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P42081

- CD86_HUMAN

UniProt

P42081 - CD86_HUMAN

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Protein
T-lymphocyte activation antigen CD86
Gene
CD86, CD28LG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

GO - Molecular functioni

  1. coreceptor activity Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. B cell activation Source: Ensembl
  2. Fc-epsilon receptor signaling pathway Source: Reactome
  3. T cell activation Source: UniProtKB
  4. T cell costimulation Source: Reactome
  5. T cell proliferation involved in immune response Source: Ensembl
  6. aging Source: Ensembl
  7. cell-cell signaling Source: UniProtKB
  8. cellular response to cytokine stimulus Source: Ensembl
  9. cellular response to lipopolysaccharide Source: Ensembl
  10. cellular response to metal ion Source: Ensembl
  11. defense response to virus Source: Ensembl
  12. epidermal growth factor receptor signaling pathway Source: Reactome
  13. fibroblast growth factor receptor signaling pathway Source: Reactome
  14. immune response Source: ProtInc
  15. innate immune response Source: Reactome
  16. myeloid dendritic cell differentiation Source: Ensembl
  17. negative regulation of T cell anergy Source: Ensembl
  18. neurotrophin TRK receptor signaling pathway Source: Reactome
  19. phosphatidylinositol-mediated signaling Source: Reactome
  20. positive regulation of T-helper 2 cell differentiation Source: UniProtKB
  21. positive regulation of activated T cell proliferation Source: Ensembl
  22. positive regulation of cell proliferation Source: ProtInc
  23. positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
  24. positive regulation of interleukin-4 biosynthetic process Source: UniProtKB
  25. positive regulation of lymphotoxin A biosynthetic process Source: UniProtKB
  26. positive regulation of transcription, DNA-templated Source: UniProtKB
  27. response to drug Source: Ensembl
  28. response to interferon-gamma Source: Ensembl
  29. response to yeast Source: Ensembl
  30. toll-like receptor signaling pathway Source: Ensembl
  31. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_19183. CD28 co-stimulation.
REACT_19238. CD28 dependent Vav1 pathway.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_19405. CTLA4 inhibitory signaling.
REACT_75829. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-lymphocyte activation antigen CD86
Alternative name(s):
Activation B7-2 antigen
B70
BU63
CTLA-4 counter-receptor B7.2
FUN-1
CD_antigen: CD86
Gene namesi
Name:CD86
Synonyms:CD28LG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1705. CD86.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 247224Extracellular Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST
Topological domaini269 – 32961Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB
  4. intracellular membrane-bounded organelle Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 329306T-lymphocyte activation antigen CD86
PRO_0000014550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi40 ↔ 1101 Publication
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi157 ↔ 218 Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP42081.
PRIDEiP42081.

PTM databases

PhosphoSiteiP42081.

Expressioni

Tissue specificityi

Expressed by activated B-lymphocytes and monocytes.

Gene expression databases

ArrayExpressiP42081.
BgeeiP42081.
CleanExiHS_CD86.
GenevestigatoriP42081.

Organism-specific databases

HPAiCAB004319.

Interactioni

Subunit structurei

Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein Inferred. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTLA4P164102EBI-1030956,EBI-1030991

Protein-protein interaction databases

BioGridi107380. 6 interactions.
DIPiDIP-35606N.
IntActiP42081. 3 interactions.
MINTiMINT-6631610.
STRINGi9606.ENSP00000332049.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316
Beta strandi36 – 394
Helixi50 – 523
Beta strandi53 – 597
Beta strandi64 – 696
Beta strandi76 – 783
Turni80 – 845
Beta strandi85 – 895
Turni90 – 934
Beta strandi94 – 974
Helixi102 – 1043
Beta strandi106 – 11510
Beta strandi117 – 13317

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I85X-ray3.20A/B26-134[»]
1NCNX-ray2.70A/B26-134[»]
ProteinModelPortaliP42081.
SMRiP42081. Positions 26-227.

Miscellaneous databases

EvolutionaryTraceiP42081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 13199Ig-like V-type
Add
BLAST
Domaini150 – 22576Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79621.
HOGENOMiHOG000276893.
HOVERGENiHBG004093.
InParanoidiP42081.
KOiK05413.
OMAiDKGLYQC.
OrthoDBiEOG70PC0G.
PhylomeDBiP42081.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P42081-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL    50
SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL 100
QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN 150
VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS 200
ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT 250
AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 300
IHIPERSDEA QRVFKSSKTS SCDKSDTCF 329
Length:329
Mass (Da):37,682
Last modified:January 11, 2011 - v2
Checksum:iC249DAEEB889D911
GO
Isoform 2 (identifier: P42081-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:323
Mass (Da):37,007
Checksum:iA492C705D89B65B7
GO
Isoform 3 (identifier: P42081-2) [UniParc]FASTAAdd to Basket

Also known as: CD86 deltaEC

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     22-234: Missing.

