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P42081

- CD86_HUMAN

UniProt

P42081 - CD86_HUMAN

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Protein

T-lymphocyte activation antigen CD86

Gene

CD86

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

GO - Molecular functioni

  1. coreceptor activity Source: UniProtKB
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. aging Source: Ensembl
  2. B cell activation Source: Ensembl
  3. cell-cell signaling Source: UniProtKB
  4. cellular response to cytokine stimulus Source: Ensembl
  5. cellular response to lipopolysaccharide Source: Ensembl
  6. cellular response to metal ion Source: Ensembl
  7. defense response to virus Source: Ensembl
  8. epidermal growth factor receptor signaling pathway Source: Reactome
  9. Fc-epsilon receptor signaling pathway Source: Reactome
  10. fibroblast growth factor receptor signaling pathway Source: Reactome
  11. immune response Source: ProtInc
  12. innate immune response Source: Reactome
  13. myeloid dendritic cell differentiation Source: Ensembl
  14. negative regulation of T cell anergy Source: Ensembl
  15. neurotrophin TRK receptor signaling pathway Source: Reactome
  16. phosphatidylinositol-mediated signaling Source: Reactome
  17. positive regulation of activated T cell proliferation Source: Ensembl
  18. positive regulation of cell proliferation Source: ProtInc
  19. positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
  20. positive regulation of interleukin-4 biosynthetic process Source: UniProtKB
  21. positive regulation of lymphotoxin A biosynthetic process Source: UniProtKB
  22. positive regulation of T-helper 2 cell differentiation Source: UniProtKB
  23. positive regulation of transcription, DNA-templated Source: UniProtKB
  24. response to drug Source: Ensembl
  25. response to interferon-gamma Source: Ensembl
  26. response to yeast Source: Ensembl
  27. T cell activation Source: UniProtKB
  28. T cell costimulation Source: Reactome
  29. T cell proliferation involved in immune response Source: Ensembl
  30. toll-like receptor signaling pathway Source: Ensembl
  31. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_19183. CD28 co-stimulation.
REACT_19238. CD28 dependent Vav1 pathway.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_19405. CTLA4 inhibitory signaling.
REACT_75829. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-lymphocyte activation antigen CD86
Alternative name(s):
Activation B7-2 antigen
B70
BU63
CTLA-4 counter-receptor B7.2
FUN-1
CD_antigen: CD86
Gene namesi
Name:CD86
Synonyms:CD28LG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1705. CD86.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 247224ExtracellularSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST
Topological domaini269 – 32961CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: UniProtKB
  4. integral component of membrane Source: UniProtKB
  5. intracellular membrane-bounded organelle Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 329306T-lymphocyte activation antigen CD86PRO_0000014550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi40 ↔ 1101 PublicationPROSITE-ProRule annotation
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi157 ↔ 218PROSITE-ProRule annotation
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP42081.
PRIDEiP42081.

PTM databases

PhosphoSiteiP42081.

Expressioni

Tissue specificityi

Expressed by activated B-lymphocytes and monocytes.

Gene expression databases

BgeeiP42081.
CleanExiHS_CD86.
ExpressionAtlasiP42081. baseline and differential.
GenevestigatoriP42081.

Organism-specific databases

HPAiCAB004319.

Interactioni

Subunit structurei

Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.4 PublicationsCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
CTLA4P164103EBI-1030956,EBI-1030991

Protein-protein interaction databases

BioGridi107380. 6 interactions.
DIPiDIP-35606N.
IntActiP42081. 4 interactions.
MINTiMINT-6631610.
STRINGi9606.ENSP00000332049.

Structurei

Secondary structure

1
329
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi36 – 394Combined sources
Helixi50 – 523Combined sources
Beta strandi53 – 597Combined sources
Beta strandi64 – 696Combined sources
Beta strandi76 – 783Combined sources
Turni80 – 845Combined sources
Beta strandi85 – 895Combined sources
Turni90 – 934Combined sources
Beta strandi94 – 974Combined sources
Helixi102 – 1043Combined sources
Beta strandi106 – 11510Combined sources
Beta strandi117 – 13317Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I85X-ray3.20A/B26-134[»]
1NCNX-ray2.70A/B26-134[»]
ProteinModelPortaliP42081.
SMRiP42081. Positions 26-227.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 13199Ig-like V-typeAdd
BLAST
Domaini150 – 22576Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79621.
GeneTreeiENSGT00720000108819.
HOGENOMiHOG000276893.
HOVERGENiHBG004093.
InParanoidiP42081.
KOiK05413.
OMAiDKGLYQC.
OrthoDBiEOG70PC0G.
PhylomeDBiP42081.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P42081-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL
60 70 80 90 100
SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL
110 120 130 140 150
QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN
160 170 180 190 200
VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS
210 220 230 240 250
ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT
260 270 280 290 300
AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK
310 320
IHIPERSDEA QRVFKSSKTS SCDKSDTCF
Length:329
Mass (Da):37,682
Last modified:January 11, 2011 - v2
Checksum:iC249DAEEB889D911
GO
Isoform 2 (identifier: P42081-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:323
Mass (Da):37,007
Checksum:iA492C705D89B65B7
GO
Isoform 3 (identifier: P42081-2) [UniParc]FASTAAdd to Basket

Also known as: CD86 deltaEC

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     22-234: Missing.

