.G., Ng J.W., Kim J., Goldberg J.M., Hathcock K., Laszlo G., Lombard L.A., Wang S., Gray G.S., Nadler L.M., Sharpe A.H.
      J. Exp. Med. 178:2185-2192(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule."
      Chen C., Gault A., Shen L., Nabavi N.
      J. Immunol. 152:4929-4936(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Differential expression of alternate mB7-2 transcripts."
      Borriello F., Oliveros J., Freeman G.J., Nadler L.M., Sharpe A.H.
      J. Immunol. 155:5490-5497(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: 129.

    Entry informationi

    Entry nameiCD86_MOUSE
    AccessioniPrimary (citable) accession number: P42082
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3