Show »
Length:110
Mass (Da):12,818
Checksum:i0AE70C853C85F666
GO
Isoform 4 (identifier: P42081-4) [UniParc]FASTAAdd to Basket

Also known as: CD86 deltaTM

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     235-282: Missing.

Show »
Length:275
Mass (Da):31,293
Checksum:i137A523F73708BD5
GO
Isoform 5 (identifier: P42081-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-133: Missing.

Note: No experimental confirmation available.

Show »
Length:217
Mass (Da):24,773
Checksum:i7AF72282EEF8B7CE
GO
Isoform 6 (identifier: P42081-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.

Show »
Length:247
Mass (Da):28,420
Checksum:i60CBC08652F42C26
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701S → N.
Corresponds to variant rs9282642 [ dbSNP | Ensembl ].
VAR_021916
Natural varianti185 – 1851V → I.8 Publications
Corresponds to variant rs2681417 [ dbSNP | Ensembl ].
VAR_055003
Natural varianti310 – 3101A → T.2 Publications
Corresponds to variant rs1129055 [ dbSNP | Ensembl ].
VAR_014650
Natural varianti323 – 3231D → N.
Corresponds to variant rs9282648 [ dbSNP | Ensembl ].
VAR_021917

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 6.
VSP_047220Add
BLAST
Alternative sequencei1 – 66Missing in isoform 2, isoform 3 and isoform 4.
VSP_023124
Alternative sequencei22 – 234213Missing in isoform 3.
VSP_009125Add
BLAST
Alternative sequencei22 – 133112Missing in isoform 5.
VSP_047221Add
BLAST
Alternative sequencei235 – 28248Missing in isoform 4.
VSP_040324Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271K → E in AAA86473. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04343 mRNA. Translation: AAB03814.1.
L25259 mRNA. Translation: AAA58389.1.
CR541844 mRNA. Translation: CAG46642.1.
EF064748 Genomic DNA. Translation: ABK41931.1.
AK294663 mRNA. Translation: BAH11839.1.
AK301237 mRNA. Translation: BAH13438.1.
AK316203 mRNA. Translation: BAH14574.1.
AC068630 Genomic DNA. No translation available.
BC040261 mRNA. Translation: AAH40261.1.
U17722
, U17717, U17718, U17719, U17721 Genomic DNA. Translation: AAA86473.1.
CCDSiCCDS3009.1. [P42081-1]
CCDS43138.1. [P42081-3]
CCDS56272.1. [P42081-5]
CCDS56273.1. [P42081-6]
PIRiA48754.
JC7605.
RefSeqiNP_001193853.1. NM_001206924.1.
NP_001193854.1. NM_001206925.1.
NP_008820.3. NM_006889.4.
NP_787058.4. NM_175862.4.
NP_795711.1. NM_176892.1.
UniGeneiHs.171182.

Genome annotation databases

EnsembliENST00000330540; ENSP00000332049; ENSG00000114013. [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013. [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013. [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013. [P42081-5]
GeneIDi942.
KEGGihsa:942.
UCSCiuc003eet.3. human. [P42081-1]
uc021xcz.1. human. [P42081-4]

Polymorphism databases

DMDMi317373339.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD86 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04343 mRNA. Translation: AAB03814.1 .
L25259 mRNA. Translation: AAA58389.1 .
CR541844 mRNA. Translation: CAG46642.1 .
EF064748 Genomic DNA. Translation: ABK41931.1 .
AK294663 mRNA. Translation: BAH11839.1 .
AK301237 mRNA. Translation: BAH13438.1 .
AK316203 mRNA. Translation: BAH14574.1 .
AC068630 Genomic DNA. No translation available.
BC040261 mRNA. Translation: AAH40261.1 .
U17722
, U17717 , U17718 , U17719 , U17721 Genomic DNA. Translation: AAA86473.1 .
CCDSi CCDS3009.1. [P42081-1 ]
CCDS43138.1. [P42081-3 ]
CCDS56272.1. [P42081-5 ]
CCDS56273.1. [P42081-6 ]
PIRi A48754.
JC7605.
RefSeqi NP_001193853.1. NM_001206924.1.
NP_001193854.1. NM_001206925.1.
NP_008820.3. NM_006889.4.
NP_787058.4. NM_175862.4.
NP_795711.1. NM_176892.1.
UniGenei Hs.171182.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I85 X-ray 3.20 A/B 26-134 [» ]
1NCN X-ray 2.70 A/B 26-134 [» ]
ProteinModelPortali P42081.
SMRi P42081. Positions 26-227.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107380. 6 interactions.
DIPi DIP-35606N.
IntActi P42081. 3 interactions.
MINTi MINT-6631610.
STRINGi 9606.ENSP00000332049.