Show »
Length:110
Mass (Da):12,818
Checksum:i0AE70C853C85F666
GO
Isoform 4 (identifier: P42081-4) [UniParc]FASTAAdd to Basket

Also known as: CD86 deltaTM

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     235-282: Missing.

Show »
Length:275
Mass (Da):31,293
Checksum:i137A523F73708BD5
GO
Isoform 5 (identifier: P42081-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-133: Missing.

Note: No experimental confirmation available.

Show »
Length:217
Mass (Da):24,773
Checksum:i7AF72282EEF8B7CE
GO
Isoform 6 (identifier: P42081-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.

Show »
Length:247
Mass (Da):28,420
Checksum:i60CBC08652F42C26
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271K → E in AAA86473. (PubMed:7541777)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701S → N.
Corresponds to variant rs9282642 [ dbSNP | Ensembl ].
VAR_021916
Natural varianti185 – 1851V → I.8 Publications
Corresponds to variant rs2681417 [ dbSNP | Ensembl ].
VAR_055003
Natural varianti310 – 3101A → T.2 Publications
Corresponds to variant rs1129055 [ dbSNP | Ensembl ].
VAR_014650
Natural varianti323 – 3231D → N.
Corresponds to variant rs9282648 [ dbSNP | Ensembl ].
VAR_021917

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 6. CuratedVSP_047220Add
BLAST
Alternative sequencei1 – 66Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_023124
Alternative sequencei22 – 234213Missing in isoform 3. 1 PublicationVSP_009125Add
BLAST
Alternative sequencei22 – 133112Missing in isoform 5. 1 PublicationVSP_047221Add
BLAST
Alternative sequencei235 – 28248Missing in isoform 4. 1 PublicationVSP_040324Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04343 mRNA. Translation: AAB03814.1.
L25259 mRNA. Translation: AAA58389.1.
CR541844 mRNA. Translation: CAG46642.1.
EF064748 Genomic DNA. Translation: ABK41931.1.
AK294663 mRNA. Translation: BAH11839.1.
AK301237 mRNA. Translation: BAH13438.1.
AK316203 mRNA. Translation: BAH14574.1.
AC068630 Genomic DNA. No translation available.
BC040261 mRNA. Translation: AAH40261.1.
U17722
, U17717, U17718, U17719, U17721 Genomic DNA. Translation: AAA86473.1.
CCDSiCCDS3009.1. [P42081-1]
CCDS43138.1. [P42081-3]
CCDS56272.1. [P42081-5]
CCDS56273.1. [P42081-6]
CCDS74991.1. [P42081-4]
PIRiA48754.
JC7605.
RefSeqiNP_001193853.1. NM_001206924.1.
NP_001193854.1. NM_001206925.1.
NP_008820.3. NM_006889.4.
NP_787058.4. NM_175862.4.
NP_795711.1. NM_176892.1.
UniGeneiHs.171182.

Genome annotation databases

EnsembliENST00000264468; ENSP00000264468; ENSG00000114013. [P42081-4]
ENST00000330540; ENSP00000332049; ENSG00000114013. [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013. [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013. [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013. [P42081-5]
GeneIDi942.
KEGGihsa:942.
UCSCiuc003eet.3. human. [P42081-1]
uc021xcz.1. human. [P42081-4]

Polymorphism databases

DMDMi317373339.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD86 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04343 mRNA. Translation: AAB03814.1 .
L25259 mRNA. Translation: AAA58389.1 .
CR541844 mRNA. Translation: CAG46642.1 .
EF064748 Genomic DNA. Translation: ABK41931.1 .
AK294663 mRNA. Translation: BAH11839.1 .
AK301237 mRNA. Translation: BAH13438.1 .
AK316203 mRNA. Translation: BAH14574.1 .
AC068630 Genomic DNA. No translation available.
BC040261 mRNA. Translation: AAH40261.1 .
U17722
, U17717 , U17718 , U17719 , U17721 Genomic DNA. Translation: AAA86473.1 .
CCDSi CCDS3009.1. [P42081-1 ]
CCDS43138.1. [P42081-3 ]
CCDS56272.1. [P42081-5 ]
CCDS56273.1. [P42081-6 ]
CCDS74991.1. [P42081-4 ]
PIRi A48754.
JC7605.
RefSeqi NP_001193853.1. NM_001206924.1.
NP_001193854.1. NM_001206925.1.
NP_008820.3. NM_006889.4.
NP_787058.4. NM_175862.4.
NP_795711.1. NM_176892.1.
UniGenei Hs.171182.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I85 X-ray 3.20 A/B 26-134 [» ]
1NCN X-ray 2.70 A/B 26-134 [» ]
ProteinModelPortali P42081.
SMRi P42081. Positions 26-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107380. 6 interactions.
DIPi DIP-35606N.
IntActi P42081. 4 interactions.
MINTi MINT-6631610.
STRINGi 9606.ENSP00000332049.

