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P42081 (CD86_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-lymphocyte activation antigen CD86
Alternative name(s):
Activation B7-2 antigen
B70
BU63
CTLA-4 counter-receptor B7.2
FUN-1
CD_antigen=CD86
Gene names
Name:CD86
Synonyms:CD28LG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

Subunit structure

Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. Ref.12 Ref.13 Ref.15

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed by activated B-lymphocytes and monocytes.

Post-translational modification

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processAdaptive immunity
Host-virus interaction
Immunity
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell activation

Inferred from electronic annotation. Source: Ensembl

Fc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

T cell activation

Inferred by curator PubMed 9915850. Source: UniProtKB

T cell costimulation

Traceable author statement. Source: Reactome

T cell proliferation involved in immune response

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Inferred by curator PubMed 9915850. Source: UniProtKB

cellular response to cytokine stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to metal ion

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

immune response

Traceable author statement Ref.2. Source: ProtInc

innate immune response

Traceable author statement. Source: Reactome

myeloid dendritic cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell anergy

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of T-helper 2 cell differentiation

Non-traceable author statement PubMed 9915850. Source: UniProtKB

positive regulation of activated T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Traceable author statement PubMed 7513726. Source: ProtInc

positive regulation of interleukin-2 biosynthetic process

Non-traceable author statement PubMed 9915850. Source: UniProtKB

positive regulation of interleukin-4 biosynthetic process

Non-traceable author statement PubMed 9915850. Source: UniProtKB

positive regulation of lymphotoxin A biosynthetic process

Non-traceable author statement PubMed 9915850. Source: UniProtKB

positive regulation of transcription, DNA-templated

Non-traceable author statement PubMed 9915850. Source: UniProtKB

response to drug

Inferred from electronic annotation. Source: Ensembl

response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

response to yeast

Inferred from electronic annotation. Source: Ensembl

toll-like receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

integral component of membrane

Inferred by curator PubMed 9915850. Source: UniProtKB

intracellular membrane-bounded organelle

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncoreceptor activity

Non-traceable author statement PubMed 9915850. Source: UniProtKB

receptor activity

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CTLA4P164102EBI-1030956,EBI-1030991

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P42081-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P42081-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
Isoform 3 (identifier: P42081-2)

Also known as: CD86 deltaEC;

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     22-234: Missing.
Isoform 4 (identifier: P42081-4)

Also known as: CD86 deltaTM;

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     235-282: Missing.
Isoform 5 (identifier: P42081-5)

The sequence of this isoform differs from the canonical sequence as follows:
     22-133: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: P42081-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 329306T-lymphocyte activation antigen CD86
PRO_0000014550

Regions

Topological domain24 – 247224Extracellular Potential
Transmembrane248 – 26821Helical; Potential
Topological domain269 – 32961Cytoplasmic Potential
Domain33 – 13199Ig-like V-type
Domain150 – 22576Ig-like C2-type

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 110 Ref.15
Disulfide bond157 ↔ 218 Potential

Natural variations

Alternative sequence1 – 8282Missing in isoform 6.
VSP_047220
Alternative sequence1 – 66Missing in isoform 2, isoform 3 and isoform 4.
VSP_023124
Alternative sequence22 – 234213Missing in isoform 3.
VSP_009125
Alternative sequence22 – 133112Missing in isoform 5.
VSP_047221
Alternative sequence235 – 28248Missing in isoform 4.
VSP_040324
Natural variant1701S → N.
Corresponds to variant rs9282642 [ dbSNP | Ensembl ].
VAR_021916
Natural variant1851V → I. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9
Corresponds to variant rs2681417 [ dbSNP | Ensembl ].
VAR_055003
Natural variant3101A → T. Ref.6 Ref.8
Corresponds to variant rs1129055 [ dbSNP | Ensembl ].
VAR_014650
Natural variant3231D → N.
Corresponds to variant rs9282648 [ dbSNP | Ensembl ].
VAR_021917

Experimental info

Sequence conflict271K → E in AAA86473. Ref.9

Secondary structure

....................... 329
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: C249DAEEB889D911

FASTA32937,682
        10         20         30         40         50         60 
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ 

        70         80         90        100        110        120 
ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM 

       130        140        150        160        170        180 
IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI 

       190        200        210        220        230        240 
EYDGVMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ 

       250        260        270        280        290        300 
PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 

       310        320 
IHIPERSDEA QRVFKSSKTS SCDKSDTCF 

« Hide

Isoform 2 [UniParc].

Checksum: A492C705D89B65B7
Show »

FASTA32337,007
Isoform 3 (CD86 deltaEC) [UniParc].

Checksum: 0AE70C853C85F666
Show »

FASTA11012,818
Isoform 4 (CD86 deltaTM) [UniParc].

Checksum: 137A523F73708BD5
Show »

FASTA27531,293
Isoform 5 [UniParc].

Checksum: 7AF72282EEF8B7CE
Show »

FASTA21724,773
Isoform 6 [UniParc].