Chemistry

ChEMBLi CHEMBL2364156.
DrugBanki DB01281. Abatacept.
GuidetoPHARMACOLOGYi 2745.

PTM databases

PhosphoSitei P42081.

Polymorphism databases

DMDMi 317373339.

Proteomic databases

PaxDbi P42081.
PRIDEi P42081.

Protocols and materials databases

DNASUi 942.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330540 ; ENSP00000332049 ; ENSG00000114013 . [P42081-1 ]
ENST00000393627 ; ENSP00000377248 ; ENSG00000114013 . [P42081-3 ]
ENST00000469710 ; ENSP00000418988 ; ENSG00000114013 . [P42081-6 ]
ENST00000493101 ; ENSP00000420230 ; ENSG00000114013 . [P42081-5 ]
GeneIDi 942.
KEGGi hsa:942.
UCSCi uc003eet.3. human. [P42081-1 ]
uc021xcz.1. human. [P42081-4 ]

Organism-specific databases

CTDi 942.
GeneCardsi GC03P121774.
HGNCi HGNC:1705. CD86.
HPAi CAB004319.
MIMi 601020. gene.
neXtProti NX_P42081.
PharmGKBi PA26243.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79621.
HOGENOMi HOG000276893.
HOVERGENi HBG004093.
InParanoidi P42081.
KOi K05413.
OMAi DKGLYQC.
OrthoDBi EOG70PC0G.
PhylomeDBi P42081.
TreeFami TF331083.

Enzyme and pathway databases

Reactomei REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_19183. CD28 co-stimulation.
REACT_19238. CD28 dependent Vav1 pathway.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_19405. CTLA4 inhibitory signaling.
REACT_75829. PIP3 activates AKT signaling.

Miscellaneous databases

EvolutionaryTracei P42081.
GeneWikii CD86.
GenomeRNAii 942.
NextBioi 35500368.
PROi P42081.
SOURCEi Search...

Gene expression databases

ArrayExpressi P42081.
Bgeei P42081.
CleanExi HS_CD86.
Genevestigatori P42081.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-185.
  2. "Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation."
    Freeman G.J., Gribben J.G., Boussiotis V.A., Ng J.W., Restivo V.A. Jr., Lombard L.A., Gray G.S., Nadler L.M.
    Science 262:909-911(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-185.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT ILE-185.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-185.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-185.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANTS ILE-185 AND THR-310.
    Tissue: Brain.
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-185 AND THR-310.
    Tissue: Brain.
  9. "Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)."
    Jellis C.L., Wang S.S., Rennert P., Borriello F., Sharpe A.H., Green N.R., Gray G.S.
    Immunogenetics 42:85-89(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-329, VARIANT ILE-185.
    Tissue: Foreskin.
  10. "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."
    Lanier L.L., O'Fallon S., Somoza C., Phillips J.H., Linsley P.S., Okumura K., Ito D., Azuma M.
    J. Immunol. 154:97-105(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  11. "The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen."
    Engel P., Gribben J.G., Freeman G.J., Zhou L.J., Nozawa Y., Abe M., Nadler L.M., Wakasa H., Tedder T.F.
    Blood 84:1402-1407(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS CD86.
  12. "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."
    Goto E., Ishido S., Sato Y., Ohgimoto S., Ohgimoto K., Nagano-Fujii M., Hotta H.
    J. Biol. Chem. 278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH MARCH8.
  13. "Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."
    Short J.J., Vasu C., Holterman M.J., Curiel D.T., Pereboev A.
    Virus Res. 122:144-153(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADENOVIRUS SUBGROUP B FIBER PROTEINS.
  14. "Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
    Schwartz J.C., Zhang X., Fedorov A.A., Nathenson S.G., Almo S.C.
    Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 26-134 IN COMPLEX WITH CTLA4.
  15. "Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling."
    Zhang X., Schwartz J.C., Almo S.C., Nathenson S.G.
    Proc. Natl. Acad. Sci. U.S.A. 100:2586-2591(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-134, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiCD86_HUMAN
AccessioniPrimary (citable) accession number: P42081
Secondary accession number(s): A0N0P0
, B7Z2F3, B7Z702, E7ETN5, E9PC27, Q13655, Q6FHB1, Q6GTS4, Q7M4L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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