Chemistry

ChEMBLi CHEMBL2364156.
DrugBanki DB01281. Abatacept.
DB00098. Antithymocyte globulin.
DB06681. Belatacept.
GuidetoPHARMACOLOGYi 2745.

PTM databases

PhosphoSitei P42081.

Polymorphism databases

DMDMi 317373339.

Proteomic databases

PaxDbi P42081.
PRIDEi P42081.

Protocols and materials databases

DNASUi 942.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264468 ; ENSP00000264468 ; ENSG00000114013 . [P42081-4 ]
ENST00000330540 ; ENSP00000332049 ; ENSG00000114013 . [P42081-1 ]
ENST00000393627 ; ENSP00000377248 ; ENSG00000114013 . [P42081-3 ]
ENST00000469710 ; ENSP00000418988 ; ENSG00000114013 . [P42081-6 ]
ENST00000493101 ; ENSP00000420230 ; ENSG00000114013 . [P42081-5 ]
GeneIDi 942.
KEGGi hsa:942.
UCSCi uc003eet.3. human. [P42081-1 ]
uc021xcz.1. human. [P42081-4 ]

Organism-specific databases

CTDi 942.
GeneCardsi GC03P121774.
HGNCi HGNC:1705. CD86.
HPAi CAB004319.
MIMi 601020. gene.
neXtProti NX_P42081.
PharmGKBi PA26243.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79621.
GeneTreei ENSGT00720000108819.
HOGENOMi HOG000276893.
HOVERGENi HBG004093.
InParanoidi P42081.
KOi K05413.
OMAi DKGLYQC.
OrthoDBi EOG70PC0G.
PhylomeDBi P42081.
TreeFami TF331083.

Enzyme and pathway databases

Reactomei REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_19183. CD28 co-stimulation.
REACT_19238. CD28 dependent Vav1 pathway.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_19405. CTLA4 inhibitory signaling.
REACT_75829. PIP3 activates AKT signaling.

Miscellaneous databases

ChiTaRSi CD86. human.
EvolutionaryTracei P42081.
GeneWikii CD86.
GenomeRNAii 942.
NextBioi 35500368.
PROi P42081.
SOURCEi Search...

Gene expression databases

Bgeei P42081.
CleanExi HS_CD86.
ExpressionAtlasi P42081. baseline and differential.
Genevestigatori P42081.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-185.
  2. "Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation."
    Freeman G.J., Gribben J.G., Boussiotis V.A., Ng J.W., Restivo V.A. Jr., Lombard L.A., Gray G.S., Nadler L.M.
    Science 262:909-911(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-185.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT ILE-185.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-185.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-185.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANTS ILE-185 AND THR-310.
    Tissue: Brain.
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-185 AND THR-310.
    Tissue: Brain.
  9. "Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)."
    Jellis C.L., Wang S.S., Rennert P., Borriello F., Sharpe A.H., Green N.R., Gray G.S.
    Immunogenetics 42:85-89(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-329, VARIANT ILE-185.
    Tissue: Foreskin.
  10. "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."
    Lanier L.L., O'Fallon S., Somoza C., Phillips J.H., Linsley P.S., Okumura K., Ito D., Azuma M.
    J. Immunol. 154:97-105(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  11. "The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen."
    Engel P., Gribben J.G., Freeman G.J., Zhou L.J., Nozawa Y., Abe M., Nadler L.M., Wakasa H., Tedder T.F.
    Blood 84:1402-1407(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS CD86.
  12. "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."
    Goto E., Ishido S., Sato Y., Ohgimoto S., Ohgimoto K., Nagano-Fujii M., Hotta H.
    J. Biol. Chem. 278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH MARCH8.
  13. "Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."
    Short J.J., Vasu C., Holterman M.J., Curiel D.T., Pereboev A.
    Virus Res. 122:144-153(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADENOVIRUS SUBGROUP B FIBER PROTEINS.
  14. "Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
    Schwartz J.C., Zhang X., Fedorov A.A., Nathenson S.G., Almo S.C.
    Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 26-134 IN COMPLEX WITH CTLA4.
  15. "Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling."
    Zhang X., Schwartz J.C., Almo S.C., Nathenson S.G.
    Proc. Natl. Acad. Sci. U.S.A. 100:2586-2591(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-134, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiCD86_HUMAN
AccessioniPrimary (citable) accession number: P42081
Secondary accession number(s): A0N0P0
, B7Z2F3, B7Z702, E7ETN5, E9PC27, Q13655, Q6FHB1, Q6GTS4, Q7M4L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

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    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3