Checksum: 60CBC08652F42C26
Show »

FASTA24728,420

References

« Hide 'large scale' references
[1]"B70 antigen is a second ligand for CTLA-4 and CD28."
Azuma M., Ito D., Yagita K., Okumura K., Phillips J.H., Lanier L.L., Somoza C.
Nature 366:76-79(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-185.
[2]"Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation."
Freeman G.J., Gribben J.G., Boussiotis V.A., Ng J.W., Restivo V.A. Jr., Lombard L.A., Gray G.S., Nadler L.M.
Science 262:909-911(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-185.
[3]"Identification of an alternatively spliced variant of human CD86 mRNA."
Magistrelli G., Caron G., Gauchat J.-F., Jeannin P., Bonnefoy J.-Y., Delneste Y.
Biochem. Biophys. Res. Commun. 280:1211-1215(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT ILE-185.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-185.
[5]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-185.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANTS ILE-185 AND THR-310.
Tissue: Brain.
[7]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-185 AND THR-310.
Tissue: Brain.
[9]"Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)."
Jellis C.L., Wang S.S., Rennert P., Borriello F., Sharpe A.H., Green N.R., Gray G.S.
Immunogenetics 42:85-89(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-329, VARIANT ILE-185.
Tissue: Foreskin.
[10]"CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."
Lanier L.L., O'Fallon S., Somoza C., Phillips J.H., Linsley P.S., Okumura K., Ito D., Azuma M.
J. Immunol. 154:97-105(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[11]"The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen."
Engel P., Gribben J.G., Freeman G.J., Zhou L.J., Nozawa Y., Abe M., Nadler L.M., Wakasa H., Tedder T.F.
Blood 84:1402-1407(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS CD86.
[12]"c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."
Goto E., Ishido S., Sato Y., Ohgimoto S., Ohgimoto K., Nagano-Fujii M., Hotta H.
J. Biol. Chem. 278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION, INTERACTION WITH MARCH8.
[13]"Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."
Short J.J., Vasu C., Holterman M.J., Curiel D.T., Pereboev A.
Virus Res. 122:144-153(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ADENOVIRUS SUBGROUP B FIBER PROTEINS.
[14]"Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
Schwartz J.C., Zhang X., Fedorov A.A., Nathenson S.G., Almo S.C.
Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 26-134 IN COMPLEX WITH CTLA4.
[15]"Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling."
Zhang X., Schwartz J.C., Almo S.C., Nathenson S.G.
Proc. Natl. Acad. Sci. U.S.A. 100:2586-2591(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-134, SUBUNIT, DISULFIDE BOND.
+Additional computationally mapped references.

Web resources

Wikipedia

CD86 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U04343 mRNA. Translation: AAB03814.1.
L25259 mRNA. Translation: AAA58389.1.
CR541844 mRNA. Translation: CAG46642.1.
EF064748 Genomic DNA. Translation: ABK41931.1.
AK294663 mRNA. Translation: BAH11839.1.
AK301237 mRNA. Translation: BAH13438.1.
AK316203 mRNA. Translation: BAH14574.1.
AC068630 Genomic DNA. No translation available.
BC040261 mRNA. Translation: AAH40261.1.
U17722 expand/collapse EMBL AC list , U17717, U17718, U17719, U17721 Genomic DNA. Translation: AAA86473.1.
PIRA48754.
JC7605.
RefSeqNP_001193853.1. NM_001206924.1.
NP_001193854.1. NM_001206925.1.
NP_008820.3. NM_006889.4.
NP_787058.4. NM_175862.4.
NP_795711.1. NM_176892.1.
UniGeneHs.171182.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1I85X-ray3.20A/B26-134[»]
1NCNX-ray2.70A/B26-134[»]
ProteinModelPortalP42081.
SMRP42081. Positions 26-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107380. 6 interactions.
DIPDIP-35606N.
IntActP42081. 3 interactions.
MINTMINT-6631610.
STRING9606.ENSP00000332049.

Chemistry

ChEMBLCHEMBL2364156.
DrugBankDB01281. Abatacept.

PTM databases

PhosphoSiteP42081.

Polymorphism databases

DMDM317373339.

Proteomic databases

PaxDbP42081.
PRIDEP42081.

Protocols and materials databases

DNASU942.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330540; ENSP00000332049; ENSG00000114013. [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013. [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013. [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013. [P42081-5]
GeneID942.
KEGGhsa:942.
UCSCuc003eet.3. human. [P42081-1]
uc021xcz.1. human. [P42081-4]

Organism-specific databases

CTD942.
GeneCardsGC03P121774.
HGNCHGNC:1705. CD86.
HPACAB004319.
MIM601020. gene.
neXtProtNX_P42081.
PharmGKBPA26243.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79621.
HOGENOMHOG000276893.
HOVERGENHBG004093.
InParanoidP42081.
KOK05413.
OMADKGLYQC.
OrthoDBEOG70PC0G.
PhylomeDBP42081.
TreeFamTF331083.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP42081.
BgeeP42081.
CleanExHS_CD86.
GenevestigatorP42081.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP42081.
GeneWikiCD86.
GenomeRNAi942.
NextBio35500368.
PROP42081.
SOURCESearch...

Entry information

Entry nameCD86_HUMAN
AccessionPrimary (citable) accession number: P42081
Secondary accession number(s): A0N0P0 expand/collapse secondary AC list , B7Z2F3, B7Z702, E7ETN5, E9PC27, Q13655, Q6FHB1, Q6GTS4, Q7M4L5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries