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P42081

- CD86_HUMAN

UniProt

P42081 - CD86_HUMAN

Protein

T-lymphocyte activation antigen CD86

Gene

CD86

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

    GO - Molecular functioni

    1. coreceptor activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. receptor activity Source: ProtInc

    GO - Biological processi

    1. aging Source: Ensembl
    2. B cell activation Source: Ensembl
    3. cell-cell signaling Source: UniProtKB
    4. cellular response to cytokine stimulus Source: Ensembl
    5. cellular response to lipopolysaccharide Source: Ensembl
    6. cellular response to metal ion Source: Ensembl
    7. defense response to virus Source: Ensembl
    8. epidermal growth factor receptor signaling pathway Source: Reactome
    9. Fc-epsilon receptor signaling pathway Source: Reactome
    10. fibroblast growth factor receptor signaling pathway Source: Reactome
    11. immune response Source: ProtInc
    12. innate immune response Source: Reactome
    13. myeloid dendritic cell differentiation Source: Ensembl
    14. negative regulation of T cell anergy Source: Ensembl
    15. neurotrophin TRK receptor signaling pathway Source: Reactome
    16. phosphatidylinositol-mediated signaling Source: Reactome
    17. positive regulation of activated T cell proliferation Source: Ensembl
    18. positive regulation of cell proliferation Source: ProtInc
    19. positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
    20. positive regulation of interleukin-4 biosynthetic process Source: UniProtKB
    21. positive regulation of lymphotoxin A biosynthetic process Source: UniProtKB
    22. positive regulation of T-helper 2 cell differentiation Source: UniProtKB
    23. positive regulation of transcription, DNA-templated Source: UniProtKB
    24. response to drug Source: Ensembl
    25. response to interferon-gamma Source: Ensembl
    26. response to yeast Source: Ensembl
    27. T cell activation Source: UniProtKB
    28. T cell costimulation Source: Reactome
    29. T cell proliferation involved in immune response Source: Ensembl
    30. toll-like receptor signaling pathway Source: Ensembl
    31. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_19183. CD28 co-stimulation.
    REACT_19238. CD28 dependent Vav1 pathway.
    REACT_19358. CD28 dependent PI3K/Akt signaling.
    REACT_19405. CTLA4 inhibitory signaling.
    REACT_75829. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-lymphocyte activation antigen CD86
    Alternative name(s):
    Activation B7-2 antigen
    B70
    BU63
    CTLA-4 counter-receptor B7.2
    FUN-1
    CD_antigen: CD86
    Gene namesi
    Name:CD86
    Synonyms:CD28LG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1705. CD86.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. intracellular membrane-bounded organelle Source: Ensembl
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26243.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 329306T-lymphocyte activation antigen CD86PRO_0000014550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 1101 PublicationPROSITE-ProRule annotation
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 218PROSITE-ProRule annotation
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP42081.
    PRIDEiP42081.

    PTM databases

    PhosphoSiteiP42081.

    Expressioni

    Tissue specificityi

    Expressed by activated B-lymphocytes and monocytes.

    Gene expression databases

    ArrayExpressiP42081.
    BgeeiP42081.
    CleanExiHS_CD86.
    GenevestigatoriP42081.

    Organism-specific databases

    HPAiCAB004319.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.4 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTLA4P164103EBI-1030956,EBI-1030991

    Protein-protein interaction databases

    BioGridi107380. 6 interactions.
    DIPiDIP-35606N.
    IntActiP42081. 4 interactions.
    MINTiMINT-6631610.
    STRINGi9606.ENSP00000332049.

    Structurei

    Secondary structure

    1
    329
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 316
    Beta strandi36 – 394
    Helixi50 – 523
    Beta strandi53 – 597
    Beta strandi64 – 696
    Beta strandi76 – 783
    Turni80 – 845
    Beta strandi85 – 895
    Turni90 – 934
    Beta strandi94 – 974
    Helixi102 – 1043
    Beta strandi106 – 11510
    Beta strandi117 – 13317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I85X-ray3.20A/B26-134[»]
    1NCNX-ray2.70A/B26-134[»]
    ProteinModelPortaliP42081.
    SMRiP42081. Positions 26-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42081.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 247224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini269 – 32961CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 13199Ig-like V-typeAdd
    BLAST
    Domaini150 – 22576Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79621.
    HOGENOMiHOG000276893.
    HOVERGENiHBG004093.
    InParanoidiP42081.
    KOiK05413.
    OMAiDKGLYQC.
    OrthoDBiEOG70PC0G.
    PhylomeDBiP42081.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P42081-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL    50
    SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL 100
    QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN 150
    VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS 200
    ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT 250
    AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 300
    IHIPERSDEA QRVFKSSKTS SCDKSDTCF 329
    Length:329
    Mass (Da):37,682
    Last modified:January 11, 2011 - v2
    Checksum:iC249DAEEB889D911
    GO
    Isoform 2 (identifier: P42081-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: Missing.

    Show »
    Length:323
    Mass (Da):37,007
    Checksum:iA492C705D89B65B7
    GO
    Isoform 3 (identifier: P42081-2) [UniParc]FASTAAdd to Basket

    Also known as: CD86 deltaEC

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: Missing.
         22-234: Missing.

    Show »
    Length:110
    Mass (Da):12,818
    Checksum:i0AE70C853C85F666
    GO
    Isoform 4 (identifier: P42081-4) [UniParc]FASTAAdd to Basket

    Also known as: CD86 deltaTM

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: Missing.
         235-282: Missing.

    Show »
    Length:275
    Mass (Da):31,293
    Checksum:i137A523F73708BD5
    GO
    Isoform 5 (identifier: P42081-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-133: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:217
    Mass (Da):24,773
    Checksum:i7AF72282EEF8B7CE
    GO
    Isoform 6 (identifier: P42081-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:247
    Mass (Da):28,420
    Checksum:i60CBC08652F42C26
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271K → E in AAA86473. (PubMed:7541777)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701S → N.
    Corresponds to variant rs9282642 [ dbSNP | Ensembl ].
    VAR_021916
    Natural varianti185 – 1851V → I.8 Publications
    Corresponds to variant rs2681417 [ dbSNP | Ensembl ].
    VAR_055003
    Natural varianti310 – 3101A → T.2 Publications
    Corresponds to variant rs1129055 [ dbSNP | Ensembl ].
    VAR_014650
    Natural varianti323 – 3231D → N.
    Corresponds to variant rs9282648 [ dbSNP | Ensembl ].
    VAR_021917

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 6. CuratedVSP_047220Add
    BLAST
    Alternative sequencei1 – 66Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_023124
    Alternative sequencei22 – 234213Missing in isoform 3. 1 PublicationVSP_009125Add
    BLAST
    Alternative sequencei22 – 133112Missing in isoform 5. 1 PublicationVSP_047221Add
    BLAST
    Alternative sequencei235 – 28248Missing in isoform 4. 1 PublicationVSP_040324Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04343 mRNA. Translation: AAB03814.1.
    L25259 mRNA. Translation: AAA58389.1.
    CR541844 mRNA. Translation: CAG46642.1.
    EF064748 Genomic DNA. Translation: ABK41931.1.
    AK294663 mRNA. Translation: BAH11839.1.
    AK301237 mRNA. Translation: BAH13438.1.
    AK316203 mRNA. Translation: BAH14574.1.
    AC068630 Genomic DNA. No translation available.
    BC040261 mRNA. Translation: AAH40261.1.
    U17722
    , U17717, U17718, U17719, U17721 Genomic DNA. Translation: AAA86473.1.
    CCDSiCCDS3009.1. [P42081-1]
    CCDS43138.1. [P42081-3]
    CCDS56272.1. [P42081-5]
    CCDS56273.1. [P42081-6]
    PIRiA48754.
    JC7605.
    RefSeqiNP_001193853.1. NM_001206924.1.
    NP_001193854.1. NM_001206925.1.
    NP_008820.3. NM_006889.4.
    NP_787058.4. NM_175862.4.
    NP_795711.1. NM_176892.1.
    UniGeneiHs.171182.

    Genome annotation databases

    EnsembliENST00000330540; ENSP00000332049; ENSG00000114013. [P42081-1]
    ENST00000393627; ENSP00000377248; ENSG00000114013. [P42081-3]
    ENST00000469710; ENSP00000418988; ENSG00000114013. [P42081-6]
    ENST00000493101; ENSP00000420230; ENSG00000114013. [P42081-5]
    GeneIDi942.
    KEGGihsa:942.
    UCSCiuc003eet.3. human. [P42081-1]
    uc021xcz.1. human. [P42081-4]

    Polymorphism databases

    DMDMi317373339.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CD86 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04343 mRNA. Translation: AAB03814.1 .
    L25259 mRNA. Translation: AAA58389.1 .
    CR541844 mRNA. Translation: CAG46642.1 .
    EF064748 Genomic DNA. Translation: ABK41931.1 .
    AK294663 mRNA. Translation: BAH11839.1 .
    AK301237 mRNA. Translation: BAH13438.1 .
    AK316203 mRNA. Translation: BAH14574.1 .
    AC068630 Genomic DNA. No translation available.
    BC040261 mRNA. Translation: AAH40261.1 .
    U17722
    , U17717 , U17718 , U17719 , U17721 Genomic DNA. Translation: AAA86473.1 .
    CCDSi CCDS3009.1. [P42081-1 ]
    CCDS43138.1. [P42081-3 ]
    CCDS56272.1. [P42081-5 ]
    CCDS56273.1. [P42081-6 ]
    PIRi A48754.
    JC7605.
    RefSeqi NP_001193853.1. NM_001206924.1.
    NP_001193854.1. NM_001206925.1.
    NP_008820.3. NM_006889.4.
    NP_787058.4. NM_175862.4.
    NP_795711.1. NM_176892.1.
    UniGenei Hs.171182.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I85 X-ray 3.20 A/B 26-134 [» ]
    1NCN X-ray 2.70 A/B 26-134 [» ]
    ProteinModelPortali P42081.
    SMRi P42081. Positions 26-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107380. 6 interactions.
    DIPi DIP-35606N.
    IntActi P42081. 4 interactions.
    MINTi MINT-6631610.
    STRINGi 9606.ENSP00000332049.

    Chemistry

    ChEMBLi CHEMBL2364156.
    DrugBanki DB01281. Abatacept.
    GuidetoPHARMACOLOGYi 2745.

    PTM databases

    PhosphoSitei P42081.

    Polymorphism databases

    DMDMi 317373339.

    Proteomic databases

    PaxDbi P42081.
    PRIDEi P42081.

    Protocols and materials databases

    DNASUi 942.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330540 ; ENSP00000332049 ; ENSG00000114013 . [P42081-1 ]
    ENST00000393627 ; ENSP00000377248 ; ENSG00000114013 . [P42081-3 ]
    ENST00000469710 ; ENSP00000418988 ; ENSG00000114013 . [P42081-6 ]
    ENST00000493101 ; ENSP00000420230 ; ENSG00000114013 . [P42081-5 ]
    GeneIDi 942.
    KEGGi hsa:942.
    UCSCi uc003eet.3. human. [P42081-1 ]
    uc021xcz.1. human. [P42081-4 ]

    Organism-specific databases

    CTDi 942.
    GeneCardsi GC03P121774.
    HGNCi HGNC:1705. CD86.
    HPAi CAB004319.
    MIMi 601020. gene.
    neXtProti NX_P42081.
    PharmGKBi PA26243.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79621.
    HOGENOMi HOG000276893.
    HOVERGENi HBG004093.
    InParanoidi P42081.
    KOi K05413.
    OMAi DKGLYQC.
    OrthoDBi EOG70PC0G.
    PhylomeDBi P42081.
    TreeFami TF331083.

    Enzyme and pathway databases

    Reactomei REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_19183. CD28 co-stimulation.
    REACT_19238. CD28 dependent Vav1 pathway.
    REACT_19358. CD28 dependent PI3K/Akt signaling.
    REACT_19405. CTLA4 inhibitory signaling.
    REACT_75829. PIP3 activates AKT signaling.

    Miscellaneous databases

    EvolutionaryTracei P42081.
    GeneWikii CD86.
    GenomeRNAii 942.
    NextBioi 35500368.
    PROi P42081.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42081.
    Bgeei P42081.
    CleanExi HS_CD86.
    Genevestigatori P42081.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-185.
    2. "Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation."
      Freeman G.J., Gribben J.G., Boussiotis V.A., Ng J.W., Restivo V.A. Jr., Lombard L.A., Gray G.S., Nadler L.M.
      Science 262:909-911(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-185.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT ILE-185.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-185.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-185.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANTS ILE-185 AND THR-310.
      Tissue: Brain.
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-185 AND THR-310.
      Tissue: Brain.
    9. "Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)."
      Jellis C.L., Wang S.S., Rennert P., Borriello F., Sharpe A.H., Green N.R., Gray G.S.
      Immunogenetics 42:85-89(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-329, VARIANT ILE-185.
      Tissue: Foreskin.
    10. "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."
      Lanier L.L., O'Fallon S., Somoza C., Phillips J.H., Linsley P.S., Okumura K., Ito D., Azuma M.
      J. Immunol. 154:97-105(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    11. "The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen."
      Engel P., Gribben J.G., Freeman G.J., Zhou L.J., Nozawa Y., Abe M., Nadler L.M., Wakasa H., Tedder T.F.
      Blood 84:1402-1407(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS CD86.
    12. "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."
      Goto E., Ishido S., Sato Y., Ohgimoto S., Ohgimoto K., Nagano-Fujii M., Hotta H.
      J. Biol. Chem. 278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, INTERACTION WITH MARCH8.
    13. "Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."
      Short J.J., Vasu C., Holterman M.J., Curiel D.T., Pereboev A.
      Virus Res. 122:144-153(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ADENOVIRUS SUBGROUP B FIBER PROTEINS.
    14. "Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
      Schwartz J.C., Zhang X., Fedorov A.A., Nathenson S.G., Almo S.C.
      Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 26-134 IN COMPLEX WITH CTLA4.
    15. "Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling."
      Zhang X., Schwartz J.C., Almo S.C., Nathenson S.G.
      Proc. Natl. Acad. Sci. U.S.A. 100:2586-2591(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-134, SUBUNIT, DISULFIDE BOND.

    Entry informationi

    Entry nameiCD86_HUMAN
    AccessioniPrimary (citable) accession number: P42081
    Secondary accession number(s): A0N0P0
    , B7Z2F3, B7Z702, E7ETN5, E9PC27, Q13655, Q6FHB1, Q6GTS4, Q7M4L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3